Abstract: The present disclosure generally relates to systems and methods of use for draining cerebrospinal fluid (CSF) from a brain or a spinal canal in a subject, for example, to treat hydrocephalus or other conditions. In some embodiments, the disclosure relates to a device comprising a flow controller positioned within a conduit that allows CSF to flow through the conduit from a first end to a second end. This may allow the CSF to drain, for example, from an intradural space (such as a thecal sac) into, for example, a paraspinal space, paraspinal vein or other venous space, or peritoneal cavity. A variety of methods may be used to hold or anchor the device in place, for example, an expansion apparatus. In some embodiments, the device can be implanted percutaneously at a location along or within a subject's spinal column, thus reducing the need for surgery, general anesthesia, and hospitalizations.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: The present invention provides a compound, and method of selectively inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure:

Abstract: A method of a receiver in a communication system may comprise: transmitting, to a transmitter, artificial intelligence (AI) capability information of the receiver; receiving, from the transmitter, AI model information generated based on the AI capability information; selecting one or more AI models from among a plurality of AI models indicated by the AI model information; transmitting information of the one or more AI models to the transmitter; receiving, from the transmitter, channel state information (CSI) configuration information including information of at least one AI model among the one or more AI models; generating CSI feedback information based on the at least one AI model indicated by the CSI configuration information; and transmitting the CSI feedback information to the transmitter.

Abstract: The image decoding method according to the present invention comprises the steps of: determining the availability of a block adjacent to a current block; configuring a merge candidate list for the current block on the basis of the result of the determined availability; and performing motion compensation for the current block on the basis of the merge candidate list, wherein the step of determining availability comprises the steps of inducing block availability information on the adjacent block and inducing the availability of motion information on the adjacent block, and the step of determining the availability of the adjacent block is such that when there is more than one adjacent block, the availability of adjacent blocks can be determined in accordance with a predetermined order restriction.

Abstract: Aspects of the disclosure relate to compositions and methods for treating certain (e.g., CD33-positive) cancers. In some aspects, the disclosure provides antibodies that specifically bind to CD33 protein variants that lack an IgV domain. In some aspects, the disclosure provides adaptable cell engagers (ACEs) and recombinant proteins (e.g., BiTEs) comprising an anti-CD33 antibody of the disclosure and an anti-CD3 antibody. In some embodiments, the disclosure provides methods of treating cancer by administering the antibodies, ACEs, or recombinant proteins (e.g., BiTEs) to a subject in need thereof.

Abstract: A flexible guide assembly (10) including a fixed support (22) and three flexible guides arranged in series, the first flexible guide including a first movable element (23) relative to the fixed support (22), a first pair of uncrossed flexible blades (26, 27) connected to the first movable element (23), the second flexible guide including a second movable element (24) relative to the first movable element (23), a second pair of uncrossed flexible blades (28, 29) connecting the second movable element (24) to the first movable element (23), the third flexible guide including a third movable element (25) and a third pair of uncrossed flexible blades (31, 32) connecting the third movable element (25) to the second movable element (24), the third movable element (25) forming a balance or a balance support of the rotary resonator mechanism.

Abstract: The present disclosure relates to a deep neural network-based object detection device, system, and method, and more particularly, to a deep neural network-based object detection device, system, and method capable of rapidly detecting an object in an image in real time.

Abstract: An alloy powder preparation method according to an embodiment comprises the steps of: forming a mixture by mixing a plurality of metal compounds; and thermally treating the mixture, wherein, in the step of thermally treating the mixture, the process temperature changes according to the particle diameter of alloy powder. In addition, the step of thermally treating the mixture proceeds through hydrogen reduction at a process temperature of 300 to 700° C.

Abstract: A high-temperature polymer electrolyte membrane fuel cell including a polymer of intrinsic microporosity that prevents phosphoric acid poisoning and a method for manufacturing the same are disclosed. It is possible to improve the electrochemical efficiency of high-temperature polymer electrolyte membrane fuel cells based on development of a polymer of intrinsic microporosity with thermal stability and cationic conductivity.

Abstract: A method for localization of a drone within a building, the method may include (a) detecting, by an acoustic detection unit of the drone, sounds generated by a propulsion unit of the drone while the drone is located within the building; and (b) determining, by a processing unit of the drone, the location of the drone within the building, based on the sounds and on building acoustic information regarding sounds detected at different portions of the building.

Abstract: The disclosure presented herein provides DNA constructs, recombinant cells comprising thereof, system comprising thereof, bacterial probes, and/or a recombinant cell decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying cells, preferably bacteria cells, and methods for using thereof.

Abstract: The invention relates to systems, methods, network devices, and machine-readable media for encoding an input message with robustness against noise by executing a compressing hash function on the input message, encoding an output of the hash function and the input message to generate a single combined message, executing a permutation function on the combined message, and encoding the result of the permutation function with a list-decodable code.

Abstract: The image decoding method according to the present invention comprises the steps of: determining the availability of a block adjacent to a current block; configuring a merge candidate list for the current block on the basis of the result of the determined availability; and performing motion compensation for the current block on the basis of the merge candidate list, wherein the step of determining availability comprises the steps of inducing block availability information on the adjacent block and inducing the availability of motion information on the adjacent block, and the step of determining the availability of the adjacent block is such that when there is more than one adjacent block, the availability of adjacent blocks can be determined in accordance with a predetermined order restriction.

Abstract: A method of performing dynamic edge application server (EAS) instantiation triggering and an apparatus for performing the method are provided. The method of performing dynamic EAS triggering includes triggering dynamic EAS instantiation in response to an EAS discovery subscription request, transmitting a report on a need of instantiation of a target EAS, and transmitting a result of the target EAS instantiation to an edge enabler server (EES) that transmits the EAS discovery subscription request.

Abstract: The present invention relates to a method for direct reprogramming from somatic cells into pancreatic beta cells by using microRNA and small-molecule materials. The inventors of the present invention confirmed that, as a result of having attempted direct reprogramming upon co-treatment of microRNA and small-molecules (e.g., various differentiation-inducing materials), the expression level of PDX1 remarkably increased in pancreatic beta cells, and, when pancreatic beta-like cells were induced using such a method, direct reprogramming was performed with very high yield. In addition, since autologous cells are used, the present invention has the advantages of no occurrence of immune rejection responses and a low possibility of developing cancer, and thus is expected to be effectively used in the development of safer cellular therapeutic agents.

Abstract: An electronic device includes a stack of a first level having a SPAD, a second level having a quench circuit for said SPAD, and a third level having a circuit for processing data generated by said SPAD. A method for making the device includes: a) forming of the first level; b) bonding, on the first level, by molecular bonding, of a stack of layers including a semiconductor layer; and c) forming the quench circuit of the second level in the semiconductor layer.

Abstract: A method for estimating stream flow data of a channel includes steps of acquiring direct measurement of an index velocity of the channel, acquiring stage measurements for the channel for use in determining slope of a free surface, and applying a data-driven model combining the index velocity and a continuous slope-area method which uses the slope of the free surface to estimate stream flow data of the channel without using conventional rating curves. The direct measurement of the index velocity and the stage measurements may be received at a computing device executing instructions for applying the data-driven model.

Abstract: A system includes a mobile device for capturing raw video of a subject, a preprocessing system communicatively coupled to the mobile device for splitting the raw video into an image stream and an audio stream, an image processing system communicatively coupled to the preprocessing system for processing the image stream into a spatiotemporal facial frame sequence proposal, an audio processing system for processing the audio stream into a preprocessed audio component, one or more machine learning devices that analyze the facial frame sequence proposal and the preprocessed audio component according to a trained model to determine whether the subject is exhibiting signs of a neurological condition, and a user device for receiving data corresponding to a confirmed indication of neurological condition from the one or more machine learning devices and providing the confirmed indication of neurological condition to the subject and/or a clinician via a user interface.

Abstract: The disclosed subject matter provides systems and methods for processing light. An example system can include one or more substrates, and a plurality of meta-units, which are patterned on each of the substrates and configured to modify a phase, an amplitude, or a polarization of the light with a subwavelength resolution. The system can be in a form of a diffractive neural network and be configured to perform target recognition.