Patents Assigned to Rhode Island Hospital
  • Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging
    Patent number: 9316645
    Abstract: Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: April 19, 2016
    Assignees: BROWN UNIVERSITY, RHODE ISLAND HOSPITAL
    Inventors: Christoph Rose-Petruck, Jack R. Wands, Danielle Rand, Zoltan Derdak, Vivian Ortiz
  • Treatment, prevention, and reversal of alcohol-induced brain disease
    Patent number: 9308198
    Abstract: This invention relates to methods for treating, preventing, or reversing brain disease or damage produced by chronic alcohol intake by administering a peroxisome proliferator activated receptor (PPAR) agonist.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: April 12, 2016
    Assignee: RHODE ISLAND HOSPITAL
    Inventors: Jack R. Wands, Suzanne Marie de la Monte
  • Schistosoma vaccine
    Patent number: 9283264
    Abstract: The method for large scale production of a full length Schistosomal paramyosin coiled coil dimer composition is carried out by providing a composition comprising recombinant paramyosin, contacting the composition with a strand separation agent to remove paramyosin fragments and other contaminants. The purified paramyosin is used in vaccines for humans and bovine animals to induce immunity against schistosomal infection.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: March 15, 2016
    Assignee: Rhode Island Hospital
    Inventors: Jonathan Kurtis, Mario Jiz, Haiwei Wu, Sunthorn Pond-Tor
  • Advanced radiotherapy treatment planning optimization
    Patent number: 9254396
    Abstract: A method of radiotherapy treatment planning is described. A planned target volume is identified for radiotherapy treatment and at least one volume of interest is identified. The mass, density, and total deposited energy contained in the planned target volume and the volumes of interest are identified and dose objectives are determined. At least one of the objectives is a function of the identified mass, density, or deposited energy. A composite objective function is determined using the dose objectives for the planned target volume and the volumes of interest. A near optimal solution to the composite objective function is determined to produce a radiotherapy treatment plan.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 9, 2016
    Assignee: Rhode Island Hospital
    Inventor: Ivaylo B. Mihaylov
  • Compositions and Methods for the Prevention and Treatment of Osteolysis and Osteoporosis
    Publication number: 20150352131
    Abstract: This application discloses compositions, devices, and methods for the prevention and treatment of osteolysis and osteoporosis. Treatment or prevention of osteolysis or osteoporosis is carried out by targeting the enzyme, Shp2 (a Src homology 2 (SH2) domain containing non-transmembrane Protein Tyrosine Phosphatase (PTP)), or proteins involved in the Shp2 signaling pathway by administering a Shp2 pathway inhibitor that inhibits fusion of pre-osteoclasts.
    Type: Application
    Filed: January 16, 2014
    Publication date: December 10, 2015
    Applicant: RHODE ISLAND HOSPITAL
    Inventors: Wentian Yang, Michael G. Ehrlich, Yi Zhou, Douglas Moore
  • Peripheral pain management
    Patent number: 8977362
    Abstract: A system including a processor configured to be coupled to an electrical lead that is configured to sense electrical activity in a patient, a memory coupled to the processor, the memory containing computer readable instructions that, when executed by the processor, cause the processor to detect a pain signature in the sensed electrical activity, determine a treatment protocol in response to the detected pain signature, and cause the treatment protocol to be delivered to the patient via the electrical lead.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: March 10, 2015
    Assignee: Rhode Island Hospital
    Inventor: Carl Y. Saab
  • BIOMATERIAL FOR ARTICULAR CARTILAGE MAINTENANCE AND TREATMENT OF ARTHRITIS
    Publication number: 20140369984
    Abstract: The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and/or joint surgery.
    Type: Application
    Filed: February 1, 2013
    Publication date: December 18, 2014
    Applicants: Children's Medical Center Corporation, Rhode Island Hospital
    Inventors: Martha M. Murray, Braden C. Fleming
  • Stromal Derived Factor Inhibition And CXCR4 Blockade
    Publication number: 20140206629
    Abstract: The invention relates to inhibition of SDF-1? expression in subacromial bursa cells by CXCR-4 inhibitors. Bursal cell migration in response to SDF-? stimulation is also decreased in the presence of CXCR4 inhibitors. Accordingly, provided are methods for treating or ameliorating a musculoskeletal disorder.
    Type: Application
    Filed: February 17, 2012
    Publication date: July 24, 2014
    Applicant: RHODE ISLAND HOSPITAL
    Inventor: Theodore A. Blaine
  • TRIBONECTINS
    Publication number: 20140179611
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Application
    Filed: January 29, 2014
    Publication date: June 26, 2014
    Applicant: RHODE ISLAND HOSPITAL
    Inventor: Gregory D. Jay
  • Nanotubes as Carriers of Nucleic Acids into Cells
    Publication number: 20140171482
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Application
    Filed: January 3, 2012
    Publication date: June 19, 2014
    Applicants: RHODE ISLAND HOSPITAL, Brown University
    Inventors: Thomas J. Webster, Qian Chen, Yupeng Chen
  • Device controller with conformable fitting system
    Patent number: 8708825
    Abstract: A controller with a conformable fitting system is configured for controlling a device, such as a toy or game, is pliable, flexible and cushioning to provide a custom fit of the device controller to the body part of the patient or user. The device controller spans across a joint, such as a wrist, and includes a pivot between preferably two main portions. The rotation axis of the device controller is aligned with the pivot axis of the joint to receive the physical therapy. A sensor, such as a digital encoder, is located proximal thereto to determine the relative positioning of the main portions to each other. The sensor electronically communicates with the device, such as a toy or game, to serve as a controller therefor.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: April 29, 2014
    Assignee: Rhode Island Hospital
    Inventor: Joseph John Crisco, III
  • Inhibition of Renal Fibrosis
    Publication number: 20140088191
    Abstract: The invention provides compositions and methods for inhibiting renal fibrosis.
    Type: Application
    Filed: May 21, 2012
    Publication date: March 27, 2014
    Applicant: RHODE ISLAND HOSPITAL
    Inventor: Shougang Zhuang
  • Tribonectins
    Patent number: 8680057
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: March 25, 2014
    Assignee: Rhode Island Hospital
    Inventor: Gregory D. Jay
  • Method and Apparatus for Rehabilitation Using Adapted Video Games
    Publication number: 20140081432
    Abstract: A participant, engages in healthcare provider prescribed physical rehabilitation exercises utilizing specifically designed controllers, and these exercises are mapped to one or more video game commands. These commands are coupled with other inputs to control the video game that will be used to ensure adherence to a prescribed rehabilitation regimen. Information is gathered on the participant, in order to aid in rehabilitation.
    Type: Application
    Filed: September 12, 2013
    Publication date: March 20, 2014
    Applicants: Rhode Island Hospital, Brown University
    Inventors: Angus Kingon, John Donoghue, Yi-Ning Wu, Karen Kerman, Brian Monetti
  • Compositions and Methods For The Treatment of Orthopedic Disease or Injury
    Publication number: 20130288972
    Abstract: Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment.
    Type: Application
    Filed: January 5, 2012
    Publication date: October 31, 2013
    Applicant: RHODE ISLAND HOSPITAL
    Inventors: Qian Chen, Chathuraka T. Jayasuriya
  • Advanced Radiotherapy Treatment Planning Optimization
    Publication number: 20130217948
    Abstract: A method of radiotherapy treatment planning is described. A planned target volume is identified for radiotherapy treatment and at least one volume of interest is identified. The mass, density, and total deposited energy contained in the planned target volume and the volumes of interest are identified and dose objectives are determined. At least one of the objectives is a function of the identified mass, density, or deposited energy. A composite objective function is determined using the dose objectives for the planned target volume and the volumes of interest. A near optimal solution to the composite objective function is determined to produce a radiotherapy treatment plan.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 22, 2013
    Applicant: RHODE ISLAND HOSPITAL
    Inventor: Rhode Island Hospital
  • LUBRICIN INJECTIONS TO MAINTAIN CARTILAGE HEALTH
    Publication number: 20130116186
    Abstract: Disclosed are novel methods of maintaining articular cartilage health in an atraumatic, non-diseased joint of a mammal, either human or non-human. The methods involve injecting into the joint capsule of the mammal an amount of a lubricin polypeptide to prevent shear-induced chondrocyte apoptosis and to maintain a lubricin-expressing phenotype of chondrocytes.
    Type: Application
    Filed: October 4, 2012
    Publication date: May 9, 2013
    Applicant: Rhode Island Hospital, A Lifespan Partner
    Inventor: Rhode Island Hospital, A Lifespan Partner
  • TRIBONECTINS
    Publication number: 20130072435
    Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
    Type: Application
    Filed: May 14, 2012
    Publication date: March 21, 2013
    Applicant: Rhode Island Hospital
    Inventor: Gregory D. Jay
  • Pain Management
    Publication number: 20130066394
    Abstract: A system including a processor configured to be coupled to an electrical lead that is configured to sense electrical activity in a patient, a memory coupled to the processor, the memory containing computer readable instructions that, when executed by the processor, cause the processor to detect a pain signature in the sensed electrical activity, determine a treatment protocol in response to the detected pain signature, and cause the treatment protocol to be delivered to the patient via the electrical lead.
    Type: Application
    Filed: April 27, 2011
    Publication date: March 14, 2013
    Applicant: RHODE ISLAND HOSPITAL
    Inventor: Carl Y. Saab
  • DEVICE CONTROLLER WITH CONFORMABLE FITTING SYSTEM
    Publication number: 20120270655
    Abstract: A controller with a conformable fitting system is configured for controlling a device, such as a toy or game, is pliable, flexible and cushioning to provide a custom fit of the device controller to the body part of the patient or user. The device controller spans across a joint, such as a wrist, and includes a pivot between preferably two main portions. The rotation axis of the device controller is aligned with the pivot axis of the joint to receive the physical therapy. A sensor, such as a digital encoder, is located proximal thereto to determine the relative positioning of the main portions to each other. The sensor electronically communicates with the device, such as a toy or game, to serve as a controller therefor.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 25, 2012
    Applicant: Rhode Island Hospital
    Inventor: Joseph John Crisco, III