Patents Assigned to Research
  • Oxadiazoles and thiadiazoles as TGF-? inhibitors
    Patent number: 10653682
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 19, 2020
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Expandable vertebral body replacement device and method
    Patent number: 10653530
    Abstract: An expandable vertebral body device, system, instrument, and methods of assembly and using the device, system, and instrument are disclosed. The vertebral body device includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, a second rotating member rotatably coupled to the second end, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body device and an insertion instrument. Methods for assembling and using the vertebral body device and instrument are also disclosed.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: May 19, 2020
    Assignee: MUSC Foundation for Research Development
    Inventors: Mark Evald Semler, Bruce Frankel, Joseph Ruscito
  • Methods and compositions for vaccinating against
    Patent number: 10653757
    Abstract: The invention features a method of vaccinating a mammal against Staphylococcus aureus which includes the steps of: a) identifying a mammal at risk for the development of a Staphylococcus aureus skin or soft tissue infection; and b) administering to said mammal an immunogenic amount of a vaccine that includes a polypeptide including an isolated agglutinin-like sequence (Als) 3 protein (Als3p), or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: May 19, 2020
    Assignees: NovaDigm Therapeutics, Inc., Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
    Inventors: Michael R. Yeaman, John E. Edwards, Jr., Scott G. Filler, Ashraf S. Ibrahim, Yue Fu, John P. Hennessey, Jr.
  • ApoE mimetic peptides and higher potency to clear plasma cholesterol
    Patent number: 10653747
    Abstract: Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 19, 2020
    Assignees: UAB RESEARCH FOUNDATION, LIPIMETIX DEVELOPMENT, LLC
    Inventors: Gattadahalli M. Anantharamaiah, Dennis Goldberg
  • Method of dynamic adaptive streaming for 360-degree videos
    Patent number: 10659815
    Abstract: Disclosed aspects may include, for example, maximizing a quality of experience when selecting encoding bitrates for downloading dynamically adaptive 360-degree panoramic video. Some embodiments include predicting a future orientation of a display region based on a first display region of the video, identifying predicted list of tiles for rendering the second display region, calculating a quality of experience from a plurality of encoding bitrates for the tiles in the second display region and one or more tiles in a margin area so that downloading the plurality of tiles at one or more bitrates is within estimated available embodiments, and downloading tiles for display.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: May 19, 2020
    Assignees: AT&T Intellectual Property I, L.P., Indiana University Research and Technology Corporation
    Inventors: Bo Han, Vijay Gopalakrishnan, Jackson Jarrell Pair, Vikash Sharma, Feng Qian, Qingyang Xiao
  • Foot pulse oximeter for screening congenital heart disease before newborn discharge
    Patent number: 10653348
    Abstract: A method including placing a portion of a foot of a newborn in a device, the device including a light emitter and a corresponding receiver coupled on opposite sides of the device, the device further including a processor for processing data from the light emitter and receiver; and determining a presence of congenital heart disease. An apparatus including a body including a chamber of a size to accommodate a portion of a newborn's foot; at least one light emitter and a corresponding detector coupled on opposite sides of the body, the emitter configured to emit light of a prescribed wavelength into the chamber; and a processor coupled to the body and configured to receive a signal from the at least one detector.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: May 19, 2020
    Assignee: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER
    Inventors: Ruey-Kang Chang, Yann Ping Pan
  • Conical wafer centering and holding device for semiconductor processing
    Patent number: 10655224
    Abstract: A semiconductor system includes a chamber, a pedestal disposed in the chamber, and a focus ring that surrounds the pedestal. The pedestal has a center region for supporting a central region of a substrate, e.g., a wafer. The focus ring is configured to surround the center region of the pedestal. The focus ring has an annular support region that extends between an inner portion of the focus ring and an outer portion of the focus ring. The annular support region, which is disposed at an angle relative to a horizontal line, provides a knife-edge contact for the substrate when present over the center region of the pedestal and the annular support region of the focus ring. The knife-edge contact between the edge of the substrate and the annular support region of the focus ring disables chemical access to the substrate backside and thereby reduces unwanted backside deposition.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: May 19, 2020
    Assignee: Lam Research Corporation
    Inventors: Pulkit Agarwal, Ishtak Karim, Purushottam Kumar, Adrien LaVoie, Sung Je Kim, Patrick Breiling
  • Catalyst and method for biodiesel production from unrefined low-grade oil and crude aqueous alcohols
    Patent number: 10654789
    Abstract: A catalyst for catalyzing transesterification of esters or esterification of fatty acids, the catalyst is selected from the group consisting of manganese (II) glycerolate, cobalt (II) glycerolate, iron (II) glycerolate, and any combination thereof. A method for transesterification reaction, includes: a) providing a catalyst, wherein the catalyst is selected from the group consisting of manganese (II) glycerolate, cobalt (II) glycerolate, iron (II) glycerolate, and any combination thereof; b) adding the catalyst, one or more alcohols, and a composition comprising one or more esters to a reactor to form a reaction mixture; and c) stirring while heating the reaction mixture for reaction to form transesterification products.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 19, 2020
    Assignee: THE HONG KONG POLYTECHNIC UNIVERSITY SHENZHEN RESEARCH INSTITUTE
    Inventors: Ka-fu Yung, Wing-tak Wong, Tsz-lung Kwong, Pak-chung Lau
  • Methods for diagnosis and prognosis of epithelial tumors
    Patent number: 10655185
    Abstract: A biomarker is disclosed that can distinguish aggressive epithelial tumors in a tissue biopsy from, for example, normal, hyperplastic, and benign neoplastic tumors. The biomarker can also identify epithelial tumors that have become resistant to hormone therapy. Therefore, methods are disclosed for providing diagnosis and prognosis of a subject having, or suspected of having, an epithelial tumor, such as a prostate tumor.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 19, 2020
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of Center Florida Research Foundation, Inc.
    Inventors: Ratna Chakrabarti, Richard Ottman, Domenico Coppola, Nupam Mahajan
  • Process for the preparation of blue-flourescence emitting carbon dots (CDTS) from sub-bituminous tertiary high sulfur Indian coals
    Patent number: 10655061
    Abstract: The present invention relates to a process for the preparation of blue-fluorescence emitting carbon dots (CDTs) from sub-bituminous tertiary high sulfur Indian coals. More particularly, the present invention relates to the production of characteristics carbon dots from low-quality Indian coals by an ultrasonic-assisted wet-chemical method. Also, the present invention provides a simple and environmentally benign method for fabrication of characteristics and size-controlled carbon dots.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: May 19, 2020
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Binoy Kumar Saikia, Tonkeswar Das, Sonali Roy, Bardwi Narzary, Hari Prasanna Dekaboruah, Manobjyoti Bordoloi, Jiumoni Lahkar, Dipankar Neog, Danaboyina Ramaiah
  • Motion and noise artifact detection and reconstruction algorithms for photoplethysmogram and equivalent signals
    Patent number: 10653362
    Abstract: A pulse oximeter embedded with a motion and noise artifact (MNA) detection algorithm based on extraction of time-varying spectral features that are unique to the clean and corrupted components.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: May 19, 2020
    Assignee: Wavefront Research Inc.
    Inventors: Ki H. Chon, Jo Woon Chong, Duy Dao, Hamed Salehizadeh
  • Binder composition for improved tack coat and stress absorbing membrane interlayer application for road construction
    Patent number: 10655281
    Abstract: A binder composition for asphalt pavements that includes: an asphalt binder; an elastomeric polymer; a wax modifier; and optionally at least one of: i) fumed silica or fumed alumina; and ii) a saponified fatty acid and a resin acid gelling compound. The composition is applied as a tack coat and/or a stress absorbing membrane interlayer and is non-tracking.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: May 19, 2020
    Assignee: Heritage Research Group
    Inventors: Anthony J. Kriech, Marvin Exline, James Joseph Cunningham, Andreas Redick Horton
  • Hydrophobic highly branched carbohydrate polymers
    Patent number: 10653784
    Abstract: A material comprising a highly branched carbohydrate polymer, a polyalkylene glycol (or polyalkylene oxide) linked to the highly branched carbohydrate polymer, and a hydrophobic or amphiphilic group linked to the highly branched carbohydrate polymer and/or the polyalkylene glycol (or polyalkylene oxide), is described. Methods of making and using the material, as well as a soluble composition that contains the material and a hydrophobic solute compound, are also described.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: May 19, 2020
    Assignee: Purdue Research Foundation
    Inventors: Yuan Yao, Jingmin Zhang
  • Radio-frequency isolated gate driver for power semiconductors
    Patent number: 10659036
    Abstract: A gate driver for power semiconductors is disclosed. The gate driver includes modulation to modulate signals from a controller to a radio frequency (RF) range that is much higher than frequencies associated with conducted EMI. The gate driver also includes RF transformer and tank circuit to that couples the modulated signals, filters EMI, and provides galvanic isolation. The gate driver further includes a RF demodulator and unfolder circuit for converting the RF signal into a signal appropriate for controlling the gate of a power semiconductor for switching. Additionally, the disclosed gate driver provides active gate control using programmable waveforms with values that can range over a continuous range of voltages.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: May 19, 2020
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hui Li, Yanjun Shi
  • Rare event detection using mass tags
    Patent number: 10656157
    Abstract: The invention generally relates to methods for rare event detection using mass tags. In certain embodiments, the invention provides methods for detecting a target analyte in a sample that involve conducting an assay that specifically associates a mass tag with a target analyte in a sample, generating ions of the mass tag, and analyzing the generated ions of the mass tag, thereby detecting the target analyte from the sample.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: May 19, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • Polymers with antimicrobial functionalities
    Patent number: 10653142
    Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 19, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Magnetic nanoparticle embedded nanofibrous membrane
    Patent number: 10653818
    Abstract: Various examples are provided for magnetic particle imbedded nanofibrous membranes. In one example, among others, a nanofibrous membrane includes one or more electrospun nanofibers forming form a layer of nanofibers, and a plurality of magnetic nanoparticles embedded in the one or more electrospun nanofibers. In another example, a method includes generating one or more electrospun nanofibers including magnetic nanoparticles from one or more nozzles positioned over a substrate to form a magnetic nanofibrous layer, and affixing the magnetic nanofibrous layer to a support structure. In another example, a system includes a magnetic nanofibrous membrane affixed to a support structure, and a magnetic field generator configured to generate a magnetic field that passes through the magnetic nanofibrous membrane.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: May 19, 2020
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Yong-Kyu Yoon, Sheng-Po Fang
  • Apparatus and method for transmitting shelter location information based on ATSC 3.0, and apparatus and method for receiving shelter location information based on ATSC 3.0
    Patent number: 10659947
    Abstract: An apparatus for transmitting shelter location information is disclosed. The apparatus for transmitting shelter location information according to an embodiment of the present disclosure includes a wake-up information checking unit that checks a value of a wake-up indicator provided in a head of a data file to determine whether a disaster has occurred; and a shelter location information insertion unit inserting the shelter location information into an advanced emergency alert table (AEAT), as it is confirmed by the wake-up information checking unit that a disaster has occurred.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: May 19, 2020
    Assignees: Electronics and Telecommunications Research Institute, FOUNDATION FOR RESEARCH AND BUSINESS, SEOUL NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Sung Hoon Kim, Byung Jun Bae, Dong Ho Kim, Bong Seok Seo, Chang Jong Hyun, Eun Yeong Jeong
  • Method and apparatus for controlling frame transmission
    Patent number: 10659374
    Abstract: A frame transmission controlling apparatus includes: a list configuration unit managing a parameter related to a gate control; a cycle timer unit managing a start timing of a cycle; a list executing unit performing the gate control based on the parameter, wherein the list executing unit includes: a cycle executing state machine setting an expiration time of at least one section included in the cycle, checking gate operation information corresponding to a list pointer indicating the at least one section, and performing a control corresponding to the gate operation information; a delaying state machine deducting and updating the expiration time by a predetermined unit; a cycle holding state machine generating a control signal indicating stopping transmission in MAC; and a cycle releasing state machine generating a control signal indicating resuming the transmission in MAC.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: May 19, 2020
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Chang Ho Choi, Tae Kyu Kang, Jeong Dong Ryoo, Tae Sik Cheung
  • In vitro process for the quantification of carboxymethyl and carboxyethyl level of albumin in a sample
    Patent number: 10656165
    Abstract: An in vitro method for the identification and quantification of glycated human serum albumin to assess the extent of diabetic complications in diseased individuals. Further, a diagnostic kit for identifying the extent of diabetes in a diseased individual by estimating glycated serum albumin levels in such individuals.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: May 19, 2020
    Assignee: Council of Scientific & Industrial Research
    Inventor: Mahesh Jagdishrao Kulkarni