Abstract: Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(?O), CH2 and NH are disclosed for use in inhibiting DNA-PK.

Abstract: Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen, hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO2R2 wherein R1 is selected from the group consisting of alkyl, aryl, alkaryl, and NH2, and R2 is selected from the group consisting of alkyl, aryl and aralkyl, and provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain, as immunomodulators and for treating drug abuse.

Abstract: Nanoadditive is constituted of organophilic polymer or copolymer covalently bonded by linking group to silicate and is blended with polypropylene to produce nanocomposite which is useful in all cases where polypropylene is used and resists breakage and is not flammable and has improved barrier properties compared to neat polypropylene.

Abstract: A chip package structure and a process for fabricating the same is disclosed. The chip package structure mainly comprises a carrier, a chip and an encapsulating material layer. To fabricate the chip package, a carrier and a plurality of chips are provided. Each chip has at least an active surface with a plurality of bumps thereon. The chips and the carrier are electrically connected. An encapsulating material layer that fills the bonding gap between the chips and the carriers and covers the chips and carrier is formed. The encapsulating material layer between the chips and the carrier has a first thickness and the encapsulating material layer over the chips has a second thickness. The second thickness has a value between half to twice the first thickness.

Abstract: The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.

Abstract: The invention relates to colon and prostate tumor associated antigen peptides obtainable from prostate specific G protein-coupled receptor (PSGR), six-transmembrane epithelial antigen of prostate (STEAP) and proteins encoded by genes found overexpressed in colon carcinoma cells, such as human 1-8D interferon induced transmembrane protein 2. The invention further relates to a polynucleotide encoding the tumor associated antigen peptides and to pharmaceutical compositions, which are preferably anti-tumor vaccine compositions, containing a tumor associated antigen, at least one tumor associated antigen peptide thereof, or encoding polynucleotide thereof as an active ingredient. The pharmaceutical compositions can be administered to a patient in need thereof to treat or inhibit the development of colon or prostate cancer.

Abstract: A physical keyboard for a handheld mobile communication device having a plurality of keys with corresponding indicia including keys simultaneously presenting associated alphabetic indicia and associated numeric indicia. The alphabetic indicia correspond to letters A-Z that are arranged in a QWERTY pattern and the numeric indicia correspond to at least numerals 1-9 that are arranged in an ITU Standard E.161 phone keypad pattern. At least some of the numerals and at least some of the letters are presented on the same keys thereby establishing an overlaid relationship. The keys that present alphabetic indicia number fewer than 26.

Abstract: A large-scale field-programmable analog array (FPAA) for rapidly prototyping analog systems and an arbitrary analog waveform generator. The large-scale FPAA includes a floating-gate transistor array and a plurality of computational analog blocks (CABs), which may be adapted to set bias voltages for operational transconductance amplifiers (OTAs), adjust corner frequencies on the capacitively coupled current conveyors, set multiplier coefficients in vector-matrix multipliers, and a variety of other operations. The floating-gate transistors may be used as switch elements, programmable resistor elements, precision current sources, and programmable transistors. Accordingly, the floating-gate transistors within the array allow on-chip programming of the characteristics of the computational elements, while still maintaining compact CABs. The arbitrary analog waveform generator may include programmable floating-gate MOS transistors for use as analog memory cells to store samples of the waveforms.

Abstract: Electrospun nanofiber incorporating a binder (e.g., biotin) is used in the form of a nonwoven or composite with a substrate. The nonwoven and composite can be joined to biosensor, e.g., by binding the biotin to streptavidin and binding streptavidin to biotinylated detector, and because of the high surface area to volume of electrospun nanofiber provides increased sensitivity.

Abstract: The image sensor includes a plurality of pixels, arranged in rows and columns to form a pixel array, each pixel having a pixel output. The image sensor includes at least two column bitlines for each pixel column, each column bitline connected to each pixel output in the pixel column and to a common readout amplifier. In one embodiment, the bitlines are not in the same plane and multiple bitlines are positioned one above the other, maximizing pixel efficiency.

Abstract: The present invention relates to the enhancement of bioavailability of chemotherapeutic agents for the treatmnet of disease. In particular the present invention relates to a method of enhancing the bioavailability of a chemotherapeutice agent comprsing the step of administering to a submect in need thereof a therapeutically effective amount of hyaluronan.

Abstract: A system and method for preventing the lapse of a recurring event includes an electronic calendar program having the capability of establishing a recurring event with a predetermined end date. A processor is operative for notifying an organizer of the event at a predetermined time of the end date for the recurring event and permitting the organizer to modify the end date of the recurring event if the event is to continue. The electronic calendar program and processor is operative in a mobile wireless communications device that includes a housing and radio frequency (RF) transceiver contained within the housing such that notifications of the new end date can be transmitted to and received by attendees of the event, including any changed meeting information.

Abstract: The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4polypeptide variant. The invention also provides a method of promoting wound healing in a subject comprising administering to the subject a composition comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4polypeptide variant. The invention also relates to methods of treating the above mentioned conditions in a subject comprising administering to the subject a nucleic acid encoding a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4 polypeptide variant. The invention also relates to pharmaceutical compositions comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4polypeptide variant, or salt thereof, and a pharmaceutically acceptable carrier.

Abstract: Disclosed are methods and compositions for efficiently expressing antibody fusion proteins. Antibody fusion proteins of the invention include a hybrid antibody moiety containing sequences from more than one type of antibody and/or mutant antibody sequences. Hybrid antibody fusion proteins of the invention may be produced at high levels and may combine functional properties characteristic of different antibody types in addition to functional properties of a non-antibody moiety.

Abstract: The invention provides pharmaceutical compositions and methods of treating immunological disorders. The invention also provides pharmaceutical compositions and methods of inducing eosinophil apoptosis, and methods for treating eosinophil-associated disorders comprising inducing eosinophil apoptosis in an individual in need thereof.

Abstract: A method and system for an embeddable electronic information resource which may be cognitively enabled by a human host using a neurological electronic interface. In an embodiment, the electronic information resource is provided as an RFID device or an ISO-14443 compatible device. The various embodiments allow the human host to selectively enable and/or disable the embeddable electronic information resource through thought-commands issued to the neurological electronic interface, thus providing an affirmative access control of the information contained in the electronic information resource. Embodiments are provided which alerts the human host through direct neural feedback, about the state and/or status of accesses and/or attempted accesses to the electronic information resource, and/or about the result of an authentication performed by a remote device that has just scanned the electronic information resource.

Abstract: Compounds of formula l: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; are disclosed for use in inhibiting DNA-PK.

Abstract: Abstract of the Disclosure The invention provides a method of, and a kit for, assessing a pulmonary abnormality in a human by providing a standard that relates a degree of pulmonary abnormality with a level of a prostaglandin E2 metabolite, determining the level of the prostaglandin E2 metabolite in a human, and comparing the level determined in the human to the standard whereby the pulmonary abnormality in the human is assessed.

Abstract: An electroplating apparatus for depositing a metallic layer on a surface of a wafer is provided. In one example, a proximity head capable of being electrically charged as an anode is placed in close proximity to the surface of the wafer. A plating fluid is provided between the wafer and the proximity head to create localized metallic plating.

Abstract: A method to determine the properties of a water-lain sediment body from a measurement of grain size distribution and deposit thickness at one location in the body is disclosed. In one embodiment, the method comprises (a) determining the flow properties at the measured location, (b) extrapolating the flow properties back to the inlet through which the depositing flow was emitted, (c) determining at least one property of the water-lain sediment throughout the sediment body by modeling the flow properties using the extrapolated flow properties at the inlet from step (b) as a boundary condition. The flow properties associated with the sediment body include flow velocity, suspended sediment volume fractions, deposition time, and flow height. The properties of the water-lain sediments include, in addition to the flow properties associated with deposition of the sediments, the thickness of the sediment body, the size of the body, the shape of the body, and the grain size distribution at each point within the body.