Abstract: A method for enhancing extracellular vesicle production is described. A peptide that induces polymer formation is incubated with a cell culture which results in enhanced EV production. The peptide penetrates the cells and subsequently polymerizes upon exposure to enzymes (e.g. phosphatase) within the cell. The cells that contain the newly formed polymers have an increased production of EVs. These EVs can be harvested using centrifugation techniques.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
April 1, 2025
Assignees:
Research Foundation of the City University of New York, Japanese Foundation for Cancer Research
Inventors:
Hiroshi Matsui, Kiyotaka Shiba, Min A. Kang
Abstract: The present invention relates to an image information decoding method. The decoding method includes receiving a bit stream including a Network Abstraction Layer (NAL) unit that includes information related to encoded image, and parsing a NAL unit header of the NAL unit. The NAL unit header may not include 1 bit flag information that represents whether a picture is a non-reference picture or a reference picture in the entire bit stream during encoding.
Type:
Grant
Filed:
January 19, 2024
Date of Patent:
April 1, 2025
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Jung Won Kang, Ha Hyun Lee, Jin Soo Choi, Jin Woong Kim
Abstract: The disclosure relates to a 5G or 6G communication system for supporting higher data transmission rates than 4G communication systems such as LTE systems. A method performed by a receiving apparatus in a wireless communication system is provided.
Type:
Grant
Filed:
May 16, 2022
Date of Patent:
April 1, 2025
Assignees:
Samsung Electronics Co., Ltd., KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Abstract: Provided are an imaging method and system for residual stress of a basin insulator and a method for preparing a test block. The imaging method includes cutting and preparing a standard industrial sample of a basin insulator and testing the acoustoelastic coefficient of the standard industrial sample; then obtaining the residual stress data of the basin insulator and obtaining the spatial point sound velocity distribution of the basin insulator; finally, obtaining a stress distribution cloud map of the basin insulator by calculation of the attribute value and the coordinate data of a to-be-measured location, and performing reliability verification based on the residual stress data.
Type:
Grant
Filed:
October 8, 2023
Date of Patent:
April 1, 2025
Assignees:
ELECTRIC POWER SCIENCE &RESEARCH INSTITUTE OF STATE GRID TIANJIN ELECTRIC POWER COMPANY, STATE GRID TIANJIN ELECTRIC POWER COMPANY, STATE GRID CORPORATION OF CHINA
Inventors:
Jin He, Chun He, Songyuan Li, Qinghua Tang, Chi Zhang, Rong Chen, Qi Zhao, Jin Li, Xiaobo Song, Yue Han, Meng Cao, Lin Li, Suya Li, Yanwei Dong, Zhengzheng Meng
Abstract: The present disclosure provides a radiation detector, including a substrate, a pixel array formed on the substrate, a perovskite thick film formed on the pixel array and having a cubic crystal phase, a first electrode formed on the perovskite thick film and is opposite to the pixel array, and a readout circuit. The radiation detector has significantly reduced dark current density and high sensing sensitivity. The present disclosure also provides a method for preparing the perovskite thick film.
Type:
Grant
Filed:
December 29, 2022
Date of Patent:
April 1, 2025
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: A method for ZQ calibration for a data transmission driving circuit of each memory die in a memory chip package in which memory dies are stacked, includes generating a reference current through a reference resistor connected between a power terminal supplying a power voltage of the data transmission driving circuit and a ground terminal and a first transistor that is diode-connected; supplying first currents corresponding to the reference currents to a pull-up driver of each memory die; performing ZQ calibration of a pull-up driver of a corresponding memory die by comparing a first voltage formed by each first current with a reference voltage formed by the reference current in each of the plurality of memory dies; and performing ZQ calibration of a pull-down driver of the corresponding memory die based on an output impedance of the ZQ calibrated pull-up driver in each of the memory dies.
Type:
Grant
Filed:
November 8, 2022
Date of Patent:
April 1, 2025
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Min-Hyung Cho, Young-Deuk Jeon, Jin Ho Han
Abstract: Fiber optic connectors having a sealing membrane such as a foil or the like disposed on the front end of the connector housing for inhibiting dirt, debris or dust from reaching a ferrule end face are disclosed. The fiber optic connectors may have one or more ferrules with a mating end face that is located rearward of a front end of a connector housing of the fiber optic connector. The sealing membrane is disposed on the front end about a perimeter of the connector housing for inhibiting contaminants from reaching the one or more mating end faces of the respective ferrules until the fiber optic connector is desired to be mated. The sealing membrane is quick and easy to remove and/or pierce, thereby allowing optical mating of the fiber optic connector while providing single-use contaminant protection beforehand.
Type:
Grant
Filed:
September 26, 2022
Date of Patent:
April 1, 2025
Assignee:
CORNING RESEARCH & DEVELOPMENT CORPORATION
Inventors:
Thomas Theuerkorn, Christopher Robin Towery
Abstract: A method for atomic layer etching a metal containing layer is provided. At least a region of a surface of the metal containing layer is modified to form a modified metal containing region by exposing a surface of the metal containing layer to a modification gas, wherein adjacent to the modified metal containing region remains an unmodified metal containing region. The modified metal containing region is selectively removed with respect to the unmodified metal containing region by exposing the surface of the metal containing layer to an inert bombardment plasma generated from an inert gas.
Type:
Grant
Filed:
February 7, 2024
Date of Patent:
April 1, 2025
Assignee:
Lam Research Corpporation
Inventors:
Wenbing Yang, Mohand Brouri, Samantha SiamHwa Tan, Shih-Ked Lee, Yiwen Fan, Wook Choi, Tamal Mukherjee, Ran Lin, Yang Pan
Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.
Type:
Grant
Filed:
December 16, 2022
Date of Patent:
April 1, 2025
Assignees:
National University of Singapore, St. Jude Children's Research Hospital, Inc.
Inventors:
Dario Campana, David Shook, Masaru Imamura
Abstract: Provided is a particle detection device and method of fabrication thereof. The particle detection device includes a scintillator array that includes a plurality of scintillator crystals; a plurality of detectors provided on a bottom end of the scintillator array; and a plurality of prismatoids provided on a top end of the scintillator array. Prismatoids of the plurality of prismatoids are configured to redirect particles between top ends of crystals of the scintillator array. Bottom ends of a first group of crystals of the scintillator array are configured to direct particles to a first detector of the plurality of detectors and bottom ends of a second group of crystals of the scintillator array are configured to direct particles to a second detector substantially adjacent to the first detector.
Type:
Grant
Filed:
August 28, 2023
Date of Patent:
April 1, 2025
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
Amirhossein Goldan, Andrew Labella, Wei Zhao, Anthony R. Lubinsky
Abstract: A calculation device used in a manufacturing apparatus for producing a 3D manufactured object from a solidified layer formed by heating a layer-shaped material layer formed of a powder material by irradiation with an energy beam includes a detection unit configured to obtain a state of the material layer based on a shape of the formed material layer, and an output unit configured to output information on the state of the material layer obtained by the detection unit to set a manufacturing condition of the manufacturing apparatus.
Type:
Grant
Filed:
June 13, 2018
Date of Patent:
April 1, 2025
Assignees:
Nikon Corporation, Technology Research Association For Future Additive Manufacturing
Abstract: A lift-up roller arrangement for electronic float glass, including a plurality of lift-up rollers rotatably arranged on the inner wall of an annealing kiln, wherein a plurality of boron nitride rings are fixedly sleeved on the outer side wall of each lift-up roller; a heat-resisting steel tubes is arranged on each of both sides of each lift-up roller; a plurality of exhaust holes are arranged on an outer side wall of the heat-resisting steel tube; the heat-resisting steel tube is in communication with an external hot gas supply case; and a plurality of cleaning assemblies used in cooperation with the lift-up rollers are arranged at the inner bottom of the annealing kiln.
Type:
Grant
Filed:
May 17, 2023
Date of Patent:
April 1, 2025
Assignees:
BENGBU CHINA OPTOELECTRONIC TECHNOLOGY CO., LTD, CNBM RESEARCH INSTITUTE FOR ADVANCED GLASS MATERIALS GROUP CO., LTD, CHINA NATIONAL BUILDING MATERIAL GROUP CO., LTD
Abstract: As disclosed herein, inhibition of the ornithine decarboxylase 1-driven pathway can restore immunotherapeutic efficacy in lung cancer with lost STK11 function. Therefore, disclosed herein are compositions and methods for treating a lung cancer in a subject using an ornithine decarboxylase (ODC) inhibitor, such as difluoromethylornithine. In particular, disclosed is a method for using an ODC inhibitor to sensitize a lung cancer to immunotherapy. The method can involve assaying the subject for STK11 function. The method can also involve treating the subject with an immunotherapy, such as anti-PD-1/PD-L1 immunotherapy.
Type:
Grant
Filed:
December 26, 2019
Date of Patent:
April 1, 2025
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
Douglas W. Cress, John Cleveland, Nicholas Gimbrone
Abstract: A semiconductor nanoparticle includes a core and a shell covering a surface of the core. The shell has a larger bandgap energy than the core and is in heterojunction with the core. The semiconductor nanoparticle emits light when irradiated with light. The core is made of a semiconductor that contains M1, M2, and Z. M1 is at least one element selected from the group consisting of Ag, Cu, and Au. M2 is at least one element selected from the group consisting of Al, Ga, In and Tl. Z is at least one element selected from the group consisting of S, Se, and Te. The shell is made of a semiconductor that consists essentially of a Group 13 element and a Group 16 element.
Type:
Grant
Filed:
September 11, 2023
Date of Patent:
April 1, 2025
Assignees:
OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, NICHIA CORPORATION
Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
Type:
Grant
Filed:
July 11, 2023
Date of Patent:
April 1, 2025
Assignees:
The Scripps Research Institute, Board of Regents, The University of Texas System
Inventors:
Luke L. Lairson, Michael J. Bollong, Peter G. Schultz, Sendurai A. Mani
Abstract: Embodiments of the disclosure relate to a flame retardant composition. The flame retardant composition includes 70 wt % to 90 wt % of at least one polybutylene terephthalate (PBT) resin, 15 wt % to 25 wt % of a flame retardant additive, an ethylene vinyl alcohol (EVOH), an organoclay synergist, and at least one of a PBT chain extender having epoxide functional groups or a reactive compound including at least two functional groups selected from the group consisting of an epoxide, a maleic anhydride, an isocyanate, an acrylate, and an acetate. The flame retardant composition is particularly suitable for buffer tubes of optical fiber cables.
Type:
Grant
Filed:
February 21, 2022
Date of Patent:
April 1, 2025
Assignee:
CORNING RESEARCH & DEVELOPMENT CORPORATION
Inventors:
Xiaole Cheng, Dayue Jiang, Kevin Andrew Vasilakos
Abstract: Contactor structures are provided that can allow for improved heat management while reducing or minimizing the potential for contamination of process gas streams with heat transfer fluids. The contactor structures can include one or more sets of flow channels for process gas flows, such as gas flows introduced to allow adsorption of components from a gas stream or gas flows introduced to facilitate desorption of previously adsorbed components into a purge gas stream. The process gas flow channels can correspond to flow channels defined by a structural material of unitary structure. The unitary structure can correspond to the entire contactor, or the unitary structure can correspond to a monolith that forms a portion of the contactor. The contactor structures can also include one or more sets of flow channels for heat transfer fluids. The heat transfer flow channels can also be defined by the structural material of a unitary structure.
Type:
Grant
Filed:
May 20, 2022
Date of Patent:
April 1, 2025
Assignees:
ExxonMobil Technology and Engineering Company, Georgia Tech Research Corporation
Inventors:
Simon C. Weston, Ryan P. Lively, Matthew J. Realff, William J. Koros, Wenying Quan, Fengyi Zhang, Dong Hwi Jeong, Seongbin Ga, Stephen J. A. DeWitt, Yang Liu, Hannah E. Holmes
Abstract: An augmented reality system for developing and providing augmented reality learning experiences is disclosed. The augmented reality system advantageously combines augmented reality with the capabilities of cloud technology to provide a pull-based collaborative model, in which students and instructors collaborate by uploading, sharing, and downloading augmented reality learning content. The augmented reality system enables students to improve the augmented reality learning content by adding contributions to the original augmented reality learning content that was created by an instructor.