Abstract: The present disclosure relates, in part, to a method for preparing a carbon nanomaterial from a plastic material. In certain embodiments, the method comprises nonsolvent induced phase separation of the plastic material to provide plastic nanoparticles. In certain embodiments, the method comprises hydrothermal conversion of the plastic nanoparticles to carbon nanomaterials. In certain embodiments, the plastic material is derived from waste material. In certain embodiments, the plastic material is polypropylene (PP). In certain embodiments, the carbon nanomaterial is carbon dots (CDs). In another aspect, the disclosure provides a method for altering the properties of CDs by post-processing to afford graphitic materials.

Abstract: The invention provides methods of inhibiting a bacterial RNA polymerase and methods of treating a bacterial infection with salts of formula Ia, Ib, Ic, or Id: wherein variables are as described in the specification.

Abstract: An acoustic transducer system for projecting and sensing acoustic waves or sound in fluid is disclosed in accordance with the present disclosure and figures herein. The system includes a transducer array of a plurality of channels, each channel having an inlet and an outlet, and a reservoir containing a liquid solution. A first electrode is disposed proximate to the inlet and a second electrode is disposed proximate to the outlet. A voltage source, connected to the first and second electrodes, is configured to apply voltage across a length of the array of the channels to generate an electric field parallel to each channel. The electric field causes an electroosmotic flow of ions from the reservoir to the outlet, producing a plurality of acoustic waves or sound at the outlet. A method for projecting and sensing acoustic waves or sound in fluid using the acoustic transducer system is also disclosed herein.

Abstract: This document discloses a hybrid and multifunctional biosensing technology consisting of a dual gate thin-film transistor (DGTFT) biosensor with an extended gate covered with magnesium zinc oxide nanostructures (MZOnano) and an MZOnano modified bulk acoustic wave resonator (MZOnano BAW). The technology is used for the full-scale dynamic monitoring of bacterial biofilm formation from its early stage to the maturation stage.

Abstract: The present disclosure relates to a new modular approach for the generation of genetically modified cells, particularly immune cells and iPSCs, enabling the simultaneous precise editing of defined nucleic acid targets (knock-out) and the introduction of an exogenous sequence of choice at a desired locus (knock-in) using a common Cas9 element.

Abstract: Sensors employing elastomers enhanced with electrically conductive 2D nanoparticles are provided. The nanoparticles are formed by applying shear to layered materials present in elastomer precursors (e.g., elastomeric monomer(s) and/or curing agent(s)). Subsequent exfoliation of the layers occurs directly within the precursor and/or curing agent. The cured elastomer nanocomposites can be employed for electrochemical sensing, flexible touchpads, pressure sensors, and wireless sensors, amongst other applications.

Abstract: A tiltable near-vertical bifacial (TNVBF) solar panel assembly comprising one or more BF solar panels configured to be positioned in a first (AM) tilt position to improve energy conversion of morning sunlight incident upon a first side of the one or more BF solar panels, and to be positioned in a second (PM) tilt position to improve energy conversion of afternoon sunlight incident upon a second side of the one or more BF solar panels.

Abstract: The invention provides methods and compositions that are useful for treating allergic diseases, bacterial infections, fungal infections, viral infections, mastocytosis, mast cell-mediated inflammation and parasite infections (e.g., helminth infections).

Abstract: The present disclosure provides compounds which are useful for a number of catalytic transformations of organic molecules, non-limiting examples including dehydrogenation of alkanes. The present disclosure further relates to methods of preparing the compounds of the present disclosure.

Abstract: The present invention discloses a system for targeted gene editing and related uses.

Abstract: Described herein is a diagnostic catheter and a catheter system including the same. The diagnostic catheter of the disclosure is configured for advancing from a first blood vessel (such as a subclavian artery or descending aorta artery) into a second blood vessel (such as a patient head or neck artery) that forms a large angle with the first blood vessel at the bifurcation point of the two blood vessels. The diagnostic catheter of the disclosure includes an inflatable balloon coupled to or formed on an exterior surface of the distal region, which is able to anchor the distal portion of the diagnostic catheter near or just inside the second blood vessel, thereby simplifying the subsequent navigation steps. Also described herein are methods of using the diagnostic catheter and the catheter system to navigate in the blood vessel networks of patients.

Abstract: The invention provides dual-targeted inhibitors of bacterial RNA polymerase having the general structural formula (I): wherein a is a benzoxazino-rifamycin or a spiro-rifamycin: y is a moiety that binds to the bridge-helix N-terminus target of a bacterial RNA polymerase; and P is a bond, two bonds, or a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

Abstract: Endophytic bacteria, compositions comprising the same, and methods of use thereof are disclosed which increase the root and shoot growth of grass hosts, suppress growth of soil borne fungal pathogens of host plants, increase resistance of the grass to diseases and reduce competitiveness of distantly related competitor weeds of the crop.

Abstract: A device for catheterization includes a catheter sheath support mounted to a catheterization device and holding a catheter sheath, a carriage supporting a guide needle, and a connector to removably engage the catheter sheath support to the carriage. The carriage translates along an axis of insertion of the guide needle independent of the catheter sheath support when disengaged from the connector. An actuator controls separation of the carriage from the catheter sheath support at a uniform velocity in response to disengagement of the connector. Translation and separation may be automated. In response to detection of the vessel wall puncture, the carriage automatically releases from the catheter sheath support and retracts along the axis of insertion at the uniform velocity relative to the catheter sheath support, and the catheter sheath automatically advances into the target vessel along the axis of insertion at the uniform velocity while the carriage retracts.

Abstract: The invention provides a compound of formula I. or a salt thereof, wherein R1—R2 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antiviral agents.

Abstract: The invention provides compounds of formula (16) and (17); and salts thereof, as well as compositions comprising such compounds and salts, complexes comprising such compounds and salts, and methods for treating cancer, inhibiting BMI1 expression, or treating Huntington's disease using such compounds, salts, and complexes. The compounds, salts, and complexes have potency, permeability, and oral bioavailability that make them particularly useful, for example, for the treatment of glioblastoma.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus providing secure physical layer (PHY) transmission via metamaterial (MTM) leaky-wave antennas (LWAs) using directed modulation (DM) transmitters such as for orthogonal frequency-division multiplexing (OFDM) and non-contiguous (NC) OFDM transmissions, where the DM functionalities exploit the property of time-modulated arrays (TMAs) realized in 1-D and 2-D spaces through the MTM-LWAs.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for optical, radio frequency (RF), and/or acoustic data transmission by dividing each of one or more sequences of channel coded bits d into N blocks thereof, which are respectively spatially modulated (SM) with respective pilot sequences and mapped to constellations to provide thereby respective symbol streams, which are modulated in accordance with orthogonal signal division multiplexing (OSDM) to provide respective SM-OSDM signals, which are transmitted via optical sources, RF antennae, acoustic transducers, and the like during respective timeslots such that a receiver associated with a plurality of receiving devices may reconstruct the bitstream used to form the one or more sequences of channel coded bits d.

Abstract: This disclosure relates to assays and reagents for the detection of drug-resistance mutations in Mycobacterium. tuberculosis or of multidrug-resistant Mycobacterium tuberculosis.

Abstract: A novel yeast strain and methods of use thereof for robust biosynthesis of demethylated polymethoxy flavones are disclosed. Also provided are method of administering demethylated polymethoxy flavones for the treatment of obesity and inflammatory a disease.