Abstract: This document provides methods and materials involved in the early detection of pancreatic cancer. For example, this document provides methods and materials for assessing nucleic acid obtained from a blood sample of a human for a CpG methylation site profile that, at least in part, indicates that the human has pancreatic cancer.

Abstract: A selectably transmissive internally focused intermediate image lens and a lens based optical window include a number of such lenses. Each selectably transmissive internally focused intermediate image lens in a lens based optical window includes a first and second lens portion. The first lens portion receives light and focuses it into a focused image at a focal plane that is coplanar with a second side of the first portion. A second lens portion has an image side adjacent to the second side of the first lens portion and an opposite side opposite the image side. The second lens portion refracts the focused image as an image projected through its rear side. Each lens further includes a selectably transmissive shutter that is located at the internal focal plane and that is controllable to block at least a portion of light passing therethrough.

Abstract: The present invention relates to a method for enhancing arginase activity in a damaged or injured cell. In other aspects, the invention provides a method for treating a disorder that can be treated by enhancing arginase activity in a human in need thereof, the method comprising administering to the human an effective amount of a compound that enhances arginase activity. Such disorders include ischemia, hypoxia, neurodegenerative disease or condition, stroke or trauma of the nervous system. In yet another aspect, the invention provides methods for promoting regeneration of a neural cell in a human in need thereof.

Abstract: The disclosure provides an arrangement structure suitable for an inverted pulverized coal boiler with ultra-high steam temperature steam parameters, including a hearth, wherein the hearth is communicated with a middle uplink flue, and the top of the middle uplink flue is communicated with that of a tail downlink flue.

Abstract: A lighting device (100) includes a housing (104), a light converter (136), one or more light sources (132), and one or more optical waveguides (160). The housing includes a light exit (124) for outputting a combination of primary light (140) and secondary light (156,158). The light source emits a primary light beam of a primary wavelength. The optical waveguide includes an input end (162) optically coupled to the light source, and an output end (164) facing a housing interior (108) and positioned at an angle to an axial direction through the housing interior. The optical waveguide directs the primary light beam from the light source, through the housing interior and toward a luminescent material of the light converter. The luminescent material emits secondary light of one or more wavelengths different from the primary wavelength in response to excitation by the primary light beam. The light source may be mounted outside the housing interior so as not to obstruct light propagation.

Abstract: A method and apparatus for scheduling data transmission, during error control operation, in which data is scheduled dependent upon satisfying a criterion relating to a characteristic of the error control operation.

Abstract: An image augmenting window and method of operation. An image augmenting window has at least one selectably transmissive internally focused intermediate image lens with a first and rear side opposite one another. Each lens respectively has a first portion that receives light and focuses it into a focused image on an internal focal plane. Each lens also has a projecting output optical structure that refracts the focused image as a projected image exiting the rear side at an exit angle. A selectably transmissive shutter is located in the internal focal plane and is controllable to block at least a portion of light passing through the lens. At least one controllable light source, positioned adjacent to a lateral side of a respective selectably transmissive internally focused intermediate image lens, emits projected light parallel to the exit angle. A controller independently controls each shutter and each controllable light source.

Abstract: Methods and compositions for reducing intraocular pressure in a patient, particularly a human patient, are described. In particular, compositions are disclosed that contain an anthocyanoside or an extract comprising it, a proanthhocyanidin or an extract comprising it and combinations thereof. The compositions are useful for lowering intraocular pressure.

Abstract: Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance to at least one ALK kinase inhibitor. Polynucleotides and polypeptides having at least one ALK inhibitor resistance mutation are provided and find use in methods and compositions useful in the diagnosis, prognosis, and/or treatment of diseases associated with aberrant ALK activity, more particularly, those that are resistant to at least one ALK kinase inhibitors. Methods and compositions are also provided for the identification of agents that can inhibit the kinase activity and/or reduce the expression level of the ALK resistance mutants.

Abstract: According to the embodiments described herein, a tricyclic SUMOylation inhibitor compound is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a SUMOylation inhibitor compound. In some embodiments, the method for treating a disease may further comprise administering one or more DNA-damaging therapy in combination with administration of the pharmaceutical composition.

Abstract: Methods and systems for predicting user input on a keyboard. Methods include enabling user input on a display comprising at least three fields. The first field displays an input string that is based on input selections such as keyboard entries. The second field displays a candidate prediction generated based on other input selections, consisting at least in part of a proposed completion to the input selection, and partially based on the input string in the first field. The third field displays another candidate prediction generated based on the input string in the first field as well as the candidate prediction in the second field.

Abstract: A process for the selective separation of hydrogen sulfide from gas mixtures containing carbon dioxide as well as other acidic gases uses severely sterically hindered amino alcohol absorbents based on amino alcohols and ethers containing secondary nitrogen atoms hindered by an alpha tertiary carbon atom. Preferred absorbents include 2-(N-methylamino)-2-methylpropan-1-ol, (2-(N-ethylamino))-2-methylpropan-1-ol, (2-(N-isopropylamino)-2-methylpropan-1-ol, SBAE (2-(N-sec-butylamino)-2-methylpropan-1-ol) and (2-(N-t-butylamino)-2-methylpropan-1-ol.

Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasia (CRN) associated with inflammatory bowel disease (IBD). The present invention provides markers specific for colorectal neoplasia associated with inflammatory bowel disease in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having colorectal neoplasia associated with inflammatory bowel disease by detecting the presence and level of indicators of colorectal neoplasia such as, for example, epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of BMP3, NDRG4, vimentin, EYA4) in DNA from a stool sample obtained from the mammal.

Abstract: There is provided a method for secure communications. The method comprises receiving a transmission comprising a signature of a broadcast message at a communication device, and verifying the signature using a certificate.

Abstract: Cosmetic/dermatological compositions for topical application and useful for the treatment, e.g., of acne, contain, formulated into a physiologically acceptable medium, at least one naphthoic acid compound and at least one polyurethane polymer or derivative thereof, the at least one naphthoic acid compound being dispersed therein.

Abstract: A needle safety guard device adapted to attach to a liquid container is provided. The device includes a disk-shaped shield having a medial opening connected with a radial opening between two radial edges. The device also includes a substantially U-shaped holder having two sidewalls coupled substantially perpendicular to the disk-shaped shield along the two radial edges, and a top cover connecting to the two sidewalls and extending from the shield above the radial opening. The U-shaped holder includes a wedged protrusion and a curved protrusion extending from each of the two sidewalls, the curved protrusion being between the top cover and the wedged protrusion for blocking a cap of the liquid container from moving toward the medial opening.

Abstract: The present invention provides an acoustic flow meter assembly (2) for pipes or open channels, said assembly including a frame (24) with a predetermined geometry. The frame has at least one user accessible port (36-42) with the at least one user accessible port (36-42) adapted to receive an interchangeable cartridge (44) which contains at least one acoustic transducer (46) to measure fluid velocity through said frame (24).

Abstract: A process for absorbing H2S and CO2 from a gas mixture containing both these gases comprises contacting the gas mixture with an absorbent combination of (i) primary absorbent component comprising a severely sterically hindered tertiary etheramine triethylene glycol alcohol or derivative of such an alcohol and (ii) secondary absorbent component for acidic gases comprising a liquid amine such as methyldiethylamine (MDEA), monoethanolamine (MEA), 2-amino-2-methyl-1-propanol (AMP), piperazine (PZ), diethanolamine (DEA), triethanolamine (TEA), diglycolamine (aminoethoxyethanol, DGA) and diisopropylamine (DIPA) another etheramine alcohol or diamine. By using the combination of amine absorbents, the overall selectivity of CO2 pickup can be maintained while retaining good H2S sorption selectivity; the selectivity of the combination for H2S and CO2 may be controlled over a range of gas loadings in the absorbent.

Abstract: The present disclosure proposes a method for device to device (D2D) communication. The method includes the step of receiving from the first device a first callee identification (ID) as the first device is handed over to the control node, searching for the second device having a second callee ID in response to receiving from the first device the first callee ID, determining that the second device has been found includes when the first callee ID is identical to the second callee ID, and arranging for the D2D communication between the first device and the second device in response to the second device is found when a first condition is fulfilled, wherein the first condition is fulfilled at least includes the second device has been found when the first callee ID is identical to the second callee ID.

Abstract: Audio processing devices and methods. An ambient microphone picks up ambient sound and a voice microphone picks up a speaker's voice. The voice microphone is located farther from the speaker's mouth when a device is held to one side of the speaker's face than when held to the other side. A signal indicates whether an expected position of the handheld body is a position on a left side or right side of a speaker's face. Ambient sound in the voice signal is reduced by applying a first algorithm configuration selected to process voice signals with lower signal-to-noise ratio when the expected position in on one side of the speaker's face, and by applying a second sound cancellation algorithm configuration selected to process higher signal-to-noise ratios when the expected position is on the other side of the speaker's face.