Patents Assigned to Rutgers, The State University of New Jersey
  • Polymeric biomaterials derived from phenolic monomers and their medical uses
    Patent number: 11649203
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: May 16, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • Systems and methods for joint reconstruction and segmentation of organs from magnetic resonance imaging data
    Patent number: 11645791
    Abstract: Systems and methods for joint reconstruction and segmentation of organs from magnetic resonance imaging (MRI) data are provided. Sparse MRI data is received at a computer system, which jointly processes the MRI data using a plurality of reconstruction and segmentation processes. The MRI data is processed using a joint reconstruction and segmentation process to identify an organ from the MRI data. Additionally, the MRI data is processed using a channel-wise attention network to perform static reconstruction of the organ from the MRI data. Further, the MRI data can is processed using a motion-guided network to perform dynamic reconstruction of the organ from the MRI data. The joint processing allows for rapid static and dynamic reconstruction and segmentation of organs from sparse MRI data, with particular advantage in clinical settings.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: May 9, 2023
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Qiaoying Huang, Dimitris Metaxas
  • Computer vision systems and methods for real-time needle detection, enhancement and localization in ultrasound
    Patent number: 11638569
    Abstract: Systems and methods for detecting placement of an object in a digital image are provided. The system receives a digital image and processes the digital image to generate one or more candidate regions within the digital image using a first neural network. The system then selects a proposed region from the one or more candidate regions using the first neural network and assigns a score to the proposed region using the first neural network. Lastly, the system processes the proposed region using a second neural network to detect an object in the proposed region.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: May 2, 2023
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Cosmas Mwikirize, John L. Nosher, Ilker Hacihaliloglu
  • MASKED FLUOROGENIC COMPOUNDS AND METHODS OF USING THE SAME
    Publication number: 20230121031
    Abstract: In one aspect, the present disclosure relates to a masked fluorogenic compound comprising a small molecule protecting group that can be cleaved following a reaction with a biomarker. In some embodiments, cleavage of the small molecule protecting group provides a fluorogenic ligand that binds to an aptamer, leading to fluorescence emission. In another aspect, the present disclosure relates to a method of detecting a disease or a disorder in a subject and/or in a biological sample from the subject.
    Type: Application
    Filed: August 30, 2022
    Publication date: April 20, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Enver Izgu, Tushar Aggarwal
  • DNA RECOMBINASE MEDIATED ASSEMBLY OF DNA LONG ADAPTER SINGLE STRANDED OLIGONUCLEOTIDE (LASSO) PROBES
    Publication number: 20230123171
    Abstract: Methods of generating mature ssDNA LASSO probes using DNA recombinase mediated assembly are provided. Also provided are mature ssDNA LASSO probes made by the methods, methods of their use, and kits including such.
    Type: Application
    Filed: October 14, 2022
    Publication date: April 20, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Biju Parekkadan, Lorenzo Tosi
  • Peptide linker and combination for prodrugs activated by prostate-specific antigen
    Patent number: 11628221
    Abstract: The present disclosure is directed to a series of target-selective chemotherapeutic ester prodrugs comprising PSA-cleavable peptides that promote the delivery of free doxorubicin and other chemotherapeutic agents into the prostate and/or prostate tumors with greater efficiency.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: April 18, 2023
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Longqin Hu, Herve Aloysius
  • METHODS FOR LOW ENERGY INORGANIC MATERIAL SYNTHESIS
    Publication number: 20230115706
    Abstract: The present invention relates to solvothermal vapor synthesis methods for the crystallization of a phase from a mixture of selected inorganic or organic precursors in an unsaturated vapor-phase reaction medium.
    Type: Application
    Filed: May 17, 2022
    Publication date: April 13, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Daniel Kopp
  • CONTINUOUS MELT-COATING OF ACTIVE PHARMACEUTICAL INGREDIENTS USING SURFACTANTS FOR DISSOLUTION ENHANCEMENT
    Publication number: 20230114357
    Abstract: The present disclosure relates to a continuous process for melt-coating active pharmaceutical ingredients, including introducing at least one active pharmaceutical ingredient (API) and at least one surfactant into a processor; and continuously and simultaneously heating and shearing the API and surfactant in the processor at a temperature close to the melting point of the surfactant so as to continuously form melt-coated API particles having at least a partial coating of surfactant. The disclosure also relates to melt-coated API particles prepared by the disclosed continuous melt-coating process, and pharmaceutical drug products prepared from such melt-coated API particles.
    Type: Application
    Filed: March 16, 2021
    Publication date: April 13, 2023
    Applicant: Rutgers,The State University of New Jersey
    Inventors: Fernando J. Muzzio, Zhanjie Liu, Gerardo Callegari, Douglas Hausner
  • COMPOSITIONS AND METHODS FOR BIOORTHOGONAL SURFACE COATING
    Publication number: 20230105381
    Abstract: The present disclosure relates to compositions and methods useful for the functionalization of surfaces in the absence of a metal catalyst. The compositions include compounds of formula (I), which react with strained alkene-containing compounds, before or after molecular assembly catalyzed by tyrosinase, to afford cycloadducts. The strained alkene-containing compound may further comprise any molecule of interest, including small molecules and macromolecules, thereby enabling surface functionalization. In certain embodiments, the strained alkene-containing molecule comprises a moiety selected from the group consisting of a trans-cyclooctene (TCO), cyclopropene, cyclobutene, and norbornene.
    Type: Application
    Filed: September 30, 2022
    Publication date: April 6, 2023
    Applicant: Rutgers, The state University of New Jersey
    Inventors: Enver Cagri Izgu, Kern Hast, Zhaojun Jia, Melih Baci
  • Luminescent and dispersible hybrid materials combining ionic and coordinate bonds in molecular crystals
    Patent number: 11613695
    Abstract: Inorganic-organic hybrid structures having both ionic and coordinate bonds in a molecular cluster possessing the features of structural diversity, high luminescence and stability, and excellent dispersibility, suitable for use as lighting phosphors.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: March 28, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Jing Li, Wei Liu, Kun Zhu
  • Polymer-based railroad tie having enhanced ballast interaction
    Patent number: 11613851
    Abstract: A railroad tie formed of a polymeric or polymeric composite material and configured for enhanced mechanical interaction with an underlying ballast. The tie includes at least a top longitudinal surface, a pair of side longitudinal surfaces, a bottom longitudinal surface, and two end faces. At least the bottom longitudinal surface includes a plurality of indentations formed along a length thereof. Additionally, the tie includes at least one serrated edge portion having a plurality of serrations, the at least one serrated edge portion formed along at least part of the longitudinal length of the tie at an edge between at least one of the side longitudinal surfaces and the bottom longitudinal surface to provide for enhanced mechanical interaction with the ballast.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: March 28, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Thomas J. Nosker, Arya S. Tewatia
  • Method of treating autoimmune inflammatory crohn's disease
    Patent number: 11612636
    Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: March 28, 2023
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, ACTINOBAC BIOMED, INC.
    Inventors: Scott C. Kachlany, Benjamin A. Belinka, Jr.
  • REINFORCEMENT LEARNING FOR MOTION POLICIES IN MOBILE RELAYING NETWORKS
    Publication number: 20230081408
    Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for determining a subsequent time slot position for each of a plurality of spatially distributed relays configured for time slot based beamforming supporting a communication channel between a source and a destination.
    Type: Application
    Filed: August 15, 2022
    Publication date: March 16, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Athina Petropulu, SPILIOS EVMORFOS
  • Elastomers Enhanced with in situ Formation of 2D Nanoparticles from Layered Materials for Multifunctional Sensors
    Publication number: 20230080867
    Abstract: Disclosed is a concise, inexpensive and scalable method for preparing elastomers filled with conductive 2D nanoparticies. The method comprises independently filling elastomer polymer precursors and/or corresponding elastomer polymer curing agents or their precursors with conductive 2D nanoparticles by shear exfoliation of a layered material, followed by mixing the two components nd curing to form the elastomer. Such filled elastomers have utility in preparing various types of sensors which are useful in a variety of practical applications and devices.
    Type: Application
    Filed: January 28, 2021
    Publication date: March 16, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Jennifer K. Lynch-Branzoi, Ali Ashraf
  • Use of multi-frequency impedance cytometry in conjunction with machine learning for classification of biological particles
    Patent number: 11604133
    Abstract: This disclosure provides methods and systems for classifying biological particles, e.g., blood cells, microbes, circulating tumor cells (CTCs). Using impedance flow cytometry, such as multi-frequency impedance cytometry, in conjunction with supervised machine learning, the disclosed methods and systems demonstrated improved accuracy in classifying biological particles.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: March 14, 2023
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Mehdi Javanmard, Karan Ahuja, Jianye Sui, Joseph R. Bertino
  • MICRORNA-7 COMPOSITIONS FOR PROMOTING FUNCTIONAL RECOVERY FOLLOWING SPINAL CORD INJURY AND METHODS OF USE THEREOF
    Publication number: 20230070049
    Abstract: Compositions, recombinant viral vectors, recombinant viruses, and nanoparticles for treating a subject having a spinal cord injury include a therapeutically effective amount of a nucleic acid sequence encoding pre-microRNA-7 (pre-miR-7). Methods of using these compositions, recombinant viral vectors, recombinant viruses, and nanoparticles are also described herein. These compositions, recombinant viral vectors, recombinant viruses, and nanoparticles and methods of use provide novel therapies for SCI based on the discovery that miR-7 expression provides neuroprotection and recovery of locomotor function in subjects having SCI.
    Type: Application
    Filed: February 1, 2021
    Publication date: March 9, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Eunsung Junn, Mary M. Mouradian, Myung-Sik Yoo
  • COMPOSITIONS AND METHODS FOR TREATING, PREVENTING, AND/OR AMELIORATING CHEMOTHERAPY-INDUCED PREMATURE OVARIAN FAILURE (POF)
    Publication number: 20230062911
    Abstract: In one aspect, the present disclosure provides a method of treating, preventing, and/or ameliorating premature ovarian failure (POF) in a subject in need thereof, wherein the subject is a female cancer patient being administered at least one chemotherapeutic drug, the method comprising administering to the subject at least one c-Jun N-terminal Kinase (JNK) inhibitor. In certain embodiments, the JNK inhibitor is SP600125. In another aspect, the present disclosure provides a pharmaceutical composition comprising a JNK inhibitor.
    Type: Application
    Filed: September 2, 2022
    Publication date: March 2, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Shuo Xiao
  • Data exploration as search over automated pre-generated plot objects
    Patent number: 11580118
    Abstract: Data exploration as search over automated pre-generated plot objects can include data analytics systems with automated data mining and simplified user experience front ends. A computer-implemented method, that can be performed by the described data analytics systems, includes receiving a request for plots or plot types of a specified criteria; searching a plot object resource for plots relevant to the specified criteria, the plot object resource comprising an indexed repository of available plots; sorting and ranking the plots or plot types according to associated scores, the associated scores for each plot being based on information theoretic metrics relevant to a measure of interest; and providing plots satisfying a criteria of the sorting and the ranking to a source of the request.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: February 14, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Tomasz Imielinski
  • NOVEL METHODS OF GENERATING ANTIBODIES
    Publication number: 20230042877
    Abstract: The invention describes a method of generating antibodies to a mixture of peptidogenic proteins wherein the peptidogenic protein has altered conformational dynamics as compared to a starting protein and wherein the peptidogenic protein has a similar conformation to the starting protein. The peptidogenic proteins can be used to induce an immune response, which can lead to the generation of antibodies and/or can be used to vaccinate a mammal.
    Type: Application
    Filed: June 8, 2022
    Publication date: February 9, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Stephen Anderson, Elliot Campbell
  • USE OF GRAPHENE-POLYMER COMPOSITES TO IMPROVE BARRIER RESISTANCE OF POLYMERS TO LIQUID AND GAS PERMEANTS
    Publication number: 20230039392
    Abstract: A packaging material comprising a graphene-reinforced polymer matrix composite (G-PMC) is disclosed. The packaging material has improved barrier resistance to gas and liquid permeants. Also disclosed is a method of improving barrier resistance of a polymer to a permeant, the method comprising forming a graphene-reinforced polymer matrix composite within the polymer. The packaging material may be used for packaging food, drug, perfume, etc. and to make various containers.
    Type: Application
    Filed: August 29, 2022
    Publication date: February 9, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Jennifer K. Lynch-Branzoi, Thomas J. Nosker, Bernard H. Kear, Charles T. Chang