Abstract: In some embodiments, a device for generating mid-infrared radiation is provided. The device may include a thin film quadratic nonlinear waveguide formed on a mid-infrared transparent cladding by a thin film material of a predetermined film thickness, the waveguide having a predetermined etch depth and a predetermined top width. At least one of the predetermined film thickness, the predetermined etch depth, and the predetermined top width may be tuned for the device to generate a coherent idler wave as a mid-infrared radiation from a fixed pump wave and a tunable signal wave.

Abstract: Methods of using a soft tissue cutting device are disclosed. The methods include providing the soft tissue cutting device, positioning the soft tissue cutting device in a priming slot of a tray configured for receiving and holding the soft tissue cutting device, attaching a priming syringe to the soft tissue cutting device, priming a balloon disposed on a distal end of the soft tissue cutting device by equalizing a first pressure inside the balloon to a second pressure inside the priming syringe, removing the soft tissue cutting device from the priming slot, and positioning the distal end of the soft tissue cutting device on a safety slot included in the tray to determine whether the tissue cutting device has been properly primed.

Abstract: Systems and methods for self-cleaning a surface of an object where an electrodynamic shield is mounted to a surface of the object. The electrodynamic shield includes one or more sets of electrodes atop a substrate, at least one or more sets of electrodes being covered in a protective film. A coating is applied to the top surface of the protection film. A signal pulse generator is connected to the one or more sets of electrodes. The signal pulse generator generates a pulse signal that causes the one or more sets of electrodes to generate an electric field. The pulse signal comprises a plurality of different pulse signals which have phase differences between consecutive signals, and the electric field causes a particle atop the coating to experience an electrostatic force and be repelled away from the coating. These pulse signals (including shapes, amplitudes, shifts, and frequencies) can be tuned to increase efficiency of removal depending on dust type and relative humidity.

Abstract: There is provided a computer implemented method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving a plurality of EEG datasets, each respective EEG dataset from a respective EEG electrode of a plurality of EEG electrodes monitoring a head of the subject, clustering the plurality of EEG datasets into a plurality of clusters, computing a p-adic representation of the plurality of clusters, extracting a quantum potential value from p-adic representation of the plurality of clusters, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the quantum potential relative to a threshold that separates between presence of the medical state and non-presence of the medical state.

Abstract: The disclosure relates to a voice signal analysis method and device and a chip design method and device. The voice signal analysis method includes: in a first updating gradient, training a resolution recovery model by using first voice training data meeting a same grouping condition in multiple mission sets; in a second updating gradient, training the resolution recovery model by interleavingly using second voice training data meeting different grouping conditions in the mission sets; iteratively executing the first and second updating gradients to set an initial model parameter of the resolution recovery model; and recovering a high-resolution snore signal from a low-resolution snore signal by using the resolution recovery model. The low-resolution snore signal has a lower resolution than the high-resolution snore signal.

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating obesity or diabetes, and to a food composition and feed composition for preventing or alleviating obesity or diabetes, comprising as an active ingredient, an Acanthopanax extract, a garcinia cambogia extract, or compounds isolated therefrom. The composition has synergistic antidiabetic and antiobesity activity compared to that of using only an Acanthopanax extract, a garcinia cambogia extract, or compounds isolated therefrom. Therefore, it is possible to reduce the possibility of any side effects that may be caused by an overdose of or long-term administration of the garcinia cambogia extract and a substance isolated therefrom, and thus the composition can be very effectively utilized in the development of a therapeutic agent for diabetes or obesity.

Abstract: A fluid transport device includes a conduit unit having a wall for separating an inside from an outside of the conduit unit. The device also includes an energy supply unit coupled to the conduit unit and configured to provide electrical energy based on a temperature gradient between the inside and the outside of the conduit unit. The device also includes a monitoring unit configured to monitor a state of the conduit unit and to generate data representative for the state of the conduit unit. The energy supply unit supplies the electrical energy to the monitoring unit, thereby enabling the monitoring unit to monitor the state of the conduit unit. A method for manufacturing a fluid transport device is also described.

Abstract: A method is disclosed for treating or preventing a myeloid malignancy in a subject harboring a mutation in SRSF2 comprising: (a) analyzing in a sample of the subject for the presence of an SRSF2 mutation; and (b) administering to the subject a therapeutically effective amount of a Rho Kinase inhibitor, or an inhibitor of a downstream effector thereof, upon identification of SRSF2 mutation.

Abstract: Various embodiments may relate to a gas cell. The gas cell may include a chamber body. The gas cell may also include a chamber lid cooperating with the chamber body to form a space. The gas cell may further include an infrared source provided in a through hole of the chamber lid such that the infrared source extends through a thickness of the chamber lid. The gas cell may additionally include a detector provided in a through hole of the chamber body. The gas cell may further include an optical chip arranged within the space such that the optical chip is between the infrared source and the detector. The gas cell may also include three O-rings.

Abstract: There is provided a method and corresponding system for processing a set including Head-Related Transfer Functions, HRTFs, for at least two different directions of sound incidence to enable improved generation, modeling or simulation of ear signals corresponding to a diffuse sound field. For each direction of sound incidence to the head, a left-ear HRTF represents the transfer function from a sound source to the left ear, and a right-ear HRTF represents the corresponding transfer function to the right ear. The method comprises applying (S1) a phase adjustment to each HRTF, for each ear and direction, for reducing Interaural Time Differences, ITD, above a threshold frequency or in a frequency band above the threshold frequency; and adding (S2) a direction-dependent Interaural Phase Difference, IPD, to each HRTF, for each ear and direction, for reducing Interaural Coherence when modelling or simulating a diffuse sound field.

Abstract: According to various embodiment of the present invention, in a diagnosis system including a sensing module that senses the state of a motor is installed in a car, disclosed are a method for determining failure of a motor in a car comprising the steps of: (a) acquiring sensed values by sensing the state variables of the motor by the sensing module; (b) extracting two or more feature values by converting the sensed values acquired by the sensing module; (c) generating two clusters which classify and include the two or more feature values based on the two or more feature values and determining a normal cluster among the two clusters; and (d) determining the state of the motor as a failure-expected state or a safe state by applying at least one classifier to the feature values included in the normal cluster.

Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a biomolecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.

Abstract: A method and an apparatus for equipment anomaly detection are provided. In the method, multiple signals of an equipment during normal operation or appearance images of the equipment when an appearance is not damaged are acquired in advance by using a data acquisition device to train a machine learning model stored in a storage device. A real-time signal of the equipment during a current operation or a current image of the appearance of the equipment is acquired by using the data acquisition device, and input to the trained machine learning model to output a detection result indicating a current operation state of the equipment or a current state of the appearance of the equipment.

Abstract: Provided is a surveillance system employing a plurality of unmanned aerial vehicles (UAVs), the surveillance system showing improved surveillance performance while optimizing common energy consumption for computing of all the UAVs and also providing a stable visual monitoring service using autonomous mobility of the plurality of UAVs regardless of movement of an object to be monitored and action uncertainty of an adjacent UAV.

Abstract: Various embodiments provide an optical lens that includes wafer level diffractive microstructures. In one embodiment, the optical lens includes a substrate, a microstructure layer having a first refractive index, and a protective layer having a second refractive index that is different from the first refractive index. The microstructure layer is formed on the substrate and includes a plurality of diffractive microstructures. The protective layer is formed on the diffractive microstructures. The protective layer provides a cleanable surface and encapsulates the diffractive microstructures to prevent damage and contamination to the diffractive microstructures. In another embodiment, the optical lens includes a substrate and an anti-reflective layer. The anti-reflective layer is formed on the substrate and includes a plurality of diffractive microstructures.

Abstract: A feed forward equalizer includes a plurality of delay circuits connected to each other in series and configured to delay input signals. A plurality of filters respectively correspond to outputs of the plurality of delay circuits, except for a reference output which is an output of a first delay circuit among the plurality of delay circuits, and the input signals. A calculator configured to sum the reference output and outputs of the plurality of filters. Each of the plurality of filters is configured to receive an output of a delay circuit corresponding thereto, among the plurality of filters, and the reference output.

Abstract: The present disclosure provides a standardized and virus-free rapid propagation method of Dianthus caryophyllus, belonging to the technical field of asexual propagation. The method includes the following steps: conducting virus detection on a Dianthus caryophyllus explant, and inoculating the explant into an induction medium for induction culture; after the explant germinates, cutting buds, and determining whether a virus-free treatment is required according to a virus detection result, and continuing cultivating the buds; after cultivating to obtain cluster buds, inoculating the cluster buds into an expanding propagation medium for expanding propagation, and conducting the virus detection to eliminate a virus-carrying material; conducting expanding propagation on a virus-free material to a certain base, and transferring the virus-free material to a rooting medium for rooting culture.

Abstract: The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.

Abstract: Disclosed herein are an apparatus and method for a multiplication operation based on an outer product. The apparatus may include first internal calculators, each of which generates an intermediate accumulation value by performing a Multiply-Accumulate (MAC) operation, second internal calculators, each of which generates a chunking accumulation value using the intermediate accumulation value, and accumulation data transmission paths for enabling the output of any one of the first internal calculators to be input to any one of the second internal calculators.