Patents Assigned to Rhode Island Hospital
  • Wnt proteins and detection and treatment of cancer
    Patent number: 8158761
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 17, 2012
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Miran Kim
  • Compositions and methods for detecting and treating renal injury and inflammation
    Patent number: 8110365
    Abstract: Renal injury and inflammation is diagnosed by detecting an elevation in GSK3b level or activity. Inflammation of bodily tissues such as renal tissue is inhibited by administration of GSK3b inhibitory compositions.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: February 7, 2012
    Assignee: Rhode Island Hospital
    Inventors: Lance Dworkin, Rujun Gong
  • Tribonectins
    Patent number: 8026346
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: September 27, 2011
    Assignee: Rhode Island Hospital
    Inventor: Gregory D. Jay
  • Methods for detecting sepsis
    Patent number: 7939282
    Abstract: Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the concentration of GRK compared to that of a normal, healthy control sample indicates that the subject from which the sample is obtained is suffering from or at risk of developing sepsis.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: May 10, 2011
    Assignee: Rhode Island Hospital
    Inventors: Loren D. Fast, Yow-Pin Lim
  • Liver stem cell
    Patent number: 7935528
    Abstract: The invention provides a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantation are also within the invention.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: May 3, 2011
    Assignee: Rhode Island Hospital, a Lifespan Partner
    Inventor: Ronald A. Faris
  • Kinematic total wrist arthroplasty
    Patent number: 7918894
    Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: April 5, 2011
    Assignees: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, Rhode Island Hospital
    Inventors: Scott W. Wolfe, Joseph John Crisco, III
  • Wrist implants
    Patent number: 7914583
    Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: March 29, 2011
    Assignees: New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgey, Rhode Island Hospital
    Inventors: Scott W. Wolfe, Joseph John Crisco, III
  • Frizzled proteins and detection and treatment of cancer
    Patent number: 7867705
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: January 11, 2011
    Assignee: Rhode Island Hospital, a Lifespan-Partner
    Inventors: Jack R. Wands, Philippe Merle, Suzanne M. De La Monte
  • Treatment of Alzheimer's Disease
    Patent number: 7833513
    Abstract: This invention relates to methods for diagnosing Alzheimer's Disease (AD) by determining the level or function of insulin, insulin-like growth factors, their receptors and/or their downstream signaling molecules. The invention further relates to methods for the treatment of AD by administering an insulin agonist and an insulin-like growth factor agonist. The invention additionally provides an animal model of AD and methods of screening for agents useful in the treatment, amelioration, or prevention of AD.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: November 16, 2010
    Assignee: Rhode Island Hospital
    Inventors: Suzanne Marie de la Monte, Jack Raymond Wands
  • GPR30 estrogen receptor in breast cancers
    Patent number: 7803561
    Abstract: The invention provides methods of identifying metastatic disease as well as ligands such as antibodies that bind to GPR30. These antibodies are useful in the detection or treatment of endocrine tumors.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: September 28, 2010
    Assignee: Rhode Island Hospital
    Inventors: Edward J. Filardo, Edmond Sabo
  • TRIBONECTINS
    Publication number: 20100204087
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Application
    Filed: February 9, 2010
    Publication date: August 12, 2010
    Applicant: RHODE ISLAND HOSPITAL
    Inventor: GREGORY D. JAY
  • Wnt Proteins and Detection and Treatment of Cancer
    Publication number: 20100203054
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins and genes, and Wnt- and FZD-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Application
    Filed: February 5, 2010
    Publication date: August 12, 2010
    Applicant: RHODE ISLAND HOSPITAL, A LIFESPAN-PARTNER
    Inventors: Jack R. Wands, Miran Kim
  • GPR30 ESTROGEN RECEPTOR IN BREAST AND OVARIAN CANCERS
    Publication number: 20100190199
    Abstract: A method of prognosis for ovarian or breast cancer patients is carried out by detecting GPR30 in a sample of tissue. An elevation in the level of GPR30 compared to a normal control level indicates presentation of late stage disease and indicates responsiveness of the tumor to hormonal therapy.
    Type: Application
    Filed: September 28, 2009
    Publication date: July 29, 2010
    Applicant: Rhode Island Hospital
    Inventors: Edward J. Filardo, Edmond Sabo
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100172832
    Abstract: The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.
    Type: Application
    Filed: December 21, 2009
    Publication date: July 8, 2010
    Applicant: RHODE ISLAND HOSPITAL
    Inventors: JACK R. WANDS, SUZANNE M. DE LA MONTE, ALAN H. DEUTCH, HOSSEIN A. GHANBARI
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100144837
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 10, 2010
    Applicant: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100136581
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 3, 2010
    Applicant: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Non-invasive determination of blood components
    Patent number: 7711403
    Abstract: A method of estimating an amount of a substance in a bodily fluid from the color of a tissue surface of a subject includes capturing an image including at least a portion-of-interest of the subject and at least a reference portion of a color reference, the image being a digital image of pixels of at least one color, the image including a component value for each pixel for each of the at least one color, obtaining a first value associated with at least one component value corresponding to the portion-of-interest of the subject, obtaining a second value associated with at least one component value corresponding to the reference portion, and calculating an estimated amount of the substance using the first and second values.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: May 4, 2010
    Assignee: Rhode Island Hospital
    Inventors: Gregory D. Jay, Selim Suner, Kevin S. Ernsting
  • TRIBONECTINS
    Publication number: 20100048458
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Application
    Filed: October 29, 2009
    Publication date: February 25, 2010
    Applicant: Rhode Island Hospital
    Inventor: Gregory D. Jay
  • Active Sunscreen Composition
    Publication number: 20100021400
    Abstract: The invention relates to topical compositions comprising a fluorescent dye that absorbs UVA and UVB radiation and converts it into a healing light, in combination with a dermatologically acceptable excipient. The compositions of the invention are useful for repairing photo-damaged skin cells and reducing or preventing future skin damage as a result of exposure to UV light.
    Type: Application
    Filed: April 27, 2009
    Publication date: January 28, 2010
    Applicant: Rhode Island Hospital
    Inventors: Gregory D. Jay, Gregory Crawford
  • Treating degenerative joint disorders with tribonectins
    Patent number: 7618941
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: November 17, 2009
    Assignee: Rhode Island Hospital
    Inventor: Gregory D. Jay