Patents Assigned to Rutgers, The States University of New Jersey
  • ANTIMICROBIAL AGENTS
    Publication number: 20180338957
    Abstract: The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound:
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Antibacterial agents
    Patent number: 10138203
    Abstract: The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, X, Y and n have any of the values defined in the specification.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: November 27, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Allison Faig
  • Compositions and methods for altering second messenger signaling
    Patent number: 10131686
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: November 20, 2018
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Independently inducible system of gene expression
    Patent number: 10131915
    Abstract: The present invention is directed to the improved methods for the temporal induction of proteins using the condensed single protein production (cSPP) system.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: November 20, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Monica Roth, William Schneider, Gaetano T. Montelione, Masayori Inouye, Yuefeng Tang
  • Nuclease-Independent Targeted Gene Editing Platform and Uses Thereof
    Publication number: 20180327784
    Abstract: The present invention discloses a system for targeted gene editing and related uses.
    Type: Application
    Filed: July 15, 2016
    Publication date: November 15, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Shengkan Jin, Juan-Carlos Collantes
  • Mathematical musical orchestral method for predicting classes of patients for medical treatment
    Patent number: 10114929
    Abstract: Methods for classifying patients as responders or non-responders to treatment of a disease and predicting recurrence of disease in a patient using audio tunes are provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 30, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Emmanuel S. Zachariah
  • Electrochemical Cell Having Thin Metal Foil Packaging And A Method For Making Same
    Publication number: 20180309093
    Abstract: An electrochemical cell is provided comprising a thin metal foil packaging made from at least one sheet of metal foil and having a perimeter extending around at least a portion of the electrochemical cell, as well as an electrochemical cell stack contained within the thin metal foil packaging, and a metal-to-metal welded seal around at least a portion of the perimeter of the thin metal foil packaging. The metal-to-metal welded seal is hermetic or nearly hermetic. Furthermore, the metal-to-metal welded seal is narrow, having a width of less than about 1 mm, and is less than about 5 mm away from the electrochemical cell stack. In some embodiments, the thin metal foil packaging functions not only as a hermetically or near hermetically sealed packaging, but also as either electrode of the cell bonded to the foil packaging.
    Type: Application
    Filed: October 27, 2016
    Publication date: October 25, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Glenn Amatucci, Irene Plitz, Linda Sung, Anthony Ferrer
  • Augmenting Moieties for Anti-Inflammatory Compounds
    Publication number: 20180305310
    Abstract: Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory amino acids covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids and ketone bodies. Further conjugation with a choline bioisostere or an additional anti-inflammatory moiety further augments the anti-inflammatory activity.
    Type: Application
    Filed: June 28, 2018
    Publication date: October 25, 2018
    Applicants: Rutgers, The State University of New Jersey, Lehigh University
    Inventors: Jeffrey D. Laskin, Diane E. Heck, Carl J. Lacey, Ned D. Heindel, Sherri C. Young
  • Direct inhibitors of Keap1-Nrf2 interaction as antioxidant inflammation modulators
    Patent number: 10106502
    Abstract: A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 23, 2018
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE BROAD INSTITUTE, INC.
    Inventors: Longqin Hu, Sadagopan Magesh, Lin Chen, Timothy Lewis, Ben Munoz, Lili Wang
  • Biocompatible polymer compositions for tissue void filling
    Patent number: 10105467
    Abstract: Biodegradable, bioabsorbable cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: October 23, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Atif J. Khan, Nava Shpaisman
  • Scalable multiple-inverse diffusion flame burner for synthesis and processing of carbon-based and other nanostructured materials and films and fuels
    Patent number: 10099928
    Abstract: Apparatus and methods of use thereof for the production of carbon-based and other nanostructures, as well as fuels and reformed products, are provided.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: October 16, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Stephen D. Tse, Nasir K. Memon, Bernard H. Kear
  • Molecular constructs for differentiating a target molecule from an off-target molecule
    Patent number: 10100350
    Abstract: Molecular constructs, populations thereof, arrays, compositions, methods and kits for differentiating a target molecule from an off-target molecule are provided.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: October 16, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kenneth J. Breslauer, William H. Braunlin, Leslie C. Beadling, Jens Volker
  • Biologically active synthetic nanoparticle constructs and methods of use thereof
    Patent number: 10100332
    Abstract: This application discloses the compositions comprising biologically active synthetic nanoparticle constructs and methods of use thereof to modify gene expression including transcriptional activation and transcriptional repression.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: October 16, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ki-Bum Lee, Sahishnu Patel
  • Nickel Phosphide Catalysts for Direct Electrochemical CO2 Reduction to Hydrocarbons
    Publication number: 20180282885
    Abstract: Disclosed are cathodes comprising a conductive support substrate having a catalyst coating containing nickel phosphide nanoparticles. The conductive support substrate is capable of incorporating a material to be reduced, such as CO2 or CO. Also disclosed are electrochemical methods for generating hydrocarbon and/or carbohydrate products from CO2 or CO using water as a source of hydrogen.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 4, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: G. Charles Dismukes, Anders Laursen, Martha Greenblatt, Karin Calvinho
  • Biocompatible iodinated diphenol monomers and polymers
    Patent number: 10087285
    Abstract: Disclosed are monomeric compounds which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: October 2, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION
    Publication number: 20180263982
    Abstract: The invention provides methods and compositions that are useful for treating allergic diseases, bacterial infections, fungal infections, viral infections, mastocytosis, mast cell-mediated inflammation and parasite infections (e.g., helminth infections).
    Type: Application
    Filed: August 12, 2016
    Publication date: September 20, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Mark C. Siracusa
  • CELL PENETRATING PEPTIDES THAT INHIBIT IRF5 NUCLEAR LOCALIZATION
    Publication number: 20180258148
    Abstract: The invention provides inhibitors of interferon regulatory factor 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE).
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Betsy J. BAMES
  • Antimicrobial agents
    Patent number: 10071082
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: September 11, 2018
    Assignees: Rutgers, The State University of New Jersey, Taxis Pharmaceuticals, Inc.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION
    Publication number: 20180250344
    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
    Type: Application
    Filed: October 12, 2017
    Publication date: September 6, 2018
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: DONGMING SUN, WISE YOUNG
  • Method of cryopreserving an amniotic membrane of a placenta tissue sample
    Patent number: 10066202
    Abstract: The present invention relates to stem cells obtained from the amnion and their methods of obtaining and culturing. The present invention further relates to compositions comprising amnion-derived stem cells (ADSCs) and to methods of using ADSCs.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: September 4, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Dale Woodbury, Akiva J. Marcus