Abstract: Novel [substituted(2-oxo-1-pyridinyl)acetylamino] penicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.

Abstract: Novel [substituted(2,4-dioxo-1-pyrimidinyl)acetylamino]penicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.

Abstract: Novel triazolobenzocycloalkylthiadiazines, their preparation, and use as central nervous system antidepressants.

Abstract: Novel triazolocycloalkylthiadiazines, their preparation, and use as antisecretory agents and central nervous system depressants.

Abstract: Novel triazolocycloalkylhydrothiadiazines and their preparation, which are useful as antisecretory agents, central nervous system stimulants, and central nervous system depressants, are disclosed.

Abstract: Compounds of the following general formula are useful in the treatment of conditions of delayed hypersensitivity: ##SPC1##Wherein X represents a bond, --CH.sub.2 --, or carbonyl; Y represents a vinylene group, ##EQU1## carbonyl, oxygen, divalent sulfur, or carbonyloxy with the proviso that when Y is ##EQU2## or vinylene, X is not carbonyl; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is vinylene, A contains from 1 to 5 carbon atoms and with the proviso that when Y is carbonyloxy or carbonylthio, A contains from 2 to 6 carbon atoms; each of R.sup.1 and R.sup.2 represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms; or alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than 1-position; and pharmaceutically acceptable acid addition salts thereof.

Abstract: Novel bis basic esters of 9-substituted phenanthrene and related 9-oxa and 9-aza derivatives thereof, their preparation and use for the prevention and inhibition of viral infections are disclosed.

Abstract: Novel bis-basic esters and amides of dibenzothiophene of the formula ##SPC1##Wherein:A. each of R.sup.1 and R.sup.2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkylpiperazino, or morpholino;B. each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms;C. each Y is oxygen, or N--R wherein R is hydrogen or (lower)alkyl of 1 to 4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

Abstract: The compounds are ferrocene derivatives useful as organo-iron sources and hematinic agents. Compounds disclosed are 1,1'-diethyl-.alpha.,.alpha.'-thiabiscyclopentadienyl-iron-S-oxide and 1,1'-diethyl-.alpha.,.alpha.'-thiabiscyclopentadienyl-iron-S-dioxide.

Abstract: Pure cis or trans-6-substituted-11-aminoalkylidenemorphanthridines are prepared by treating the corresponding cis or trans-5,6-dihydromorphanthridines with oxygen in the presence of a platinum on carbon catalyst. Among the compounds prepared are:Cis-2-Chloro-11-(3-dimethylaminopropylidene)-6-phenylmorphanthridine, andTrans-2-Chloro-11-(3-dimethylaminopropylidene)-6-methylmorphanthridine.The compounds are useful as antihypertensive and anti-Parkinson agents.

Abstract: Compounds of the following general structure are useful in treating conditions of delayed hypersensitivity: ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, N-(lower) alkyl carbazole or anthraquinone; Y represents carbonyl, divalent sulfur or oxygen; with the proviso that when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 represents hydrogen, lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.

Abstract: Compounds of the following general formula are useful as antihistamine agents, antiallergy agents and bronchodilators: ##SPC1##Wherein R represents hydrogen or hydroxy; R.sup.1 represents hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is the integer 4 or 5; Y represents ##EQU1## or ##EQU2## Z represents phenyl or a substituted phenyl ring wherein the substituent on the substituted phenyl ring is attached at the ortho, meta, or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, alkoxy of from 1 to 6 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group selected from pyrrolidino, piperidino, morpholino or N-(lower)alkyl-piperazino; and pharmaceutically acceptable acid addition salts and individual optical isomers.

Abstract: Novel compounds of the following general formula are useful pharmacologic agents and are useful as intermediates for the preparation of pharmacologically useful compounds. ##EQU1## wherein R.sub.1 is selected from a lower alkyl group having from 1 to 4 carbon atoms, R.sub.2 is selected from hydrogen and phenyl; and R.sub.3 is selected from phenyl and trialkylmethyl; and acid addition salts thereof.

Abstract: Bis-basic ester derivatives of the following general formula are useful in the treatment of conditions of delayed hypersensitivity. ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, or N-(lower)alkyl carbazole; X represents oxygen or sulfur; A represents a straight or branched alkylene chain of from 2 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 is hydrogen, straight or branched lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.

Abstract: The novel bis-basic ketones of carbazole of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1##Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; orB. the group ##SPC2##Wherein n is a whole integer of 4 or 5, and R.sup.3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##SPC3##Wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt of said base.These new compounds can be prepared by several different methods which are described.

Abstract: Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##Wherein R.sup.1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R.sup.2 represents hydrogen or hydroxy; R.sup.3 represents hydrogen, or R.sup.2 and R.sup.3 taken together form a second bond between the carbon atoms bearing R.sup.2 and R.sup.

Abstract: Bis-basic substituted aromatic polycyclic compounds of the following structure are useful in treating conditions of delayed hypersensitivity: ##SPC1##Wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, dibenzofuran, dibenzothiophene, carbazole, N-(lower)alkyl carbazole, xanthene, xanthone, thioxanthene, phenoxathiin, or anthraquinone; Y represents carbonyloxy, carbonylthio, oxygen, divalent sulfur or carbonyl with the provisos that when Y is carbonyloxy or carbonylthio, [W] is other than thioxanthene, phenoxathiin or anthraquinone, when Y is oxygen or divalent sulfur, [W] is other than thioxanthene or phenoxathiin, and when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is carbonyloxy or carbonylthio, A contains at least 2 straight chain carbon atoms, that is, an ethylene radical; R represents hydrogen, a straight or b

Abstract: Novel 3,6-bis basic ketone derivatives of acenaphthene useful in treating conditions of delayed hypersensitivity are disclosed.

Abstract: Compounds of the following general formula are useful in the treatment of conditions of delayed hypersensitivity. ##SPC1##Wherein X represents a bond, --CH.sub.2 --, or oxygen; Y represents a vinlyene group, --CH(OH)--, carbonyl, oxygen, divalent sulfur, or carbonyloxy with the proviso that when Y is oxygen, divalent sulfur or carbonyloxy, X represents a bond; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is vinlyene, A contains from 1 to 5 carbon atoms; and with the proviso that when Y is carbonyloxy, A contains from 2 to 6 carbon atoms; each of R.sup.1 and R.sup.2 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms; or alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position, and pharmaceutically acceptable acid addition salts thereof.

Abstract: Novel bis basic esters of 9-substituted phenanthrene and related 9-oxa and 9-aza derivatives thereof, their preparation and use for the prevention and inhibition of viral infections are disclosed.