Abstract: The present disclosure relates to a novel method for preparing selenyl-substituted aromatic aldehyde compounds by forming a selenolate nucleophile and performing a nucleophilic substitution reaction between the selenolate nucleophile and an aromatic aldehyde starting material.

Abstract: One embodiment of the present invention provides a detection kit for detecting c-Met gene expression, wherein the detection kit includes a primer set which is specifically bound to the c-Met gene; and a cleavable probe which is specifically bound to the inside of a c-Met gene amplification product which is amplified by the primer set. Another embodiment of the present invention provides a method of measuring the c-Met gene expression by using the detection kit according to one embodiment of the present invention. The method according to one embodiment of the present invention is used to efficiently detect a low concentration of c-Met gene expression for cancer diagnosis and prognosis diagnosis.

Abstract: The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (OTC) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.

Abstract: An ultrasound irradiation apparatus includes first transducers configured to irradiate first ultrasound energy upon an object with respect to a potential diagnosis and to receive an echo signal which corresponds to the irradiated first ultrasound energy, second transducers configured to irradiate second ultrasound energy upon a region of interest which is determined based on a result of processing of the received echo signal, and a contact pad configured to facilitate a contact between the first transducers and the object, and to facilitate a contact between the second transducers and the object.

Abstract: Disclosed herein are an X-ray imaging apparatus and an X-ray image generating method in which constituent materials of a target object are separated and mapped to different colors in order to provide one image which has improved distinction between tissues. The X-ray imaging apparatus includes an X-ray generator which generates X-rays and irradiates the X-rays toward a target object, an X-ray detector which acquires X-ray data which corresponds to a plurality of energy bands by detecting X-rays which have passed through the target object, and a controller which acquires a plurality of material images in which a plurality of materials constituting the target object are respectively displayed and brightness information from the X-ray data, generates one image by mapping different color channels to the plurality of material images and combining the plurality material images into a single image, and applying the brightness information to the generated image.

Abstract: Disclosed are a biological sample analysis system and method for determining whether or not each of a plurality of biological samples has a test-target property using the plurality of biological samples and a plurality of pools generated by pooling samples. The system includes a determiner configured to determine whether or not there is a possibility of a determination of a false positive according to test values for the test-target property of the plurality of pools, an additional sample selector configured to select a minimum number of additional test-target samples on which an individual test of whether or not a sample has the test-target property will be carried out from among the plurality of samples when it is determined that there is the possibility of a determination of a false positive, and a test result determiner configured to determine whether or not each of the plurality of samples has the test-target property according to test results of the additional test-target samples.

Abstract: Provided is a method for producing a glioblastoma mouse model and the mouse model produced thereby, the method including the steps of: (a) dividing a glioblastoma tissue, isolated from a patient, into 4 or more sections, and collecting one or more pieces from each of the sections; (b) dissociating a mixture of the collected pieces into glioblastoma cells as single cells; and (c) orthotopically transplanting a graft sample containing the glioblastoma cells obtained in step (b), into the brain of an immunodeficient mouse. Further provided are a method of screening a glioblastoma therapeutic agent using the mouse model and a method of providing information for selection of a patient-specific glioblastoma therapy using the mouse model. The glioblastoma mouse model shows the same genetic, morphological and pathological characteristics as those of the parental tumor, and it allows screening patient-specific glioblastoma therapeutic agent or selecting safer and more effective patient-specific glioblastoma therapy.

Abstract: A screening method is described for selecting patient-specific anti-cancer agents reflecting individual genetic properties, in a precise and rapid manner, using an extremely small amount of cancer cells. Such screening method is useful for development of novel anti-cancer agents and the personalized medical field.

Abstract: The present invention relates to a stem cell culture medium which can be substituted for a conventional stem cell culture medium containing the heterologous protein fetal bovine serum, and more particularly to a stem cell culture medium containing a basal medium and a knockout serum replacement and a method of culturing stem cells using the same. According to the invention, a high purity of stem cells having a reduced ability to spontaneously differentiate can be obtained without having to use the heterologous protein fetal bovine serum and expensive growth factors (EGF and bFGF), and thus the efficacy of stem cell therapy can be significantly increased.

Abstract: Disclosed herein are an X-ray imaging apparatus and a method for controlling the same. The X-ray imaging apparatus includes an X-ray generator configured to radiate first-energy X-rays toward an object, an X-ray detector configured to detect the first-energy X-rays which propagate through the object, an image processor configured to generate a first object image which correspond to the detected first-energy X-rays and to estimate a second object image which corresponds to second-energy X-rays based on the generated first object image, and a controller configured to control the image processor to repeatedly estimate the second object image by controlling the X-ray generator to repeatedly radiate the first-energy X-rays toward the object.

Abstract: A method for registering medical images of different types, includes: receiving a selection of at least one point in a first medical image that is acquired in non-real time; extracting, from the first medical image, a first anatomic object which includes the selected point and a second anatomic object which is adjacent to the selected point; extracting, from a second medical image that is acquired in real time, a third anatomic object which corresponds to the first anatomic object and a fourth anatomic object which corresponds to the second anatomic object; and registering the first medical image and the second medical image based on a geometric relation between the first, second, third, and fourth anatomic objects.

Abstract: The present invention relates to a composition including stem cell-derived microvesicles as an active ingredient for promoting neurogenesis. The stem cell-derived microvesicles according to the present invention can promote neurogenesis and migration of nerves and also promote angiogenesis in vascular endothelial cells, and thus can be usefully used in treatment of neurological damage.

Abstract: Disclosed are a method and an apparatus for manufacturing a radiation intensity bolus.

Abstract: Disclosed herein are an X-ray imaging apparatus and a control method thereof in which a clear 3D volume of an object may be acquired when the 3D volume of the object is reconstructed from X-ray images acquired by radiating X-rays to the object. The X-ray imaging apparatus includes an image processing unit configured to acquire a plurality of X-ray images of an object from converted electrical signals, group the plurality of X-ray images into groups of X-ray images acquired from the same cardiac phase, and perform image reconstruction of each of the groups acquired as a result of the grouping.

Abstract: An apparatus for objectively detecting a cochlea dead region based on electrophysiology and an information provision method for detecting a cochlea dead region using the apparatus. A cochlea dead region detection apparatus including a control unit is also disclosed. The control unit includes a stimulus generation unit for generating stimuli and an Acoustic Change Complex (ACC) measurement unit for measuring ACCs depending on the stimuli.

Abstract: The antibody of the invention has high specificity to human c-Met and is cross-reactive to mouse c-Met. The antibody or its antigen-binding fragment of the invention is capable of specifically binding to human c-Met as well as mouse c-Met, more accurate preclinical results can be confirmed in the efficacy evaluation using mouse tumor models. The antibody of the invention inhibits the growth of cancer cells derived from various cancers by a considerable binding affinity to c-Met and the suppression of c-Met function therefrom, inhibits the phosphorylation of c-Met and downstream signaling molecules to suppress c-Met signaling, and inhibits neovascularization, thereby being very efficient in the prevention and treatment of cancers.

Abstract: Provided are medical apparatuses for simultaneously performing radiotherapy and hyperthermia therapy and methods of treating an affected area. The medical apparatus includes a table where a subject is placed; a driving unit configured to move the table; a treatment device configured to treat an affected area of the subject; and an ultrasonic transducer configured to increase treatment efficiency of the affected area.

Abstract: Provided is a medical imaging apparatus including: a scanner configured to obtain projection data of an object; a three-dimensional restoring module configured to restore a volume of the object based on the projection data; a volume segmentation module configured to segment a plurality of material volumes corresponding to a plurality of materials included in the object based on the volume of the object; a reprojection module configured to generate a plurality of reprojection images according to the plurality of materials by reprojecting the plurality of material volumes from a plurality of virtual viewpoints; and an image fusion module configured to generate a plurality of fusion images according to the plurality of virtual viewpoints, each of the plurality of fusion images being generated by fusing reprojection images according to plurality of materials obtained from the same virtual viewpoint.

Abstract: A medical imaging apparatus includes: a scanner configured to obtain projection data of an object; a three-dimensional restorer configured to restore a volume of the object from the projection data; a volume segmentor configured to generate at least one partial volume based on the volume of the object; a reprojector configured to generate a plurality of reprojection images according to a plurality of virtual viewpoints by reprojecting at least one from among the volume and the at least one partial volume from the plurality of virtual viewpoints; and an image fuser configured to generate a plurality of fusion images by fusing at least two of the plurality of reprojection images according to the virtual viewpoints.

Abstract: Provided is a medical imaging apparatus including a scanner configured to acquire projection data of an object, a three dimensional (3D) recovery module configured to recover a volume of the object based on the projection data, a two dimensional (2D) image generator configured to generate a 2D image of the object based on the volume of the object, a 3D image generator configure to generate a 3D image of the object based on the volume of the object, a 2D display configured to display the 2D image of the object, and a 3D display configured to display the 3D image of the object.