Abstract: A system and method provide extractions of regions of interest from images hand annotated by reviewers by lifting annotations from images, filtering out text labels, reconstructing continuous closed boundaries, and marking the contained region.

Abstract: The present invention relates to a polymerase chain reaction (hereinafter, referred to as ‘PCR’) disc apparatus for performing a PCR on a compact disc and an analysis method using the same, more specifically to a PCR disc apparatus and an analysis method using the same that are capable of allowing micro-needle tunnelling channels and different types of chambers to be integratedly arranged on a compact disc to perform DNA or RNA amplification, so that in a situation such as Coronavirus disease pandemic, a user can perform PCR analysis of non-face-to-face easily even at home to permit a doctor to remotely check PCR analysis results through the Internet network.

Abstract: Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.

Abstract: A time-limited power generation device (100) for a timepiece (1000), including a manoeuvring member (1) manoeuvrable by a user against an elastic return (2) arranged to indirectly drive an electric generator (6) for generating an electric current for a limited time period, and including a toothed member (3) movable with a degree of freedom relative to said manoeuvring member (1) and delimiting therewith a separate chamber (20) for receiving each elastic return (2), held compressed in its chamber (20) between a pre-stressed position of rest and a maximum compression position, between a first support banking (11) that includes the manoeuvring member (1) and a second support banking (32) that includes the toothed member (3), arranged to be driven by the elastic return (2) for driving the electric generator (6) directly or indirectly through a geartrain.

Abstract: A device includes a single photon avalanche diode in a portion of a substrate, wherein the portion has an octagonal profile. The octagonal profile is delimited by a wall forming an octagonal contour around the portion. The device further includes an array of diodes, wherein each diode is located in a corner between four adjacent single photon avalanche diodes. Each single photon avalanche diode further includes a doped anode region. A shallow trench isolation is formed in each doped anode region. A polysilicon line forming a resistor is supported at the upper surface of the shallow trench isolation.

Abstract: A method of closed loop simulation for accelerated material discovery is described. The method includes ranking a plurality of candidate systems according to corresponding properties of interest predicted by a first prediction model. The method also includes simulating a first top-N of the plurality of candidate systems according to the corresponding properties of interest predicted by the first prediction model. The method further includes re-ranking the plurality of candidate systems according to the corresponding properties of interest predicted by a second prediction model. The method also includes simulating a second top-N of the plurality of candidate systems according to the corresponding properties of interest predicted by the second prediction model.

Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.

Abstract: An optical sensor includes pixels. Each pixel has a photodetector. A readout circuit performs a process over an exposure time where the photodetector is connected to a reverse bias voltage supply to reset a voltage across the photodetector, and the photodetector is disconnected from the reverse bias voltage supply until that the voltage across the photodetector decreases in response to received ambient light. An ambient light level is then determine an based on a number of times the voltage across the photodetector is reset over the exposure time.

Abstract: A method for multiple object tracking includes receiving, with a computing device, a point cloud dataset, detecting one or more objects in the point cloud dataset, each of the detected one or more objects defined by points of the point cloud dataset and a bounding box, querying one or more historical tracklets for historical tracklet states corresponding to each of the one or more detected objects, implementing a 4D encoding backbone comprising two branches: a first branch configured to compute per-point features for each of the one or more objects and the corresponding historical tracklet states, and a second branch configured to obtain 4D point features, concatenating the per-point features and the 4D point features, and predicting, with a decoder receiving the concatenated per-point features, current tracklet states for each of the one or more objects.

Abstract: A device includes a single photon avalanche diode in a substrate and a resistor. The resistor is provided resting on an insulating trench located in a doped anode region of the single photon avalanche diode.

Abstract: Methods for treating uremic cardiomyopathy are provided and include the step of administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. The polypeptide anatagonist can further include a cell penetrating polypeptide. Methods of treating anemia, including anemia-associated with chronic kidney disease, are also provided.

Abstract: A method of modelling data, comprising: training an objective function of a linear classifier, based on a set of labeled data, to derive a set of classifier weights; defining a posterior probability distribution on the set of classifier weights of the linear classifier; approximating a marginalized loss function for an autoencoder as a Bregman divergence, based on the posterior probability distribution on the set of classifier weights learned from the linear classifier; and classifying unlabeled data using the autoencoder according to the marginalized loss function.

Abstract: Disclosed are a method for inducing a prediction motion vector and an apparatus using the same. An image decoding method can include: a step of determining the information related to a plurality of spatial candidate prediction motion vectors from peripheral predicted blocks of a predicted target block; and a step of determining the information related to temporal candidate prediction motion vectors on the basis of the information related to the plurality of spatial candidate prediction motion vectors. Accordingly, the present invention can reduce complexity and can enhance coding efficiency when inducing the optimum prediction motion vector.

Abstract: Embodiments of the present disclosure provide for systems for removing contaminants from a leachate, methods of removing contaminants from a leachate, and the like.

Abstract: The present disclosure relates to various types of optical fibers that are spliced together with a splice protector provided to house the spliced optical fibers. The splice protector has dimensions that enable improved mechanical properties of the spliced optical fiber.

Abstract: Provided are a memory access method and a server for performing the same. A memory access method performed by an optical interleaver included in a server includes receiving a request message from a requester processing engine included in the server, setting receiving buffers corresponding to different wavelengths corresponding to the number of external memory/storage devices connected to the server, multiplexing the same request message at the different wavelengths according to a wavelength division multiplexing (WDM) scheme, and transmitting the multiplexed request messages to the respective external memory/storage devices, wherein an address of a virtual memory managed by the server is separated and stored according to an interleaving scheme by a responder included in each of the external memory/storage devices.

Abstract: An exemplary embodiment of the present disclosure provides a robot comprising a body, a processor, and a memory. The memory further comprising instructions that, when executed by the processor cause the body to engage a first wire to support the robot from the first wire, traverse the first wire, engage a second wire simultaneously while engaging the first wire, the second wire branching from the first wire, then after engaging the second wire, disengage the first wire and traverse the second wire.

Abstract: Methods, systems, and computer programs are presented for selective deposition of etch-stop layers for enhanced patterning during semiconductor manufacturing. One method includes an operation for adding a photo-resist material (M2) on top of a base material (M1) of a substrate, M2 defining a pattern for etching M1 in areas where M2 is not present above M1. The method further includes operations for conformally capping the substrate with an oxide material (M3) after adding M2, and for gap filling the substrate with filling material M4 after the conformally capping. Further, a stop-etch material (M5) is selectively grown on exposed surfaces of M3 and not on surfaces of M4 after the gap filling. Additionally, the method includes operations for removing M4 from the substrate after selectively growing M5, and for etching the substrate after removing M4 to transfer the pattern into M1. M5 adds etching protection to enable deeper etching into M1.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

Abstract: Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(II) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein.