Abstract: Novel inhibitors of MetAp2 enzymatic activity and uses thereof are provided.

Abstract: The method of manufacturing a copper foil with a high elongation rate includes: preparing a plating solution by mixing a copper ion, an additive for improving conductivity, a plating inhibitor, and a plating accelerator; and manufacturing the copper foil by immersing a substrate in the plating solution and applying an electric current to the plating solution to electroplate the copper foil on a surface of the substrate.

Abstract: A transmitter system includes a mapper that maps data bits and power information to N subcarriers. A first-level modulator converts the mapped information of subcarriers into subcarrier specifications, defining their amplitude and phase (or real and imaginary amplitudes). An orthogonal subcarrier generator, for example an IFFT, calculates N successive values of baseband real and imaginary signals. A second-level modulator multiplies the baseband signals with in-phase and quadrature intermediate frequency (IF) components to generate an orthogonal IF signal. A single-sideband (SSB) prep unit may remove the lower or upper sideband. A beam former modifies the phase and/or the amplitude of the orthogonal IF signal for transmission through multiple sub-antennas in a phased array antenna.

Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

Abstract: An apparatus for treating clubfoot is provided that includes a pair of vertically stacked and parallel cross bars that are connected to shoe attachment member via four hinges to define a parallelogram shaped gap therebetween. As the user raises a knee, one shoe attachment member can be displaced via the hinges (primarily in the y-axis or anterior/superior plane) relative to the other shoe attachment member, while the distance between the crossbars remains constant.

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Abstract: Apparatus comprising: a fumehood; and an air treatment device for purging unwanted substances from the exhaust air of the fumehood, the air treatment device comprising: a non-thermal plasma reactor stage for producing air byproducts comprising O?, N?, OH? and O3 and introducing those air byproducts into the exhaust air of the fumehood so as to treat the exhaust air of the fumehood; and a catalyst stage downstream of the non-thermal plasma reactor stage for further treating the air downstream of the non-thermal plasma reactor stage.

Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: Provided is a monorail independent dual-slider synchronous belt sliding table module component with a compact structure, which includes a sliding table base module, a sliding table module, a first driving end module and a second driving end module. A first slide rail and a second slide rail are spaced from each other to form a transmission groove. A first slider is provided with a first transmission part corresponding to the transmission groove, a second slider is convexly provided with a second transmission part corresponding to the transmission groove, and the second transmission part is provided with an avoidance part which is in a same horizontal plane as the first transmission part. A first synchronous belt is arranged in an extension direction of the transmission groove, is in transmission connection with the first transmission part after passing through the avoidance part, and is sleeved outside the second synchronous belt.

Abstract: Described herein are novel ?- and ?-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.

Abstract: A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest is disclosed. Use of the composition and methods of generating same are also disclosed.

Abstract: Methods of transferring a metallic film to a flexible substrate using a roll-to-roll nanoforming assembly include transferring the metallic film to a nanomold such that a metal layer of the metallic film contacts the nanomold and an ablative layer of the metallic film contacts a confinement layer during continuous motion of the metallic film relative to the confinement layer. Further, the method includes directing a laser beam through the confinement layer onto the ablative layer of the metallic film to form a nanoformed metal from the metallic film as the metallic film moves relative to the confinement layer and the laser generator, and transferring the nanoformed metal onto the flexible substrate.

Abstract: In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle.

Abstract: The present application is direction to a system and method for preparing filter media from macro and nanofibers by ventilating a nanofiber media, combining the nanofiber media with macro fibers to form a hybrid media, inserting the hybrid media between a stitching plate and a stripper plate and alternatively inserting and withdrawing needles to combine the macro fibers with the nanofiber media and create a fiber web along at least one surface of the nanofiber media.

Abstract: A DNA expression construct comprising a polynucleotide encoding an unnatural UstD enzyme, the unnatural enzyme itself, and a method of making gamma-hydroxy amino acids by contacting an aldehyde-containing substrate, an amino acid, and the unnatural, purified UstD enzyme under conditions and for a time sufficient to react at least a portion of the aldehyde-containing substrate with at least a portion of the amino acid, to yield a gamma-hydroxy amino acid product.

Abstract: Solids dissolution may be promoted using a solvent blend comprising a disulfide solvent, particularly additional solids present in combination with elemental sulfur deposits. The solvent blends may comprise at least one disulfide solvent, at least one amine solvent, at least one ketone solvent, at least one ester solvent, and optionally water. Solids dissolution methods may comprise: identifying one or more solids in addition to elemental sulfur to be contacted by the solvent blend; adjusting a composition of the solvent blend to afford selectivity for dissolution of at least a portion of the one or more solids; and contacting the solvent blend with elemental sulfur and the one or more solids to promote at least partial dissolution thereof.

Abstract: Provided is a method performed by a system for distribution storage of blockchain transaction data based on an erasure code. The method includes performing RS encoding on a predetermined number of blockchain transaction original data; and after the RS encoding is performed, applying LRC encoding technique to blockchain transaction original data (LRC-encoded original data), which needs to be accessed high speed, among the RS-encoded transaction original data to encode and store the LRC-encoded original data, and repairing the LRC-encoded original data through decoding.

Abstract: A method and an apparatus for manufacturing a silicon carbide single crystal, and a silicon carbide single crystal ingot, obtaining a silicon carbide single crystal reduced in defects such as threading dislocations, are provided. The method manufactures a silicon carbide single crystal by supplying a raw material gas into a reaction vessel with a seed substrate, and heats the interior to grow a silicon carbide single crystal on the surface of the seed substrate. The method includes growing the silicon carbide single crystal on the seed substrate surface, while controlling the temperature, to perform pair annihilation of threading dislocations or synthesis of the threading dislocations; and a second step of maintaining the temperature inside the reaction vessel in the state of the first predetermined temperature after execution of the first step, to bring the leading ends of the threading dislocations close to the surface of the seed substrate.

Abstract: The present invention relates to a substrate for nucleic acid amplification, and a method for manufacturing same, the substrate for rapid and accurate PCR analysis comprising: a transparent substrate; a metal layer formed on the transparent substrate; an N-heterocyclic carbene compound having one end annealed to the surface of the metal layer; and a primer immobilized on the other end of the N-heterocyclic carbene compound.

Abstract: The present disclosure discloses a system and a method for controlling an operation of a machine according to a task. The method comprises formulating an original quadratic program (QP) for optimizing an objective function subject to equality constraints and inequality constraints, lifting the equality constraints and the inequality constraints into a lifted space by a lifting operation introducing an additional non-negative variable, and transforming the objective function of the original QP into a quadratic objective function. The quadratic objective function subject to the lifted equality and inequality constraints forms a homogeneous QP in the lifted space. The method further comprises solving the homogeneous QP to produce a solution in the lifted space and controlling the machine according to an infeasibility protocol when a value of the additional non-negative variable in the solution in the lifted space equals zero.