Patents Assigned to Rutgers, The State University of New Jersey
  • Publication number: 20240238340
    Abstract: The present disclosure includes compositions and methods for treating gastrointestinal inflammatory disease and/or cancers. In certain aspects, the disclosure includes an isolated cell comprising a nucleic acid vector comprising a gene encoding the transcription factor ZBTB20 which is operably linked to a promoter.
    Type: Application
    Filed: April 28, 2022
    Publication date: July 18, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Derek B. Sant'Angelo, Lisa K. Denzin
  • Patent number: 12041178
    Abstract: Systems and methods for enforcing contract/protocol/law execution having a wide range of applicability. The disclosed systems and methods have very low latency between a transaction and its validation and have strong scalability. One example embodiment is a system for enforcing execution of a protocol among a plurality of parties. The example system includes a controller provider configured to manage a plurality of automated controllers. The system also includes a ledger and an inspector. The plurality of automated controllers correspond to the plurality of parties. Each automated controller is configured to enforce execution of the protocol using a computer program integrated with the automated controller. The controller provider intercepts messages sent or received by the automated controllers and stores them in the ledger. The ledger, thus, represents the history of events or operations between the parties, and the treatment of those events or operations by the controllers.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: July 16, 2024
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Naftaly H. Minsky, Chen Cong, David M. Zimmerman
  • Patent number: 12037529
    Abstract: Disclosed herein are embodiments of a composition comprising at least three layers. Layers one and two each either comprises a sensitizer or an emitter, typically a metal ion or a dye, and the third layer may or may not comprise a sensitizer or emitter. Upon exposure to light, such as infrared light, the composition produces visible and/or UV light. The composition may further comprise a capping moiety, a therapeutic agent, an uptake enhancer, a detection moiety that binds to a desired target, a quenching moiety, or a combination thereof. The composition may be a particle, such as a nanoparticle, or it may be a planar composition. Also disclosed are embodiments of a method for using the composition, including, but not limited to, a method for delivering a therapeutic agent, or a method for detecting a target, such as a biological target.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: July 16, 2024
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Ki-Bum Lee, Hudifah Rabie, Nicholas Pasquale, Yixiao Zhang
  • Publication number: 20240229031
    Abstract: MicroRNAs, or mimics thereof, for treating a subject suffering from nervous system dysfunction are described. Pharmaceutical compositions, viral vectors or viral particles, and nanoparticles comprising these microRNAs, or mimics thereof, are described. Methods of using these microRNAs, or mimics thereof, pharmaceutical compositions comprising the microRNAs, viral vectors, or nanoparticles are also described herein. These compositions and methods of use will provide novel therapies for patients suffering nervous system dysfunction, including but not limited to alpha-synucleinopathies and SCI.
    Type: Application
    Filed: October 10, 2023
    Publication date: July 11, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: M. Maral Mouradian, Eunsung Junn
  • Patent number: 12030983
    Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: July 9, 2024
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Patent number: 12027660
    Abstract: An electrochemical cell is provided comprising a thin metal foil packaging made from at least one sheet of metal foil and having a perimeter extending around at least a portion of the electrochemical cell, as well as an electrochemical cell stack contained within the thin metal foil packaging, and a metal-to-metal welded seal around at least a portion of the perimeter of the thin metal foil packaging. The metal-to-metal welded seal is hermetic or nearly hermetic. Furthermore, the metal-to-metal welded seal is narrow, having a width of less than about 1 mm, and is less than about 5 mm away from the electrochemical cell stack. In some embodiments, the thin metal foil packaging functions not only as a hermetically or near hermetically sealed packaging, but also as either electrode of the cell bonded to the foil packaging.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: July 2, 2024
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Glenn Amatucci, Irene Plitz, Linda Sung, Anthony Ferrer
  • Publication number: 20240210958
    Abstract: A first robot performs navigation to a predetermined first static or dynamic target location. A first set of velocity candidates is generated for the first robot based on the detection of a first set of one or more velocity obstacles. A first new velocity is selected from the first set of velocity candidates. The first robot is moved at a first velocity corresponding to the first new velocity. The first new velocity is a first desired velocity or a velocity closest to the first desired velocity when at least one velocity candidate of the first set of velocity candidates corresponds to a safe and reachable velocity for the first robot. The first new velocity is a minimum velocity possible by the first robot when each one of the first set of velocity candidates corresponds to a respective unsafe velocity for the first robot.
    Type: Application
    Filed: April 28, 2022
    Publication date: June 27, 2024
    Applicant: Rutgers, The State University of New Jersey.
    Inventors: Zhimin Xi, Elnaz Asghari Torkamani
  • Patent number: 12018099
    Abstract: The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: June 25, 2024
    Assignees: Rutgers, The State University of New Jersey, Rowan University
    Inventors: David Salas de la Cruz, Xiao Hu, Stacy Love, David Verrill
  • Publication number: 20240181438
    Abstract: The present disclosure relates in part to novel complexes of unsymmetrical N-heterocylic carbene (NHC) ligands and group 10 or 11 metals. The present disclosure further relates to methods of electrophilic functionalization of alkynes and/or nitriles using the NHC catalysts described herein.
    Type: Application
    Filed: March 1, 2022
    Publication date: June 6, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Michal Szostak, Qun Zhao, Md. Mahbubur Rahman
  • Publication number: 20240182917
    Abstract: Compositions and methods for improving plastid transformation in difficult to transform plants are disclosed.
    Type: Application
    Filed: November 8, 2023
    Publication date: June 6, 2024
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Pal Maliga
  • Publication number: 20240180981
    Abstract: Disclosed herein are methods of identifying and treating subjects with cancer, and methods of predicting a survival outcome in a subject with cancer, such as pancreatic cancer. In one aspect, the application provides methods for detecting the presence of cancer or infectious disease in a subject by collecting and analyzing sequencing information from the subject, such as by performing single cell RNA sequencing analysis of individual cells obtained from a sample from the subject. In a further aspect, the application provides methods for detecting the presence of cancer or infectious disease in a subject by determining microbial diversity and/or assessing the presence or absence of particular microbes in individual cells from the subject as compared to a control. Also provided are methods of determining T-cell microenvironment reaction, for example by sequencing nucleic acid molecules in individual T-cells obtained from the subject.
    Type: Application
    Filed: April 21, 2022
    Publication date: June 6, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Bassel Ghaddar, Subhajyoti De
  • Publication number: 20240180838
    Abstract: The present disclosure relates to compositions and methods for treating a wound, or location of interest, in a subject by topically administering to the subject a therapeutic composition of the present disclosure. The composition of the disclosure comprises nanoparticle (NP) composites for delivering at least two cargos to the wound. In certain embodiments, the at least two cargos comprise a metal and a small molecule drug.
    Type: Application
    Filed: December 5, 2023
    Publication date: June 6, 2024
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Maricely Ramirez Hernandez, Tewodros Asefa, Jeffrey M. Boyd, Javiera Norambuena-Morales
  • Patent number: 11993571
    Abstract: Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: May 28, 2024
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • Patent number: 11993592
    Abstract: The present disclosure provides compounds which are useful for a number of catalytic transformations of organic molecules, non-limiting examples including dehydrogenation of alkanes. The present disclosure further relates to methods of preparing the compounds of the present disclosure.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: May 28, 2024
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alan S. Goldman, Thomas R. Dugan
  • Patent number: 11992362
    Abstract: A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and the device pose data.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: May 28, 2024
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Martin L. Yarmush, Alvin Chen, Max Balter, Joshua Leipheimer
  • Patent number: 11995986
    Abstract: Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: May 28, 2024
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Marco Gruteser, Suhas Mathur
  • Publication number: 20240165597
    Abstract: The present disclosure relates in part to sterically hindered N-aliphatic N-heterocyclic carbene (NHC) ligands, which are readily synthetically available from inexpensive starting materials. The present disclosure further relates to NHC catalyst complexes comprising transition metals such as Cu, Ag, Au, and Pd. Furthermore, the present disclosure provides methods for using the catalysts described herein in a number of organic transformations, including alkyne hydroboration and hydration, in addition to C—O, C—C, and C—N coupling reactions.
    Type: Application
    Filed: March 2, 2022
    Publication date: May 23, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Michal Szostak, Md. Mahbubur Rahman
  • Patent number: 11987777
    Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: May 21, 2024
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Jeffrey Zahn, Mingde Zheng, David I. Shreiber, Hao Lin, Jerry W. Shan
  • Publication number: 20240158772
    Abstract: This disclosure provides a method of reducing neuroinflammation or correcting brain weight loss in a subject. The method comprises administering to the subject a therapeutically effective amount of an agent that increases a level or activity of TPP1.
    Type: Application
    Filed: December 5, 2023
    Publication date: May 16, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David Sleat, Peter Lobel
  • Publication number: 20240157000
    Abstract: Methods for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as bacterium. Surface-modified tissue grafts prepared by these methods are also disclosed.
    Type: Application
    Filed: January 26, 2024
    Publication date: May 16, 2024
    Applicants: Rutgers, The State University Of New Jersey, CreOsso, LLC
    Inventors: Joseph Benevenia, Sheldon S. Lin, Michael J. Vives