Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: A laser protection eyewear lens includes a lens substrate comprising an embedded wavelength filter having a first filter function, and a multi-layer dielectric filter applied to at least one of an inside and an outside surface of the lens substrate that comprises a second filter function having at least one center wavelength and bandwidth. The first filter function of the embedded wavelength filter and the second filter function of the multilayer dielectric filter produce a combined filter function that attenuates light reflecting off the multi-layer dielectric filter.

Abstract: The disclosure relates to a fifth generation (5G) or sixth generation (6G) communication system for supporting a higher data transmission rate. An encoding apparatus may obtain state-indicator information indicating a state of each of bits included in the polar code based on an index set of the bits, identify a weak-bit or a second weak-bit corresponding to a parity bit candidate position preset according to an interconnection within a parity-check (PC)-chain of the polar code and between PC-chains of the polar code as a parity bit, based on a number of weak-bits determined according to the state-indicator information and a number of bits to be used as parity bits, and obtain a polar code including the identified parity bit.

Abstract: Provided a light emitting device including a reflective layer including a plurality of nanostructures that are periodically two-dimensionally arranged, a planarization layer disposed on the reflective layer, a first electrode disposed on the planarization layer, an organic emission layer disposed on the first electrode, and a second electrode disposed on the organic emission layer, wherein the planarization layer includes a conductive material that is transparent with respect to light emitted by the organic emission layer, and wherein the planarization layer is disposed on upper surfaces of the plurality of nanostructures such that an air gap is provided between adjacent nanostructures of the plurality of nanostructures.

Abstract: Provided is an “all natural” biologic-enhancing beverage (BioBeverage), which contains, in addition to purified water, electrolytes, vitamins, anti-oxidants, micronutrients, natural fruit infusion, natural sweetener, Citicoline, to enhance brain/neurologic function, neurologic maintenance, repair and regeneration, CoQ10, to enhance cardiovascular energy and health, Hydroxyproline, to enhance connective tissue maintenance, repair and regeneration, and a niacinamide adenine dinucleotide (NAD+) precursor to promote overall health, including neurologic, cardiovascular and connective tissues maintenance and repair, and if present, reduce risks and symptoms of multiple neurodegenerative disorders by maintenance of healthy mitochondrial function.

Abstract: The present disclosure relates to the field of microwave and optoelectronic technologies, and in particular to an integrated microwave photon transceiving front-end for a phased array system, including: a ceramic substrate, on which a control integrated circuit, a silicon-based photonic integrated chip, a first amplifying chipset, a second amplifying chipset, and a microwave switch chipset are carried. The control integrated circuit is configured to control the silicon-based photonic integrated chip and the microwave switch chipset by means of an input control signal. The silicon-based photonic integrated chip is connected at one end with an input/output optical fiber, and at the other end with the first amplifying chipset and the second amplifying chipset. The two amplifying chipsets are connected to the microwave switch chipset respectively, and the microwave switch chipset is further connected with a phased array antenna.

Abstract: The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4,5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as Mirabilis. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.

Abstract: Embodiments of the disclosure relate to an optical fiber cable having at least one optical fiber, a cable jacket, and a foam layer. The cable jacket has an inner surface and an outer surface. The outer surface is an outermost surface of the optical fiber cable, and the inner surface is disposed around the at least one optical fiber. The foam layer is disposed between the at least one optical fiber and the cable jacket. The foam layer includes a polymer component having from 30% to 100% by weight of a polyolefin elastomer (POE) or thermoplastic elastomer (TPE) and from 0% to 70% by weight of low density polyethylene (LDPE). The foam layer has a closed-cell morphology having pores with an average effective circle diameter of 10 ?m to 500 ?m. Further, the expansion ratio of the foam layer is at least 50%.

Abstract: A system of sensors integrated into toys for monitoring free play activity of a human subject wherein patterns in play activity automatically are weighted into a pattern for identification of behavioral milestones, developmental progress and/or behavioral disorders. Specifically, accelerometers detect movement of toys which determine: (1) if the toy is being played with; and (2) the intensity in which the toy is moved. Pressure sensors detect the level and location in which a child may hold a toy. Synchronized with an audiovisual record of the play therapy session and a computer-generated avatar representation of the physical object, this data is integrated to find peak levels of behavior giving clinicians more efficient analytical tools.

Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.

Abstract: Provided herein are genetically engineered cells containing one or more modulated metabolic genes, where the expression of the modulated metabolic gene(s) can be greater than that of an unmodified control. Also provided herein are methods of making the genetically engineered cells using synergistic activation mediator CRISPR-Cas9. Further provided herein are high throughput assays that can employ the genetically engineered cells provided herein.

Abstract: Multi-beamwidth radio frequency (RF) beamforming optimization in a wireless communications apparatus is disclosed. The wireless communications apparatus includes a signal processing circuit configured to process an RF communications signal for radiation in a set of RF beams optimized to maximize coverage in a wireless communications cell. In examples disclosed herein, the set of RF beams includes a center RF beam and a number of edge RF beams. Specifically, the center RF beam is formed with a wider beamwidth to cover a larger center area of the wireless communications cell and, the edge RF beams are each formed with a narrower beamwidth to improve coverage in an edge area of the wireless communications cell. As a result, it may be possible to maximize coverage in the wireless communications cell with fewer RF beams, thus helping to reduce computational complexity, processing latency, and energy consumption of the wireless communications apparatus.

Abstract: Provided are an actuator, method for manufacturing the actuator, and acoustic transmitter having the actuator. The actuator includes: an elastic metal member having a plurality of curved segments and a plurality of connection segments which constitute a ring structure with a long-axis direction and a short-axis direction; a multilayer piezoelectric member disposed within the ring structure and having a plurality of stacked piezoelectric units along the long-axis direction; and a plurality of coupling members disposed within the ring structure, wherein the multilayer piezoelectric member has two ends in the long-axis direction that are coupled to the connection segments of the elastic metal member in the long-axis direction. A preload stress is imparted to the elastic metal member. A plurality of coupling members having a size corresponding to the preload stress are disposed between the elastic metal member and the multilayer piezoelectric member.

Abstract: It is introduced that a device of manufacturing lithium sulfate comprising: a reaction body in which a reaction of lithium phosphate and sulfuric acid is performed, the reaction body being divided into an upper space and a lower space; a pressurizer for applying pressure to the inside of the reaction body; a stirrer disposed in the upper space for stirring the lithium phosphate and sulfuric acid to produce a mixture containing lithium sulfate and phosphoric acid; and a filter disposed inside the reaction body and separating the filtrate containing the phosphoric acid into the lower space by filtering the mixture.

Abstract: A photovoltaic system's configuration specification can be inferred by an evaluative process that searches through a space of candidate values for the variables in the specification. Each variable is selected in a specific ordering that narrows the field of candidate values. A constant horizon is assumed to account for diffuse irradiance insensitive to specific obstruction locations relative to the photovoltaic system's geographic location. Initial values for the azimuth angle, constant horizon obstruction elevation angle, and tilt angle are determined, followed by final values for these variables. The effects of direct obstructions that block direct irradiance in the areas where the actual horizon and the range of sun path values overlap relative to the geographic location are evaluated to find the exact obstruction elevation angle over a range of azimuth bins or directions. The photovoltaic temperature response coefficient and the inverter rating or power curve of the photovoltaic system are determined.

Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one or more objects of interest from the classified pixels.

Abstract: A phantom for calibration and quality assurance of an MR tomograph that comprises a phantom body with measuring aids and an intermediate bottom in at least four planes. The first plane contains only measuring fluid. The second plane contains wedge-shaped elements. The third plane contains marks of known distance. The fourth plane contains comb-shaped elements. The measuring aids of the second plane are arranged on one side of the intermediate bottom and those of the fourth plane on the other side. The marks of the third plane are arranged in the intermediate bottom. This arrangement enables reliable calibration of the MR tomograph in a few steps with only this phantom.

Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.

Abstract: A new and distinct cultivar of Distylium plant named ‘DISmd-15-18’, characterized by its compact, mounding and evergreen growth habit, and its ovate-elliptical shaped leaves, that are dark green once mature and blueish-purple in color when young. The inventor believes it could be used as a foundation plant in the southern United States.