Abstract: Provided herein are methods of identifying treatment-response signatures, such as in a subject with prostate cancer (such as a human or veterinary subject). In particular examples, the methods can determine with high accuracy whether a subject is likely to respond to a treatment. The methods can be computer-implemented methods.

Abstract: An antifungal peptide targeting P4-ATPase function is synthesized based on Cdc50 loop region to identify peptides sensitize caspofungin by blocking flippase function. It was found that myristylated peptides based on “AS15 sequence” was effective at high concentrations. A modified peptide, “AW9-Ma” showed minimum inhibitory concentration (MIC) of 64 ?g/mL against H99 wild type and fractional inhibitory concentration (FIC) index value of 0.5 when used with caspofungin. With the AW9-Ma peptide, C. neoformans wild type was highly sensitive to caspofungin with a MIC of 4 ?g/mL, the same as cdc50? mutant. Further assays with flow cytometry showed inhibition of lipid flippase enzyme activity and significant accumulation of phosphatidylserine on the cell surface. It was confirmed that the peptide co-localized with mCherry-tagged P4-ATPase protein Apt1 in C. neoformans.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment.

Abstract: Compositions and methods for hydrogen production are disclosed.

Abstract: A method of treating reduced pulmonary function by administering an effective dose of a Farnesoid X Receptor (FXR) agonist, particularly obeticholic acid, is disclosed. Also disclosed is an in vivo animal model of lung injury and altered functioning, useful for identifying compounds active in restoring pulmonary function.

Abstract: Described herein is a neuroaspiration catheter for removing a blood clot in a blood vessel. The neuroaspiration catheter includes a first tube, a second tube and a wire for guiding the navigation of the catheter. The wire can be navigated to the site of the blood clot, aid the navigation of the catheter, and left in the blood vessel during and after the aspiration. If the aspiration fails, the catheter can be quickly navigated back to the site of the blood clot using the wire as a guide. Also described herein is a method of removing a blood clot using the neuroaspiration catheter.

Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.

Abstract: Disclosed are co-continuous immiscible polymer blends of a polysulfone and a polyaryletherketone optionally reinforced with carbon fiber. A method of preparing such a co-continuous immiscible polymer blend of a polysulfone and a polyaryletherketone reinforced with a carbon fiber is also disclosed.

Abstract: Compositions and methods for rapid and efficient Toehold mediated strand displacement (TMSD) reactions are disclosed.

Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).

Abstract: This disclosure provides an improved assay capable of identifying and distinguishing viral variants, such as SARS-CoV-2 variants and subvariants, including Alpha, Beta, Gamma, Delta, and Omicron, with high specificity and sensitivity. The disclosed assay can be used for real-time monitoring of viral variants (e.g., SARS-CoV-2 variants) spread without the need for whole-genome sequencing on all samples.

Abstract: This disclosure provides a nano-graphitic sponge (NGS) and methods for preparing the nano-graphitic sponge. The disclosed nano-graphitic sponge possesses many excellent properties, including large surface areas and pore volumes, low-mass densities, good electrical conductivities and mechanical properties. These excellent properties make the nano-graphitic sponge an ideal material for many applications, such as electrodes for batteries and supercapacitors, fuel cells and solar cells, catalysts and catalyst supports, and sensors.

Abstract: Systems and methods of applying a prediction model to metal oxide sensors that change their electric resistances in response to surrounding gas concentrations for predicting equilibrium state resistance values of the sensors. The method includes heating a metal oxide sensor to for a predetermined period of time for the metal oxide sensor to interact with a surrounding gas; sampling transient resistance values of the metal oxide sensor to obtain sampled transient resistance values; determining an electrical resistance of the metal oxide sensor in a chemical equilibrium state of the interaction of the metal oxide sensor and the surrounding gas via applying a neural network; and determining a concentration level of the surrounding gas at the chemical equilibrium state by mapping the determined electrical resistance to a corresponding concentration level of the surrounding gas.

Abstract: The present invention relates to anti-matriptase antibodies and immunoconjugates of anti-matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising an anti-matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus providing a sensing platform wherein one or more headphone drivers are used as a versatile sensor to receive excitation signals therefrom indicative of direct or indirect pressures associated with the ear canal acoustically cooperating with the diaphragms operatively coupled to the drivers.

Abstract: Disclosed herein are methods of treating and identifying subjects with ER+ breast cancer that will or will not develop resistance of tamoxifen. In some examples such methods include measuring expression of adaptor-related protein complex 2, sigma-1 subunit (AP2S1) from the retrograde neurotrophin signaling pathway, cyclin-dependent kinase 2 (CDC2) from the loss of NLP from mitotic centrosomes pathway, general transcription factor IIIC subunit 3 (GTF3C3) from the RNA polymerase III transcription initiation from Type 2 promoter pathway, eukaryotic translation initiation factor 2-alpha kinase 3 (EIFA2AK3) from the EIF2 pathway, and leucyl-tRNA synthetase (LARS) from the valine, leucine and isoleucine biosynthesis pathway.

Abstract: Inhibitors of interferon regulatory factor 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE) are described.

Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. The present disclosure also relates to methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.

Abstract: A new and distinct peach variety of Prunus persica named ‘NJ362’ is provided. This variety is distinguished from other peach varieties by its unique combination of non-showy flowers, medium to large, round, freestone fruit, with a greyed-red to greyed-purple blush over a yellow-white ground, ripening in late-season, and possessing sweet, sub-acid flavor.