Abstract: A DCN1/2-mediated cullin neddylation modulator; a method for treating disorders associated with dysfunctional DCN1 and/or UBC12, Alzheimer's disease, other neurodegenerative diseases, bacterial infections, or viral infections; and a method for treating cancers are provided. The DCN1/2-mediated cullin neddylation modulator includes a compound according to Formula I disclosed herein. The methods include administering to a mammal a therapeutically effective amount of a compound according to Formula I. Also provided herein is a pharmaceutical composition including a therapeutically effective amount of a compound according to Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Abstract: A method of in situ point spread function (PSF) retrieval is disclosed which includes encoding 3D location of molecules into PSFs, receiving molecule-generated images containing PSFs, segmenting the images into sub-PSFs, initializing template PSFs from a pupil function, determining a maximum normalized cross correlation (NCC) coefficient (NCCmax) between the sub- and template PSFs, associating each of the sub-PSFs with a template PSF based on the NCCmax and storing the sub-PSFs in associated bins, aligning and averaging the binned sub-PSFs, applying a phase retrieval algorithm to the averaged sub-PSFs to update the pupil function, regenerating the template PSFs, repeating until a difference between a new and a prior generation pupil function is below a predetermined threshold, generating in situ PSFs from the last pupil function, and applying a maximum likelihood estimation algorithm based on the in situ PSFs and the sub-PSFs to thereby generate lateral and axial locations of molecules.

Abstract: A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.

Abstract: A method of blind spot detection is provided. The method of blind spot detection is used for a vehicle including a first vehicle body and a second vehicle body dragged by the first vehicle body. The method of blind spot detection comprises the following steps: obtaining a turning angle information of the second vehicle body relative to the first vehicle body by a first sensor while the vehicle is moving; determining a predetermined information related to the vehicle and/or a second sensor; dynamically defining a blind spot area around the vehicle according to the turning angle information and the predetermined information; and receiving a sensing signal regarding an object around the vehicle from the second sensor to determine whether the object is located in the blind spot area.

Abstract: A computer-implemented method for determining a measurement value for each operator of a plurality of operators. The method comprises grouping the plurality of operators into one or more sets of mutually commuting operators, each set comprising one or more of the plurality of operators. Determining, for each set of operators: a subset of transformed operators based on the set of operators, such that the set of operators are equal to products of the subset of transformed operators; a mapping circuit based on the subset of transformed operators, wherein the mapping circuit comprises an arrangement of quantum gates configured to operate on a plurality of qubits in a quantum computer.

Abstract: A build plate for an additive manufacturing device and methods for the same are provided. The build plate may include a base and a sacrificial plate coupled with the base. The etch rate of the sacrificial plate in an etchant may be greater than an etch rate of the base in the etchant. A method for separating a 3D printed article supported on the build plate may include contacting the sacrificial plate with the etchant.

Abstract: Described herein are non-human organisms for producing triacylglycerol wherein the non-human organism is genetically modified to express a lysophosphatidic acid acyltransferase specific for C16:0-Coenzyme A (C16:0 LPAT) and wherein, once expressed, the C16:0 LPAT is localised in the endoplasmic reticulum. Also described are non-human organisms for producing triacylglycerol in which (a) a lysophosphatidic acid acyltransferase specific for C16:0-Coenzyme A (C16:0 LPAT) is localised in the endoplasmic reticulum; and (b) activity of native endoplasmic reticulum lysophosphatidic acid acyltransferase (ER LPAT) is suppressed or prevented. Further described are non-human organisms in which a chloroplast lysophosphatidic acid acyltransferase (LPAT) is expressed, wherein said chloroplast LPAT lacks a functional chloroplast targeting signal. The disclosure also relates to methods for extracting triacylglycerol from the organisms and the use thereof in infant formula.

Abstract: Provided is a method for producing semiconductor nanoparticles. The method includes: providing first semiconductor nanoparticles containing a semiconductor containing an element M1, an element M2 and an element Z, wherein the element M1 is at least one element selected from the group consisting of Ag, Cu, Au and an alkali metal, and contains at least Ag, the element M2 is at least one element selected from the group consisting of Al, Ga, In and Tl, and contains at least one of In and Ga, and the element Z contains at least one element selected from the group consisting of S, Se and Te; and heat-treating a mixture containing the first semiconductor nanoparticles, a first compound having a Ga—S bond, a second compound containing Ga and not containing S, and an organic solvent to obtain second semiconductor nanoparticles.

Abstract: A new and distinct variety of shrub rose plant, referred to by its cultivar name, ‘VLR003’, is described. The new variety forms on a continuous basis attractive, yellow-colored double flowers from spring to fall. The growth habit is semi-upright compact bush. Attractive semi-glossy, dark green foliage is formed. The new variety is cold hardy. Additionally, the new variety is particularly well suited for growing as distinctive ornamentation in the landscape.

Abstract: Adeno associated viral (AAV) particles are emerging as a useful vehicle for gene delivery to various organs and tissues. Provided here are variant AAV capsid proteins and variant capsid protein containing particles. Compositions of these variant AAV particles can be used to alter tissue tropism and transduction efficiency. In some embodiments, compositions described in this application are useful to produce rAAV particles, and/or to deliver one or more genes of interest to a target tissue.

Abstract: The present disclosure reaches a method of a unique combination of bioinformatic technical tools together with chemical synthesis for identification of bioactive peptide molecules based on non-ribosomal peptide synthetases. Those bioactive cyclic peptide molecules are useful as antimicrobials, anticancer agents, antiparasitic, immunosuppressants, and others. Series of useful cyclic peptides and the pharmaceutical compositions thereof are within the scope of this disclosure.

Abstract: A system for fusion of Wi-Fi measurements from multiple frequency bands to monitor indoor and outdoor space is provided. The system includes a multi-band wireless network comprising a set of radio devices to provide coverage in an environment, wherein the set of radio devices are configured to establish wireless communication or sensing links over multi-band wireless channels, wherein the multi-band wireless channels use a first radio band at a millimeter wavelength and a second radio band at a centimeter wavelength. The system further includes a computing processor communicatively coupled to the set of radio devices and a data storage, wherein the data storage has data comprising a parameterized model, modules and executable programs.

Abstract: Provided is an immunogenic composition including a peptide, wherein consecutive amino acids of the peptide include at least amino acids 186-193 of SEQ ID NO:1 and one or more adjuvants. In an example, the peptide is covalently linked to an amino acid sequence including SEQ ID NO:2.

Abstract: A thermoplastic elastomer composition includes about 80 parts by weight of an ethylene propylene diene monomer (EPDM) including 5-ethylidene-2-norbornene (ENB) and polyethylene, about 30 parts by weight to about 70 parts by weight of polypropylene, about 20 parts by weight to about 40 parts by weight of a filler, and about 60 parts by weight to about 90 parts by weight of a plasticizer.

Abstract: The invention is directed towards compounds (e.g., Formulae (I)-(IX)), their mechanism of action, processes to prepare the compounds, methods of activating quorum sensing signaling activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formulae (I)-(IX)).

Abstract: Disclosed are a method and an apparatus for image encoding/decoding. The method for image decoding includes comparing whether a size of a current transform block and a size of a smallest transform block (smallest transform unit (STU)) are the same as each other, and decoding information indicating whether transformation is performed on the current transform block and determining whether to perform inverse transformation on the current transform block based on the decoded information indicating whether the transformation is performed when the size of the current transform block and the size of a smallest transform block are the same as each other.

Abstract: Processes and systems for upgrading natural gas liquids. At least a portion of the natural gas liquid components in a shale gas stream can be dehydrogenated to their corresponding olefin derivatives prior to separating any methane from the liquids. Further processing subsequent to dehydrogenation could include various separations, oligomerizing olefins produced in the dehydrogenation step, recovering desired products, etc. The order of the processing steps subsequent to dehydrogenation could be adjusted in various cases.

Abstract: The present invention provides a method of prophylaxis or treatment of a senescence-associated disease or disorder by administering to a subject in need thereof, a therapeutically effective amount of a NMT inhibitor.

Abstract: A device (102) for generating and storing a cryptographic key pair is disclosed. The device comprises a non-persistent memory unit (116) and a processor (114). The processor (114) is configured to receive a plurality of seeds from a respective plurality of users and combine the seeds to define a composite seed. The processor (114) is further configured to generate the key pair, comprising a public key and a private key (104), using the composite seed and a deterministic key generation method, and to record the private key (104) in the non-persistent memory unit (116).

Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein.