Abstract: This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent Kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification relations such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.

Abstract: Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for wireless secret communication with a device.

Abstract: The present invention relates in part to the unexpected discovery of novel complexes capable of catalyzing the selective dehydrogenative coupling of olefins. The invention further relates to the use of these complexes for the selective coupling of olefins.

Abstract: The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury.

Abstract: The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.

Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.

Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.

Abstract: Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.

Abstract: Disclosed herein are embodiments of a composition comprising at least three layers. Layers one and two each either comprises a sensitizer or an emitter, typically a metal ion or a dye, and the third layer may or may not comprise a sensitizer or emitter. Upon exposure to light, such as infrared light, the composition produces visible and/or UV light. The composition may further comprise a capping moiety, a therapeutic agent, an uptake enhancer, a detection moiety that binds to a desired target, a quenching moiety, or a combination thereof. The composition may be a particle, such as a nanoparticle, or it may be a planar composition. Also disclosed are embodiments of a method for using the composition, including, but not limited to, a method for delivering a therapeutic agent, or a method for detecting a target, such as a biological target.

Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.

Abstract: A transection device including a hollow tubular body extending from a proximal end to a distal end. A plurality of stabilizing members extend from the distal end of the tubular body and define a reduced diameter opening into a receiving chamber adjacent the distal end of the tubular body. A blade is positioned within the tubular body and moveable between an initial position within the tubular body to an extended position wherein at least a portion of the blade extends into the receiving chamber. A depressible member extends from the proximal end and is configured to move the blade between the initial position and the extended position. A compression member may be positioned between the plunger member and the blade.

Abstract: This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1? deletion mutant fungal cells.

Abstract: A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment.

Abstract: An actuator comprising a flexible substrate having a surface comprising one or more active regions, each of the active regions having disposed thereon an electrochemically active film comprising a plurality of 1T phase 2D MoS2 nanosheets which impart a first force upon the flexible substrate in response to electrochemical charging of ions in the 2D MoS2 nanosheets and impart a second force upon the flexible substrate in response to electrochemical discharging of ions in the 2D MoS2 nanosheets, wherein the first and second forces imparted to the flexible substrate each being sufficient to displace the flexible substrate. The flexible substrate may comprise a polymer substrate and the electrochemically active film may comprise a conductive layer having disposed thereon the plurality of 1T phase 2D MoS2 nanosheets.

Abstract: Systems and methods for joint reconstruction and segmentation of organs from magnetic resonance imaging (MRI) data are provided. Sparse MRI data is received at a computer system, which jointly processes the MRI data using a plurality of reconstruction and segmentation processes. The MRI data is processed using a joint reconstruction and segmentation process to identify an organ from the MRI data. Additionally, the MRI data is processed using a channel-wise attention network to perform static reconstruction of the organ from the MRI data. Further, the MRI data can is processed using a motion-guided network to perform dynamic reconstruction of the organ from the MRI data. The joint processing allows for rapid static and dynamic reconstruction and segmentation of organs from sparse MRI data, with particular advantage in clinical settings.

Abstract: Systems and methods for edge assisted real-time object detection for mobile augmented reality are provided. The system employs a low latency offloading process, decouples the rendering pipeline from the offloading pipeline, and uses a fast object tracking method to maintain detection accuracy. The system can operate on a mobile device, such as an AR device, and dynamically offloads computationally-intensive object detection functions to an edge cloud device using an adaptive offloading process. The system also includes dynamic RoI encoding and motion vector-based object tracking processes that operate in a tracking and rendering pipeline executing on the AR device.

Abstract: Provided are nucleic acid-based sensors, kits that include such sensors, and methods for making and using such sensors. The sensors permit detection of a broad array of target agents, such as nucleic acids (e.g., DNA and RNA), proteins, cells, and small molecules (e.g., toxins and metals). In some examples, the sensors determine the activity of a protein, such as an enzyme's activity. The assays provide easy-to-read signals for point-of-care diagnosis. The sensors control the conformational switch for recognizing targets and to trigger the subsequent assembly of enzyme/cofactor structures for producing and amplifying signals.

Abstract: The invention provides a compound of formula I: or a salt thereof, wherein Y, Z, L, and W have any of the values described in the specification, as well as compositions comprising a compound of formula I or a salt thereof. The compounds are useful as tools for visualizing FtsZ and monitoring cell division in a broad range of Gram-positive and Gram-negative bacterial pathogens of acute clinical importance and for identifying new FtsZ inhibitors.

Abstract: A new and distinct Origanum vulgare plant named ‘Pierre’ is disclosed, characterized by very high essential oil content, high carvacrol content, no flowering, broad plant width, and about 16 weeks to maturity.