Patents Assigned to SANDOZ
  • Patent number: 3935231
    Abstract: The present invention concerns benzothiophene acyl (2) derivatives of the formula, ##SPC1##Wherein R.sub.1, R.sub.2 and R are substituents and n is an integer 1 or 2.The compounds are useful as u.v. stabilizers for, e.g. plastic materials.
    Type: Grant
    Filed: October 11, 1973
    Date of Patent: January 27, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Lajos Avar, Kurt Hofer
  • Patent number: 3935271
    Abstract: The present invention concerns unsaturated ethers or thioethers of the formula: ##EQU1## wherein R.sub.1 is an aliphatic or alicyclic hydrocarbon, R.sub.2 and R.sub.3 are H or alkyl, Y is cyano, amido, a ketone or an acid ester, ##EQU2## is an ether, thioether or a saturated or unsaturated c--c bond and n is an integer, which exhibit insecticidal properties.
    Type: Grant
    Filed: December 19, 1973
    Date of Patent: January 27, 1976
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Schelling, Fritz Schaub
  • Patent number: 3935210
    Abstract: Disclosed is single phase multi-stage process for preparation of 1-aryl-4,5-dihalo-pyridazones-6 involving the diazotization of an amino aryl compound, e.g. aniline, followed by reduction with sulfurous acid to obtain the corresponding aryl hydrazine which is then reacted at elevated temperatures with a mucohalic acid to obtain the 1-aryl-4,5-dihalo-pyridazone-6.
    Type: Grant
    Filed: May 20, 1974
    Date of Patent: January 27, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jerome Linder
  • Patent number: 3933787
    Abstract: Azo dyes of the formula ##SPC1##WhereX stands for the radical of a coupling component of the aminobenzene, hydroxybenzene, aminonaphthalene, hydroxynaphthalene or heterocyclic series or one with a coupling methylene group,A.sub.n .sup.- for an anion equivalent to K.sub.n .sup.+,n for 1 to 6,K.sup.+ for the group ##EQU1## and where the aromatic rings B and/or D may be further substituted. The dyes are useful for dyeing and printing paper (e.g., dyeing in the stock). The dyed paper is fast to light and wet treatments and has good fastness to bleaching, water, alcohol and light.
    Type: Grant
    Filed: January 12, 1973
    Date of Patent: January 20, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventor: Helmut Moser
  • Patent number: 3933999
    Abstract: The invention concerns novel combinations of active agents a) 1-methyl-2-[2-(.alpha.-methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine and b) a non-toxic sympathicomimetic agent having a peripheral vasoconstrictive effect, useful in the treatment of rhinitis.
    Type: Grant
    Filed: December 17, 1973
    Date of Patent: January 20, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventor: Lucien Craps
  • Patent number: 3933804
    Abstract: The present invention concerns novel compounds of the formula: ##EQU1## wherein R.sub.2 to R.sub.9 have various significances including e.g. alkyl, X and Y include O and S and s, v, w and z are 0 or whole numbers, Ar.sub.1 is ##SPC1##And R.sub.1 is cycloalkyl or ##SPC2##The compounds possess insecticidal properties.
    Type: Grant
    Filed: May 21, 1974
    Date of Patent: January 20, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Hans-Peter Schelling, Fritz Schaub
  • Patent number: 3934034
    Abstract: Certain hydroxy diphenylalkyls, e.g., nordihydroguairetic acid, are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 9, 1973
    Date of Patent: January 20, 1976
    Assignee: Sandoz, Inc.
    Inventor: Robert E. Manning
  • Patent number: 3932450
    Abstract: Imidazo[2,1-a]isoindoles useful as anorexics and psychic-energizers are prepared from the N,o-dilithium derivative of substituted 2-phenyl-2-imidazoline by various routes.
    Type: Grant
    Filed: August 19, 1974
    Date of Patent: January 13, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 3932483
    Abstract: The present invention concerns unsaturated ethers or thioethers of the formula: ##EQU1## wherein R.sub.1 is an aliphatic or alicyclic hydrocarbon, R.sub.2 and R.sub.3 are H or alkyl, Y is cyano, amido, a ketone or an acid esters, ##EQU2## is an ether, thioether or a saturated or unsaturated c--c bond and n is an integer, which exhibit insecticidal properties.
    Type: Grant
    Filed: December 19, 1973
    Date of Patent: January 13, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Hans-Peter Schelling, Fritz Schaub
  • Patent number: 3932414
    Abstract: Disclosed are pigments of formula I ##SPC1##in whichThe R.sub.1 's, independently, each signify hydrogen, halogen, nitro, cyano, methyl, alkoxy, aminocarbonyl, alkylcarbonylamino, benzoylamino, phenylaminocarbonyl, alkylamino or phenylamino,The R.sub.2 's, independently, each signify hydrogen, halogen or methyl,The R.sub.3 's, independently, signify hydrogen or halogen, andR.sub.4 signifies a direct bond or a group --R.sub.5 --NH--, in which the imino group is bound to nucleus A, and R.sub.5 signifies a 1,3- or 1,4-phenylene radical, unsubstituted or substituted by up to two substituents selected from halogen, methyl, alkoxy and nitro; or a radical ##SPC2##in which X signifies a direct bond, --O--, --SO.sub.2 --, --N=N-- or --NHCO-- and rings B and C are unsubstituted or substituted by up to two substituents selected from halogen, methyl, alkoxy and nitro,And their use in pigmenting synthetic plastics and resins and paper and as colorants in surface coating media such as paints, lacquers and printing inks.
    Type: Grant
    Filed: April 1, 1974
    Date of Patent: January 13, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Rodolf Altiparmakian, Hans Bohler
  • Patent number: 3932430
    Abstract: Substituted indeno [1,2-c] pyrazoles, naphtho [1,2-c] pyrazoles and benzo [6,7] cyclohepta [1,2-c] pyrazoles e.g., 3-(2,3-dimethoxyphenyl)-4H-indeno[1,2-c] pyrazole and 4,5-dihydro-3-(4-pyridyl)-2H-naphtho[1,2-c] pyrazole, are useful as non-estrogenic anti-fertility agents and antihypertensive agents.
    Type: Grant
    Filed: April 11, 1973
    Date of Patent: January 13, 1976
    Assignee: Sandoz, Inc.
    Inventors: Dietmar A. Habeck, William J. Houlihan
  • Patent number: 3932412
    Abstract: Disclosed are compounds of the class of isoquinolines substituted at the 1-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 1-(5-hydroxypentyl)-amino-6,7-methylene-dioxyisoquinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as anti-hypertensive agents, anti-anginal agents and in the treatment of shock. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive agents or as agents in the treatment of shock.
    Type: Grant
    Filed: August 6, 1973
    Date of Patent: January 13, 1976
    Assignee: Sandoz, Inc.
    Inventor: William R. J. Simpson
  • Patent number: 3932530
    Abstract: Phenoxyphenyl-butadienols, e.g., 2-(p-phenoxyphenyl)-3,4-pentadien-2-ol, and their preparation are described. The compounds are useful as anti-inflammatories.
    Type: Grant
    Filed: December 28, 1973
    Date of Patent: January 13, 1976
    Assignee: Sandoz, Inc.
    Inventor: Paul L. Anderson
  • Patent number: 3931253
    Abstract: The present invention concerns a novel process for the production of an aminoanthraquinone, which comprises catalytically hydrogenating the corresponding nitroanthraquinone in an organic solvent. Aminoanthraquinones are known and are useful as intermediates in the production of anthraquinone dyestuffs.
    Type: Grant
    Filed: August 6, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Franz Krenmueller, Heinrich Till
  • Patent number: 3931179
    Abstract: Disclosed are N,N'-Bis(4-Quinazolinyl)alkanediamines, e.g., N,N'-Bis(7-chloro-4-quinazolinyl)-1,9-nonanediamine, having pharmacological activity in animals and useful for example, as anti-obesity agents. Said compounds may be prepared by reacting a 4-haloquinazoline with an alkanediamine.
    Type: Grant
    Filed: March 6, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: William R. J. Simpson
  • Patent number: 3931172
    Abstract: The invention discloses 1-tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxazolines having pharmacological activity in animals and useful, for example, as hypolipidemic agents. The compounds may be prepared by reacting a 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt, e.g., 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium tetrafluoroborate with morpholine. The 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt may be prepared by reaction of a corresponding 3-phenyl-2,1-benzisoxazole with tertiary-butanol in the presence of a strong inorganic acid.
    Type: Grant
    Filed: February 25, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventors: Robert V. Coombs, Goetz E. Hardtmann
  • Patent number: 3931275
    Abstract: Bis (4-[4-hyroxybenzyl]phenyl)carbonic acid ester and its pharmaceutically acceptable salts, are useful in the treatment of lipidemia.
    Type: Grant
    Filed: December 3, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: Mario Gustav Buzzolini
  • Patent number: 3931178
    Abstract: ANTI-HISTAMINICS OF THE FORMULA: ##SPC1##whereinR.sub.1 is alkyl, alkenyl or phenalkyl,R.sub.2 and R.sub.3 are hydrogen, alkyl or alkenyl, andR is an optional substituent, are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido [2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with a S-methyl-thiopseudourea.
    Type: Grant
    Filed: July 24, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 3931163
    Abstract: The present invention relates to naphthoquinone derivatives of formula I, ##SPC1##in whichR.sub.1 signifies a halogen atom, a nitro group or an unsubstituted or substituted alkoxy or amino group,R.sub.2 signifies the atoms necessary to form an unsaturated ring system, which ring system has 1 or 2 nuclei and is unsubstituted or substituted,R.sub.3 signifies an unsubstituted or substituted s-triazinyl or pyrimidyl radical, andn is 0, 1 or 2,Which compounds are free from sulphonic acid groups are useful as pigments or disperse dyes.
    Type: Grant
    Filed: October 30, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventor: Bansi Lal Kaul
  • Patent number: 3931176
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chloro-phenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-on e are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: October 25, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: William J. Houlihan