Abstract: The present disclosure provides an apparatus for intracranial drug injection including a body unit having a through-hole extending between a first opening in a topmost surface and a second opening in a bottommost surface, a cap unit having a shape corresponding to at least a part of an inner surface of the through-hole and being inserted into the first opening to cover the first opening, and a tube unit having one end coupled to the second opening and another end extending toward an affected brain lesion.

Abstract: An outpatient prediction method includes obtaining, by an outpatient prediction apparatus, data on a target to be predicted, obtaining, by the outpatient prediction apparatus, past data including at least one of a number of outpatient clinic units in past, a number of outpatients in past, a number of blood-collecting patients in past, a number of computed tomography (CT)/magnetic resonance imaging (MRI) tests in past, a number of outpatients per outpatient clinic unit in past, a number of blood-collecting patients per outpatient number in past, and a number of CT/MRI tests per outpatient number in past, calculating, by the outpatient prediction apparatus, pattern data based on the past data, and predicting, by the outpatient prediction apparatus, at least one of a number of outpatients in future, a number of blood-collecting patients in future, and a number of CT/MRI tests in future based on the pattern data.

Abstract: A surgical skill training system includes: a data collecting unit configured to collect actual surgical skill data on a patient of an operating surgeon; an image providing server configured to generate a 3-dimensional (3D) surgical image for surgical skill training, based on the actual surgical skill data; and a user device configured to display the 3D surgical image, wherein the image providing server includes: a patient image generating unit configured to generate a patient image, based on patient information of the patient; a surgical stage classifying unit configured to classify the actual surgical skill data into actual surgical skill data for each surgical stage performed by the operating surgeon; and a 3D image generating unit configured to generate the 3D surgical image by using the patient image, and feature information detected from the actual surgical skill data.

Abstract: A feeder cell for culturing natural killer (NK) cells, genetically engineered to express membrane bound interleukin-18 (mbIL-18), membrane bound interleukin-21 (mbIL-21), and/or OX40L. A method of proliferating NK cells, including: obtaining a blood sample containing a population of NK cells; and contacting at least a part of the population of NK cells with a genetically engineered cell, where the genetically engineered cell is genetically engineered to express mbIL-18, mbIL-21, and/or OX40L.

Abstract: A cell genetically engineered for activating natural killer (NK) cells. The genetically engineered cell for activating NK cells synergistically induces the proliferation and activation of NK cells in a sample, thereby producing effects that can be usefully utilized in a method of proliferating NK cells, a method of measuring NK cells proliferated by the method, or an activation degree of NK cells, or a method of diagnosing an NK cell activity-related disease. A feeder cell for culturing a natural killer (NK) cell, genetically engineered to express membrane bound interleukin-18 (mbIL-18) and membrane bound interleukin-21 (mbIL-21).

Abstract: A drowsiness warning system is disclosed.

Abstract: Provided are a method of predicting waiting days for a medical examination requiring a reservation at a hospital, the method including acquiring examination prescription and execution data, calculating, based on the examination prescription and execution data, an average ratio of executed examinations for each day required from a prescription to the execution thereof, and an average number of prescriptions based on past weekdays, estimating, based on the average number of prescriptions based on past weekdays, an average number of prescriptions based on future weekdays for a predetermined period by using at least one time-series prediction model, calculating a monthly increment in the average number of prescriptions based on future weekdays, compared to the average number of prescriptions based on the past weekdays, and allocating, based on the average number of prescriptions based on the past weekdays and the monthly increment, an expected number of prescriptions based on future weekdays.

Abstract: A method of culturing mesenchymal stem cells includes performing primary culture of umbilical cord-derived mesenchymal stem cells under hypoxic conditions with an oxygen partial pressure of 1 to 8% and pressure conditions of 1.0 to 8.0 PSI. The method of culturing umbilical cord-derived mesenchymal stem cells can maintain stemness by inhibiting the differentiation of stem cells and particularly can achieve a remarkably high proliferation rate.

Abstract: A microelectrode assembly for in vivo neurotransmitter monitoring according to one embodiment of the present disclosure includes: a microelectrode part formed of a single strand; and a polymer coating layer surrounding the microelectrode part, wherein a portion of the microelectrode part may protrude from the polymer coating layer, neurotransmitters in vivo may be sensed by the protruding portion of the microelectrode part, and plasmonic nanostructures may be formed on the surface of the microelectrode part.

Abstract: Provided are a composition for ciliogenesis, containing a mesenchymal stem cell or a culture medium of mesenchymal stem cell. The mesenchymal stem cell or the culture medium of mesenchymal stem cell increases the number and promotes growth of primary cilia in cells. The mesenchymal stem cell or the culture medium of mesenchymal stem cell can be used as a pharmaceutical composition for preventing or treating diseases caused by ciliopathy or ciliary impairment. The mesenchymal stem cell or the culture medium of mesenchymal stem cell can be used as a cosmetic composition. A method for preventing or treating ciliopathy or ciliary impairment is disclosed.

Abstract: Provided are a method and an apparatus for measuring an endolymphatic hydrops ratio of inner ear organs using an artificial neural network. The method of measuring an endolymphatic hydrops ratio includes obtaining a plurality of frame images obtained by capturing inner ear organs, obtaining a plurality of pieces of mask data corresponding to each of the plurality of frame images by inputting the plurality of frame images into a neural network, clustering the plurality of pieces of mask data according to the inner ear organs and obtaining representative images according to the inner ear organs according to certain conditions, and overlapping a target image synthesized by using the plurality of frame images and the representative images according to the inner ear organs so as to measure an endolymphatic hydrops ratio.

Abstract: Disclosed is a stereotactic guidance device which rotates a driving part of a drug injection device in order to find a target point in a patient's skull and which can be assembled and disassembled so that a guide tube unit is provided inside the driving part.

Abstract: Disclosed is a drug injection device that is fixedly implanted a patient's skull and scalp to inject a drug.

Abstract: Provided are a method and a device for encapsulating a cell in droplet for single-cell analysis, or a method and a device for forming droplet for single-cell analysis. According to the method and the device of one aspect, by using the effects of inertial ordering, not only a ratio at which one cell is encapsulated in one droplet is increased, but also a yield of generating droplet is improved.

Abstract: According to an embodiment, an embolic apparatus includes: a main body portion extending in a longitudinal direction; a plurality of first frame portions foldably connected to the main body portion; a plurality of second frame portions foldably connected to an end opposite to the other end of the main body portion connected to the plurality of first frame portions; and a blocking film portion connecting the plurality of first frame portions and covering the first frame portion, wherein the first frame portion and the second frame portion extend in directions away from each other.

Abstract: Disclosed is a drug injection device that is implanted between the skull and the subcutaneous layer of an animal. The disclosed drug injection device includes: a main body that is positioned on the skull and implanted and fixed in the subcutaneous layer; a guide member that guides a trocar such that the drug is injected into brain parenchyma inside the skull of the animal; a cover member that is installed inside the main body and connected to the guide member in the center and has a hole for guiding drug injection trocar so as to be inserted; and a sealing member that is installed between the main body and the cover member and prevents reverse flow of drugs and the introduction of foreign substances.

Abstract: The present invention relates to an apparatus for predicting a region-specific cerebral cortical contraction rate on the basis of a CT image.

Abstract: A vision assistance apparatus may include an image acquisition unit configured to acquire an image by capturing the scene of the front which a user watches, a sensor unit configured to acquire sensing information on objects located in front of the user, a control unit configured to analyze the image acquired by the image acquisition unit and generate a notification signal for the front scene through an analysis result of the image and the sensing information acquired by the sensor unit, and an output unit configured to provide the user with the notification signal generated by the control unit in the form of sound.

Abstract: Provided is a colorectal cancer-specific methylation biomarker for diagnosing colorectal cancer. Since a gene marker according to an embodiment exhibits a specific methylation pattern in colorectal cancer tissue, it can be usefully used as a methylation marker for diagnosing colorectal cancer, thereby increasing the cure rate of colorectal cancer by early diagnosis and treatment of colorectal cancer.

Abstract: The present invention relates to a amyotrophic lateral sclerosis (ALS) diagnostic composition using acid sphingomyelinase (ASM), and a method for detecting diagnostic markers and, more specifically, to a method and a composition for detecting markers for ALS, the method comprising the steps of: (a) providing a sample of a subject; (b) measuring the ASM expression level or the enzyme activation level in the sample; (c) determining that a subject, of which the ASM expression level or the enzyme activation level is increased compared to that of a normal person, has ALS. According to the investigation of the present inventors, the activity of ASM, among lipids and enzymes related to the sphingolipid metabolism, is specifically increased in a sample of an ALS patient compared to that of a normal person. ASM can be used as a marker for diagnosing ALS, thereby enabling the development of a novel and effective diagnostic reagent.