Abstract: The present invention provides monoclonal antibodies that recognize human CD 112R with high affinity and specificity and inhibit its binding to Nectin-2. The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy and in diagnosis.

Abstract: A method for labeling keypoints includes labeling, via a keypoint model, a first set of keypoints in a first image associated with a three-dimensional (3D) map of an environment, the first image having been captured during a first time period. The method also includes labeling, via the keypoint model, a second set of keypoints in a second image associated with the 3D map, the second image having been captured during a second time period. The method further includes updating, via the keypoint model, one of more of the first set of keypoints based on labeling the second set of keypoints.

Abstract: A deblurring method of an embodiment is a method for deblurring a motion in a light field image in a processing device including at least one processor, and includes a first step of modeling PSF for a sub-aperture image of an acquired light field image on the basis of optical parameters, and a second step of deriving an optimization code on the basis of the obtained PSF of each sub-aperture image.

Abstract: The present disclosure provides a text-driven motion recommendation and neural mesh stylization system and a method producing human mesh animation using the same. The system comprises at least one instruction stored in a memory, and a processor that executes the at least one instruction, wherein the at least one instruction, when executed by the processor, causes the processor to find raw action labels matching a query given as a text prompt in a human motion dataset stored in a database, encode the raw action labels and the query for vectorizing the raw action labels and the query, and measure similarity between the raw action labels and the query based on the vectorized vectors.

Abstract: Provided are a system, device, and method for controlling rehabilitation of a patient. The system includes a first device configured to create a virtual model for a first user on the basis of physical information of the first user using digital twin technology and a second device configured to visualize the virtual model and provide the visualized virtual model to a second user.

Abstract: The disclosure provides compositions and methods for producing micro-dystrophin proteins, and the use thereof (e.g., in gene therapy). The disclosure also provides skeletal muscle-specific promoters and the use thereof (e.g., in gene therapy). The disclosure further provides catheter-based methods of delivering gene therapy vectors to skeletal muscle and/or cardiac muscle.

Abstract: The present disclosure relates to a holographic sheet and a hologram display apparatus including the same. The hologram sheet may include a prism array configured to refract light incident from the outside, and a reflective sheet disposed to face the prism array and configured to reflect the light refracted by the prism array and generate a floating image.

Abstract: A method of in situ point spread function (PSF) retrieval is disclosed which includes encoding 3D location of molecules into PSFs, receiving molecule-generated images containing PSFs, segmenting the images into sub-PSF, initializing template PSFs from a pupil function, determining a statistical measure of a predetermined function between the sub- and template PSFs, associating each of the sub-PSFs with a template PSF, aligning and averaging the sub-PSF, applying a phase retrieval algorithm to the averaged sub-PSFs to update the pupil function, regenerating the template PSFs, repeating until a difference between a new and a prior generation pupil function is below a predetermined threshold, generating in situ PSFs from the last pupil function, and applying a maximum likelihood estimation algorithm based on the in situ PSFs and the sub-PSF to thereby generate lateral and axial locations of molecules.

Abstract: A screen-printing ink, a method (10) of manufacturing the screen-printing ink, a 5 method (50) of producing a screen-printed electrode, and a screen-printed electrode are provided. The screen-printing ink includes graphite, an electrically conductive binder to bind the graphite, a cross-linking agent to cross-link the binder, and at least one of a conductivity modifier and a hydrophobicity modifier.

Abstract: A method of generating an image or video of a field of interest of a sample which includes obtaining i) a first RGB image from a field of interest of a sample, and ii) hyperspectral data from a subarea of the field of interest, extracting an RGB image of the subarea from the first RGB image of the field of interest, applying the hyperspectral data of the subarea to conduct a spectroscopic analysis of a sample thereby generating spectral parameters, inputting i) the spectral parameters, and ii) the first RGB image, collectively as training input data to a deep learning model (DLM), training the DLM with the training input data thus generating a trained DLM, obtaining and inputting a second RGB image of about the field of interest to the trained DLM, and outputting from the trained DLM a spectral map for the field of interest.

Abstract: Tricyclic heterocycles are useful as TEAD binders and/or inhibitors of YAP-TEAD. Tricyclic heterocycles can be used for TAZ-TEAD protein-protein interaction or binding and for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases, in particular cancer.

Abstract: The present disclosure provides the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-ATG (RAN) proteins, and reducing the accumulation of RAN proteins in a subject and/or biological sample. Also provided is the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in inhibiting RAN protein translation in a subject and in a biological sample (e.g., cells, tissue). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) for treating diseases associated with repeat expansions.

Abstract: A multimode diode laser (with a single transverse mode) is optically locked to a single Whispering Gallery Mode (WGM) of a microresonator via self-injection feedback. The tunability of the WGM-locked laser is achieved by locking the diode laser to different WGMs of the microresonator.

Abstract: A method for providing an information to assist validity judgement of a content by measuring a gaze information, a pupil diameter and an attention level of a subject when the subject of a provided content perceives the content is provided. A subject analysis device (1) comprising a content providing unit (5) for providing a content of a still image, a movie or a demonstration to be viewed by a subject; and a gaze position analysis unit (7) for analyzing a gaze position of the subject.

Abstract: The present disclosure relates to a sample and an evaluation method for measuring galvanic corrosion between a conductive coating and a protected substrate. A micropore insulating layer is arranged between the conductive coating and the substrate, the micropore insulating layer is composed of an insulating material and contains a micropore structure, the micropore structure can form an ion pathway on the surfaces of the conductive coating and the substrate after being filled with a conductive medium, and the substrate and the conductive coating are both connected with an independent leading wire. The sample of the present disclosure can evaluate galvanic corrosion between a conductive coating and other conductive materials more fully.

Abstract: The invention provides a tissue cutting device comprising a handle, a first blade. and a second blade. The second blade is coupled to the handle. The second blade is rotatable relative to the first blade such that the second blade is configured to rotate between a first position and a second position. The second blade is in a same plane as the first blade when the second blade is in the first position. The second blade is rotated into a different plane from the first blade when the second blade is rotated from the first position toward the second position.

Abstract: An auto-injector includes a housing and an actuation assembly. The housing includes a central cavity, opposing ends, and a longitudinal axis defined spanning between the opposing ends. The actuation assembly is shaped to position within the central cavity. The actuation assembly is configured to at least partially internally house a spring, a spring compression member, a needle operable to eject a fluid therefrom, a firing member selectively translatable between an unfired position and a fired position, and a firing initiation member. While in the unfired position, the needle is held within the central cavity of the housing. While in the fired position, the needle is extended outward from the central cavity of the housing.

Abstract: A method for operating a fast start-up oscillator system, which includes a reference oscillator and a quartz oscillator connected to an electronic oscillator circuit, which is provided to supply a master clock signal to a start-up controller configured to perform a fast start-up procedure of the quartz oscillator via the reference oscillator. The start-up controller includes a calculation unit and a memory unit for storing data in connection with the reference oscillator for starting the quartz oscillator. The method includes parameterising the calculation unit for starting the quartz oscillator, generating excitation bursts, determining a phase deviation in different successive periods between the oscillation of the reference oscillator and the oscillation of the quartz oscillator, calculating a frequency error in the calculation unit, and correcting the frequency of the reference oscillator to the frequency of the quartz oscillator.

Abstract: A polymer, a polymer electrolyte and a lithium ion battery are provided. The polymer includes a main chain and side chains of the polymer, the side chains contain conjugated cyclic groups and epoxy multi-element cyclic groups; the conjugated cyclic group is selected from saturated or unsaturated C10-C20 conjugated aromatic groups; the epoxy multi-element cyclic group is selected from saturated or unsaturated C3-C8 epoxy multi-element cyclic groups; the main chain of the polymer is selected from polyalkoxy ether. The polymer, the polymer electrolyte and the lithium ion battery can improve interaction between the polymer electrolyte and an active substance in an electrode plate, increase the adhesion of the polymer electrolyte, avoid detachment occurring at an interface between the plate and the electrolyte, and improve the interface stability of the battery.

Abstract: Analogues of an alternatively spliced form of atrial natriuretic peptide (MANP) that exhibit pGC-A gain of function and can be used to treat cardiorenal and metabolic disease are described herein.