Abstract: Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein each R and R? pair are independently selected from (i) or (ii); (i) R and R? are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or (ii) R and R? together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure; X is hydrogen, or an alkyl; and Y is O or S.

Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Abstract: The invention provides compounds of formula (I): and salts thereof wherein ring A, R2, HET, X, n, and R3 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.

Abstract: The present disclosure relates to compounds having an improved solubility thereby increasing their bioavailability, lower dosages, etc. The target compounds, may include but are not limited to, macrophage migration inhibitory factor (MIF) inhibitors, epidermal growth factor receptor (EGRF) inhibitors, kinase inhibitors and prodrugs of alpha4 beta1 and alpha4 beta7 integrin antagonists.

Abstract: This invention discloses multi-part primers for primer-dependent nucleic amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.

Abstract: Disclosed is a method of non-invasive infrared imaging, comprising (a) administering a composition containing infrared-emitting particles which contain rare earth elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles; and (b) irradiating with infrared radiation, where both excitation and emission spectra of the encapsulated particles are in the infrared region. Analogous methods of image-guided biomedical intervention, and drug tracking and delivery are also disclosed. Also disclosed is a composition for biomedical applications, containing infrared-emitting particles which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles.

Abstract: This disclosure provides methods and systems for classifying biological particles, e.g., blood cells, microbes, circulating tumor cells (CTCs). Using impedance flow cytometry, such as multi-frequency impedance cytometry, in conjunction with supervised machine learning, the disclosed methods and systems demonstrated improved accuracy in classifying biological particles.

Abstract: A method for determining the position in a vehicle of a first device in communication with a microprocessor may include receiving, at the microprocessor, a first set of inertial data from at least one sensor of the first device; receiving, at the microprocessor, a second set of inertial data from at least one sensor of a reference device disposed within the vehicle; and determining, using the microprocessor, the position of the first device in the vehicle by comparing the first set of inertial data with the second set of inertial data.

Abstract: Methods of treating infection including sepsis through modulation of a P2X receptor are provided.

Abstract: Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I).

Abstract: A magnesium zinc oxide (MZO) nanostructure modified quartz crystal microbalance (MZOnano-QCM) takes advantage of the unique sensing ability and biocompatibility of MZO-based nanostructures, and combines them with the dynamic impedance spectrum capability of the bulk acoustic wave (BAW) devices including QCM, to form a real-time, noninvasive and label-free cell monitoring biosensor, specifically detecting the susceptibility and resistance of bacterial and fungal strains and cancer cells to various antibiotic and antifungal drugs and anticancer drugs, respectively.

Abstract: The present application discloses the first rare-earth-free metal organic framework (MOF) yellow phosphors that can be effectively excited by blue light and assembled in a white light emission (WLED) device with a blue chip. The compounds of the present invention exhibit significantly enhanced emission intensity compared to the constituent ligand and high quantum yield and high thermal and moisture stability and photoluminescence. The invention also includes light emitting devices comprising any of these MOF yellow phosphors and methods of preparing these compounds and devices.

Abstract: A system and method for detecting a suspicious object, including a wireless signal transmitter with first and second transmitter antennas, a first wireless signal receiver on an opposite side of the object from the transmitter having first and second receiver antennas, and a second wireless signal receiver on a same side of the object as the transmitter having a third receiver antenna. The transmitter may emit wireless signals from each of the transmitter antennas. The signals emitted by the first transmitter antenna may be received at the first and second receiver antennas. The signals emitted by both transmitter antennas may be received at the third receiver antenna. The object's material type may be determined based on channel state information of the wireless signals received at first receiver. A size of the object may be determined based on channel state information of the wireless signals received at the second receiver.

Abstract: Systems (100) and methods (200, 1600) for generating a medical and/or dental diagnosis. The methods comprise: obtaining a true color image of a select part of a subject's body; converting the true color image to a grayscale intensity image; generating a histogram equalized image by adjusting the grayscale intensity image's contrast; processing the histogram equalized image to generate first information useful for generating the medical and/or dental diagnosis, the first information comprising at least one of (a) a ratio of a disease region's pixel mean intensity value and a normal region's mean pixel intensity value and (b) an indicator indicating whether a periodontal ligament space has widened or broken; and generating the medical and/or dental diagnosis based at least on the first information.

Abstract: Provided are systems and methods for medical diagnosis. The systems and methods may identify a coherence between paired sensor data respectively measured from a first sensor attached to a head of a subject and a second sensor attached to a body part of the subject. The systems and methods may determine an amount of volition in the subject's body based on the coherence. The systems and methods may determine a diagnosis or a treatment plan for a subject based on the amount of volition. The system and methods may be used to track interaction between individuals in a clinical setting or in a social group.

Abstract: A metal acoustic lens comprises a plurality of stacked plates, wherein each plate comprises an acoustically transparent two-dimensional material structure comprising a plurality of adjacent regular hexagonal cells, wherein each hexagonal cell includes a plurality of lobes extending inwardly from the vertices of the hexagonal cell, and wherein the lengths of the lobes vary across each plate in the longitudinal direction such that the speed of sound waves passing therethrough is varied and the resulting sound is focused.

Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.

Abstract: Methods of detecting immunogenic endogenous retroviruses and treating cancer are disclosed herein. In some embodiments, the methods include detecting increased expression of endogenous retroviruses in a tumor sample.

Abstract: A new and distinct Corylus avellana plant named ‘Raritan’ characterized by a vigorous and upright-spreading growth habit, the production of nuts with round kernels that fall free of the husk at maturity, and a high level of tolerance (quantitative resistance) to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller.

Abstract: A new and distinct Corylus avellana plant named ‘Hunterdon’ characterized by a vigorous and upright growth habit, the production of nuts with globular kernels that fall free of the husk at maturity, and a high level of tolerance (quantitative resistance) to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller.