Abstract: A bispecific antibody directed against Claudin 18.2 and CD3, pharmaceutical compositions including the bispecific antibody, and a use thereof in the treatment of cancer are provided. The bispecific antibody includes an anti-CLDN18.2 binding domain and an anti-CD3 binding domain, the first binding domain being capable of binding to a CLDN18.2 protein, the second binding domain being capable of binding to CD3.

Abstract: Disclosure relates to an electrochemical membrane degassing apparatus including a liquid channel in which raw water flows, a gaseous channel in which gas degassed from the raw water flows, a gas separation membrane allowing gas in the raw water to be moved to the gaseous channel, a surface modification layer formed at the gas separation membrane, and a power supply unit applying power to the surface modification layer, and selectively operated in either of a first process mode applying a low voltage power and a second process mode applying a high voltage power, wherein in the first process mode, an electrostatic repulsive force is generated between the surface modification layer and organic particles, and in the second process mode, a radical is generated, and the organic particles is oxidized by the radical. Accordingly, the efficiency of membrane degassing can be improved and membrane contamination can be prevented.

Abstract: A vaccine comprising a pharmaceutically acceptable carrier and bacteria which presents at least one cancer-associated antigen is disclosed. The bacteria are not genetically modified to express the at least one cancer-associated antigen. Uses thereof are also disclosed.

Abstract: Particles having an ACE2 targeting moiety attached to an outer surface thereof are disclosed herein. The ACE2 targeting moiety comprises a polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD), wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501. Uses of the particles for treatment and diagnosis of diseases are also disclosed.

Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

Abstract: A resin composition containing a compound including phosphorus and sulfur as constituent elements and having a disulfide bond, and a thermoplastic resin.

Abstract: An electronic device and a method for accelerating canonical polyadic (CP) decomposition are provided. The method includes: performing at least one of a Walsh-Hadamard transform (WHT) operation and a discrete cosine transform (DCT) operation on a first factor matrix, a second factor matrix, and a tensor respectively to update the first factor matrix, the second factor matrix and the tensor; sampling the updated first factor matrix and the updated second factor matrix to generate a first sampled matrix, and sampling an unfolded matrix of the updated tensor to generate a second sampled matrix; solving a least square problem of the first sampled matrix and the second sampled matrix to generate or update a third factor matrix of the tensor so as to update multiple components of the tensor; and outputting multiple components after an updating of multiple components is finished.

Abstract: Systems and methods for learning and managing robot user interfaces are disclosed herein. One embodiment generates, based on input data including information about past interactions of a particular user with a robot and with existing HMIs of the robot, a latent space using one or more encoder neural networks, wherein the latent space is a reduced-dimensionality representation of learned behavior and characteristics of the particular user, and uses the latent space as input to train a decoder neural network associated with (1) a new HMI distinct from the existing HMIs or (2) a particular HMI among the existing HMIs to alter operation of the particular HMI. The trained first decoder neural network is deployed in the robot to control, at least in part, operation of the new HMI or the particular HMI in accordance with the learned behavior and characteristics of the particular user.

Abstract: The present disclosure relates to a JAK3 gene-mutated severe combined immunodeficiency animal model and a method of constructing the same. In the JAK3 gene-mutated severe combined immunodeficiency animal model of the present disclosure, the JAK3 gene is specifically deficient, the expression of cytokines is regulated by controlling the number and activity of macrophages, and the thymus, lymphocytes, and Peyer's patches, which are observed in conventional severe combined immunodeficiency animal models, particularly mini-pigs, are completely lacking. In addition, the animal model of the present disclosure can be used as a treatment model for JAK3 SCID patients, as similar phenotypes are observed in patients with human severe combined immunodeficiency caused by a JAK3 gene mutation, and can be used for artificial blood development or xenotransplantation.

Abstract: Disclosed are a music data analysis apparatus capable of analyzing and visualizing creation principles of music and a music data generation apparatus capable of using the creation principles. The music data generation apparatus may comprise: a memory; and a processor executing at least one instruction stored in the memory, wherein the processor is configured to perform: generating a seed overlap matrix so that the seed overlap matrix represents musical features of seed music data; and generating new music data based on the seed overlap matrix.

Abstract: A method of representation learning for object detection from unlabeled point cloud sequences is described. The method includes detecting moving object traces from temporally-ordered, unlabeled point cloud sequences. The method also includes extracting a set of moving objects based on the moving object traces detected from the sequence of temporally-ordered, unlabeled point cloud sequences. The method further includes classifying the set of moving objects extracted from on the moving object traces detected from the sequence of temporally-ordered, unlabeled point cloud sequences. The method also includes estimating 3D bounding boxes for the set of moving objects based on the classifying of the set of moving objects.

Abstract: An encoding apparatus extracts features of an image by applying multiple padding operations and multiple downscaling operations to an image represented by data and transmits feature information indicating the features to a decoding apparatus. The multiple padding operations and the multiple downscaling operations are applied to the image in an order in which one padding operation is applied and thereafter one downscaling operation corresponding to the padding operation is applied. A decoding method receives feature information from an encoding apparatus, and generates a reconstructed image by applying multiple upscaling operations and multiple trimming operations to an image represented by the feature information. The multiple upscaling operations and the multiple trimming operations are applied to the image in an order in which one upscaling operation is applied and thereafter one trimming operation corresponding to the upscaling operation is applied.

Abstract: Systems and methods for virtual pancreatography (VP) are disclosed for non-invasive diagnosis and classification of pancreatic lesions. VP is an end-to-end visual diagnosis system that includes: automatic segmentation of the pancreatic gland and the lesions, extraction of the primary pancreatic duct, automatic classification of lesions into a plurality of lesion types, and specialized 3D and 2D exploratory visualizations of the pancreas, lesions and surrounding anatomy. Volume rendering is combined with pancreas and lesion centric visualizations and measurements for effective diagnosis.

Abstract: SARS-CoV-2 vaccines will be essential to reduce morbidity and mortality. The inventors produced an antibody that is directed against a surface antigen (i.e. CD40) of an antigen presenting cell (i.e. dendritic cell) wherein the heavy chain was conjugated to the receptor-binding domain of the Sars-Cov-2 spike protein for its use as vaccine. In particular, the inventors show that said vaccine induces circulating Ab-secreting hu-B cells, elicits S-specific IgG+ hu-B cells, elicits the expansion of central memory CD4+ hu-T cells and the emergence of effector memory CD4+ T cells, elicits the expansion of central memory CD8+ hu-T cells at and the emergence of effector memory CD8+ T cells at and finally induces Stem-cell like memory hu-CD8+ T cells.

Abstract: An embodiment of the present disclosure provides an ion battery electrode material that significantly improves scan rate, capacity exhibiting, safety, and energy density compared to conventional ion batteries by manufacturing bulk POM in a layered structure in which bulk POM is uniformly distributed in several nanometers on the surface of rGO/PPy, and a method for synthesizing ion battery electrode materials.

Abstract: A method and system are provided for an improved semantic segmentation using a multi-stream late fusion using pretrained encoders to encode disparate channels independently while also integrating selected image features at a more abstract level in order to provide improved localization and image classification.

Abstract: Disclosed herein is a method of controlling an autonomous vehicle driving in a lane of a main line. The method may include determining whether the autonomous vehicle is driving in a target lane to accommodate merging traffic, determining whether a merge request message is received from a merging vehicle when the autonomous vehicle is determined to drive in the target lane, determining whether a collision with the merging vehicle will occur based on the merge request message when the merge request message is received, and sending a merge approval message to the merging vehicle when the collision with the merging vehicle is expected.

Abstract: The invention relates to a genetic probe, wherein the genetic probe comprises: an oligonucleotide, or an oligonucleotide analogue, with a Raman-active moiety incorporated therein, wherein the Raman-active moiety is incorporated into a base of the oligonucleotide or oligonucleotide thereof; and associated methods, uses, kits and compositions for determining a single point variant nucleotide in a target nucleic acid.

Abstract: A tribometer and technique for determining torque at a physical interface of multiple rotating components. The tool and technique include aligning components about a rotational axis for independent rotation of each component. The components are in physical interface during the rotating with a resultant frictional torque. The torque may be measured by one or more torque meters during the rotating. This measured torque may be compared against an estimated torque for tool accuracy. Further, parameters such as load, temperature, component material, rotating rpm differentials and others may be varied to determine effect on measured frictional torque.

Abstract: According to the invention there is provided a HFAC power supply configured to be powered by a DC supply, the HFAC power supply comprising a power circuit, a load circuit and a controller, the power circuit and the load circuit being inductively coupled, the power circuit comprising a voltage regulator configured to output an output voltage, a DC to AC driver and a driver circuit comprising an LC resonant bridge circuit and a primary inductor inductively coupled to the load circuit.