Patents Assigned to Samsung Life Public Welfare Foundation
  • Patent number: 10434135
    Abstract: A pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells are described herein. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: October 8, 2019
    Assignees: Samsung Life Public Welfare Foundation, Korea Institute of Science and Technology
    Inventors: Sang Jun Kim, Young Mee Jung, Soo Hyun Kim
  • Patent number: 10429458
    Abstract: An RF coil structure used for a magnetic resonance imaging (MRI) system includes an RF shield, an RF coil provided inside the RF shield, and a high dielectric material arranged between the RF shield and the RF coil, in which an interval between the RF shield and the RF coil is changed or a thickness of the high dielectric material is changed.
    Type: Grant
    Filed: January 2, 2015
    Date of Patent: October 1, 2019
    Assignees: Samsung Electronics Co., Ltd., Samsung Life Public Welfare Foundation
    Inventors: Kyoungnam Kim, Yeon Hyeon Choe
  • Patent number: 10429826
    Abstract: Provided are a method and apparatus for verifying a radiation beam intensity modulator. The apparatus includes a scanner; and a verification system verifying the verification target radiation beam intensity modulator, wherein the verification system includes: a modulator structure reconstruction unit extracting thickness information of the verification target radiation beam intensity modulator based on the 3D structure information of the verification target radiation beam intensity modulator; an original modulator structure information receiver receiving structure information of the original radiation beam intensity modulator; a modulator matching unit matching the verification target radiation beam intensity modulator with the original radiation beam intensity modulator based on the thickness information; and a modulator verification unit verifying the verification target radiation beam intensity modulator matched with the original radiation beam intensity modulator.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: October 1, 2019
    Assignee: Samsung Life Public Welfare Foundation
    Inventor: Sang Gyu Ju
  • Patent number: 10421234
    Abstract: Provided are a method and apparatus for manufacturing a radiation beam intensity modulator.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: September 24, 2019
    Assignee: Samsung Life Public Welfare Foundation
    Inventor: Sang Gyu Ju
  • Patent number: 10406180
    Abstract: The present invention relates to a composition including stem cell-derived microvesicles as an active ingredient for promoting neurogenesis. The stem cell-derived microvesicles according to the present invention can promote neurogenesis and migration of nerves and also promote angiogenesis in vascular endothelial cells, and thus can be usefully used in treatment of neurological damage.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: September 10, 2019
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Oh Young Bang, Gyeong Joon Moon, Yeon Hee Cho, Suk Jae Kim, Dong Hee Kim, Ji Hee Sung
  • Patent number: 10364289
    Abstract: The present disclosure relates to an antibody binding to Neuropilin 1 (NRP1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a method for preparing the antibody or the antigen-binding fragment thereof, an antibody-drug conjugate comprising the antibody or the antigen-binding fragment thereof, and a composition thereof for preventing or treating a cancer.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: July 30, 2019
    Assignee: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Do-Hyun Nam, Yeup Yoon, Jae Hyun Lee, Jin Ku Lee
  • Patent number: 10357665
    Abstract: Provided is a radiation therapy apparatus on which quality management is performed. The radiation therapy apparatus includes: a body unit; a gantry coupled to one side of the body unit and formed to be rotatable in at least one direction with regard to the body unit; a radiation irradiating head formed at one side of the gantry to irradiate a radiation; and a level control module formed at one side of the radiation irradiating head to measure a rotation angle of the gantry or the radiation irradiating head, compare the measured rotation angle with a rotation angle indicated by an angle indicator of the radiation therapy apparatus, and correct an error of the angle indicator.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 23, 2019
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Sang Gyu Ju, Chae Seon Hong, Doo Ho Choi
  • Patent number: 10345405
    Abstract: A radiofrequency (RF) coil for use in a magnetic resonance imaging (MRI) system using a plurality of RF coils includes a main loop coil including a plurality of electrical conductors, and an auxiliary loop coil disposed around the plurality of electrical conductors and including a plurality of electrical conductors.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: July 9, 2019
    Assignees: Samsung Electronics Co., Ltd., Samsung Life Public Welfare Foundation
    Inventors: Kyoungnam Kim, Yeon Hyeon Choe
  • Publication number: 20190175902
    Abstract: Disclosed are a medical device apparatus, system, and method. A method includes receiving biometric information, by an external device external to a body of a user, of the user from an internal device within the body of the user, and wirelessly transmitting stimulus information configured to specify a stimulus based on the biometric information, and power to the internal device configured to drive the internal device and to apply the stimulus in response to the transmitted stimulus information. A method also includes wirelessly transmitting, from an internal device in a body of a user, biometric information of the user to an external device located outside the body of the user, and wirelessly receiving from the external device stimulus information configured to specify a stimulus, and power configured to drive the internal device and to apply the stimulus to the user in response to the received stimulus information.
    Type: Application
    Filed: November 13, 2018
    Publication date: June 13, 2019
    Applicants: Samsung Electronics Co., Ltd., Samsung Life Public Welfare Foundation
    Inventors: Hyungwoo LEE, Duk Lyul NA, Dae Won SEO, Young Min SHON, Jin San LEE, Woo Ram JUNG, Sang Joon KIM, Joonseong KANG, Wonseok LEE
  • Patent number: 10316319
    Abstract: The present disclosure relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a composition for diagnosis of liver metastasis of colorectal cancer, which comprises either a substance for measuring the mRNA level of CCL7 (Chemokine (C-C motif) ligand 7) gene or a substance for measuring the level of a protein which is encoded by the gene. According to the present disclosure, whether liver metastasis of colorectal cancer occurred can be diagnosed by measuring the mRNA expression level of the CCL7 gene or the expression level of the CCL7 protein, and the use of the composition comprising an inhibitor of CCL7 gene allows the treatment of colorectal cancer or the liver metastasis of colorectal cancer.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: June 11, 2019
    Assignee: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Woo Yong Lee, Yong Beom Cho, Ho-Kyung Chun
  • Publication number: 20190142355
    Abstract: An X-ray imaging apparatus includes an X-ray generator configured to generate X-rays and radiate the X-rays to an object; an X-ray detector configured to detect the X-rays that have passed through the object and convert the X-rays into a signal; and a controller configured to generate a single energy X-ray image and multiple energy X-ray images including a first X-ray image generated using an X-ray having determined energy band that is extracted from the X-rays detected by the X-ray detector. The multiple energy X-ray images further include a second X-ray image in which a specific substance is separated, which is image is generated using the image signals corresponding to the energy bands from the detected X-rays, respectively, and the controller is further configured to control a display to display the single energy X-ray image and the first X-ray image and the second X-ray image on a screen of the display.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 16, 2019
    Applicants: SAMSUNG ELECTRONICS CO., LTD., SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Hyun Hwa OH, Young Hun SUNG, Kang Eui LEE, Myung Jin CHUNG
  • Publication number: 20190090802
    Abstract: Disclosed is a VR (Virtual Reality) device for diagnosis of nerve disorder, system and method thereof, wherein the device comprises: a display part providing a user with a VR environment in response to an image; and a user response receiver receiving a user response relative to the image, and wherein the image includes an introduction video included with two or more characters, and a question video image provided subsequent to the introduction video to include an inquiry related to the characters, whereby a user's linguistic competence, visual ability and associative ability can be comprehensively evaluated, and more accurately grasp a degree of user's nerve disorder can be accurately grasped without being influenced by a user's academic background and age.
    Type: Application
    Filed: September 14, 2018
    Publication date: March 28, 2019
    Applicants: Samsung Life Public Welfare Foundation, Korea Institute of Science and Technology
    Inventors: Duk Lyul NA, Ko Woon Kim, Jong Doo Choi, Ju Hee Chin, Byung Hwa Lee, Jee Hyun Choi, Hye Joo Lee, Hyo Been Han
  • Patent number: 10232000
    Abstract: The present disclosure relates to stem cells derived from the basal portion of the chorionic trophoblast layer (bCT), which is a part of the issues of the placenta, and cell therapy comprising same. Stem cells derived from the basal portion of the chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristic as compared with the conventional stem cells derived from the full placenta or other tissues, and exhibit excellent tissue regeneration effect in an animal model, thus can be effectively used in cell therapy.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: March 19, 2019
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Chul Won Ha, Jin A. Kim
  • Publication number: 20190070223
    Abstract: The present invention relates to a selection method of a highly active stem cell for treatment of cerebrovascular diseases, comprising a step of measuring a level of a neurotrophic factor, and a highly active stem cell selected thereby. According to the present invention, BDNF secreted by mesenchymal stem cells mediate inhibitory effects on cell death, inflammation, astrogliosis, and posthemorrhagic hydrocephalus and plays a very important role in improving myelination after intraventricular hemorrhage. Hence, the method according to the present invention can be usefully applied to the treatment of various cerebrovascular diseases including intraventricular hemorrhage in preterm infants.
    Type: Application
    Filed: March 30, 2017
    Publication date: March 7, 2019
    Applicant: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Yun Sil CHANG, Won Soon PARK, So Yoon AHN, Dong Kyung SUNG
  • Patent number: 10201319
    Abstract: An X-ray imaging apparatus includes an X-ray generator configured to generate X-rays and radiate the X-rays to an object; an X-ray detector configured to detect the X-rays that have passed through the object and convert the detected X-rays into a signal; and a controller configured to generate a single energy X-ray image and a plurality of multiple energy X-ray images using the signal and control a display to display the generated single energy X-ray image and the plurality of multiple energy X-ray images together.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: February 12, 2019
    Assignees: SAMSUNG ELECTRONICS CO., LTD., SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Hyun Hwa Oh, Young Hun Sung, Kang Eui Lee, Myung Jin Chung
  • Patent number: 10167448
    Abstract: The present invention relates to a pharmaceutical composition for treating cerebrovascular diseases including stem cell-derived exosomes as an active ingredient. The stem cell-derived exosomes according to the present invention have superior nerve cell protective effects, such as inhibition of cerebral ventricular distention, reduction of hydrocephalus, and inhibition of nerve cell death and cellular inflammation in an intraventricular hemorrhage (IVH) animal model, and thus, can be useful in treating cerebrovascular diseases including intraventricular hemorrhage, etc.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: January 1, 2019
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Yun Sil Chang, Won Soon Park, Dong Kyung Sung, So Yoon Ahn
  • Publication number: 20180320178
    Abstract: The present invention relates to a stem cell having an immunosuppressive ability in which the expression or activity of a suppressor of cytokine signaling (SOCS) is inhibited, and a pharmaceutical composition for inhibiting immunity, which includes the stem cell. In addition, the present invention relates to a composition for inducing the immunosuppressive activity of a stem cell, including a suppressor of cytokine signaling (SOCS) expression or activity inhibitor. The inhibition of suppressor of cytokine signaling (SOCS) expression or activity, according to the present invention, may enhance the immunosuppressive ability of a stem cell, and the stem cell with enhanced immunosuppressive ability may be used as an effective cell therapeutic agent in an autoimmune disease, rejection upon organ transplantation, or an allergic disease.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 8, 2018
    Applicant: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Keon Hee YOO, Hong Hoe KOO, Myoung Woo LEE, Dae Seong KIM
  • Patent number: 10119142
    Abstract: An siRNA for specifically targeting a PMP22 mutant gene and a pharmaceutical composition for preventing or treating Charcot Marie Tooth disease, which includes the same, are provided. According to the present invention, it is confirmed that selective suppression of a PMP22 mutant allele by a non-viral delivery system of siRNA may improve demyelinating neuropathic symptoms of CMT in vivo, enhance a motor ability and increase a volume of muscle. Therefore, the siRNA may be used in a useful method for treating various dominantly inherited peripheral neuropathies including CMT.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: November 6, 2018
    Assignee: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Byung-Ok Choi, Young Bin Hong
  • Patent number: 10078891
    Abstract: A quality assurance system for radiation therapy equipment includes an image capturing unit installed on radiation therapy equipment and capturing an image of an indicating part indicating an operational state of the radiation therapy equipment, an image processing unit extracting an edge of the indicating part in image captured by the image capturing unit, a center point extraction unit extracting a center point with respect to the edge, and a quality evaluation unit evaluating quality of the radiation therapy equipment by tracking movement of the center point.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: September 18, 2018
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Youngyih Han, Eun Hyuk Shin, Jung Suk Shin, Hee Chul Park, Doo Ho Chol, Jun Sang Cho
  • Patent number: 10072247
    Abstract: The present invention relates to a composition comprising an ischemic serum for promoting the activation of a stem cell, to a method for promoting the activation of a stem cell and to a stem cell, the activation of which is promoted by the composition or the method. The ischemic serum according to the present invention may stimulate the stem cell to facilitate the secretion of a growth factor, improve survival rate, improve mobility to an injured part, improve proliferation rate and maintain characteristics of the stem cell, thus promoting an activation of the stem cell such that the stem cell becomes suitable for transplantation of the stem cell to a patient having a brain injury.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: September 11, 2018
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Oh Young Bang, Gyeong Joon Moon, Yeon Hee Cho, Suk Jae Kim, Dong Hee Kim, Soo Kyung Ryoo, Ji Hyun Lee, Ji Yoon Nam, Ji Hee Sung