Abstract: Provided herein are AAV inverted terminal repeats (ITRs) comprising modifications that are useful for improved expression of a transgene to muscle cells/tissue. ITRs as described herein comprise a myoblast determination protein (MyoD) binding site and/or myocyte enhancer factor (MEF) binding site. to improve transgene expression in muscle cells/tissue. Provided herein are also AAV particles comprising modified ITRs. and method of making and using them.

Abstract: In one embodiment, a computer-implemented method for driver training using zone of proximal learning (ZPL) includes receiving, by one or more processors, driving data with respect to a driver operating a vehicle, estimating, using a personal behavior model, a driver profile based on the driving data, estimating one or more zone of proximal development (ZPD) states based at least in part on the driver profile, and performing one or more vehicle actions to place the driver into the one or more ZPD states.

Abstract: Provided is an apparatus for diagnosing a disease, which includes an acquisition module configured to acquire multi-modal data including at least two types of data among text data, speech data, and image data related to each depression patient, a preprocessing module configured to visualize data that is not the image data among the multi-modal data and output image datasets including the image data among the multi-modal data and the visualized data, and a classification module configured to classify whether each depression patient has depression based on the image datasets.

Abstract: A dynamic compression implant may be insertable into a bone, and may have a distal member with distal bone-engaging threads, a proximal member that slidably engages the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member distally away from the proximal member, the tension member elongates and urges the distal member to move proximally toward the proximal member. The bone screw may further have an interpositional member, formed separately from the proximal member and the distal member, that cooperates with the proximal member and the distal member to form a torque transmission feature that transmits torque between the proximal member and the distal member. The dynamic compression implant may be a bone screw, intramedullary implant, or other implant that applies compression across two bone portions.

Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.

Abstract: Provided are a resist composition and a method of forming a pattern by using the same, the resist composition including a polymer including a first repeating unit represented by Formula 1, a photoacid generator, and an organic solvent: Formula 1 is as defined in the specification.

Abstract: A system for training an operator of a vehicle to perform a maneuver of the vehicle can include a processor and a memory. The memory can store an automated motion module, an instruction module, and a communications module. The automated motion module can cause the processor to cause the vehicle to perform, in an automated manner, a first iteration of the maneuver. The instruction module can cause the processor to cause an instruction to be provided to the operator during a second iteration of the maneuver. The communications module can cause the processor to receive, during the second iteration, a query from the operator about a performance of the second iteration. The communications module can cause the processor to communicate a response to the query to train the operator to perform the second iteration or a third iteration of the maneuver in a manner that mimics the first iteration.

Abstract: The present disclosure discloses a method and device for detecting a starting point of a signal, a storage medium and an electronic device. Therein, the method includes: receiving a sensing signal collected by a sensor; after segmenting the sensing signal into at least one segment signal, calculating a segment energy value of each segment signal, and acquiring a signal band containing a starting point of a signal of a pulse signal based on each segment energy value; based on a measured energy value at each sampling point in the signal band, calculating an instantaneous energy value at each sampling point in the signal band by using a sliding window method; acquiring a first energy ratio between a first sampling point and a second sampling point in the signal band; and if the first energy ratio is greater than an initial-ratio threshold value, determining a sampling time corresponding to the first sampling point as the starting point of the signal.

Abstract: The present disclosure is directed to methods for training and using an artificial intelligence model for use with predicting a task output. The method includes generating a plurality of individual datasets, each of the plurality of individual datasets comprising data of at least one answer to at least one of a plurality of questions of each of a plurality of questionnaires, generating a first batch of individual datasets, the first batch of individual datasets comprising one or more of the plurality of individual datasets, inputting the first batch of individual datasets into the artificial intelligence model, and encoding the data of the first batch of individual datasets with an autoencoder.

Abstract: Provided is a method and system for determining a final result using federated learning. The method includes, based on performance of artificial intelligence (AI) models of each of federated learning devices, determining weights of each of the AI models, inputting input data to each of the AI models by each of the federated learning devices, and determining a final result for the input data by a final result determination server based on outputs and the weights of the AI models.

Abstract: A method and apparatus for training a short circuit detection model are disclosed. The method includes generating virtual battery models with different battery parameter sets, based on battery data measured by a real battery in a non-short circuit state, by applying a constraint corresponding to a short circuit state to the virtual battery models, generating a virtual test result of the short circuit state, and training a short circuit detection model configured to detect the short circuit state using the virtual test result.

Abstract: A direct gaseous reformate injector that includes an inlet for receiving a gaseous reformate; a plunger; and an outward-opening valve that comprises a valve body and a needle that is movable, by the plunger, in relation to the valve body, between a (a) closed position in which the gaseous reformate is not outputted from the direct gaseous reformate injector, and (b) an open position in which the gaseous reformate is outputted from the direct gaseous reformate injector.

Abstract: A prednisone enteric-coated preparation and a preparation method and use thereof are provided. The prednisone enteric-coated preparation includes: 5% to 35% of an active prednisone micro-enteric-coated preparation unit, such as an enteric-coated microsphere; and an inactive pharmaceutical adjuvant. The enteric-coated microsphere has an average particle size of 100 ?m to 1,000 ?m, and a dissolution behavior of the enteric-coated microsphere conforms to the provisions for enteric-coated preparations. The enteric-coated microsphere characteristic not only avoids the stimulation of prednisone to a gastric mucosa, but also makes the active ingredient quickly released and absorbed in an intestinal tract to prevent the active ingredient from being destroyed by intestinal floras. The prednisone enteric-coated preparation can be any dosage form such as a suspension or a capsule suitable for patients with difficult swallowing or normal patients.

Abstract: Disclosed herein are a method for decomposing a Mixed Polarity Multiple Controlled Toffoli (MPMCT) gate in a quantum circuit and a quantum circuit designed using the method. The method includes dividing a process of decomposing an MPMCT gate in a quantum circuit into a front step, a central step, and a back step, selecting one of multiple decomposition methods in consideration of the sub-MCT gate assigned to each of the steps and the number (k) of work qubits of which the initial states are known (Clean Work Qubits (CWQs)), and decomposing the MPMCT gate into gates of a Clifford+T set, which is a standard fault-tolerant gate set, by applying the selected decomposition method.

Abstract: The present disclosure provides a method for executing random access resource selection in UE served by an NTN. The method includes: detecting a synchronization signal block (SSB) transmitted by an NTN cell, based on a predefined communication resource associated with the SSB; determining an identifier (ID) associated with the detected SSB; maintaining assistance information, wherein the assistance information comprises at least one of the following: first information associated with a presentation order of the detected SSB; and second information associated with an available service duration d of a random access resource associated with the detected SSB; selecting one of the detected SSB as a first SSB based on the assistance information when a plurality of SSB are detected; and applying a random access resource associated with the first SSB for performing a random access procedure.

Abstract: A method for preparing an adjustable organic fertilizer is provided. The method includes providing a ratio of nitrogen, phosphorus, and potassium required for a target crop and collecting a plurality of wastes. The method includes categorizing the fertilizer concentrations of the same type of feeding substrates within the wastes separately, and adjusting the composition of the categorized wastes to form a composite feeding substrate according to the ratio of nitrogen, phosphorus, and potassium required for the target crop. The method includes subjecting the composite feeding substrate to an anaerobic fermentation process. The anaerobic fermentation process includes introducing the composite feeding substrate into an acidification tank to obtain a first mixture and introducing the first mixture into a methanogenesis tank to obtain a second mixture.

Abstract: Selection systems, such as selection systems for determining peptides that inhibit protein aggregation, peptides determined with the selection systems, and methods of using the selection systems and the peptides.

Abstract: A mask design device for 3D proximity field pattering based on electric field control is provided. The mask design service, for producing a nanostructure having a constant period, may include: a material selector configured to select a material of the nanostructure having a specific refractive index; an objective function executor configured to execute an objective function based on a 2D electric field intensity map of the nanostructure formed from the material having a specific height and width; and an optimizer configured to set at least one of a period, the refractive index of the nanostructure, and the objective function, as an input variable, and configured to input the input variable into a predetermined algorithm to calculate design parameters of the nanostructure. A mask having the nanostructure, a method for manufacturing the mask, and a nano patterning device are also provided.

Abstract: Disclosed is a neuron synapse bifunctional element, which includes a gate electrode, a charge supply layer provided on the gate electrode and formed of an oxide dielectric, a channel layer provided on the charge supply layer and formed of an oxide semiconductor, and a source electrode and a drain electrode provided on both sides of the channel layer, respectively, and as electrons or holes are trapped in a charge trapping layer between the channel layer and the charge supply layer, a magnitude and pattern of a current flow flowing in the channel layer change depending on a change in a signal applied to the gate electrode.

Abstract: Provided is a federated learning method and system using shared learning data. The federated learning method includes determining shared learning data to be provided to federated learning devices, learning each of artificial intelligence (AI) models by each of the federated learning devices using the shared learning data and unique learning data of each of the federated learning devices, and determining a final model by a final model determination server based on a learning result of the AI models.