Patents Assigned to Rutgers, The State University of New Jersey
  • Patent number: 10783871
    Abstract: A metal acoustic lens comprises a plurality of stacked plates, wherein each plate comprises an acoustically transparent two-dimensional material structure comprising a plurality of adjacent regular hexagonal cells, wherein each hexagonal cell includes a plurality of lobes extending inwardly from the vertices of the hexagonal cell, and wherein the lengths of the lobes vary across each plate in the longitudinal direction such that the speed of sound waves passing therethrough is varied and the resulting sound is focused.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: September 22, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Andrew N. Norris, Xiaoshi Su
  • Patent number: 10774030
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 15, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • Publication number: 20200283858
    Abstract: Methods of detecting immunogenic endogenous retroviruses and treating cancer are disclosed herein. In some embodiments, the methods include detecting increased expression of endogenous retroviruses in a tumor sample.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 10, 2020
    Applicants: Rutgers, The State University of New Jersey, Vanderbilt University
    Inventors: Shridar Ganesan, Gyan Bhanot, Anshuman Panda, W. Kimryn Rathmell, Aguirre Andres de Cubas
  • Patent number: 10758537
    Abstract: The invention provides methods and compositions that are useful for treating allergic diseases, bacterial infections, fungal infections, viral infections, mastocytosis, mast cell-mediated inflammation and parasite infections (e.g., helminth infections).
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 1, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Mark C. Siracusa
  • Patent number: 10759740
    Abstract: The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, W, X, Y and n have any of the values defined in the specification.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: September 1, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael Chikindas
  • Patent number: 10752885
    Abstract: Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: August 25, 2020
    Assignees: Rutgers, the State University of New Jersey, Beijing Wantai Biological Pharmacy Enterprise Co., Ltd., Xiamen University
    Inventors: Hua Zhu, Yimin Li, Ningshao Xia, Tong Cheng, Xiangzhong Ye
  • Patent number: 10744079
    Abstract: Described herein are oral care compositions comprising amphiphilic macromolecules, along with methods of making and using same.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: August 18, 2020
    Assignees: Colgate-Palmolive Company, Rutgers, the State University of New Jersey
    Inventors: Carl Myers, Guillaume Picquet, Kathryn E. Uhrich, Jennifer Chan Woo, Jeannette Elizabeth Marine
  • Patent number: 10736889
    Abstract: Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action ?-opioid receptor antagonist/?-opioid receptor agonists or prodrug thereof to a subject in need thereof, sufficient to mitigate the dyskinesia. Alternatively, a combination of both a ?-opioid receptor antagonist or prodrug thereof, and a ?-opioid receptor agonist or prodrug thereof can be administered, either together or separately.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: August 11, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: M. Maral Mouradian, Steven Braithwaite, Michael Voronkov
  • Publication number: 20200248182
    Abstract: Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.
    Type: Application
    Filed: August 1, 2018
    Publication date: August 6, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Gregory R. Weidman, Yanan Zhao
  • Patent number: 10729771
    Abstract: The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: August 4, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Abraham Pinter, Alok Choudhary
  • Patent number: 10729671
    Abstract: The invention provides complexes of Zn2+ of formulae (la) and (IIa) that are useful for treating cancer, as well as compositions and kits comprising such complexes.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: August 4, 2020
    Assignees: Rutgers, the State University of New Jersey, The Research Foundation for the State University of New York
    Inventors: David J. Augeri, Anthony F. Bencivenga, Adam Blanden, Darren R. Carpizo, John A. Gilleran, Spencer David Kimball, Stewart N. Loh, Xin Yu
  • Patent number: 10722743
    Abstract: A multi-catalytic material that includes a polyelectrolyte membrane and methods of preparing the same are provided herein.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: July 28, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: John Landers, Alexander V. Neimark, Tewodros Asefa, Aleksey Vishnyakov, Anandarup Goswami, Jonathan Colon Ortiz
  • Patent number: 10717810
    Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: July 21, 2020
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, REVA MEDICAL, INC.
    Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
  • Patent number: 10716860
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: July 21, 2020
    Assignees: Matinas BioPharma Nanotechnologies, Inc., Rutgers, The State University of New Jersey
    Inventors: Raphael Mannino, Ruying Lu
  • Patent number: 10695322
    Abstract: New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among ?-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: June 30, 2020
    Assignees: The Johns Hopkins University, Rutgers, The State University of New Jersey
    Inventors: Gyanu Lamichhane, Craig A. Townsend, Evan Lloyd, Amit Kaushik, Pankaj Kumar, Joel Freundlich, Shaogang Li, Sean Ekins, Nicole Parrish
  • Publication number: 20200197382
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: May 25, 2018
    Publication date: June 25, 2020
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • Publication number: 20200199076
    Abstract: The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
    Type: Application
    Filed: August 29, 2018
    Publication date: June 25, 2020
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joel S. FREUNDLICH, David ALLAND, Matthew B. NEIDITCH, Pradeep KUMAR, Glenn CAPODAGLI, Divya AWASTHI, Sean EKINS
  • Patent number: 10693098
    Abstract: Light-emitting devices having an emitting layer containing a light-emitting organic or organometallic material and a nanostructure, the nanostructure having strong local electric fields at visible electromagnetic wavelengths that spectrally and spatially overlap with the light-emitting material. The spectral and spatial overlap of the electric fields of the nanostructure with the light emitting material uses high LDOS provided by the nanostructures to enable excited triplet electronic states in the material to emit light faster than without the nanostructure. This faster light emission from triplet-excited states leads to more stable emission from the light emitting material because it prevents buildup of triplet-excited states, which ordinarily can lead to quenching of light emission from the light emitting material. Among the many different possibilities contemplated, the nanostructure may advantageously be made of a dielectric material or a plasmonic metal material, such as SiO2, TiO2, ZnO, Al or Ag.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: June 23, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Deirdre O'Carroll
  • Publication number: 20200194108
    Abstract: A device to detect an object in a medical image is described. An image analysis application, executed by the device, receives the medical image as an input. The medical image is next partitioned to sub-regions. Parts of the object are detected in a selection of the sub-regions using a deep-learning neural network (DNN) model. Bounding boxes for the selection are also determined. The bounding boxes are evaluated based on a confidence score detected as above a threshold level. The confidence score designates the parts as contained within the selection. Next, a region of interest (ROI) is determined as a group including the selection. Similar orientations associated with the bounding boxes are comparable to similar orientations of a positive training model of the DNN model. Furthermore, the selection is designated as the ROI within the medical image. The medical image is provided with the ROI to a user.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 18, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Christine I. Podilchuk, Richard Mammone
  • Patent number: 10676833
    Abstract: Disclosed are cathodes comprising a conductive support substrate having a catalyst coating containing nickel phosphide nanoparticles. The conductive support substrate is capable of incorporating a material to be reduced, such as CO2 or CO. Also disclosed are electrochemical methods for generating hydrocarbon and/or carbohydrate products from CO2 or CO using water as a source of hydrogen.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: June 9, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: G. Charles Dismukes, Anders Laursen, Martha Greenblatt, Karin Calvinho