Abstract: The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.

Abstract: A spectral imaging device includes an imager, a scanning stage to establish relative motion between the imager and a sample in a scanning direction and an optical system controlling a light characteristic of a light beam constituting an image of the sample to the imager. The optical system includes a light varying element to receive the light beam and provide an output light beam with spatially varying light characteristic over a cross-section thereof. A set of redirecting optical elements direct light rays from the sample to form the light beam, and to focus the output light beam onto the imager. A controller controls the scanning stage and the imager to capture a plurality of image frames with an overlap including a defined shift that is greater than 1 pixel along the scanning direction between consecutive image frames. A computing device consolidates image data to provide an image of the sample.

Abstract: The present disclosure relates to a positive electrode additive for a lithium secondary battery, a manufacturing method thereof. The positive electrode additive for a lithium secondary battery is represented by Chemical Formula 1 below. Li6xCo1-yMyO4??[Chemical Formula 1] (In the Chemical Formula 1, 0.9?x?1.1, 0<y?0.1, My=BaWb, 0?a?0.1, 0?b?0.1, and, a and b are not simultaneously 0.) Another positive electrode additive for a lithium secondary battery includes a core represented by Chemical Formula 2 below; and a coating layer comprising at least one of boron (B) and tungsten (W). Li6xCoO4??[Chemical Formula 2] (In the Chemical Formula 2, 0.9?x?1.1.

Abstract: The present invention provides antibody compounds that contain a substitution of arginine for the reactive lysine residue (Lys99) in the hydrophobic cleft (38C2_Arg). The invention also provides antibody drug conjugate compounds (ADCs) that contain cargo moieties that are site-specifically conjugated to the engineered arginine residue in the 38C2_Arg variant antibody. Further provided in the invention are therapeutic applications of the compounds.

Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.

Abstract: Approaches, techniques, and mechanisms are disclosed for packaging electric power components. A power module comprises: a three-dimensional (3D) cooling structure that has a plurality of planar sides; a first set of mountable power components that are mounted on a first planar side in the plurality of planar sides of the 3D cooling structure; a second set of mountable power components that are mounted on a second planar side in the plurality of planar sides of the 3D cooling structure. The second planar side represents an opposing side, of the 3D cooling structure, to the first planar side. The 3D cooling structure includes an interior space containing one or more cooling channels in which cooling fluid is to flow. The interior space of the 3D cooling structure is spatially surrounded by other planar sides in the plurality of planar sides in combination with the first and second planar sides.

Abstract: A supported catalyst has a support and a metal active component disposed on the support. The metal active component is at least one selected from the group consisting of a Group VIB metal element and a Group VIII metal element. The support contains at least one of heat-resistant inorganic oxides and molecular sieves and includes an internal channel penetrating the support. The ratio of the cross-section area of the channel to the cross-section area of the support is 0.05-3:100. The difference R between the water absorption rate and the BET pore volume of the support is not less than 0.2 mL/g. The supported catalyst can be used as a hydrogenation catalyst. When used in the hydrocracking of hydrocarbon oils, it can achieve high catalytic activity and high yield of jet fuels at the same time. The supported catalyst can also be used as a Fischer-Tropsch synthesis catalyst.

Abstract: A method for verifying a set of computer-executable instructions using at least one failing test generated by a test-case generator is disclosed herein. The method comprises verifying the set of computer-executable instructions by a verification module using a plurality of predefined verification conditions; determining if the verification is successful; in response to successful verification, label the set of computer-executable instructions as successful; and in response to unsuccessful verification, generate at least one counterexample, with respect to a proof failure and corresponding to at least one failed verification condition of the plurality of the predefined verification conditions, and generate a failing test, by a test-case generator, based on at least one counterexample. A program verification tool for testing the set of computer-executable instructions is also disclosed.

Abstract: Disclosed systems and techniques are directed to efficient integrity monitoring of computational operations using multiple memory arrays collectively representative of known events associated with the computational operations. Disclosed techniques include obtaining event identification value representative of a state of the computing device associated with execution of an operation on the computing device, obtaining memory pointers and selecting, based on the memory pointers, mapping values from multiple memory arrays, computing an event response value, and classifying the operation among a plurality of classes, based on the event response value.

Abstract: Radial-armed thin-film bilayers are designed and fabricated from a metal and an oxide to produce grippers that interact with the yarns or fibers of the fabric and form a mechanical tangle attachment to the fabric. MEMs devices attached to the grippers enable the MEMs devices to be adhered to a flexible and/or extensible fabric. Fabrics comprise conventional textile, smart textiles, functional fibers or other smart materials. The fabrics thus incorporate wearable sensors, medical devices, and other functional MEMs for commercial, biomedical, industrial and scientific applications.

Abstract: A steering wheel-based HMI system for a vehicle includes a steer-by-wire system and a control module. The steer-by-wire system includes a steering wheel and a torque feedback unit mechanically connected to the steering wheel. The control module is communicatively connected to the torque feedback unit. The control module is configured to identify a communication, gather information about user securement of the steering wheel, and operate the torque feedback unit to apply a supplementary torque to the steering wheel for haptically issuing the communication through the steering wheel. The supplementary torque has a magnitude that is scaled based on the information about user securement of the steering wheel.

Abstract: A preparation method for a tungsten sulfide (WS2) solid lubricating film based on high power impulse magnetron sputtering (HiPIMS) is provided. The preparation method includes the following steps: step 1: depositing a metal conductive film on a surface of a WS2 target; step 2: using magnetic field sputtering to remove the metal conductive film in a target sputtering area on the surface of the WS2 target, thereby obtaining a first WS2 target; and step 3: performing the HiPIMS on the first WS2 target to obtain the WS2 solid lubricating film. The preparation method can achieve stable glow discharge of a WS2 target and use the high deposition energy of HiPIMS to prepare the WS2 solid lubricating film with high compactness and excellent wear resistance.

Abstract: One or more techniques and/or systems are disclosed for a harvester vehicle that includes a crop processing system comprising at least an accumulator and a round module builder. The harvester vehicle has a feedback fusion system that operably provides crop processing data indicative of an estimated accumulator fill level to a crop feed rate control system. The feedback fusion system has a plurality of feedback devices that operably provide feedback signals including data indicative of two or more of: crop mass flow, module builder status, module size, and accumulator fill level. The feedback fusion system has a control module that operably receives the feedback signals and generates an accumulator fill level signal based at least upon two or more of the feedback signals. The accumulator fill level signal is indicative of the estimated fill level in the accumulator.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: A method comprising identifying a content item having stated facts and/or opinions which a user is unsure whether to trust; during a first time period, obtaining first content evaluations of the content item from first users, each first content evaluation evaluating a belief state of the stated facts and/or opinions; displaying the first content evaluations; during a second time period initiating later than the first time period, obtaining second evaluations from second users regardless of second user expertise, the second users defined as having hindsight and thus knowledge as to the belief state of the stated facts and/or opinions greater than the first users; generating and issuing expert scores for the first users based on the second evaluations; and elevating an influential characteristic of each first user having an expert score higher than a certain threshold when providing another evaluation during another time period.

Abstract: A fiber-optic storage tray is disclosed, comprising a fiber splicing portion; wherein the fiber splicing portion is configured to retain a plurality of optical fiber splices, such that adjacent optical fiber splices are offset with respect to one another in the direction of the depth of the tray and the adjacent optical fiber splices are also offset with respect to one another in the direction of their length.

Abstract: The invention relates to an isolated polypeptide encoded by Sghrt and related uses. In addition, methods of assessing a heart function, treating impaired heart function by inhibiting Sghrt, identifying a potential drug for treating impaired heart function, and dedifferentiating and/or proliferating a heart cell by inhibiting Sghrt are claimed.

Abstract: The present application relates to boron nitride nanotube (BNNT)-nanoparticle composites, to methods of preparing such composites and their use, for example, in metal/ceramic matrix composites and/or macroscopic assemblies. For example, the methods comprise subjecting a source of hydrogen, a source of boron, a source of nitrogen and a nanoparticle precursor to a stable induction thermal plasma and cooling the reaction mixture to obtain the composite.

Abstract: Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.

Abstract: A method for depth estimation performed by a depth estimation system associated with an agent includes determining a first depth of a first image and a second depth of a second image, the first image and the second image being captured by a sensor associated with the agent. The method also includes generating a first 3D image of the first image based on the first depth, a first pose associated with the sensor, and the second image. The method further includes generating a warped depth image based on transforming the first depth in accordance with the first pose. The method also includes updating the first pose based on a second pose associated with the warped depth image and the second depth, and updating the first 3D image based on the updated first pose. The method further includes controlling an action of the agent based on the updated first 3D image.