Patents Assigned to Roche Molecular Systems, Inc.
  • Patent number: 10416177
    Abstract: The invention provides for an analysis system (100, 300, 400) for analyzing a biological sample (108) comprising an analyzer (102) with an analytical unit (106) for analyzing the biological sample to obtain an analysis result (140). The analyzer is configured for receiving a cartridge (110) comprising an identifier (114) and containing at least one reagent for analyzing the biological sample. The analyzer comprises an identification unit (116) for reading the identifier. The analyzer accepts the cartridge if the identifier is valid. The analysis system further comprises a protocol creation system (150, 104).
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: September 17, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Christopher Newhouse, Sascha Roehrig
  • Patent number: 10393659
    Abstract: The present disclosure provides an instrument and methods for detecting an analyte, comprising a light source capable of generating excitation light for exciting a plurality of luminescence labels, an excitation beam path extending between said light source and said analyte, a detector capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, a filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam pat
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 27, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alan Furlan
  • Patent number: 10393764
    Abstract: Disclosed herein is a method for depositing solid waste into a waste bin in an automated analyzer having a transport mechanism for transporting solid waste to a waste bin. The method includes providing a transport mechanism including a sliding mechanism, a parking position, and an opening that is proximal to the waste bin. The sliding mechanism includes a slider and an extendable ramp and the slider pushes the solid waste along the ramp into the waste bin. The method also includes placing solid waste into the parking position, contacting the solid waste with the slider, and pushing said solid waste towards the waste bin along the ramp until the solid waste moves along the extendable ramp into the waste bin.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: August 27, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andre Peter, Markus Troxler
  • Patent number: 10395073
    Abstract: A method is provided for associating an RFID tag to an RFID reader antenna in a laboratory device with a number N RFID reader antennae, the method including the steps of reading a unique identifier corresponding to each of a number M of RFID tag(s); registering received signal strength indications by each of the N RFID reader antennae of corresponding response signals from each RFID tag(s) and associating each RFID tag with the reader antenna having received the strongest received signal strength indication corresponding to the RFID tag. A laboratory device is also provided which is configured to perform the disclosed method.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: August 27, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Armin Birrer, Riccardo Leone Benedetti, Gregor Hotz
  • Patent number: 10370731
    Abstract: Methods for the rapid detection of the presence or absence of Hepatitis C Virus (HCV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting HCV and kits are provided that are designed for the detection of HCV.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: August 6, 2019
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventor: Rochak Mehta
  • Patent number: 10371664
    Abstract: A nanopore cell includes a titanium nitride (TiN) counter electrode configured to be at a first electric potential. The nanopore cell also include a working electrode configured to be at a second electric potential and an insulating wall. The insulating wall and the working electrode form at least a portion of a well configured to contain an electrolyte at a voltage that is at least a portion of an electric potential difference between the first electric potential of the titanium nitride counter electrode and the second electric potential of the working electrode.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: August 6, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Markus Wallgren, Janusz B. Wójtowicz, Robert A. Yuan, John Foster, Jason Komadina
  • Patent number: 10358675
    Abstract: Methods and oligonucleotides are provided for detecting an internal control nucleic acid for qualitative and/or quantitative purposes.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: July 23, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ellen H. Fiss, Nicolas Newton
  • Patent number: 10351843
    Abstract: The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 16, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
  • Patent number: 10308381
    Abstract: A method for capping vessels containing biological samples is described providing a cap supply with a plurality of caps for the vessels within compartments in a predefined geometrical arrangement. The cap supply is introduced through an interface into a preanalytical system including a housing, and is reversibly docked to a feeder for inserting the cap supply into the preanalytical system and retrieving it therefrom. Subsequently, a cap is retrieved from the supply by a robotic manipulator, and transported to a workstation holding the vessels. A vessel is then capped using the manipulator. The steps from introducing the cap supply into the preanalytical system to capping a vessel are repeated a certain number of times or until all caps of the supply have been retrieved. Finally, the cap supply is retrieved from the preanalytical system. A preanalytical system and a cap supply for capping vessels containing biological samples is also provided.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: June 4, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Thomas Guggisberg, Christian Kaelin
  • Patent number: 10308918
    Abstract: Described herein are variant pol6 polymerase having at least having at least two substitutions, wherein at least one of the substitutions is at position S366 of SEQ ID NO: 2. The disclosed polymerases may be coupled to alpha-hemolysin nanopores, and may be used in nanopore-based sequencing apparatuses.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: June 4, 2019
    Assignees: Roche Molecular Systems, Inc., Genia Technologies, Inc.
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Cleoma Renetta Arnold, Charles Wayan Schwab, Eileen Thai, Ilya Lederman, Colin Alexander McGaw, Tyler O'Brien Shultz, Barbara Eckert, Shawn Suko, Mara Boenitz-Dulat, Bigna Woersdoerfer, David Daniel Wunderlich
  • Patent number: 10311205
    Abstract: An analysis system for biological samples is disclosed that includes at least one analyzer with an analytical unit for analyzing the biological samples and an analyzer controller. The analysis system further includes an analyzer data management system (ADMS) operable for receiving a selection of an operating environment chosen from multiple operating environments. In some embodiments, an analytical system is provided which offers a switch between sample testing and software validation on the same hardware, thereby offering efficiency and flexibility. For example, if sample testing is typically restricted to a particular time of the day (e.g., blood banks often get their samples in the evening and conduct the sample testing at night), the daytime hours can be used to validate new software. In such a case, additional instruments for software validation are not required and expensive idle times of analytical systems are reduced.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: June 4, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Sascha Roehrig, Stephan Schweighauser
  • Publication number: 20190162665
    Abstract: An analysis method is provided aimed at improving the linearity (precision and/or accuracy) of a quantification by a real-time nucleic acid amplification reaction RNR such as a polymerase chain reaction PCR over a wide range of analyte concentrations and/or limiting the effects of the presence of interfering substances by way of determining a quantification cycle number (Cq) of the RNR as the cycle number corresponding to an intersection of the growth curve with a combined threshold function (CTF) over the RNR cycle range comprising at least two different threshold levels, the quantification cycle number (Cq) being indicative of a quantitative and/or qualitative analysis result of a growth curve, the growth curve being indicative of the intensity of the fluorescence emission of an analyte for each amplification reaction cycle of the RNR over a RNR cycle range.
    Type: Application
    Filed: February 1, 2019
    Publication date: May 30, 2019
    Applicant: Roche Molecular Systems, Inc.
    Inventor: Rolf Knobel
  • Patent number: 10300480
    Abstract: A pipetting device (100) for an apparatus (164) for processing a sample or reagent is disclosed. The pipetting device (100) comprises a coupling mechanism (102), wherein the coupling mechanism (102) comprises at least a first coupling unit (104) adapted to be coupled to a first pipetting tip and a second coupling unit (106) adapted to be coupled to a second pipetting tip, and a tilt mechanism (112) for moving the first coupling unit (104) between an untilted position, in which the first coupling unit (104) and the second coupling unit (106) are arranged parallel to one another, and a tilted position, in which the first coupling unit (104) is tilted relative to the second coupling unit (106).
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: May 28, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hans-Rudolf Bachmann, Rolf Schneebeli
  • Publication number: 20190154716
    Abstract: An analytical apparatus and a method for isolating and analyzing at least one analyte are described, comprising at least one module for receiving and dispensing a sample to be analyzed, at least one module for isolating said analyte to be analyzed, at least one module for analyzing said analyte, wherein said modules (i) to (iii) are arranged along an axis.
    Type: Application
    Filed: January 23, 2019
    Publication date: May 23, 2019
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Andreas Gisler, Robert Huesler, Urs Knecht, Rolf Knobel, Heinz Trueeb
  • Patent number: 10294462
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: May 21, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas W. Myers, Shawn Suko
  • Patent number: 10296769
    Abstract: A method for teaching positioning of a bar code scanner is disclosed. The method includes moving the bar code scanner relative to a first bar code so as to sweep a light beam emitted from the bar code scanner across the first bar code, detecting an orientation of the bar code scanner relative to the first bar code and positioning the bar code scanner based on the orientation. Further, an apparatus for processing a sample or reagent is disclosed.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 21, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Armin Birrer, Marco Sangermano
  • Patent number: 10273536
    Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: April 30, 2019
    Assignees: GENIA TECHNOLOGIES, INC., ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech, Hui Tian, Robert Yuan, John Foster, Roger Chen
  • Patent number: 10260102
    Abstract: The invention comprises reagents and methods for detecting cancer-associated mutations in the human EZH2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: April 16, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Xiaoju Max Ma, Chitra Manohar, Alison Tsan
  • Patent number: 10253349
    Abstract: Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: April 9, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ann Begovich, Rajiv Dua, Dwight Kuo, Xiaoju Max Ma, Ellen Ordinario
  • Patent number: 10253308
    Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: April 9, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Tomas R. Martinez, Edward S. Smith