Patents Assigned to Rhode Island Hospital
  • Methods of inhibiting metastases
    Publication number: 20050032785
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Application
    Filed: June 21, 2004
    Publication date: February 10, 2005
    Applicant: Rhode Island Hospital
    Inventors: Jack Wands, Rolf Carlson, Paul Maggio
  • Combination drug therapy
    Patent number: 6849599
    Abstract: The invention provides antineoplastic composition containing an inhibitor of angiogenesis and an inhibitor of DNA topoisomerase type I enzyme activity.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: February 1, 2005
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6835370
    Abstract: The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: December 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Alan H. Deutch, Hossein A. Ghanbari
  • Tribonectins
    Publication number: 20040229804
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Application
    Filed: June 1, 2004
    Publication date: November 18, 2004
    Applicant: Rhode Island Hospital
    Inventor: Gregory D. Jay
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6815415
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 9, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Taurine compounds
    Patent number: 6812251
    Abstract: The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: November 2, 2004
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, Bai-Chuan Pan, James Darnowski
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6812206
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 2, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6797696
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6783758
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 31, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
    Patent number: 6770797
    Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 3, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte
  • Methods of inhibiting metastases
    Patent number: 6753328
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: June 22, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • Tribonectins
    Patent number: 6743774
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: June 1, 2004
    Assignee: Rhode Island Hospital
    Inventor: Gregory D. Jay
  • Use of taurolidine to treat tumors
    Patent number: 6703413
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: March 9, 2004
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski
  • Inter-alpha-trypsin inhibitor as a marker for sepsis
    Patent number: 6660482
    Abstract: The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under conditions sufficient to form an ITI-ligand complex and detecting the complex.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: December 9, 2003
    Assignee: Rhode Island Hospital
    Inventors: Yow-Pin Lim, Douglas C. Hixson
  • Cardiac valve replacement
    Patent number: 6652583
    Abstract: The invention provides a replacement heart valve which contains an acellular matrix as a structural scaffold. The scaffold is seeded with isolated myofibroblasts and/or endothelial cells prior to implantation into a recipient mammal.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: November 25, 2003
    Assignee: Rhode Island Hospital
    Inventors: Richard A. Hopkins, Diane Hoffman-Kim
  • Methods of treating tumors with taurolidine
    Patent number: 6521616
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: February 18, 2003
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Paul Calabresi, James Darnowski
  • Taurine compounds
    Publication number: 20020183286
    Abstract: The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death.
    Type: Application
    Filed: March 15, 2002
    Publication date: December 5, 2002
    Applicant: Rhode Island Hospital
    Inventors: Paul Calabresi, Bai-Chuan Pan, James Darnowski
  • Methods for detecting cancer of the central nervous system
    Patent number: 6489128
    Abstract: A method for diagnosing a tumor in the central nervous system of a mammal is carried out by contacting a bodily fluid from the mammal with a ligand which binds to inter-alpha trypsin inhibitor.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: December 3, 2002
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Yow-Pin Lim, Douglas C. Hixson
  • Use of taurolidine to treat tumors
    Patent number: 6429224
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: August 6, 2002
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Paul Calabresi, James Darnowski
  • Chondrosarcoma associated genes
    Patent number: 6207812
    Abstract: The invention features a nucleic acid molecule encoding a chondrosarcoma associated polypeptide and methods for diagnosing patients with chondrosarcoma. the gene.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: March 27, 2001
    Assignee: Rhode Island Hospital
    Inventor: Richard M. Terek