Patents Assigned to Rutger, The State University
  • System and method for measuring physiologically relevant motion
    Patent number: 10898122
    Abstract: A system for measuring and monitoring physiologically relevant motion of a subject includes at least a motion sensor to measure movement of the subject and produce a series of movement data representing the movement of the subject over a period of time. The system also includes at least a biometric sensor to simultaneously measure biometrics of the subject and produce a series of biometric values of the subject over the period of time. The system is configured to determine a noise-to-signal ratio for the series of movement data as a function of biometric intervals in the series of biometric values and identify at least a portion of the series of movement data as corresponding to a physiologically relevant biorhythm. The system can be used to diagnose and monitor a disease or disorder, including a neurological disorder or a traumatic brain injury.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: January 26, 2021
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Elizabeth B. Torres
  • Rapid assays for T-cell activation by RNA measurements using flow cytometry
    Patent number: 10900072
    Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: January 26, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Yuri Bushkin, Maria L. Gennaro, Sanjay Tyagi, Richard Pine
  • Antibacterial Agents: Arylalkylcarboxamido Phloroglucinols
    Publication number: 20210017126
    Abstract: The invention provides compounds of formula (I) or (II) and tautomers and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula (I) or (II) or a tautomer or salt thereof, methods of making a compound of formula (I) or (II) or a tautomer or salt thereof, and methods of using a compound of formula (I) or (II) or a tautomer or salt thereof as, e.g., inhibitors of bacterial RNA polymerase or as antibacterial agents.
    Type: Application
    Filed: March 6, 2019
    Publication date: January 21, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Richard H. EBRIGHT, Yon W. EBRIGHT, Joel S. FREUNDLICH, Ricardo GALLARDO-MACIAS, Shao-Gang LI
  • ANTIBACTERIAL AGENTS: SOLUBLE SALTS AND AQUEOUS FORMULATIONS OF PYRONINS
    Publication number: 20210002266
    Abstract: The invention provides salts of formula Ia, Ib, Ic, or Id: wherein variables are as described in the specification, as well as compositions comprising a salt of formula Ia-Id, methods of making such salts, and methods of using such salts as, e.g., inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Application
    Filed: February 12, 2019
    Publication date: January 7, 2021
    Applicant: Rutgers, the State University of New Jersey
    Inventors: Richard H. Ebright, Yon W. Ebright
  • ANTIBACTERIAL AGENTS: O-ALKYL-DEUTERATED PYRONINS
    Publication number: 20210002246
    Abstract: The invention provides compounds of formula Ia, Ib, Ic, or as well as compositions comprising a compound of formula Ia-Id, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Application
    Filed: February 12, 2019
    Publication date: January 7, 2021
    Applicant: Rutgers, the State University of New Jersey
    Inventors: Richard H. Ebright, Yon W. Ebright
  • Apparatus and method for dewetting-based spatial light modulation for high-power lasers
    Patent number: 10884253
    Abstract: An apparatus and method for dynamic and reversible patterning of mask layers and manipulation and redistribution of energy sources such as laser beams. An embodiment of the present invention provides an apparatus including a mirror-like thin film comprising a front surface and a back surface configured to reflect a laser beam; a layer of a mask material on top of the front surface of the mirror-like thin film, wherein the mask material is transparent to the laser beam and is dewetted by a heat source to create a height profile in the mask material.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: January 5, 2021
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Jonathan Phillip Singer, Tianxing Ma
  • Electrochemical devices and methods for making same
    Patent number: 10886537
    Abstract: A current collector for use in an electrochemical cell is provided. The current collector comprises: a reticulated core comprising a polymer and having continuous porosity; a first reticulated surface; a second reticulated surface opposite said first reticulated surface; and a thin metal film disposed on at least one of said first and second reticulated surfaces, wherein said current collector has continuous porosity. A high temperature resistant polymer is preferred for the reticulated core where the current collector may be exposed to high temperatures during production or use. The continuous porosity of the reticulated core 12 and the current collector allows for passage of electrolyte and ions, as necessary for operation of an electrochemical device that includes the current collector.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: January 5, 2021
    Assignee: Rutgers. The State University of New Jersey
    Inventors: Glenn G. Amatucci, Anna B. Halajko, Linda Wu Sung
  • Sustainable supply of recipe components for ceramic composites produced by hydrothermal liquid phase sintering
    Patent number: 10875815
    Abstract: A method for preparing a ceramic composition while simultaneously reducing the quantity of carbon dioxide from municipal solid waste that would discharge into environment includes decomposing the municipal solid waste to generate a carbon dioxide-water vapor mixture, providing a matrix, the matrix containing a reactant; and contacting the carbon dioxide-water vapor mixture with the matrix to promote a reaction between the carbon dioxide of the carbon dioxide-water vapor mixture and the reactant of the matrix. The reaction forms a product, thereby producing the ceramic composition.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: December 29, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Richard E. Riman
  • Therapeutic compounds
    Patent number: 10875861
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R2-R4 and p have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as anti-cancer agents.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: December 29, 2020
    Assignee: Rutgers, the State University of New Jersey
    Inventors: David J. Augeri, Hatem E. Sabaawy
  • Combination therapy using riluzole to enhance tumor sensitivity to ionizing radiation
    Patent number: 10864271
    Abstract: Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: December 15, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Atif Jalees Khan, Suzie Chen, James S. Goydos, Bruce G. Haffty
  • Unmanned air and underwater vehicle
    Patent number: 10858100
    Abstract: An unmanned vehicle including a body and a frame structure extending from the body and supporting a plurality of propeller assemblies, each propeller assembly including at least one propeller and a corresponding motor with the motor housed in a watertight housing or coated and made corrosion resistant. The propellers comprise a first subset of propellers of the propeller assemblies and a second subset of propellers of the propeller assemblies which rotate in a plane positioned below a plane in which the first subset of propellers rotate, wherein said first and second subset of propellers are configured for independent operation of one another as the vehicle transitions from an air medium to a water medium.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: December 8, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Francisco J. Diez-Garias, Marco M. Maia
  • Aerated composite materials, methods of production and uses thereof
    Patent number: 10851022
    Abstract: The invention provides novel aerated composite materials that possess excellent physical and performance characteristics of aerated concretes, and methods of production and uses thereof. These composite materials can be readily produced from widely available, low cost raw materials by a process suitable for large-scale production with improved energy consumption, desirable carbon footprint and minimal environmental impact.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: December 1, 2020
    Assignees: SOLIDIA TECHNOLOGIES, INC., RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Omkar Deo, Vahit Atakan, Deepak Ravikumar, Xudong Hu, Sadananda Sahu, Surojit Gupta, Richard Riman
  • Aryl and heteroaryl amides for use as anti-proliferative, anti-thrombotic, and anti-viral agents
    Patent number: 10851096
    Abstract: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: December 1, 2020
    Assignees: Rutgers, The State University of New Jersey, The Curators of the University of Missouri
    Inventors: William J. Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Thomas Walter Comollo, Stanley G. Kimani, Kamlendra Singh
  • Creative GAN generating art deviating from style norms
    Patent number: 10853986
    Abstract: A method and system for generating art uses artificial intelligence to analyze existing art forms and then creates art that deviates from the learned styles. Known art created by humans is presented in digitized form along with a style designator to a computer for analysis, including recognition of artistic elements and association of particular styles. A graphics processor generates a draft graphic image for similar analysis by the computer. The computer ranks such draft image for correlation with artistic elements and known styles. The graphics processor modifies the draft image using an iterative process until the resulting image is recognizable as art but is distinctive in style.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: December 1, 2020
    Assignee: Rutgers, the State University of New Jersey
    Inventor: Ahmed Elgammal
  • POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES
    Publication number: 20200369597
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 26, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • Augmenting Moieties for Anti-Inflammatory Compounds
    Publication number: 20200369688
    Abstract: Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory terpenes and/or vanilloids covalently conjugated to one another so that the activity of the conjugate is greater than the sum of its parts. Also disclosed are methods of improving the potency of an anti-inflammatory terpene or vanilloid by linking it to another anti-inflammatory terpene or vanilloid via a carbamate linkage, where the potency of the conjugate is greater than the sum of its parts.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Applicants: Rutgers, The State University of New Jersey, Lehigh University
    Inventors: Jeffrey D. Laskin, Diane E. Heck, Carl J. Lacey, Ned D. Heindel, Sherri C. Young
  • Prodrugs of riluzole and their method of use
    Patent number: 10844026
    Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: November 24, 2020
    Assignees: Biohaven Pharmaceutical Holding Company Ltd., Rutgers, The State University of New Jersey
    Inventors: Garry Robert Smith, Allen B. Reitz, Mark McDonnell, Suzie Chen, Matthew D. Vera, Benjamin E. Blass, Jeffrey Claude Pelletier, Venkata N. Velvadapu, Jay Edward Wrobel
  • USE OF GRAPHENE-POLYMER COMPOSITES TO IMPROVE BARRIER RESISTANCE OF POLYMERS TO LIQUID AND GAS PERMEANTS
    Publication number: 20200362137
    Abstract: A packaging material comprising a graphene-reinforced polymer matrix composite (G-PMC) is disclosed. The packaging material has improved barrier resistance to gas and liquid permeants. Also disclosed is a method of improving barrier resistance of a polymer to a permeant, the method comprising forming a graphene-reinforced polymer matrix composite within the polymer. The packaging material may be used for packaging food, drug, perfume, etc. and to make various containers.
    Type: Application
    Filed: January 16, 2019
    Publication date: November 19, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Thomas J. Nosker, Jennifer K. Lynch-Branzoi, Bernard H. Kear, Charles T. Chang
  • plant named ‘Monmouth’
    Patent number: PP32462
    Abstract: A new and distinct Corylus avellana plant named ‘Monmouth’ characterized by a vigorous and upright growth habit, the production of nuts with globular kernels that fall free of the husk at maturity, and a high level of tolerance (quantitative resistance) to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: November 17, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Thomas J. Molnar, Shawn A. Mehlenbacher, John M. Capik
  • plant named ‘Somerset’
    Patent number: PP32494
    Abstract: A new and distinct Corylus avellana plant named ‘Somerset’ characterized by a semi-vigorous, compact growth habit, the production of nuts with thin shells and globular kernels that fall free of the husk at maturity, and resistance to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: November 24, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Thomas J. Molnar, Shawn A. Mehlenbacher, John M. Capik