Abstract: A method for diagnosing follicular thyroid carcinoma is described. The method measures protein expression levels of an aminoacyl-tRNA synthetase (ARS) or an aminoacyl-tRNA synthetase complex-interacting multifunctional protein (AIMP) in a sample, such as a thyroid tissue sample, from a subject suspected of having follicular thyroid carcinoma. The protein expression levels of ARS or AIMP are compared to the measured protein expression levels in a control.

Abstract: A method comprising obtaining, from a master user, a device usage allocation applicable to two or more devices, the two or more devices being associated with another user, the another user being different from the master user, obtaining an aggregate measure of device usage associated with the two or more devices, if the aggregate measure of device usage associated with the two or more devices satisfies a condition relative to the device usage allocation, managing an activity of the two or more devices, and sending a notification to at least one of the two or more devices, the notification for presentation to the another user through a user interface of the at least one of the two or more devices.

Abstract: Switchable adhesion devices, systems and methods are provided. A switchable adhesion component includes a switchable body. At least one portion of the body is adapted to carry an adhesive layer and another portion a load. At least a portion of the body is switchable between one or more varying states without imparting change to the surface chemistries or area at the adhesive joint.

Abstract: A culture system comprises: a preparatory culture vessel and a main culture vessel that accommodate cells and a solution; a main stage that holds the preparatory culture vessel and the main culture vessel; a connecting tube that connects the culture vessels; a valve that opens and closes the connecting tube; and a rotating mechanism that rotates the main stage and imparts a height difference between the culture vessels to transfer the cells and solution by dropping between the culture vessels.

Abstract: A chimeric protein having deubiquitinase activity, methods of identifying anti-deubiquitinase compounds using chimeric proteins, and kits comprising chimeric proteins are described herein. In one aspect, a chimeric protein comprises a mammalian deubiquitinase catalytic domain, a linker domain, and a non-human deubiquitinase proteasome binding domain. In another aspect, a method of identifying a compound having deubiquitinase inhibition activity comprises a) providing an assay for identifying a compound having deubiquitinase inhibition activity, wherein the assay comprises one or more biological cells comprising a chimeric protein comprising a mammalian deubiquitinase catalytic domain, a linker domain, and a non-human deubiquitinase proteasome binding domain; b) screening the assay with at least one compound; and c) identifying a compound having deubiquitinase inhibition activity based on survival of the biological cell.

Abstract: A preparation method of separation membrane is provided. First, a polyimide composition including a dissolvable polyimide, a crosslinking agent and a solvent is provided. The dissolvable polyimide is represented by formula 1: wherein B is a tetravalent organic group derived from a tetracarboxylic dianhydride containing aromatic group, A is a divalent organic group derived from a diamine containing aromatic group, A? is a divalent organic group derived from a diamine containing aromatic group and carboxylic acid group, and 0.1?X?0.9. The crosslinking agent is an aziridine crosslinking agent, an isocyanate crosslinking agent, an epoxy crosslinking agent, a diamine crosslinking agent, or a triamine crosslinking agent. A crosslinking process is performed on the polyimide composition. The polyimide composition which has been subjected to the crosslinking process is coated on a substrate to form a polyimide membrane. A wet phase inversion process is performed on the polyimide membrane.

Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A system for monitoring a user of a firearm generally includes an inertial measurement unit configured to be disposed inside a grip of the firearm for measuring motion of the firearm. The system also includes an event detection system for detecting a detected event that includes at least one of gripping of the firearm, raising of the firearm, aiming of the firearm, and discharging of the firearm based on the motion of the firearm measured by the inertial measurement unit. The system further includes a communication system for wirelessly communicating the detected event.

Abstract: Provided is a method for automatically generating a search heuristic that is optimal for a test subject program and a method of concolic testing that uses a parameterized search heuristic to yield a consistent test performance for any program.

Abstract: A computing system framework and method for configuration thereof are provided. A plurality of processing modules is accessed. Each processing module includes a plurality of processing nodes and each processing node is associated with an intramodule port and an intermodule port. The processing modules are connected in a ring via intermodule connections between at least a portion of the intermodule ports of the processing modules. A network switch is arranged in a center of the ring of processing modules and connections are formed between the network switch and at least one of the processing modules by connecting every Sth processing module to the network switch, connecting every Sth and Sth?1 processing modules to the network switch, or by connecting every Sth and Sth?r processing modules to the network switch. S is a number of steps between the processing modules.

Abstract: The present disclosure provides a device and method for powder distribution and an additive manufacturing method, wherein different size or kind of powders could be chosen to be accommodated within a receptacle. The receptacle can uniformly mix the powder by a rotation movement, pour out the powders by the rotation movement and distribute the powders for forming a layer by a translation movement. In another embodiment, the receptacle further comprises a heating element for preheating the powders. Not only can the present disclosure uniformly mix the powders so as to reduce the thermal deformation and distribute the powder layer compactly, but also can the present disclosure distribute different kinds of powder in different layer so as to increase the diversity in additive manufacturing.

Abstract: An apparatus for processing wafer-shaped articles comprises a rotary chuck and a heating assembly that faces a wafer-shaped article when positioned on the rotary chuck. A liquid dispenser positioned so as to dispense liquid onto a surface of a wafer-shaped article that faces away from the rotary chuck when positioned on the rotary chuck. The heating assembly comprises an array of radiant heating elements distributed among at least five individually controllable groups. The liquid dispenser comprises one or more dispensing orifices configured to move a discharge point from a more central region of the rotary chuck to a more peripheral region of the rotary chuck. A controller controls power supplied to each of the at least five individually controllable groups of radiant heating elements based on a position of the discharge point of the liquid dispenser.

Abstract: New exemplary heat exchange configurations that incorporate internal or external surfaces equipped with perturbators, for changing the thermal behavior of the system, or for modulating the surface temperature distribution of the flow surfaces. This is achieved by applying an acoustic wave to the fluid flow in a heat exchange passage, and selecting the frequency of the acoustic exciting wave to be the same as the acoustic resonance frequency of the heat exchange passage itself. As the traveling waves interact with the boundaries confining the heat exchange passages, constructive interference of the incident and reflected waves give rise to a standing wave. Thus, the heat exchange passages act as a resonator, and by superimposing this standing wave on the separating and reattaching fluid flow, significant heat transfer improvement can be achieved. This is accomplished without the need to significantly increase the pressure required to achieve the desired through flow.

Abstract: A method of forming a thermal insulation porous film includes mixing 100 parts by weight of polysilsesquioxane-containing polymer, 20 to 75 parts by weight of surfactant, and 20 to 2000 parts by weight of solvent to form a thermal insulation coating material, wherein the polysilsesquioxane-containing polymer in the thermal insulation coating material is tube-shaped or sheet-shaped. The thermal insulation coating material is coated on a substrate, and then dried and sintered to form a thermal insulation porous film.

Abstract: In various aspects, systems and methods are provided for operating a molten carbonate fuel cell, such as a fuel cell assembly, with increased production of syngas while also reducing or minimizing the amount of CO2 exiting the fuel cell in the cathode exhaust stream. This can allow for improved efficiency of syngas production while also generating electrical power.

Abstract: The present invention provides a self-positioning system of a deepwater underwater robot of an irregular dam surface of a reservoir, including cross reflection metal plates arranged on the irregular dam surface, and an underwater robot provided with a control motherboard, a water level indicator and a sonar system, wherein the water level indicator and the sonar system are respectively connected with the control motherboard, and the control motherboard is connected with a computer via a cable. The cross reflection metal plate has known coordinates and has four quadrants. A sonar signal emitted by the sonar system is reflected by the cross reflection metal plate to generate sonar reflection signals of four quadrants, and the sonar signals in the effective quadrants correspond to known coordinate parameters of the cross reflection metal plate so as to obtain the horizontal distance between the underwater robot and the irregular dam surface.

Abstract: Semiconductor device and fabrication method are provided.

Abstract: Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.

Abstract: A low-noise wide band amplifier is realized utilizing a superconductor-insulator-superconductor (SIS) junction, quasiparticle frequency mixers connected in tandem or in cascade, a first quasiparticle mixer performs first frequency mixing with use of a first local signal having a frequency not less than twice a frequency of an input signal to the first quasiparticle mixer, a second quasiparticle mixer performs second frequency mixing with use of a second local signal having a frequency not more than twice a frequency of an input signal to the second quasiparticle mixer, and signal amplification is performed through frequency conversion by extracting, from among a plurality of signals generated with the first and the second frequency mixing, a signal in a frequency band not more than a frequency band of the signal before the first frequency mixing and the second frequency mixing, using a transmission line or a filter.

Abstract: Novel compositions of recombinant human CC10 protein have been generated by chemically modifying the pure protein in vitro. Several new synthetic preparations containing isoforms of chemically modified rhCC10 have been generated by processes that utilize reactive oxygen species and reactive nitrogen species. These preparations contain novel isoforms of rhCC10 which have been characterized with enhanced or altered biological properties compared to the unmodified protein. Preparations containing novel isoforms may be used as standards to identify and characterize naturally occurring isoforms of native CC10 protein from blood or urine and ultimately to measure new CC10-based biomarkers to assess patient disease status. These preparations may also be used to treat respiratory, autoimmune, inflammatory, and other medical conditions that are not effectively treated with the unmodified protein.