Abstract: Anti-CD33 antibodies are described. The anti-CD33 antibodies can bind within the V-set Ig-like domain or the C2-set Ig-like domain of CD33. Epitopes on the C2-set Ig-like domain can provide a “pan-binding” site, to which the cognate antibody will bind regardless of whether the CD33 molecule also contains the V-set domain (as in, for example, CD33FL) or not (as in, for example, CD33?E2). Alternative epitopes on the C2-set Ig-like domain are accessible for binding if the V-set domain is absent (e.g., as in CD33?E2). Antibodies that bind an epitope on the C2-set Ig-like domain (whether they exhibit pan or V-set absent binding) are directed at novel therapeutic targets and can increase therapeutic efficacy against CD33-related disorders. Also described are molecules comprising a binding-competent domain from at least one described anti-CD33 antibody, including scFvs, bi-specific antibody molecules, chimeric antigen receptors, and immunoconjugates. Methods of use are also provided.

Abstract: In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R1, R2, and R3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.

Abstract: Methods, systems, and computer readable media for controlling ventricular assist devices are disclosed. In some embodiments, the method includes receiving at least one reference pump speed differential associated with a pump of a ventricular assist device; determining a filtered pump speed differential associated with the pump of a ventricular assist device; and adjusting, using a feedback based controller algorithm, current to the pump based on the at least one reference pump speed differential and the filtered pump speed differential.

Abstract: An ensemble learning prediction method includes: establishing a plurality of base predictors based on a plurality of training data; initializing a plurality of sample weights of a plurality of sample data and initializing a processing set; in each iteration round, based on the sample data and the sample weights, establishing a plurality of predictor weighting functions of the predictors in the processing set and predicting each of the sample data by each of the predictors in the processing set for identifying a prediction result; evaluating the predictor weighting functions, and selecting a respective target predictor weighting function from the predictor weighting functions established in each iteration round and selecting a target predictor from the predictors in the processing set to update the processing set and to update the sample weights of the sample data.

Abstract: A handover method for a satellite base station, performed by a terminal, may comprise selecting at least one candidate satellite base station; performing signal strength measurement on a first candidate satellite base station among the at least one candidate satellite base station; in response to determining that the first candidate satellite base station is available according to a result of the signal strength measurement, selecting the first candidate satellite base station as a target satellite base station; and in response to determining that the first candidate satellite base station is not available according to the result of the signal strength measurement, performing signal strength measurement on a second candidate satellite base station among the at least one candidate satellite base station.

Abstract: According to some aspects, a method of producing a permanent magnet shim configured to improve a profile of a B0 magnetic field produced by a B0 magnet is provided. The method comprises determining deviation of the B0 magnetic field from a desired B0 magnetic field, determining a magnetic pattern that, when applied to magnetic material, produces a corrective magnetic field that corrects for at least some of the determined deviation, and applying the magnetic pattern to the magnetic material to produce the permanent magnet shim. According to some aspects, a permanent magnet shim for improving a profile of a B0 magnetic field produced by a B0 magnet is provided. The permanent magnet shim comprises magnetic material having a predetermined magnetic pattern applied thereto that produces a corrective magnetic field to improve the profile of the B0 magnetic field.

Abstract: Provided herein are fusion polypeptides comprising at least two Mycobacterial antigens, wherein one Mycobacterial antigen is a strong central memory T cell activator, and wherein one Mycobacterial antigen is a strong effector memory T cell activator. Also provided herein are methods of making and using such fusion polypeptides for the prevention or treatment of a secondary Mycobacterium tuberculosis infection as well as for the prevention or treatment of a nontuberculous Mycobacterium infection in a mammal.

Abstract: A method of forming a thermal insulation porous film includes mixing 100 parts by weight of polysilsesquioxane-containing polymer, 20 to 75 parts by weight of surfactant, and 20 to 2000 parts by weight of solvent to form a thermal insulation coating material, wherein the polysilsesquioxane-containing polymer in the thermal insulation coating material is tube-shaped or sheet-shaped. The thermal insulation coating material is coated on a substrate, and then dried and sintered to form a thermal insulation porous film.

Abstract: Provided is a forming method of a metal layer suitable for a 3D printing process. The method includes the steps of providing a plurality of metal particles on a substrate; applying an oxide-removing agent to the metal particles to remove metal oxides on the metal particles; at a first temperature, performing a first heat treatment on the metal particles for which the metal oxides are removed to form a near shape; and at a second temperature, performing a second heat treatment on the near shape to form a sintered body. The first temperature is lower than the second temperature.

Abstract: This invention provides a copper powder to which tin (Sn) is added such that a high-density laminated and shaped product can be obtained by a laminating and shaping method using a fiber laser as a heat source by appropriately reducing the electrical conductivity of copper, so a laminated and shaped product having a high density and a high electrical conductivity can be obtained. That is, this invention provides a copper powder for lamination shaping in which a tin element is added to pure copper. Desirably, the copper powder contains 0.5 wt % or more of the tin element. More desirably, the copper powder contains 5.0 wt % or more of the tin element. When the product has an electrical conductivity sufficient as a copper product, the copper powder desirably contains 6.0 wt % or less of the tin element. Furthermore, no element other than the tin element is desirably added to the copper powder.

Abstract: Disclosed herein are a decoy apparatus and a method for expanding a fake attack surface using a deception network. The method includes determining, by a protected server, whether a packet is a target to be processed when the packet is received; converting, by the protected server, the packet and transmitting, by the protected server, the converted packet to the decoy apparatus of the deception network when the packet is determined not to be such a target; receiving, by the protected server, a response packet from a decoy virtual machine included in the decoy apparatus as a reply to the converted packet; and modifying, by the protected server, the response packet and transmitting, by the protected server, the modified response packet to the source from which the packet was transmitted, in order to expand the fake attack surface.

Abstract: An energy harvesting system based on reverse electro wetting on a dielectric includes: a dielectric material layer molded with a dielectric material in a panel shape and including an upper end and a lower end; and an electrode layer including a plurality of electrodes coupled to a lower surface of the dielectric material layer. In particular, the upper end of the dielectric material layer is located higher than the lower end and allows a liquid drop to flow from the upper end to the lower end, and the dielectric material layer generates dielectric polarization in the dielectric material layer and continuously varies a flow rate of the liquid drop between the upper end and the lower end of the dielectric material layer. The plurality of electrodes are disposed to be spaced apart from one another in a direction from the upper end to the lower end.

Abstract: A thermal management system includes a refrigerant system, which includes a compressor, a flow control device, a valve member, a first heat exchanger, a second heat exchanger, and a third heat exchanger. The flow control device includes a first throttle unit, a second throttle unit, and a valve assembly; the flow control device includes a first port, a second port, and a third port; a first connection port of the first heat exchanger is in communication with the second port, and a first connection port of the second heat exchanger is in communication with the third port, while a first connection port of the third heat exchanger is in communication with the first port. The thermal management system includes a first operating state and a second operating state.

Abstract: Devices and methods can be used to treat dermatologic disorders using low dose DC electroporation. Such electroporation is essentially non-thermal modulation. In some implementations, the devices and methods described herein can be used for anti-aging treatments. In some implementations, the devices and methods described herein can be used for detecting/screening of various types of skin cancers. In some implementations, the devices and methods described herein can be used for therapy delivery for the treatment of early or pre-malignant skin cancers.

Abstract: A method for estimating a plurality of camera, comprising using at least one processor executing a code for: extracting a plurality of image features of a plurality of landmarks from a plurality of images captured by at least one camera from at least one pose, the plurality of landmarks calibrated with respect to a certain coordinate system; identifying among the plurality of image features at least one image feature documented in at least some of the images; producing scale values of at least one common image feature by analyzing the at least some of the images; determining a plurality of estimated poses of the at least one camera with respect to the certain coordinate system by using the scale values in calculating a minimal re-projection error between the plurality of image features and a plurality of predicted image features; and outputting the plurality of estimated poses.

Abstract: An information display system and an information display method are provided. The information display system includes a display screen, an image-capture device, and a processing device. The image-capture device captures a picture sequence. The processing device is coupled to the display screen and the image-capture device. The processing device recognizes at least one dynamic object in the picture sequence and generates a recognition frame and a recognition information corresponding to the dynamic object. The processing device tracks a recognition frame of a plurality of first pictures in the picture sequence to obtain a tracking result.

Abstract: This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.

Abstract: The present invention relates to an apparatus and method for encoding and decoding an image by skip encoding. The image-encoding method by skip encoding, which performs intra-prediction, comprises: performing a filtering operation on the signal which is reconstructed prior to an encoding object signal in an encoding object image; using the filtered reconstructed signal to generate a prediction signal for the encoding object signal; setting the generated prediction signal as a reconstruction signal for the encoding object signal; and not encoding the residual signal which can be generated on the basis of the difference between the encoding object signal and the prediction signal, thereby performing skip encoding on the encoding object signal.

Abstract: A method for adjusting a frequency response parameter of a machine tool and a system using the same are provided. The method includes the following steps. Firstly, an actual frequency sweep is performed on the machine tool to acquire an original system closed loop data of the machine tool. Then, an original system open loop transfer function of the original system closed loop data is acquired. Then, a speed optimization procedure is executed to determine an optimized speed parameter. Then, a speed optimized open loop transfer function corresponding to a speed optimized close loop transfer function is acquired. Then, a filter transfer function of a filter is determined. Then, a filter optimization procedure is executed.

Abstract: The present disclosure is directed to a kit and methods for using the same. The kit includes a plate including at least one well, wherein the well includes a silver nitrate and a catalyst. The method includes providing a sample of synovial fluid to a well of a plate, wherein the well includes a silver nitrate and a catalyst and determining a presence of monosodium urate (MSU) crystals, wherein the presence of MSU crystals indicates that gout is detected in the sample.