Patents Assigned to Rutgers, The States University of New Jersey
  • Clearing agent and mounting medium for microscopy
    Patent number: 10067041
    Abstract: A clearing agent and mounting solution for microscopy is disclosed comprising (a) trichloroethanol, (b) optionally, trichloroacetic acid, (c) optionally, glycerol and (d) optionally, water, where the refractive index of the solution is greater than or equal to about 1.3810. The solution can further comprise a C1-C6 alcohol, other acids, and/or a stain. The solution can also comprise derivatives and/or analogs of 2,2,2-trichloroethanol and/or trichloroacetic acid. Also disclosed is a method of preparing specimens for microscopy comprising (a) applying a specimen to a microscope slide or a cuvette, (b) applying a quantity of the above solution sufficient to mount the specimen, and (c) optionally applying a cover slip. The solution can be used effectively with stains or dyes, and with fresh, partially dry or dried materials, and for temporary or semi-permanent to permanent mounting.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: September 4, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: James E. Simon, Thomas Villani, Adolfina Koroch
  • NOVEL METHODS OF GENERATING ANTIBODIES
    Publication number: 20180244759
    Abstract: The invention describes a method of generating antibodies to a mixture of peptidogenic proteins wherein the peptidogenic protein has altered conformational dynamics as compared to a starting protein and wherein the peptidogenic protein has a similar conformation to the starting protein. The peptidogenic proteins can be used to induce an immune response, which can lead to the generation of antibodies and/or can be used to vaccinate a mammal.
    Type: Application
    Filed: August 18, 2016
    Publication date: August 30, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Stephen Anderson, Elliot Campbell
  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20180237517
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: January 2, 2014
    Publication date: August 23, 2018
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracchiolo, Anthony Popowicz, Paul M. Clement
  • Compositions for inducing or suppressing an immune response
    Patent number: 10046011
    Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).
    Type: Grant
    Filed: December 14, 2013
    Date of Patent: August 14, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Yufang Shi, Guangwen Ren, Liying Zhang
  • High speed adaptive-multi-loop mode imaging atomic force microscopy
    Patent number: 10041970
    Abstract: A method for imaging a sample using a high speed dynamic mode atomic force microscope may include scanning a tip of a cantilever probe over a surface of the sample, regulating a vibration amplitude of the tip to remain constant at a set point value (Aset), via a first signal generated in a first feedback controller, measuring a mean tapping deflection of the tip, regulating the mean tapping deflection via a second signal generated in a second feedback controller, tracking and measuring an adjustment to the measured mean tapping deflection during the regulating. The method may further include generating an image topography of the sample based on the first signal, the second signal, and the measured adjustment of the mean tapping deflection of the cantilever probe.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: August 7, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Qingze Zou, Juan Ren, Jiangbo Liu
  • Vehicular information systems and methods
    Patent number: 10043389
    Abstract: Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: August 7, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Marco Gruteser, Suhas Mathur
  • HIGHLY SELECTIVE NUCLEIC ACID AMPLIFICATION PRIMERS
    Publication number: 20180216151
    Abstract: This invention discloses multi-part primers for primer-dependent nucleic amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.
    Type: Application
    Filed: January 22, 2018
    Publication date: August 2, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred R. Kramer
  • Electrostatic ion trap mass spectrometer utilizing autoresonant ion excitation and methods of using the same
    Patent number: 10037880
    Abstract: Methods of operation of electrostatic ion trap mass spectrometers in which ions are autoresonantly driven at selected higher integer (>2) multiples of ion oscillation frequencies are provided. Excitation at multiples higher than the fundamental or double the fundamental ion oscillation frequency significantly improves both signal intensity and mass resolution. Each method allows excitation exclusively at one selected frequency that is an integer multiple of an ion's natural oscillation frequency, and thereby virtually eliminates ion excitation at unwanted harmonic frequencies. The resultant mass spectra are therefore clean, and do not display spectral features associated with rf excitation at unintended multiple harmonic frequencies. This has been demonstrated explicitly for 4× and 6× modes, and it is fully implementable at any odd or even multiples of ion oscillation frequencies.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: July 31, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alexei Ermakov, Barbara J. Hinch
  • CERAMIDE DERIVATIVES AS ANTICANCER AGENTS
    Publication number: 20180207123
    Abstract: The invention provides a compound of formula (I): (I) wherein R1-R4 have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) and methods for treating diseases (e.g. cancer).
    Type: Application
    Filed: July 19, 2016
    Publication date: July 26, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Richard Lutz, Eric Andrianasolo, Paul Falkowski, Eileen White, Liti Haramaty
  • Process and intermediates for preparing poly(anhydride-esters)
    Patent number: 10023521
    Abstract: Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is independently a leaving group; and wherein X is a residue of a biologically active compound.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: July 17, 2018
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Kathryn E. Uhrich, Jonathan J. Faig, Kervin Smith
  • Gold nanostar substrates for SERS sensing in the femtomolar regime
    Patent number: 10024800
    Abstract: The invention relates to Raman spectroscopy-based sensing technique. More particularly, the invention relates to a surface enhanced Raman spectroscopy (SERS) composite and methods of its use and fabrication.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: July 17, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Laura Fabris, A. Swarnapali D. S. Indrasekara
  • Clearing agent and mounting media for microscopy
    Patent number: 10018540
    Abstract: A clearing agent and mounting solution for microscopy is disclosed comprising at least trichloroethanol and/or derivatives thereof, where the refractive index of the solution is greater than or equal to about 1.3810. Also disclosed are methods of preparing specimens for microscopy.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: July 10, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: James E. Simon, Thomas Villani, Adolfina Koroch
  • Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity
    Patent number: 10016517
    Abstract: The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 10, 2018
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Adam W. York, Prabhas V. Moghe, Kathryn E. Uhrich, Robert Prud'homme
  • Alkane-alkene coupling via tandem alkane-dehydrogenation/alkene-dimerization catalyzed by pincer iridium catalyst heterogenized on solid supports
    Patent number: 10017430
    Abstract: Disclosed herein are processes for tandem alkene dehydrogenation/alkene dimerization using an iridium pincer complex catalyst on a support comprising magnesium silicates (e.g., Florisil®). The reaction process comprises providing an iridium pincer complex bound to a solid support comprising magnesium silicates; providing a gaseous alkane feedstock comprising at least one alkane; and contacting the gaseous alkane feedstock with the iridium pincer complex bound to the solid support in the presence of a hydrogen acceptor to form dimerized alkenes. The processes disclosed herein can accomplish facile, low-temperature tandem transfer dehydrogenation of alkanes and dimerization of alkenes with unprecedented TONs at a reasonable rate of conversion.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 10, 2018
    Assignees: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Oleg Mironov, Robert J. Saxton, Alan S. Goldman, Akshai Kumar
  • Bipartite inhibitors of bacterial RNA polymerase
    Patent number: 10010619
    Abstract: The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y??(I) wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and ? is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: July 3, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard H. Ebright, David Degen, Yu Zhang, Yon Ebright
  • ANTIMICROBIAL AGENTS
    Publication number: 20180179225
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 28, 2018
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers
    Patent number: 10004682
    Abstract: The present invention provides methods for impregnating a porous carrier with an active pharmaceutical ingredient (“AP”), the methods comprising steps: a) dissolving at least one API in a solvent to form an API solution; b) contacting a porous carrier with the at least one API of step (a) in a contactor to form an API impregnated porous carrier; and c) drying the at least one API impregnated porous carrier.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: June 26, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Fernando J. Muzzio, Benjamin J. Glasser, Plamen I. Grigorov
  • IMAGING INDIVIDUAL MRNA MOLECULES USING MULTIPLE SINGLY LABELED PROBES
    Publication number: 20180171396
    Abstract: A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hybridization probes, each singly labeled with the same fluorescent label and each containing a nucleic acid sequence that is complementary to a different probe binding region of said target sequence; washing said fixed cell to remove unbound probes; and detecting fluorescence from said probes.
    Type: Application
    Filed: January 30, 2018
    Publication date: June 21, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Arjun Raj, Sanjay Tyagi
  • Insulin-mimetics as therapeutic adjuncts for bone regeneration
    Patent number: 9999636
    Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic, agents or compositions thereof to patients in need of such treatment are also disclosed.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 19, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John Koerner, Paul Chirichella, Michael J. Vives
  • Controlled release hydrogels
    Patent number: 9999596
    Abstract: Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: June 19, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Anita Lalloo