Patents Assigned to Roche Molecular Systems, Inc.
  • Patent number: 12013318
    Abstract: The present disclosure relates to a composition and its use for treating a sputum sample suspected to contain mycobacteria. The composition comprises thymol, a linear or branched alcohol, a chaotropic agent, a reducing agent, a detergent, and a buffer, and has a pH value between 8.5 and 10. Also disclosed is a method for treating a sputum sample suspected to contain mycobacteria.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: June 18, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Carolin Bier, Stefan Lange, Pirmin Hans Loetscher
  • Patent number: 12013407
    Abstract: The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: June 18, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Gisler, Mike Mohns, Vijay Namasivayam, Maren Christin Wolff, Devorah Klein, Tim Moulton, Sam Palmer, Eric Saperstein
  • Patent number: 12005439
    Abstract: A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 11, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alexander Meier, Chris Steinert, Michael Zeder
  • Patent number: 12000847
    Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: June 4, 2024
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Thomas Nguyen, Sean Ford, Nikolas James Hansen
  • Patent number: 11993804
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: May 28, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Patent number: 11981954
    Abstract: The present invention relates to compositions and methods for the use of polymerase chain reaction (PCR) as a reporter assay for rapid and simultaneous bacterial identification and phenotype testing for antimicrobial susceptibility (AST). The current invention uses a strategy that has shown the ability for multiplexing and for handling polymicrobial samples for antimicrobial susceptibility testing.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: May 14, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Kyle C. Cady, Brett Hanson, Paulino Abdon, Ryan Chan, Patrick Lin, Rochak Mehta, Troy Rabang
  • Publication number: 20240139747
    Abstract: The present invention describes a base module (100) and a tray insert (200, 300, 400) of a multipurpose tray (100) for an automated processing system, such as an analytical, pre-analytical or post-analytical processing system, as well as to a multipurpose tray comprising such base module and such tray insert, wherein the tray insert can be particularly used for holding a plurality of reagent or sample tubes to be processed in the automated processing system. The present invention further relates to a method of simplified loading/unloading of such a multipurpose tray into/from the automated processing system.
    Type: Application
    Filed: December 19, 2023
    Publication date: May 2, 2024
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Lawrence Chiu, Ion Iordanoaia, Reiner Hitt, Vijay Namasivayam, Eduard Nawrocki, Michael Neugebauer, Tim Moulton, Sam Palmer, Gerd Schmieta
  • Patent number: 11964273
    Abstract: The present disclosure relates to reversible sealing of a microfluidic chip used for thermal incubation of an aqueous sample suspected to contain a target nucleic acid. The microfluidic chip contains a flow channel and a plurality of reaction compartments, into which the sample and a displacement fluid are introduced through an inlet port sealable by means of a sealing agent having a melting point above room temperature.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: April 23, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Michael Glauser, Daniel Müller, Michael Zeder, Uta Schaffner
  • Patent number: 11952618
    Abstract: This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: April 9, 2024
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Jon Faiz Kayyem, Jayashankar Srinivasan, Sean Ford
  • Patent number: 11920185
    Abstract: The present invention provides inactivated microbes, methods of preparing and using the same, as well as compositions and kits containing the same. The inactivated microbes are useful in the formulation of internal control reagents for use in recombinant nucleic acid techniques, especially nucleic acid amplification, e.g., by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: March 5, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Ellen Fiss
  • Patent number: 11913072
    Abstract: Provided herein are methods and compositions to detect MET exon 14 skipping using RT-PCR, and methods of treating individuals with MET exon 14 deleted cancers.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: February 27, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy Cheung, Grantland Hillman, Xiaoju Max Ma, Chitra Manohar, Lily Wong
  • Patent number: 11866772
    Abstract: Techniques are provided for determining settings of a dPCR experiment for the detection of a chromosomal aneuploidy in a plasma sample from a female pregnant with a fetus. Data about the sample, the dPCR process, and a desired accuracy can be used to determine the settings. Such settings can include a minimal input number of control chromosome molecules for the dPCR experiment, a minimal number of control chromosome molecules for a pre-amplification procedure, and a number of PCR cycles in the pre-amplification procedure. These settings can be used to satisfy the accuracy specified by the accuracy data. Thus, the dPCR experiment can be designed to achieve the desired accuracy while reducing cost, e.g., by not using more of a sample than needed and not performing more pre-amplification than needed or performing more manipulations than needed.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: January 9, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Yu Chuan Tai, Nancy Schoenbrunner
  • Patent number: 11862345
    Abstract: In one example, an apparatus comprises a treatment metric model database that stores a plurality of treatment metric models, each of the plurality of treatment metric models being generated for a first cluster of cluster features vectors, each cluster feature vector representing a distribution for each of a plurality of data categories of patients data represented by patient feature vectors clustered in a second cluster. The apparatus is further configured to: receive patient characteristics features data of a patient; identify a first treatment metric model based on the patient characteristics features data of the patient; input the first patient characteristic features data and data representing a range of administrations of the treatment to the first treatment metric model to compute a range of the treatment metric; and select an administration of the treatment from the range of administrations of the treatment having optimal treatment metric.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: January 2, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Naghmeh Ghazaleh, Jaya Madala, Tyler O'Neill
  • Patent number: 11860072
    Abstract: The subject disclosure presents systems and methods for improved meso-dissection of biological specimens and tissue slides including importing one or more reference slides with annotations, using inter-marker registration algorithms to automatically map the annotations to an image of a milling slide, and dissecting the annotated tissue from the selected regions in the milling slide for analysis, while concurrently tracking the data and analysis using unique identifiers such as bar codes.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: January 2, 2024
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Barnes, Christophe Chefd'hotel, Srinivas Chukka, Mohammad Qadri
  • Publication number: 20230352159
    Abstract: Disclosed are methods, systems and apparatuses in which a diagnostic instrument analyzes data collected over time, and based on that information, disables a bay, suggests a bay, puts a bay on standby or combinations thereof. In some embodiments, the method, system and apparatus allows the diagnostic instrument to have higher validity rates in the field and allows the provider to set up service calls, schedule maintenance and perform remote maintenance, as well as other functions based on the data collected over time.
    Type: Application
    Filed: June 11, 2021
    Publication date: November 2, 2023
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Tyler David Jensen, Michael Nguyen, Dustin K. Harshman
  • Patent number: 11796500
    Abstract: Disclosed are methods of measuring moisture. Specifically, methods of measuring moisture on dry or nearly dry surfaces using an electrochemical sensor are disclosed. The method comprises applying a coating comprising an electrolyte to an electrode wherein water in the air can permeate the coating, applying a voltage to the electrode, detecting a current and, determining if the current indicates the presence of moisture. As a voltage is applied, oxygen in the water is reduced and produces a measurable signal. The method includes measuring the amount of or decrease of dissolved oxygen (in the form of water) at the surface of the electrode over time. Reduction of oxygen acts as a surrogate for water/moisture and, as such, the dryness of the surface of the electrode is calculated based on a predetermined relationship between current and dissolved oxygen (in the form of water).
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: October 24, 2023
    Assignee: ROCHE MOLECULAR SYSTEMS, INC
    Inventor: Christopher E. Uhegbu
  • Patent number: 11788068
    Abstract: Modified or mutant bacterial luciferases having improved activity, as compared to wild type or unmodified bacterial luciferases, are described. The modified or mutant bacterial luciferases display increased light production and/or slower signal decay. Employing these modified or mutant bacterial luciferases improve a luminescence reporter system assay by increasing the detection sensitivity, resulting in improved bioreporter/reporter assays. The invention further provides methods for using the modified or mutant bacterial luciferases, reporter assays using the modified or mutant bacterial luciferases, and kits and articles of manufacture.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: October 17, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Shawn Lee Suko
  • Publication number: 20230326640
    Abstract: The disclosure provides improved magnetic glass particles for use in nucleic acid capture, enrichment, analysis, and/or purification. Various modifications to the disclosed compositions and methods of using the same, as well as devices and kits are described.
    Type: Application
    Filed: June 15, 2023
    Publication date: October 12, 2023
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Stephan Hug, Fangbing Liu, Nancy Schoenbrunner, Martin Eduardo Silvestre
  • Patent number: D1012871
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: January 30, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Uichong Brandon Yi
  • Patent number: D1024093
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: April 23, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy K. Barnard, Sambasivarao Byrapuneni, Diwakar Chapagain, Archana P. Dorge, Catherine M. Jeu, Rengaraja Kesavan, Kaushal D. Parekh, Raman Ramanathan, David M. Schlossman, Vishakha Sharma