Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention relates to a method for converting heavy oil by means of high dispersion of asphaltenes, comprising the steps of: preparing a mixture by mixing an amphiphilic additive and the heavy oil; and performing a hydrogenation reaction on the mixture, wherein the amphiphilic additive comprises both a polar group and a nonpolar group.

Abstract: Disclosed are compositions and methods for measuring tyrosine kinase activity using degradation resistant biosensors comprising a reporter sequence, a target sequence, and a transduction sequence. In certain embodiments, the invention includes a biosensor comprising a peptide comprising a reporter sequence, i.e., an amino acid sequence including a tyrosine residue that can be phosphorylated by a tyrosine kinase. In certain embodiments, a biosensor comprises a reporter sequence configured to resist degradation from proteases, a targeting sequence coupled to the reporter sequence and configured to bind to a protein interaction domain of a kinase, and a transduction sequence coupled to the targeting sequence.

Abstract: A gray control rod having a neutron absorber comprising terbium and dysprosium is provided. The neutron absorber comprises at least one first component and at least one second component, the reactivity worth of the first component increases as the service time of the neutron absorber increases, the reactivity worth of the second component decreases as the service time of the neutron absorber increases; the reactivity worth of the neutron absorber varying no more than 15% within the service time of the neutron absorber. By using the first component and the second component to form the neutron absorber, and adjusting the proportion of the respective components in the neutron absorber, the neutron absorber having a substantially planar reactivity worth loss characteristic can be obtained. The gray control rod and the assembly having required reactivity controlling ability can be obtained by increasing or decreasing the material dosage of the neutron absorber.

Abstract: The present research relates to controlling rendering of multi-object or multi-channel audio signals. The present research provides a method and apparatus for controlling rendering of multi-object or multi-channel audio signals based on spatial cues in a process of decoding the multi-object or multi-channel audio signals. To achieve the purpose, the method suggested in the research controls rendering in a spatial cue domain in the process of decoding the multi-object or multi-channel audio signals.

Abstract: A vertical field-effect transistor is provided, comprising a first electrode, a porous conductor layer formed from a layer of conductive material with a plurality of holes extending through the conductive material disposed therein, a dielectric layer between the first electrode and the porous conductor layer, a charge transport layer in contact with the porous conductor layer, and a second electrode electrically connected to the charge transport layer. A photoactive layer may be provided between the dielectric layer and the first electrode. A method of manufacturing a vertical field-effect transistor may also be provided, comprising forming a dielectric layer and depositing a conductor layer in contact with the dielectric layer, wherein one or more regions of the dielectric layer are masked during deposition such that the conductor layer includes a plurality of pores that extend through the conductor layer.

Abstract: The present invention relates to plant fiber processes (e.g., washing, drying, and/or grinding) that utilize recycle and/or make-up streams to use water resources efficiently and/or produce intermediate and/or final products with desired properties.

Abstract: The present disclosure relates to an organic light emitting device including: a first electrode; a second electrode provided to face the first electrode; and an electron transport layer, an emitting layer and a hole transport layer provided between the first electrode and the second electrode, and the emitting layer contains doped protein quantum dots.

Abstract: A method for the production of hydrocarbon(s), such as methane, substituted hydrocarbons, such as methanol, or the production of hydrogen, the method comprising the steps of contacting a first catalyst with water in order to photocatalyse the splitting of at least some of the water into hydrogen and oxygen; and contacting a second catalyst with a gas stream comprising carbon dioxide and at least some of the hydrogen produced from step (a) in order to photocatalyse the reaction between the hydrogen and carbon dioxide to produce hydrocarbon(s), such as methane, and/or substituted hydrocarbons, such as methanol. In an embodiment, the catalyst comprises gold and or ruthenium nanoclusters supported on a substrate.

Abstract: Embodiments of the invention relate to a method and apparatus for self-sterilizing a surface or other portion of the apparatus and/or sterilizing other objects. Embodiments can utilize self-generated and/or remotely controlled plasma fields for the purpose of self-sterilization and/or sterilization of another object. Embodiments of the invention can have broad applications in procedures and equipment requiring the sterility of devices used for medical procedures, decontamination procedures, drug delivery, sterility of consumer products, and sterility of food preparation equipment and tools.

Abstract: The present invention discloses a method for carrying out phosphide in-situ injection synthesis by carrier gas, relating to a synthetic method of semiconductor crystal: step A, shielding inert gas is introduced into a furnace body through a carrier gas intake conduit; step B, a crucible is heated in the furnace body to melt a pre-synthesized raw material in the crucible; step C, the heated shielding inert gas is introduced into the furnace body through the carrier gas intake conduit; step D, a phosphorus source furnace loaded with red phosphorus is moved downwards until an injection conduit of the phosphorus source furnace is submerged in the melt; step E, the red phosphorus is heated by the phosphorus source furnace to produce phosphorus gas, and the phosphorus gas is mixed with the shielding inert gas and then injected into the melt through the injection conduit, and the phosphorus gas reacts with the melt to produce phosphide; and step F, each device is turned off after the synthesis is finished.

Abstract: A method for the fabrication of h-WO3/WS2 core/shell nanowires and their use in flexible supercapacitor applications. The novel nanowire assemblies exhibit multifold advantages desired for high-performance supercapacitors, including superior material properties and electrode design. The material design principle can be extended to other material systems, implying its great potential for a variety of energy storage devices compatible with emerging flexible and wearable technologies.

Abstract: Fuels and/or fuel blending components can be formed from hydroprocessing of high lift deasphalted oil. The high lift deasphalting can correspond to solvent deasphalting to produce a yield of deasphalted oil of at least 50 wt %, or at least 65 wt %, or at least 75 wt %. The resulting fuels and/or fuel blending components formed by hydroprocessing of the deasphalted oil can have unexpectedly high naphthene content and/or density. Additionally or alternately, deasphalted oil generated from high lift deasphalting represents a disadvantaged feed that can be converted into a fuel and/or fuel blending components with unexpected compositions. Additionally or alternately, the resulting fuels and/or fuel blending components can have unexpectedly beneficial cold flow properties, such as cloud point, pour point, and/or freeze point.

Abstract: Implantable infusion apparatus, systems and methods that involve the use of a sensor that is associated with the catheter outlet.

Abstract: The invention discloses an air-ground integrated geomagnetic field combined observation method and system. The method comprises the following steps of validating local geomagnetic field model parameters using the geomagnetic field data collected by a mobile earth station before the geomagnetic field survey mission is executed; getting a dynamic model along the flight path using the geomagnetic field data collected by the airborne console over the flight path and the model parameters when the geomagnetic field survey mission is executed; getting a measuring error model along the flight path using the attitude measuring error obtained by the airborne console when the aircraft flies as per the preset attitude; getting the estimation of the geomagnetic field data collected over the flight path in a geographic coordinate frame using the dynamic model and the measuring error model.

Abstract: Provided herein are bi-specific chimeric antigen receptors (CARs), such as those specific for CD138 and BCMA. Use of the CARs in immune cells (e.g., T cells), compositions, and methods are also contemplated.

Abstract: This invention relates to a photocleavable mass tag and the use thereof, and particularly to a thiochromene-type compound useful for MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight) mass spectrometry or matrix-less LDI-TOF (Laser Desorption/Ionization Time-Of-Flight) mass spectrometry and the use thereof.

Abstract: A modified effector cell includes a non-reversibly produced vector-encoded anti-GD2-BB-? chimeric receptor for use in disialoganglioside GD2-expressing neoplasia, which is inserted in the cell, to obtain an effector cell that stably produces the anti-GD2-BB-? chimeric receptor, the chimeric receptor having two distinct mutually fused portions, i.e. an intra-cytoplasmic portion and an extra-cytoplasmic portion.

Abstract: The present disclosure, among other things, provides low-viscosity, high concentration therapeutic protein agent formulations.

Abstract: Modified Factor IX (FIX) polypeptides, nucleic acid encoding the same, and methods of generating modified Factor IX polypeptides are provided. Also provided are pharmaceutical compositions that contain the modified Factor IX polypeptides, methods of treatment using modified Factor IX polypeptides, and assay for Factor IX activity.