Patents Assigned to Roche Molecular Systems, Inc.
  • Patent number: 11517905
    Abstract: A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: December 6, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Sven Ebert, Paul Federer, Pius Hermann, Stefan Vollenweider
  • Publication number: 20220381798
    Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
    Type: Application
    Filed: March 2, 2022
    Publication date: December 1, 2022
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Thomas NGUYEN, Sean FORD, Nikolas James HANSEN
  • Patent number: 11505830
    Abstract: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: November 22, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ann Begovich, Cindy Cheung, Javelin Chi, Grantland Hillman, Dwight Kuo, Michael Lee, Chitra Manohar, Xiaoju Max Ma, Ellen Ordinario, Jaya Rajamani, Huan Truong
  • Publication number: 20220365146
    Abstract: Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.
    Type: Application
    Filed: June 15, 2022
    Publication date: November 17, 2022
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Roger Harry Taylor, John B. Gorman, Tyler David Jensen
  • Patent number: 11498074
    Abstract: A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: November 15, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventor: David Walter Wright
  • Publication number: 20220347637
    Abstract: A device for the mixing fluid media. The device is a bladeless mixer. The device comprises a hollow body with at least a single inlet opening in its bottom and at least a single outflow region in its side. The device is rotated at a speed at which the media due to centrifugal forces enters the device's hollow cavity via the inflow opening or unit. The media is discharged from the cavity through one or more outlet units or openings in the sides or in the top of the device. During mixing the media does not rise above the level of the undisturbed media.
    Type: Application
    Filed: April 4, 2022
    Publication date: November 3, 2022
    Applicant: Roche Molecular Systems, Inc.
    Inventor: Mohammad Sotoudeh
  • Patent number: 11462325
    Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: October 4, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Antoaneta Petkova Vladimirova, Yogesh P. Pandit, Vishakha Sharma, Tod M. Klingler, Hari Singhal
  • Patent number: 11441185
    Abstract: The present invention provides assay systems and methods for determining the percent fetal contribution of cell-free DNA in a maternal sample from a pregnant female with an egg donor pregnancy. Further provided, are assay systems and methods for determining a statistical likelihood of the presence or absence of a fetal aneuploidy in a maternal sample using a determined percent fetal cell-free DNA in the sample.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: September 13, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Arnold Oliphant, Eric Wang, Craig Struble
  • Patent number: 11441167
    Abstract: The present invention relates to compositions and methods for the use of polymerase chain reaction (PCR) as a reporter assay for rapid and simultaneous bacterial identification and phenotype testing for antimicrobial susceptibility (AST). The current invention uses a strategy that has shown the ability for multiplexing and for handling polymicrobial samples for antimicrobial susceptibility testing.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: September 13, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Kyle C. Cady, Brett Hanson, Paulino Abdon, Ryan Chan, Patrick Lin, Rochak Mehta, Troy Rabang
  • Patent number: 11421266
    Abstract: The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: August 23, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Frank Bergmann, Walter Eberle, Thomas Fischer, Herbert von der Eltz
  • Patent number: 11421268
    Abstract: Methods, compositions, reaction mixtures, kits, and/or systems for producing a complementary sequence to a region in a target polynucleotide in a sample are provided. In some aspects, the methods, compositions, reaction mixtures, kits, and/or systems comprise subjecting the sample to a nucleic acid amplification reaction in a reaction mixture under conditions to yield the complete sequence to the region of the target polynucleotide. In some aspects, the complementary sequence produced is amplified.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 23, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Mikael Kubista, Robert Sjöback
  • Patent number: 11404142
    Abstract: The present invention provides processes for calculating phased genomic sequences of the fetal genome using fetal DNA obtained from a maternal sample. The processes and systems of the present invention utilize novel technological and computational approaches to detect fetal genomic sequences and determine the phased heritable genomic sequences. The invention could be used, e.g., to identify in utero deleterious mutations carried by the parents and inherited by a fetus within a particular heritable genomic region.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: August 2, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: John Stuelpnagel, Craig Struble, Eric Wang
  • Patent number: 11391790
    Abstract: Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: July 19, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Roger Harry Taylor, John B. Gorman, Tyler David Jensen
  • Patent number: 11384376
    Abstract: The present invention relates to compositions and methods (reagents and protocols) for the post-synthetic modification of nucleic acids obtained from solid-phase oligonucleotide synthesis with a label (such as fluorescent dyes). The coupling reagent is the triazine-based salt 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMT-MM) in the presence of a counteranion.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: July 12, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alexander Nierth
  • Patent number: 11385170
    Abstract: The present disclosure provides a plate comprising an array of wells for chemical or biological reactions, wherein each of the wells comprises a reaction chamber with at least one opening on a surface of the plate. The array of wells consist of a plurality of adjacent blocks of wells, wherein each block of wells consists of a plurality of adjacent rows of wells, and wherein at least one void is provided in each block of wells in between the rows of wells. Here, the void is particularly part of the surface of the plate and lacks a well opening. Furthermore, a method for multiple imaging of such a plate by means of an imaging system is provided with the present disclosure.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: July 12, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Michael Zeder
  • Patent number: 11385247
    Abstract: Disclosed herein is a system for depositing solid waste into a waste bin in an automated analyzer having a transport mechanism for transporting solid waste to a waste bin. The system includes a transport mechanism including a sliding mechanism, a parking position, and an opening that is proximal to the waste bin. The sliding mechanism includes a slider and an extendable ramp and the slider pushes the solid waste along the ramp into the waste bin. The transport mechanism is configured to place the solid waste into the parking position, contact the solid waste with the slider, and push said solid waste towards the waste bin along the ramp until the solid waste moves along the extendable ramp into the waste bin.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: July 12, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andre Peter, Markus Troxler
  • Patent number: 11353382
    Abstract: A multi-layer plasma separation card comprising (a) a first layer including a sample receiving member comprising (i) a top planar surface for applying or receiving a blood sample, said sample receiving portion being adapted to permit contact of said blood sample with a separating member; and (ii) a bottom planar surface being adapted to contact said separating member, (b) a second layer including at least three separating members, each separating member being adapted to permit the passage of plasma to an absorptive member and comprising (i) a top planar surface for receiving said blood sample; and (ii) a bottom planar shield-shaped surface being adapted to contact said absorptive member, and (c) a third layer including at least two absorptive members for absorbing plasma from the bottom planar surface of each corresponding separating member and a backing member arranged in a manner to support said absorptive members, each absorptive member comprising a removable absorptive element having a top planar surface
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: June 7, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Siegfried Dick, Markus Fischer, Alexander Schmelzer, Andreas Trapp, Stephen G. Will
  • Patent number: 11352654
    Abstract: The present disclosure relates to a composition and its use for treating a sputum sample suspected to contain mycobacteria. The composition comprises thymol, a linear or branched alcohol, a chaotropic agent, a reducing agent, a detergent, and a buffer, and has a pH value between 8.5 and 10. Also disclosed is a method for treating a sputum sample suspected to contain mycobacteria.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: June 7, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Carolin Bier, Stefan Lange, Pirmin Hans Loetscher
  • Patent number: D954092
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: June 7, 2022
    Assignees: Hoffmann-La Roche Inc., Roche Molecular Systems, Inc.
    Inventors: Jorge Cancela Gonzalez, Geraint Iwan Davies, Jean-Philippe Guy Roger Guyon, Christin Rene Kreml, Tommy Park
  • Patent number: D969838
    Type: Grant
    Filed: May 3, 2020
    Date of Patent: November 15, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Matteus Pan, Shilpa Shenoy, Brigitta Monz, Brian Lee, Guillaume Bousquet, Niro Wijesekera, Huy Nam Doan, Alessandro Barbato, Joseph Rogers