Abstract: The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

Abstract: A curable composition and an electronic device employing the same are provided. The curable composition includes 100 parts by mole of a first siloxane compound represented by Formula (I) wherein n is 8 to 232, wherein R1 is independently C1-3 alkyl group; 1 to 15 parts by mole of a second siloxane compound represented by Formula (II) wherein x?2, y?2, and x/y is between 0.1 and 3, and R2, R3 and R4 are independently C1-3 alkyl group; 1 to 15 parts by mole of a third siloxane compound represented by Formula (III) and 90 to 250 parts by mole of a curing agent represented by Formula (IV) wherein m is 7 to 230, wherein R5 is independently C1-3 alkyl group.

Abstract: An optical fiber carrying structure that includes a jacket and a rip cord is provided. Optical fiber cables are used to transmit data over distance. Generally, large distribution cables that carry a multitude of optical fibers from a hub are sub-divided at network nodes into subunits. To remove a jacket of a subunit, the subunit may be provided with an access feature such as a rip cord. Described herein is a rip cord for use with optical fiber carrying structures.

Abstract: The embodiments described herein describe technologies to address initial establishment of device credentials in an Internet of Things (IoT) infrastructure. The embodiments are directed to unifying secure credential establishment regardless of the endpoint type, thus addressing the challenge of a great diversity among IoT devices. This approach is designed to address a challenge of initial trusted enrollment of the IoT endpoints into a secure infrastructure, which allows secure communications between the devices in the IoT environment.

Abstract: Provided is a method of reducing autoimmunity, including reducing an amount of self-reactive B cells in a subject expressing elevated levels of an autoantibody, wherein reducing includes administering 2-hydroxyoleic acid to the subject. Also provided is a method of treatment including administering 2-hydroxyoleic acid to a subject expressing elevated levels of an auto-antibody. Also provided is a method of promoting B cell tolerance, including promoting apoptosis of self-reactive B cells in a subject, wherein promoting includes administering 2-hydroxyoleic acid to the subject.

Abstract: Systems and methods for tracking objects are disclosed herein. In one embodiment, a system having a processor merges features of detected objects extracted from a point cloud and a corresponding image to generate fused features for the detected objects, generates a learned distance metric for the detected objects using the fused features, determines matched detected objects and unmatched detected objects, applies prior tracking identifiers of the detected objects at the prior time to the matched detected objects, determines a confidence score for the fused features of the unmatched detected objects, and applies new tracking identifiers to the unmatched detected objects based on the confidence score.

Abstract: Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.

Abstract: Systems, methods and devices are provided for performing diagnostic or therapeutic transcranial procedures using a patient-specific transcranial headset. The patient-specific headset may include a patient-specific frame that is fabricated, according to volumetric image data, to conform to an anatomical curvature of a portion of a patient's head. The patient-specific frame is configured to support a plurality of transducers in pre-selected positions and orientations, which may be spatially registered to the volumetric image data. This spatial registration may be employed to control at least a portion of the transducers to focus energy at a pre-selected tissue region.

Abstract: An apparatus and method for pitch-shifting an audio signal with low complexity are disclosed. The method includes identifying a distance between an audio object included in the audio signal and a listener, checking whether the distance between the audio object and the listener decreases, and performing stepwise stretching pitch-shifting of repeatedly using at least one of frequency components of the audio signal when the distance between the audio object and the listener decreases.

Abstract: A spherical LED chip, a method for manufacturing the same, and a display panel, and a method for spherical LED chip transfer are provided. The spherical LED chip includes a first electrode, a second electrode surrounding the first electrode and having magnetism, and a first insulating protective layer arranged at the outside of the first electrode. The first insulating protective layer and the second electrode form an LED housing configured to wrap the first electrode and with a spherical outer contour.

Abstract: An oxidative homocoupling method of synthesizing certain 2,2?-bithiophenes from thiophenes using oxygen as the terminal oxidant is disclosed. In non-limiting examples, the method uses oxygen along with a catalytic system that includes palladium, an assistive ligand, and a non-palladium metal additive to catalyze one of the following reactions: Associated catalytic systems and compositions are also disclosed.

Abstract: The present disclosure describes systems and methods for test pattern generation to detect a hardware Trojan using delay-based analysis. One such method comprises determining a set of initial test patterns to activate the hardware Trojan within an integrated circuit design; and generating a set of succeeding test patterns to activate the hardware Trojan within the integrated circuit design using a reinforcement learning model. The set of initial test patterns can be applied as an input to the reinforcement learning model. Further, the reinforcement learning model can be trained with a stochastic learning scheme to increase a probability of triggering one or more rare nodes in the integrated circuit design and identify optimal test vectors to maximize delay-based side-channel sensitivity when the hardware Trojan is activated in the integrated circuit design. Other methods and systems are also provided.

Abstract: Provided a filter and a redistribution layer structure including the same. The capacitor includes a first electrode, a second electrode, a third electrode, a dielectric layer, and a conductive through via. The second electrode is disposed above the first electrode. The third electrode is disposed between the first electrode and the second electrode. The dielectric layer is disposed between the first electrode and the third electrode and between the second electrode and the third electrode. The conductive through via penetrates the dielectric layer and the third electrode to be connected to the first electrode and the second electrode, and is electrically separated from the third electrode. The first electrode and the second electrode are signal electrodes, and the third electrode is a ground electrode.

Abstract: A method of managing authentication information of a certificate independently of a certificate authority (CA) is provided. The method includes issuing a certificate, into which identifier information instead of a public key is inserted, to an origin server by using the CA and reading an identifier document from an external storage by using user equipment on a basis of the identifier information received from the origin server and verifying the certificate with the public key included in the identifier document.

Abstract: Disclosed herein is a method for memory management in a memory disaggregation environment. The method includes generating virtual memory based on multiple first memory devices, determining whether a condition for allocation acceleration is satisfied by the first memory devices, and allocating a memory page to the first memory devices based on whether the condition for allocation acceleration is satisfied.

Abstract: Disclosed herein are a method and apparatus for verifying integrity in a memory-disaggregated environment. The method for verifying integrity in a memory-disaggregated environment includes receiving write data and multiple hash values generated based on write data from a remote memory, and verifying integrity of the write data based on the write data and the hash values, wherein verifying the integrity of the write data comprises selecting a hash value for the integrity verification based on an access latency of the remote memory.

Abstract: Disclosed are a noninvasive blood glucose measurement apparatus and method using multiple sensors. The noninvasive blood glucose measurement apparatus includes: a first light source unit configured to irradiate light to the biological tissue, a second light source unit configured to irradiate light to the biological tissue, a first receiving unit configured to receive a photoacoustic and/or light transmission signal generated by the light, a second receiving unit configured to receive a light reflection signal reflected by the biological tissue, and a measurement unit configured to measure light reflection characteristics of the biological tissue by using the light reflection signal, measure photoacoustic and/or light transmission characteristics of the biological tissue, and measure blood glucose of the biological tissue on the basis of the light reflection characteristics and the photoacoustic and/or light transmission characteristics.

Abstract: The present invention discloses a SERS-nanotag comprising gold nanoparticle, an encapsulating agent, a Raman reporter and an antibody. The present invention also discloses a diagnostic kit consisting of SERS-nanotags for identification of breast cancer biomarker selected from the group consisting of Estrogen Receptor (ER), Progesterone Receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67, simultaneously in abreast cancer tissue sample using a surface enhanced Raman scattering signature peaks. The multiplexing Raman peak pattern provides the presence of multiple biomarkers at a time in heterogeneous paraffin embedded breast cancer tissue samples with a concentration level of the SERS-nanotags by applying single laser (532 nm/633 nm/785 nm) revealing simultaneous Raman peaks for the respective biomarkers.

Abstract: The protein targeted medicine, Dovitinib, has been repurposed to target a non-coding RNA by using selection and computational drug design via Inforna. Selectivity was achieved for pre-miR-21 by endowing the medicine with the ability to recruit RNA quality control enzymes to cleave the target.

Abstract: An in-memory vector addition method for a dynamic random access memory (DRAM) is disclosed which includes consecutively transposing two numbers across a plurality of rows of the DRAM, each number transposed across a fixed number of rows associated with a corresponding number of bits, assigning a scratch-pad including two consecutive bits for each bit of each number being added, two consecutive bits for carry-in (Cin), and two consecutive bits for carry-out-bar (Cout), assigning a plurality of bits in a transposed orientation to hold results as a sum of the two numbers, for each bit position of the two numbers: computing the associated sum of the bit position; and placing the computed sum in the associated bit of the sum.