Abstract: Novel bis-basic esters and amides of carbazole of the formula ##SPC1##Wherein:A. each of R.sup.1 and R.sup.2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower) alkylpiperazino, or morpholino;B. each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms;C. each Y is oxygen, or N--R wherein R is hydrogen, methyl or ethyl; andD. r.sup.3 is hydrogen or (lower) primary or secondary alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

Abstract: The novel bis-basic ethers of carbazole of the present invention have useful antiviral properties. These new compounds are represented by the formula ##SPC1##Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; and each X is ##EQU1## A. the group -A-N wherein each A is a straight or branched alkylene chain having from 2 to 6 carbon atoms; R and R.sup.1 are individually hydrogen or lower alkyl having from 1 to 6 carbon atoms; or each set of R and R.sup.1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino or piperidino; orB. the group ##SPC2##Wherein n is a whole integer from 0 to 2, m is 1 or 2, and R.sup.2 is hydrogen or lower alkyl having from 1 to 4 carbon atoms.This invention also includes pharmaceutically acceptable acid addition salts of the bases represented by Formula I. These new compounds may be prepared by several different methods which are described.

Abstract: The compound N-[4-(3,4-methylenedioxyphenyl)-but-2-yl]-.beta.-(3,4-dihydroxyphenyl)ethy lamine, and salts thereof, are cardiotonic agents, central nervous system depressants and analgetic agents.

Abstract: Pure cis and trans-6-substituted-11-aminoalkylidene-5,6-dihydromorphanthridines are prepared by treating the morphanthridines unsubstituted in the 6-position with a Grignard reagent in a suitable solvent such as tetrahydrofuran. Among the compounds disclosed are:Cis-2-Chloro-11-(3-dimethylaminopropylidene)-6-phenyl-5,6-dihydromorphanthr idine, andTrans-2-Chloro-11-(3-dimethylaminopropylidene)-6-methyl-5,6-dihydromorphant hridine.The compounds are useful as antihypertensive and anti-Parkinson agents.

Abstract: A process for the preparation of 2-azacycloalkylmethyl ketones by chelating a methyl ketone with magnesium methyl carbonate and condensing the chelate with a 1-azacycloalkene in an atmosphere of carbon dioxide. The novel compounds described are useful anticoagulants.

Abstract: Novel dioxocin carboxamide derivatives, which reduce blood lipids in warm blooded animals and are useful in the treatment of hyperlipidemic states, are represented by compounds of the following formula: ##SPC1##Wherein each Y is selected from the group consisting of hydrogen, halogen such as chlorine, bromine, fluorine or iodine, or lower alkyl of from 1 to 4 carbon atoms; n is an integer of from 1 to 3; R.sup.1 and R.sup.2 may be the same or different, and each is selected from the group consisting of hydrogen, lower alkyl of from 1 to 4 carbon atoms, benzyl, picolyl, cycloalkyl of from 3 to 6 carbon atoms, phenyl, or substituted phenyl in which case the substituents on the substituted phenyl are selected from lower alkyl of from 1 to 4 carbon atoms; or NR.sup.1 R.sup.2 taken together represent a saturated monocyclic heterocyclic group such as, pyrrolidino, piperidino, morpholino, piperazino or N-(lower alkyl)piperazino, and pharmaceutically acceptable salts of the salt forming compounds.

Abstract: Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##Wherein R.sup.1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R.sup.2 represents hydrogen or hydroxy; R.sup.3 represents hydrogen; or R.sup.2 and R.sup.3 taken together form a second bond between the carbon atoms bearing R.sup.2 and R.sup.