Patents Assigned to Rutgers, The States University of New Jersey
  • PREPARATION OF ALKYLAROMATIC COMPOUNDS
    Publication number: 20180162792
    Abstract: Described herein are methods useful for preparing alkylaromatics.
    Type: Application
    Filed: June 9, 2016
    Publication date: June 14, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Alan S. Goldman, Andrew M. Steffens, William Schinski
  • Compositions and methods for functional quality control for human blood-based gene expression products
    Patent number: 9994893
    Abstract: Methods for assessing the integrity of an RNA sample from a given tissue or blood type are disclosed.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: June 12, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Jay Tischfield, Andrew Brooks, Stephanie Frahm
  • Attenuating or treating sepsis or septic shock
    Patent number: 9987336
    Abstract: Methods for attenuating or treating, or reducing the mortality of sepsis or septic shock using an ectonucleotidase such as CD39 or CD73 are provided.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: June 5, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Gyorgy Hasko, Zoltan Nemeth
  • Polymer-derived catalysts and methods of use thereof
    Patent number: 9985296
    Abstract: Electrocatalytic polyaniline-derived mesoporous carbon nanoparticles and methods of synthesizing and using the same are provided.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 29, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Tewodros Asefa, Rafael Silva
  • Encochleation methods, cochleates and methods of use
    Patent number: 9974745
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: May 22, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Kojic Acid Polymers
    Publication number: 20180116945
    Abstract: A controlled release system for kojic acid having improved stability has been identified. To minimize degradation, kojic acid was incorporated into a hydrolytically degradable polymer (e.g., a polycarbonate-ester)). By synthesizing polymer precursors containing kojic acid-linker-kojic acid chemical structures, versatile monomers were developed that can be used to modulate polymer properties. Additionally the synthetic method lends itself to the development of other polymer systems. Polymers having one or more groups that will yield kojic acid upon degradation of the polymer backbone, as well as methods of use thereof are described.
    Type: Application
    Filed: April 11, 2016
    Publication date: May 3, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Kathryn Uhrich, Kervin Smith, Jonathan Faig
  • Bacterial efflux pump inhibitors
    Patent number: 9950993
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit K. Parhi, Malvika Kaul, Daniel S. Pilch
  • miRNA169 compositions and methods for the regulation of carbohydrate metabolism and flowering in plants
    Patent number: 9949488
    Abstract: Compositions and methods for modulating flowering, sugar metabolism and stress response in plants are provided.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 24, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim Messing, Martin Calvino
  • Treatment and diagnosis of ocular disease
    Patent number: 9950030
    Abstract: This invention concerns compositions and methods of treating or diagnosing ocular disease.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: April 24, 2018
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, ACTINOBAC BIOMED, INC.
    Inventors: Scott Kachlany, Benjamin Belinka
  • Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
    Patent number: 9943606
    Abstract: Dendritic polypeptides useful for the delivery of therapeutic agents into cells are disclosed, together with their methods of preparation. These dendritic polypeptides serve as carriers of drugs, siRNA, aptamers and plasmid DNA in the treatment of various diseases, including cancer.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: April 17, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ki-Bum Lee, Prasad Subramaniam, Dipti N. Barman
  • Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
    Patent number: 9945051
    Abstract: A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: April 17, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Richard Ebright
  • High level platform trapdoor with built in moving slide for railway platform gap bridging
    Patent number: 9937933
    Abstract: A trapdoor assembly for use on railcars is provided. The trapdoor assembly is pivotable between an up position and a down position. In the up position, the trapdoor assembly provides access to stairs on the railcar so that passengers can egress between the railcar and a ground level platform at a rail station. In the down position, the trapdoor assembly covers the stairs and provides a platform so that passengers can egress between the railcar and an elevated platform at a rail station. The trapdoor assembly also includes an extendible platform for bridging the gap between the railcar and the elevated station when the trapdoor is in the down position and the railcar is stopped at the elevated station.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: April 10, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Basily B. Basily, Thomas O. Boucher
  • Compositions and methods for high-throughput nucleic acid analysis and quality control
    Patent number: 9938575
    Abstract: Methods for improved quality control of nucleic acid containing biological samples utilized in high-throughput situations such as biorepositories engaged in the collection, processing, storage, distribution and analysis of such samples are disclosed.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: April 10, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Jay A. Tischfield, Andrew I. Brooks
  • Treatment to promote wound healing
    Patent number: 9931361
    Abstract: The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains N. brasiliensis excretory/secretory antigen (NES) or an immune triggering portion thereof. The invention also relates to a method of accelerating wound healing in a subject in need of such treatment.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: April 3, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: William C. Gause, Fei Chen, Zhugong Liu, Pankaj Mishra
  • Systems and methods for detecting driver phone operation using device position and orientation data
    Patent number: 9936358
    Abstract: A method for determining the position in a vehicle of a first device in communication with a microprocessor may include receiving, at the microprocessor, a first set of inertial data from at least one sensor of the first device; receiving, at the microprocessor, a second set of inertial data from at least one sensor of a reference device disposed within the vehicle; and determining, using the microprocessor, the position of the first device in the vehicle by comparing the first set of inertial data with the second set of inertial data.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: April 3, 2018
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Marco Gruteser, Richard P. Martin, Yingying Chen, Yan Wang
  • Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
    Patent number: 9932323
    Abstract: The invention provides compounds of formula I: and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: April 3, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Joseph David Bauman, Ajit Parhi, Hye Yeon Sagong, Disha Patel, Eddy Arnold, Kalyan Das, Suyambu Kesava Vijayan
  • Vanadium compounds as therapeutic adjuncts for cartilage injury and repair
    Patent number: 9931348
    Abstract: A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: April 3, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Aaron Wey, Joseph Benevenia, Virak Tan
  • Bacterial efflux pump inhibitors
    Patent number: 9926261
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 27, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Gifty A. Blankson, Malvika Kaul, Daniel S. Pilch
  • Antibacterial agents: N?-aroyl-N-aryl-phenylalaninamides
    Patent number: 9919998
    Abstract: The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 20, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard H. Ebright, Yon W. Ebright, Soma Mandal, Richard Wilde, Shengjian Li
  • Method of treating dyskinesia
    Patent number: 9918980
    Abstract: Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action ?-opioid receptor antagonist/?-opioid receptor agonists or prodrug thereof to a subject in need thereof, sufficient to mitigate the dyskinesia. Alternatively, a combination of both a mu-opioid receptor antagonist or prodrug thereof, and a kappa-opioid receptor agonist or prodrug thereof can be administered, either together or separately.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: March 20, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: M. Maral Mouradian, Steven Braithwaite, Michael Voronkov