Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: A micro-electromechanical temperature control system including a micro-electromechanical apparatus is provided. The micro-electromechanical apparatus includes a heater and a thermal reservoir. A specific heat capacity of the thermal reservoir is greater than a specific heat capacity of the heater, so that a heating time and a heating frequency of the heater are reduced to save electrical power consumption. The micro-electromechanical temperature control system is adapted for a micro-electromechanical sensor that is required to be controlled at an operating temperature, such as a gas sensor.

Abstract: Methods, systems, and computer readable media for preventing code reuse attacks are disclosed. According to one method, the method includes executing, on a processor, code in a memory page related to an application, wherein the memory page is protected. The method also includes detecting a read request associated with the code. The method further includes after detecting the read request, modifying, without using a hypervisor, at least one memory permission associated with the memory page such that the code is no longer executable after the code is read.

Abstract: A Long Term Evolution (LTE) base station, a user equipment (UE) and pre-association and pre-authentication methods thereof in a WWAN-WLAN aggregation are provided. In a Carrier Aggregation, the LTE base station is a primary cell of an Evolved Node B (eNB) and a WLAN access point (AP) is a secondary cell of the eNB. In a Dual Connectivity, the LTE base station is a master eNB and the WLAN AP is a secondary eNB. The pre-association and pre-authentication method of the LTE base station comprises the following steps. A WLAN information is received from a user equipment (UE) by the LTE base station. A WLAN authentication procedure is assisted for the UE by the LTE base station. The UE is commanded to establish a WLAN link with the WLAN AP by the LTE base station.

Abstract: Systems and methods for controlling and operating a hybrid vehicle having a high degree of hybridization are disclosed. A power flow control system predicts vehicle power demand to drive the hybrid vehicle based on changing conditions during operation of the hybrid vehicle. The power flow control system controls the power flow so as to provide power to drive the hybrid vehicle based on the predicted vehicle power demand, wherein the predicted vehicle power demand is greater than a maximum.

Abstract: The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.

Abstract: Various methods for detecting moisture in briefs compatible with high volume manufacturing are disclosed. The embodiments herein facilitate protection of the method of adding moisture sensing to a diaper, but could also be used to add sensing to pads and bandages. The primary design intent is optimal moisture detection and low per unit cost. Electrodes within a garment measure electrical properties of the electrodes to determine if the item has contacted moisture. The target moisture is urine, however, other sources and types of moisture can also be sensed. Additional analysis capabilities can be added by selecting particular electrodes or add materials that may react with chemical components of the moisture. Applications of the research Include monitor of incontinence using smart brief (e.g. diaper); monitor perspiration, bleeding, or failure of the protective garment; and monitoring exposure of an item to moisture, including but not limited to inanimate items.

Abstract: The present invention relates to methods of treating immune disorders, particularly autoimmune and inflammatory disorders such as rheumatoid arthritis, and methods of producing antibodies for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies that specifically bind to NKG2D receptors present on the surface of cells underlying the disorders.

Abstract: A wedge osteotomy device including a cutting guide coupled to a base plate via a joint. The cutting guide configured to pivot relative to the base plate about a pivot axis extending through the joint. The cutting guide including a guide body including a cutting slot extending through the guide body, an arcuate slot extending through the guide body and defining a radius to the joint, and a plurality of markers on the guide body identifying a position of the cutting guide relative to the base plate. The base plate including planar top and bottom surfaces.

Abstract: One embodiment can provide a system for detecting faults in a machine. During operation, the system can obtain a dynamic signal associated with the machine, apply one or more signal-processing techniques to the dynamic signal to obtain frequency, amplitude, and/or time-frequency information associated with the dynamic signal, extract motion-insensitive features from the obtained frequency, amplitude, and/or time-frequency information associated with the dynamic signal, and determine whether a fault occurs in the machine based on the extracted features.

Abstract: Provided are a method of preparing in vitro-matured intestinal organoids, and intestinal organoids prepared by the method.

Abstract: A credibility evaluation device for evaluating a credibility of a user who uses a service provided by a communicable structure includes a processor including hardware. The processor is configured to: acquire structure information on the structure during and after use of the service by the user and third-party evaluation information including evaluation about the structure made by a third party other than the user after use of the service by the user; and calculate the credibility of the user, based on at least one of the structure information and the third-party evaluation information.

Abstract: A dual-view image device for monitoring a heat source includes a first thermal image sensor, a second thermal image sensor, a driver and a processor. The first thermal image sensor captures a first thermal image having a heat source within a first view angle. The second thermal image sensor captures a second thermal image having a heat source within a second view angle smaller than the first view angle. The pixels occupied by the heat source in the first thermal image are fewer than that occupied by the heat source in the second thermal image. The driver drives the first and the second thermal image sensor to track and position the heat source within the first and the second view angle. The processor combines the first and the second thermal image into a dual-view image and outputs the dual-view image having the heat source.

Abstract: Simple ?-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.

Abstract: Provided is an electronic circuit including a resonant circuit configured to output a resonance voltage having a resonance frequency to a first node, and an oscillation circuit configured to output an oscillation voltage having a level changed according to a first current and a second current based on the resonance voltage received from the first node, wherein the first current is delivered between a first voltage supply terminal and a second node in a first time period, the second current is delivered between the second node and a second voltage supply terminal in a second time period, and a sum of a length of the first time period and a length of the second time period corresponds to the resonance frequency.

Abstract: A subsurface monitoring system and method is provided that includes a sensor array and a monitoring system in communication with the array. The sensor array may include several sensors, such as subsurface temperature sensors, water-level sensors, and oxidation reduction potential sensors may be disposed in a vertical and/or horizontal fence through the subsurface of the monitored site. The sensor array may measure, collect, and analyze the subsurface conditions and provide the measurements to a monitoring system. The monitoring system may provide access the measurements via a user interface for analysis of the measurements. In addition, the monitoring system may process the measurements to generate one or more graphs of information for better understanding of the conditions of the subsurface of the monitored site.

Abstract: The invention is directed to a method for diagnosing and treating fibrosis, especially pulmonary fibrosis, associated with mutation of the S100A13 and S100A3 genes. Methods for detecting and distinguishing the mutant forms of these genes are disclosed and ways to compensate for loss of function or aberrant function of the mutated S100A13 or S100A3 proteins are disclosed.

Abstract: A package of photoelectric device including a substrate, at least one photoelectric device, a first barrier layer, a wavelength-converting layer, and a second barrier layer is provided. The photoelectric device is disposed on the substrate. The first barrier layer is disposed on the substrate and covers the photoelectric device. The wavelength-converting layer is disposed on the first barrier layer. The second barrier layer covers the wavelength-converting layer. A composition of the first barrier layer includes a nitrogen content of more than 0 atomic percent (at %) to l0 at %, an oxygen content of 50 at % to 70 at %, and a silicon content of 30 at % to 50 at %.

Abstract: The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C disorders, including diseases and disorders mediated by GPCRs.

Abstract: A firearm monitoring and remote support system monitors firearms and other assets within a deployment location to detect threats to users of the firearms and to perform actions in response to the threats. Measurements recorded using sensors of the firearms and/or of the other assets are used to determine changes in motion, position, orientation, and/or operation of the firearms and/or of the other assets. The measurements are processed to determine the nature of a threat and the particular actions to perform in response thereto. Graphical user interfaces visualizing the users within the deployment location are updated using the measurements to show, in real-time, positions and orientations of cones of fire for the users within the deployment location. In some cases, the cones of fire may be used to detect threats within the deployment location. In some cases, the actions to perform in response to a detected threat may be automated.