Abstract: Pathogenic infectious bovine rhinotracheitis (IBR) virus may be modified by serial passages in non-bovine tissue cultures until it becomes non-pathogenic when applied to the intranasal passages of bovines. Such application will result in the induction of high levels of interferon in nasal secretions as well as the production of local antibodies and a long lasting immunity against IBR infection by virtue of the induction of specific circulating antibodies. The invention includes the method of modifying the IBR virus, a method of preparing a vaccine therefrom and a method of immunizing bovines and promoting production of high levels of interferon in nasal secretions.

Abstract: .omega.-(1,3-Dithiolan-2-imino) substituted acetic acids are prepared useful as antibacterial agents, inhibitors of cholesterol and fatty acid synthesis, anti-inflammatory agents and as intermediates for cephalosporin antibiotics.

Abstract: Physiologically acceptable mouthwash formulations containing sodium ricinoleate substantially free of haze and precipitation.

Abstract: Compounds possessing hypoglycemic, hypotensive, antiinflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## where Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

Abstract: Compounds possessing hypoglycemic, hypotensive, antiinflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

Abstract: A pharmaceutically acceptable layered tablet containing nitrofurantoin in substained release form.

Abstract: Compounds of the following general structure are useful as antirhinovirus agents: ##STR1## wherein Y is a bond, oxygen or divalent sulfur; R is a straight or branched hydrocarbon chain having from 6 to 20 carbon atoms and is saturated or unsaturated having from 1 to 4 double bonds when R has from 10 to 20 carbon atoms and 1 or 2 double bonds when R has from 6 to 9 carbon atoms; and R.sub.1 is hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms.

Abstract: Novel substituted(4-oxo-1-pyridinyl)acetylaminopenicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.

Abstract: The compounds are 11-aminoalkylmorphanthridin-11-ols which are useful as antidepressant agents. The compounds disclosed are 11-(3-dimethylaminopropyl)morphanthridin-11-ol and 2-chloro-11-(3-dimethylaminopropyl)-5,6-dihydromorphanthridin-11-ol.

Abstract: Substituted furoic acids and esters and pharmaceutically acceptable salts thereof of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y represents oxygen or divalent sulfur; R represents a straight or branched alkyl chain containing from 10 to 20 carbon atoms and may be saturated or may be unsaturated containing from 1 to 4 double bonds; R.sup.1 represents hydrogen, straight or branched lower alkyl of from 1 to 6 carbon atoms, benzyl, phenethyl, pyridylmethyl, alkane-poly-yl containing from 3 to 6 carbon atoms, 1,2,3,4,5,6-cyclohexanehexayl, or Z; Z represents(A) the group ##STR2## wherein n is an integer of 2 or 3; R.sup.2 represents straight or branched lower alkyl of from 1 to 4 carbon atoms, or acyl; R.sup.3 represents hydrogen or straight or branched lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sup.3 is hydrogen, R.sup.2 is acyl; or when R.sup.2 is other than acyl, R.sup.2 and R.sup.

Abstract: Novel 1,5 and 1,8-bis-basic ketones of anthracene useful for the prevention and inhibition of viral infections are prepared by reacting 1,5 and 1,8 bis(.omega.-haloacyl)anthracenes with a secondary amine.

Abstract: Compounds of the following general formula are useful in treating the symptoms of menopause and osteoporosis: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom.

Abstract: Compounds of the following general formula are useful as antidepressant and antiparkinson agents: ##STR1## WHEREIN R represents hydrogen, hydroxy, halogen, trifluoromethyl, straight or branched lower alkyl of from 1 to 6 carbon atoms, straight or branched lower alkoxy of from 1 to 6 carbon atoms, acyloxy, alkoxycarbonyloxy, carbamoyloxy, benzoyloxy, or benzoyloxy substituted with straight or branched lower alkyl of from 1 to 6 carbon atoms, straight or branched lower alkoxy of from 1 to 6 carbon atoms or halogen; R.sub.1 represents hydrogen, straight or branched lower alkyl of from 1 to 6 carbon atoms, phenyl or benzyl; R.sub.2 represents hydrogen, straight or branched lower alkyl of from 1 to 6 carbon atoms, ethynyl, ethynyl substituted with straight or branched lower alkyl of from 1 to 6 carbon atoms; aryl, or aralkyl wherein each aryl moiety may be substituted with straight or branched lower alkyl of from 1 to 6 carbon atoms, straight or branched lower alkoxy of from 1 to 6 carbon atoms or halogen; R.sub.

Abstract: Compounds of the following general formula are testosterone 5.alpha.-reductase inhibitors rendering said compounds useful in the treatment of acne and oily skin: ##STR1## wherein n is an integer of from 0 to 4; R.sub.1 is --COOR.sub.2, --CONR.sub.3 R.sub.4, --CHO or --CH.sub.2 OR.sub.5 ; R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or benzyl; each of R.sub.3 and R.sub.4 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; and R.sub.5 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched, or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms.

Abstract: Derivatives of androst-4-en-19-ol are described which are useful in enhancing the libido and related psychic attitudes in primates.

Abstract: Compounds of the following general formula are useful in treating acne: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17- position carbon atom and the oxygen atom.

Abstract: Compounds of the following general formula are useful in inducing an estrogenic response in a patient in need thereof: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom.

Abstract: Disclosed are novel compounds and pharmaceutical formulations having antiviral activity. The disclosed compounds have the formula ##STR1## wherein one R.sup.2 is a hydrogen atom and the other R.sup.2 is the radical ##STR2## A is a straight chain alkylene group having 2 or 3 carbon atoms and each R.sup.3 and R.sup.4 is a hydrogen atom, and alkyl radical having 1 to 3 carbon atoms or each set of R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group. Also included are the acid addition salts of these bases. These compounds may be prepared by various methods which are described.