Abstract: Monoclonal antibodies and antigen binding fragments that specifically bind pneumococcal proteins, specifically pneumococcal histidine triad protein (PhtD) and pneumococcal surface protein A (PspA), are provided. Also disclosed are nucleic acid molecules encoding the antibody, antigen binding fragment, a VH or VL of the antibody, or a multipiece antibody including the VH and/or VL, vectors including these nucleic acid molecules, and host cells transfected with these vectors. Methods of inhibiting, treating, and detecting a Streptococcus pneumoniae infection are also provided.

Abstract: A humidity control system and method for controlling the humidity of ambient air is disclosed. The system includes a humidification and dehumidification systems to increase and/or decrease the humidity level of an indoor space and a sensor to sense ambient conditions of the space. The system further includes a controller that receives a humidity setpoint for the indoor space, determines the humidity level associated with the indoor space, compares the determined humidity level to the humidity setpoint, and causes activation of one of a humidification system or a dehumidification system. In response to causing the activation of one of the humidification or dehumidification system, the controller initiates a lockout condition during which the other of the one of the humidification or dehumidification system is prevented from activation. The controller also monitors for an override condition and enables activation of the other of the humidification system or the dehumidification system accordingly.

Abstract: The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The invention provides cannabinoid derivatives, methods of their preparation, compositions comprising them and uses thereof in the treatment of inflammation and/or pain and/or obesity.

Abstract: A high-frequency transformer, includes: an iron core, primary windings and secondary windings, wherein the iron core is of an integrated equilateral triangle structure, the primary windings and the secondary windings are uniformly wound around three sides of the iron core, and the primary windings and/or the secondary windings are symmetrically distributed on the three sides.

Abstract: Provided are compositions and methods of treating cell proliferative disorders, especially cancer. Also provided are methods for assessing and monitoring cell proliferative processes and processes for amelioration of cell proliferative disorders, especially cancer.

Abstract: Disclosed in the present application are a concrete protection material, and a preparation method and a construction method therefor. The concrete protection material consists of 50%-90% of a component A and 10%-50% of a component B in percentage by weight, where the component A is prepared from 30%-65% of organic silicon, 2%-5% of nano-silicon dioxide and the balance of an organic solvent in percentage by weight; and the component B is prepared from 20%-50% of an organic base and the balance of water in percentage by weight. The present application not only can form nano-particles having a strengthening effect in capillary channels of a concrete surface layer, but also can achieve a technical effect of superhydrophobicity on the concrete surface layer.

Abstract: The present invention relates to a method and apparatus for performing two dimension fast fourier transform for hologram processing. A method for processing a hologram according to an embodiment of the present disclosure may comprise: generating complex data by multiplying the digital image by a random phase value; performing inverse fast fourier transform (IFFT) processing on the complex data; generating pattern information by multiplying a result of the IFFT processing by a quadrant phase; and processing the hologram based on the pattern information. Here, the IFFT processing may comprise a IFFT core operation that performs row-base IFFT and column-base IFFT on the complex data, and a single shift IFFT operation that applies a predefined rule to a result of one or more of the row-based IFFT or the column-based IFFT.

Abstract: The method for converting a near-infrared image into an RGB image includes: (a) receiving near-infrared image data to be converted into an RGB image and inputting the received data to the first network; (b) extracting, by the first network, feature data of a near-infrared image from the input near-infrared image data; and (c) outputting, by the first network, an estimated RGB image, which enables to convert the received near-infrared image data into an RGB image, using the extracted feature data of the near-infrared image, wherein the first network performs knowledge distillation learning by receiving knowledge, which enables to mimic the behavior of extracting the feature data of the near-infrared image and the feature data of the RGB image, from the second network which has received as input data not only near-infrared image data as learning data but also RGB image data taken at the same time as the near-infrared image.

Abstract: A semiconductor design optimization system that includes: a data base configured to store design data, a training data preprocessing unit configured to preprocess the design data and generate training data, a data learning unit configured to generate a physical property prediction model by training using the training data, a physical property prediction unit configured to generate predicted physical property data including information associated with predicted physical property values for each region of a semiconductor device to be fabricated, wherein the physical property prediction unit is configured to input, into the physical property prediction model, input data including information associated with design drawings of the semiconductor device to be fabricated, and a layout generator configured generate a design layout optimized to distribute the predicted physical property values for each region of the semiconductor device to be fabricated by modifying the design drawings based on the predicted physical

Abstract: In accordance with an aspect of the present disclosure, there is provided an apparatus for determining a number of layers may comprise a data manager configured to obtain a graph structure including information between nodes; a first controller configured to control a reinforcement learning model designed to set the graph structure as an environment of reinforcement learning, set any one of nodes included in the graph structure as a state of reinforcement learning, and set a number of branches causing a highest expected value for a reward of reinforcement learning from any node as an action of reinforcement learning; a storage configured to store the number of branches determined by the reinforcement learning model as an action for a predetermined node input to the reinforcement learning model; and a second controller configured to apply the same number of layers for extracting an embedding of the predetermined node as the stored number of branches in a graph neural network designed based on the graph structu

Abstract: The present invention relates to methods and means for producing nitrogenase polypeptides in the mitochondria of plant cells.

Abstract: Glutathione support compositions and methods for increasing glutathione levels, especially intracellular glutathione levels, and/or methods for improving vaccine therapy and reducing gamma-glutamyltransferase (GGT) levels in an individual. In addition, the disclosure describes methods for boosting immunity, treating and preventing infectious diseases such as tuberculosis and MRSA, and combating the effects of aging and age-related stress, oxidative stress, and inflammation. The glutathione support compositions include a collagen source, a glutamate source, a cysteine source, and a selenium source, and, optionally, a boron source.

Abstract: A novel molecular pathway involving the MUL1 E3 ubiquitin ligase that regulates mitochondrial metabolism including regulation of lipogenesis and adiposity has been discovered. The significance of this pathway is exemplified in animals in which Mul1 is inactivated. These animals have a metabolic phenotype, and they are resistant to high fat diet (HFD)-induced obesity. Applications include an inactivator of mitochondrial Mul1 E3 ubiquitin ligase, compositions/kits including this inactivator, and methods for using this inactivator to regulate/inactivate mitochondrial Mul1 E3 ubiquitin ligase for prevention and/or treatment of conditions such as weight gain, obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD).

Abstract: Disclosed is an antibody for cancer treatment conjugated with a tumor environment-sensitive cleavable polyethylene glycol, wherein the use of the antibody for cancer treatment can suppress side effects of the antibody while maintaining therapeutic effects thereof.

Abstract: An image encoding method includes detecting at least one attention region from an original image, acquiring a reconstructed picture for the original image, generating residual data between a first attention region in the original image and a second attention region corresponding to the first attention region in the reconstructed picture, and encoding the residual data.

Abstract: System, methods, and other embodiments described herein relate to training a scene simulator for rendering 2D scenes using data from real and simulated agents. In one embodiment, a method includes acquiring trajectories and three-dimensional (3D) views for multiple agents from observations of real vehicles. The method also includes generating a 3D scene having the multiple agents using the 3D views and information from simulated agents. The method also includes training a scene simulator to render scene projections using the 3D scene. The method also includes outputting a 2D scene having simulated observations for a driving scene using the scene simulator.

Abstract: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) or a pharmaceutically acceptable salt thereof is used in treating a patient suffering from postpartum depression (PPD) wherein the 5-MeO-DMT is administered via the intravenous, intramuscular or subcutaneous route.

Abstract: A meta optical device for forming structured light by modulating incident light having a preset wavelength includes a plurality of supercells each including a plurality of nanostructures having a shape dimension less than the preset wavelength, and shapes and arrangements of the plurality of nanostructures are designed to form the structured light as a point pattern having a viewing angle greater than 160° in horizontal and vertical directions.