Abstract: An embodiment of the present disclosure can include a nanocarrier for delivering a cargo to a cell comprising: a bundle domain and a binding domain, the binding domain configured to bind to the cargo. An embodiment of the present disclosure can include a method for delivering a cargo to a cell comprising: introducing an amino-acid based nanocarrier to the cell, the nanocarrier can comprise an alpha-helical protein bundle domain and a binding domain, the cargo can bound to the binding domain and the cargo can be therapeutic cargo.
Type:
Grant
Filed:
June 7, 2017
Date of Patent:
September 6, 2022
Assignee:
Georgia Tech Research Corporation
Inventors:
Julie Champion, Sung In Lim, Anshul Dhankher
Abstract: Disclosed is a method for processing a page fault. The method includes performing demand paging depending on an application operation in a system including a processor and an operating system, and loading, at the processor, data on a memory in response to the demand paging.
Type:
Grant
Filed:
November 17, 2020
Date of Patent:
September 6, 2022
Assignees:
Research & Business Foundation Sungkyunkwan University, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
Jinkyu Jeong, Jae Wook Lee, Gyusun Lee, Wenjing Jin, Tae Jun Ham
Abstract: The present invention relates to an ultra-thin acoustic lens for subwavelength focusing in a megasonic range and a design method thereof. More particularly, the present invention relates to a super-oscillatory planar ultra-thin acoustic lens for subwavelength focusing in the megasonic range, which includes a plurality of concentric regions arranged in a concentric shape with reference to the center point, wherein the concentric regions include a plurality acoustic insulation region for insulating incident acoustic waves, and a plurality of transmission regions for transmitting acoustic waves, the acoustic insulation regions and the transmission regions being formed alternatively in a radial direction from the center point so as to focus incident acoustic wave energy onto a subwavelength region.
Type:
Grant
Filed:
May 30, 2018
Date of Patent:
September 6, 2022
Assignee:
Korea Research Institute of Standard and Science
Inventors:
Jae-yub Hyun, Yong-tae Kim, Il Doh, Bong-young Ahn, Kyung-min Baik, Se-hwa Kim
Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
Type:
Grant
Filed:
July 6, 2020
Date of Patent:
September 6, 2022
Assignee:
SUNNYBROOK RESEARCH INSTITUTE
Inventors:
Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
Abstract: A method of determining moisture content in an emulsified asphalt-aggregate system is disclosed. The method includes: placing a first electrode in an emulsified asphalt-aggregate system (Mixture) at a first depth, placing a second electrode in the Mixture at a second depth, applying an alternating current (AC) signal between the first electrode and the second electrode, measuring impedance, determining the frequency which yields the minimum measured impedance, recording the minimum measured impedance, repeating the above steps at a predetermined time interval until the recorded minimum impedance is about 10 times of the first recorded minimum impedance, and alerting a user that the Mixture has sufficiently cured.
Type:
Grant
Filed:
August 6, 2019
Date of Patent:
September 6, 2022
Assignee:
Purdue Research Foundation
Inventors:
John Ernest Haddock, William Jason Weiss, Miguel Angel Montoya Rodriguez
Abstract: The present invention discloses a method for determining a content of lost gas in a shale gas content test. The method includes: acquiring a shale core and recording the time required for acquiring the shale core; carrying out a desorption experiment on the shale core to obtain desorption data; acquiring a fitting objective function; fitting the desorption data by using the fitting objective function to obtain fitted desorption data; determining fitting parameters according to the desorption data and the fitted desorption data; correcting the time required for acquiring the shale core according to the fitting parameters; and obtaining the content of lost gas according to the fitting parameters and the corrected time required for acquiring the shale core. The present invention can improve the determining precision of the content of the lost gas.
Type:
Grant
Filed:
January 23, 2020
Date of Patent:
September 6, 2022
Assignees:
TSINGHUA UNIVERSITY, SHANXI RESEARCH INSTITUTE FOR CLEAN ENERGY, TSINGHUA UNIVERSITY
Abstract: Methods and systems for the separation of hydrogen isotopes from one another are described. Methods include utilization of a hydrogen isotope selective separation membrane that includes a hydrogen isotope selective layer (e.g., graphene) and a hydrogen ion conductive supporting layer. An electronic driving force encourages passage of isotopes selectively across the membrane at an elevated separation temperature to enrich the product in a selected hydrogen isotope.
Type:
Grant
Filed:
June 6, 2019
Date of Patent:
September 6, 2022
Assignees:
Savannah River Nuclear Solutions, LLC, Clemson University Research Foundation, Georgia Tech Research Corporation
Inventors:
Dale A. Hitchcock, Steven M. Serkiz, Timothy M. Krentz, Josef A. Velten, Kyle S. Brinkman, Eric M. Vogel, Katherine T. Young
Abstract: An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.
Type:
Grant
Filed:
October 30, 2020
Date of Patent:
September 6, 2022
Assignees:
TC1 LLC, The Penn State Research Foundation
Inventors:
Mark W. McBride, Thomas M. Mallison, Gregory P. Dillon, Robert L. Campbell, David A. Boger, Stephen A. Hambric, Robert F. Kunz, James P. Runt, Justin M. Walsh, Boris Leschinsky
Abstract: A radiation pumped heater includes a ceramic substrate which is heated by a laser beam to a steady state temperature. An optical fiber is heated by conduction and radiation emitted from the ceramic substrate.
Abstract: A nitrogen-doped catalyst for oxidative coupling of methane, which is a catalyst for obtaining a C2 hydrocarbon product with high yield, and a method for manufacturing the catalyst are provided. An embodiment of the present inventive concept relates to a nitrogen-doped catalyst for oxidative coupling of methane having a silica support; and sodium tungstate and manganese supported on the support.
Type:
Grant
Filed:
November 20, 2020
Date of Patent:
September 6, 2022
Assignee:
KOREA INSTITUTE OF ENERGY RESEARCH
Inventors:
Hee-yeon Kim, Tae-woo Kim, Ji-haeng Yu, Dae Keun Lee
Abstract: The present disclosure provides systems and methods to detect occluded objects using shadow information to anticipate moving obstacles that are occluded behind a corner or other obstacle. The system may perform a dynamic threshold analysis on enhanced images allowing the detection of even weakly visible shadows. The system may classify an image sequence as either “dynamic” or “static”, enabling an autonomous vehicle, or other moving platform, to react and respond to a moving, yet occluded object by slowing down or stopping.
Type:
Grant
Filed:
November 2, 2018
Date of Patent:
September 6, 2022
Assignees:
TOYOTA RESEARCH INSTITUTE, INC., MASSACHUSETTS INSTITUE OF TECHNOLOGY
Inventors:
Felix Maximilian Naser, Igor Gilitschenski, Guy Rosman, Alexander Andre Amini, Fredo Durand, Antonio Torralba, Gregory Wornell, William Freeman, Sertac Karaman, Daniela Rus
Abstract: The invention relates to methods of modifying DNA methylation by contacting a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences.
Type:
Grant
Filed:
August 18, 2017
Date of Patent:
September 6, 2022
Assignee:
Whitehead Institute for Biomedical Research
Abstract: A device for rapid non-destructive genetic material collection can include a multi-reservoir array (202) and a movement mechanism. The multi-reservoir array (202) can include multiple reservoirs (204). A plurality of the multiple reservoirs (204) can include an abrasive surface (210) capable of retaining a source of genetic material in a liquid carrier. The abrasive surface (210) has a roughness. The movement mechanism can be operable to move the multi-reservoir array (202) in an oscillating motion sufficient to create relative movement between the abrasive surface (210) and the source of the genetic material in order to remove a portion of genetic material from the source of the genetic material without destroying the source of the genetic material or the portion of the genetic material that is removed.
Type:
Grant
Filed:
July 3, 2018
Date of Patent:
September 6, 2022
Assignee:
University of Utah Research Foundation
Inventors:
Raheel Samuel, Christopher J. Lambert, Bruce K. Gale, Joshua L. Bonkowsky, Briana Freshner, Tak Chi Arlen Chung
Abstract: The invention relates to a composition for treatment and management of Dementia. The composition is a combination of herbs and bhasmas. It includes herbs such as Bacopa monnieri, Convolvulus pluricaulis, Mucuna pruriens, Nardostachys jatamansi, Rauwolfia serpentina, Withania somnifera, Acorus calamus, Sida cordifolia and Emblica officinalis. It further includes Shilajit, Rasa sindura and bhasmas. The composition is useful in treating Cognitive dysfunction, Dementia and other cognitive impairments associated with neuro-degenerative disorders. Further, the composition is also useful in restoring and improving cognitive function.
Abstract: A composite material and a foam prepared from the composite material are provided. The composite material includes a network polymer, a fluorine-containing polymer fiber, and a reinforcement fiber. The polymer network is a crosslinking reaction product of a polymer and an oligomer, wherein the polymer is polyamide, polyester, polyurethane, or a combination thereof, and the oligomer is a vinyl aromatic-co-acrylate oligomer with an epoxy functional group. The oligomer has a weight percentage of 1% to 10%, based on the weight of the network polymer. The ratio of the weight of the reinforcement fiber to the total weight of the network polymer and the fluorine-containing polymer fiber is from 1:9 to 4:6.
Type:
Grant
Filed:
December 31, 2019
Date of Patent:
September 6, 2022
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: The present invention provides a process of cultivating microalgae and a joint method of same jointed with denitration. During the microalgae cultivation, EM bacteria is added into the microalgae suspension. In the nutrient stream for cultivating microalgae, at least one of the nitrogen source, phosphorus source and carbon source is provided in the form of a nutrient salt. During the cultivation, the pH of the microalgae suspension is adjusted with nitric acid and/or nitrous acid. The joint method includes (1) a step of cultivating microalgae; (2) a separation step of separating a microalgae suspension obtained from step (1) into a wet microalgae (microalgae biomass) and a residual cultivation solution; and (3) a NOx absorbing/immobilizing step of denitrating an industrial waste gas with the residual cultivation solution obtained from step (2). The nutrient stream absorbed with NOx obtained from step (3) is used to provide nitrogen source to the microalgae cultivation of step (1).
Type:
Grant
Filed:
March 17, 2015
Date of Patent:
September 6, 2022
Assignees:
CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPEC
Abstract: A system may forecast a plurality of workload measurements for a database management system (DBMS) at respective times based on a workload model. The system may determine, based on the forecasted workload measurements, configuration parameter sets optimized for the DBMS at the respective times. The system may generate a reconfiguration plan. The system may determine a performance gain that would result from reconfiguring nodes of the DBMS with the configurations parameter sets. In addition, the system may determine a performance loss that would result from the respective databases of the nodes being inaccessible during reconfiguration with the configuration parameter sets. The system may select a reconfiguration plan in response to the performance gain and the performance loss satisfying a fitness criterion. The system may cause, at the reconfiguration times, the nodes to begin reconfiguration with the configuration parameter sets included in the selected reconfiguration plan.
Type:
Grant
Filed:
April 16, 2020
Date of Patent:
September 6, 2022
Assignee:
Purdue Research Foundation
Inventors:
Saurabh Bagchi, Somali Chaterji, Paul Curtis Wood, Ashraf Mahgoub
Abstract: Methods for assessing fiber and bundle orientations and mechanical properties of fiber reinforced composite materials using Thermal Digital Image Correlation (TDIC) are disclosed. In some examples, the method comprises exposing the composite material to a temperature change; imaging the composite material at a plurality of time points before, during and/or after the temperature change; and assessing the characteristic of the composite material based on the imaging. In others, temperature changes naturally occur during the cooling process after manufacturing can be employed for this method such as compression molding process, injection molding process, resin transfer molding processes and its variants.
Type:
Grant
Filed:
September 5, 2019
Date of Patent:
September 6, 2022
Assignee:
University of Tennessee Research Foundation