Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
Type:
Grant
Filed:
August 19, 2021
Date of Patent:
April 15, 2025
Assignee:
Yeda Research and Development Co. Ltd.
Inventors:
Jacob Klein, Ronit Goldberg, Jasmine Seror
Abstract: This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.
Type:
Grant
Filed:
December 30, 2022
Date of Patent:
April 15, 2025
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: A collagen-based therapeutic delivery device includes an insoluble synthetic collagen-fibril matrix comprising a polymerization product of soluble oligomeric collagen or a polymerization product of a mixture of soluble oligomeric collagen with one or more type of non-oligomeric soluble collagen molecules, such as, for example, soluble telocollagen and/or soluble atelocollagen, and an active agent dispersed throughout the collagen-fibril matrix or within a portion of the collagen-fibril matrix. A pre-matrix composition includes an aqueous solution including soluble collagen-fibril building blocks and an active agent in the aqueous solution. The soluble collagen-fibril building blocks include soluble oligomeric collagen or a mixture of soluble oligomeric collagen with non-oligomeric soluble collagen molecules. The building blocks are operable to self-assemble into a macromolecular synthetic collagen-fibril matrix in the absence of an exogenous cross-linking agent.
Abstract: A three-level prevention and control method for a rock burst roadway, the method comprising: pre-weakening a thick and hard rock layer above a roadway before the roadway is excavated; carrying out prestress support, pressure relief and reinforcement when the roadway is excavated; and carrying out stress transfer on an advance abutment pressure, and arranging a composite energy absorption protective structure around the roadway before the mining of a working face. By coordinating the spatio-temporal relationship between pressure relief, support and prevention, the energy dissipation in the rock burst roadway is changed from an unstable, disorderly and uncontrollable dissipation state to a stable, orderly and controllable dissipation state.
Abstract: Described herein are interleukin-10 receptor-2 peptides, antibodies that bind the peptides, compositions including the peptides and antibodies and methods of use of the peptides and antibodies. The interleukin-10 receptor-2 peptide consists of an 8-15 amino acid sequence that includes SEQ?ID?NO:?1 ((I/V)P(P/K/V/E)P(E/K/R/Q)N(A/V)R),? SEQ?ID?NO:?2 ((S/L/V)PAF(A/P)(K/Q)(G/T/E)(N/T/D)),?or? SEQ?ID?NO:?3 (PP(G/T/Q/V)(V/T/A)(R/H/T/S)(GN/NHP/SAA)).
Abstract: An image processing method and apparatus based on machine learning are disclosed. The image processing method based on machine learning, according to the present invention, may comprise the steps of: generating a first corrected image by inputting an input image to a first convolution neural network; generating an intermediate image on the basis of the input image; performing machine learning on a first loss function of the first convolution neural network on the basis of the first corrected image and the intermediate image; and performing machine learning on a second loss function of the first convolution neural network on the basis of the first corrected image and a natural image.
Type:
Grant
Filed:
November 11, 2020
Date of Patent:
April 15, 2025
Assignee:
POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
Inventors:
Seung Yong Lee, Sung Hyun Cho, Hyeong Seok Son
Abstract: An antenna for transmitting power in a wireless power transfer system comprises a first arm and a second arm. The first arm has a proximal end and a distal end extending helically about a first central axis. The second arm has a proximal end and a distal end extending helically about a second central axis toward the distal end of the first arm. A radius between the second arm and the second central axis increases in a distal direction away from the proximal end.
Type:
Grant
Filed:
May 12, 2022
Date of Patent:
April 15, 2025
Assignee:
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Abstract: Provided is a system and method for estimating an end-to-end delay between blockchain nodes in peer-to-peer (P2P) networks. The system includes a coordinate system construction unit configured to designate an origin node and anchor nodes among participating nodes having a distributed ledger of P2P networks, construct a first coordinate system of a predetermined dimension by exchanging control messages between the origin node and the anchor nodes and the participating nodes, and construct a second coordinate system of another predetermined dimension and a dimension determination unit configured to determine a dimension to be applied to the current P2P networks by comparing dimension-specific delays or control message overheads of the first coordinate system and the second coordinate system.
Type:
Grant
Filed:
November 16, 2023
Date of Patent:
April 15, 2025
Assignee:
POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
Abstract: A method for location of a beacon includes: executing R sequences, wherein R is a whole number equal to or greater than 2, each including reception by a first antenna network and a second antenna network of a signal originating from the beacon, wherein the signals of the R sequences are of different wavelengths; calculating a first estimation function for angles of arrival of the signal on the first antenna network and of a second estimation function for angles of arrival of the signal on the second antenna network; and executing a mutual correlation of the R first estimation functions and the R second estimation functions, for the respective determination of a first angle between the beacon and the first network, and of a second angle between the beacon and the second network.
Type:
Grant
Filed:
October 21, 2016
Date of Patent:
April 15, 2025
Assignee:
The Swatch Group Research and Development Ltd
Abstract: The present disclosure discloses a method for suppressing the azimuth ambiguity of multi-channel SAR systems based on channel cancellation, which falls within the field of radar signal processing. The method includes: imaging echoed of the multi-channel SAR system based on a linear mapping reconstruction algorithm to obtain a reconstructed high-resolution wide-swath image; estimating positions of the azimuth ambiguity regions of the reconstructed high-resolution wide-swath image; extracting ambiguity images in the azimuth ambiguity regions based on channel cancellation and the refocusing algorithm; and suppressing a repetitive ambiguity image in imaging the echo of the multi-channel SAR system.
Type:
Grant
Filed:
November 26, 2024
Date of Patent:
April 15, 2025
Assignee:
Aerospace Information Research Institute, Chinese Academy of Sciences
Inventors:
Yu Wang, JunFeng Li, YongHua Cai, Bo Li, PingPing Lu
Abstract: A time-resolved fluorescence immunochromatography kit for the simultaneous detection of a mixed pollutant of aflatoxin and carbaryl, a preparation method therefor, and an application thereof. The kit comprises a time-resolved fluorescence immunochromatography test strip and a sample reaction vial containing a europium-labeled anti-aflatoxin monoclonal antibody and a europium-labeled anti-carbaryl monoclonal antibody lyophilized product, detection lines of the time-resolved fluorescence immunochromatography test strip being coated with an aflatoxin-bovine serum albumin conjugate and a carbaryl-ovalbumin conjugate respectively, and the anti-carbaryl monoclonal antibody is produced by secretion of a hybridoma cell line Jnw1D2 with a preservation number of CCTCC NO. C201654. The kit can be used for the simultaneous detection of aflatoxin and carbaryl content in a sample, and features simple and quick operations and a high sensitivity.
Type:
Grant
Filed:
December 28, 2017
Date of Patent:
April 15, 2025
Assignee:
OILCROPS RESEARCH INSTITUTE OF CHINESE ACADAMY OF AGRICULTURE SCIENCES
Abstract: Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.
Type:
Grant
Filed:
December 13, 2021
Date of Patent:
April 15, 2025
Assignees:
Bolder Biotechnology, Inc., Indiana University Research and Technology Corporation, The Medical College of Wisconsin, Inc.
Inventors:
George N. Cox, Christie M. Orschell, Meetha Manek Medhora, Brian Fish
Abstract: A wind-speed accelerating wind turbine has the wind turbine installed in the nacelle, the nacelle has a front nacelle member having a cross-section area formed so as to linearly or curvilinearly contract from a wind inlet to an installed position of the wind turbine and has a rear nacelle member having the contracted cross-section area formed so as to linearly or curvilinearly expand or maintain the same cross-section area from the installed position of the wind turbine to a wind outlet, and a wind dispersion part or a wind dispersion shape is provided at the wind outlet of the rear nacelle member.
Type:
Grant
Filed:
March 28, 2022
Date of Patent:
April 15, 2025
Assignee:
GREEN POWER BY ACCELERATED FLOW RESEARCH LIMITED LIABILITY COMPANY
Abstract: A system for determining volume of a selectable region is configurable to (i) obtain user input directed to a 3D representation of a set of 2D images and (ii) based on the user input, selectively modify one or more mask pixels of one or more respective selection masks. Each 2D image of the set of 2D images is associated with a respective selection mask. The 3D representation represents pixels of the set of 2D images with corresponding voxels. The user input selects one or more voxels of the 3D representation. The one or more mask pixels is associated with one or more pixels of the set of 2D images that correspond to the one or more voxels of the 3D representation selected via the user input.
Type:
Grant
Filed:
January 26, 2022
Date of Patent:
April 15, 2025
Assignee:
INTUITIVE RESEARCH AND TECHNOLOGY CORPORATION
Abstract: A method of providing a barrier to diffusion of metal into a dielectric in a metal interconnect arrangement is disclosed which includes forming a damascene trench, including forming a dielectric base, with a trench made therein, depositing one or more two dimensional diffusion barrier layers formed over the trench, depositing a conductor layer formed atop the diffusion layer, wherein the one or more two-dimensional diffusion barrier layers substantially prevent diffusion of constituents of the conductor layer into the dielectric base, wherein each of the one or more two-dimensional diffusion barrier layers is a polycrystalline material selected from the group consisting of TaSex, TaTex, TiSx, TiSex, TiTex, and TaSx, and wherein x is between 1.5-1.9.
Abstract: A nondestructive method for detecting damage in parts and/or characterizing effective material properties may include: exposing a material to one or more nondestructive stimuli; measuring a response of the material to the stimuli; selecting at least one of a specific length scale or a specific time scale; and analyzing the measurement of the response with a scale-aware single- or multi-physics model to identify anomalies in the measurements as compared to an expected response of the material to the stimuli, wherein the scale-aware single- or multi-physics model is based on the at least one of the specific length scale or the specific time scale.
Abstract: Provided are methods, compositions, recombinant DNA molecules, and kits for cloning T cell receptors (TCRs). The methods facilitate construction of TCR expression libraries from biological samples containing antigen-specific T cells, including but not limited to tumor biopsies, including frozen tumor biopsies. Peripheral T cells that were engineered with library-derived TCR genes show potent therapeutic anti-tumor effects. The method can be performed using any sample that contains T cells, and can be performed with oligoclonal populations of T cells, such as T cells that have infiltrated a tumor. Primer combinations for first strand cDNA synthesis, second strand cDNA synthesis, and for cloning a plurality of distinct TCR ? and TCR ? chains into a plurality of vectors are provided. Cells containing the vectors are provided, as are kits for use in rapid cloning of the TCR ? and TCR ? chains.
Type:
Grant
Filed:
August 1, 2017
Date of Patent:
April 15, 2025
Assignee:
Health Research, Inc.
Inventors:
Kunle Odunsi, Richard Koya, Takemasa Tsuji
Abstract: A system for providing surgical planning and guidance with three-dimensional visualization is disclosed. In particular, the system obtains an image set of an anatomy of interest of a subject, and renders the image set on a user interface using volume rendering. Notably, the system accomplishes the foregoing without generating surface models or conducting bone contouring. The system may, during generation of an implant plan for implanting an implant onto the anatomy of interest, suggest landmark points in the volume rendered image set. Once the landmark points are confirmed, the system may facilitate implant positioning via implant controls. The system conducts a registration process to confirm a match between the physical anatomy of interest and the information contained in volume-rendered image set in the plan. If there is a match, the system may facilitate performance of a surgical procedure for implanting the implant onto the anatomy of interest of the subject.
Abstract: An optical fiber cable is provided. The optical fiber cable includes an outer jacket having an outer surface defining an outermost surface of the optical fiber cable and an inner surface defining a central bore. The optical fiber cable includes a plurality of aramid fibers located in the central bore, and the plurality of aramid fibers have a relatively low total linear density such that a total linear density of all aramid fibers within the central bore is less than 10,000 dtex. The optical fiber cable includes at least one optical fiber located within the central bore, and the at least one optical fiber has a proof test of greater than 100 kpsi.
Type:
Grant
Filed:
February 7, 2023
Date of Patent:
April 15, 2025
Assignee:
Corning Research & Development Corporation
Inventors:
William Carl Hurley, Martina Petra Richter-Bühling
Abstract: A compound for regulating body weight imbalance, a composition thereof and an application thereof. The inventor unexpectedly discovered that diosmin hydrogen sulfate derivatives have the effects of regulating body weight imbalance, and are expected to be developed as safe and effective weight imbalance regulators or used as synergists to improve the regulatory effects of existing weight imbalance regulators.
Type:
Grant
Filed:
April 24, 2020
Date of Patent:
April 15, 2025
Assignees:
GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD, GUANGZHOU XIN-CHUANGYI BIOPHARMACEUTICAL CO., LTD, XIANGBEI WELMAN PHARMACEUTICAL CO., LTD, GUANGZHOU WELMAN NEW DRUG R & DCO., LTD.
Inventors:
Tianyu Sun, Mingjie Sun, Guixing Deng, Changqing Li