Abstract: 5,5,7,7-tetramethyl-3-substituted or unsubstituted-phenylfuro[3,4-e]-as-triazines and corresponding 4-oxides, e.g., 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine and 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine-4-oxide, are prepared from 2,2,5,5-tetramethyl-3,4(2H,5H)-furandione-3-hydrazone-4-oximes and are useful as sleep inducers and minor tranquilizers.
Abstract: Disclosed are compounds which are tetracyclic derivatives of imidazo[2,1-b]quinazolinones, e.g., 6-(p-fluorobenzyl)-1,2,3,4,4a,12a-hexahydrobenzimidazo[2,1-b]quinazolin-11 (6H)-one. The compounds are also useful as bronchodilator agents, and certain compounds are also useful as tranquillizers and sedative/hypnotic agents. The compounds may be prepared by reacting an isatoic anhydride with a 2-organomercapto-hexahydrobenzimidazole or hexahydrocyclopentimidazole such as 3a,4,5,6,7,7a-hexahydro-2-mercaptomethyl-3H-benzimidazole.
Abstract: Anti-inflammatories and analgesics of the formula ##SPC1##WhereinX y is --OCH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 O--,R is lower alkyl, allyl or cycloalkylalkyl andR' is phenyl or phenyl monosubstituted by halo, alkyl, alkoxy or trifluoromethyl,Are prepared by oxidation of the corresponding dihydro intermediates.
Abstract: 1,3-Dihydrocarbyl-pyrazole compounds, having a 5-hydroxyl group in free or nickel salt form, characterized by a ketoxyimino group bound directly to the 4-position of the pyrazole ring through the ketoxyimino functional carbon atom, which are useful as stabilizers of organic materials against the adverse effects of ultraviolet light.
Abstract: The purpose of the invention are new benzene phosphonous acid compounds in which two to four benzene nuclei are bound together and which contain one to three phosphorus atoms. The new compounds are free acids, their salts with inorganic cations, their esters, thioesters or amides. The invention concerns also the manufacture of these benzene phosphonous acid compounds and their use for the stabilization of organic materials.
Abstract: 5,5,7,7-tetramethyl-3-substituted or unsubstituted-phenylfuro[3,4-e]-as-triazines, e.g., 5,7-dihydro-5,5,7,7-tetramethyl-3-(m-nitrophenyl)furo[3,4-e]-as-triazine, are prepared by reacting a 2,2,5,5-tetramethyl-3,4(2H,5H)furandione with substituted or unsubstituted benzimidic acid hydrazide under an inert atmosphere in the presence of an inert organic solvent and are useful as sleep inducers and minor tranquilizers.
Abstract: The .alpha.-bromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.-bromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 100.degree.C.
Abstract: Bis-substituted benzyl acetic acids, e.g., bis-(p-pivaloylbenzyl)acetic acid, are prepared by hydrolyzing and decarboxylating a corresponding bis-(p-pivaloylbenzyl)malonic acid diethyl ester and are useful as hypolipidemic agents.
Abstract: The present invention concerns a novel method of flame-proofing flammable material which comprises treating said material with a compound of the formula: ##EQU1## WHEREIN N IS 1 OR 2, AND R, when n is 1, is a radical of the formula ##EQU2## wherein R.sub.1 and R.sub.2 are substituents e.g. alkyl, or R.sub.1 and R.sub.2, together with the nitrogen atom, form a heterocyclic ring or R, when n is 2, is a radical of the formula ##EQU3## wherein R.sub.1 and R.sub.4 are substituents e.g. alkyl and R.sub.3 is a hydrocarbon bridge e.g. alkylene, or R.sub.1, R.sub.2 and R.sub.4, together with the nitrogen atoms to which they are bound, form a heterocyclic ring, or a group of the formula ##SPC1##Wherein m is 1 to 5, and novel compounds (i.e. when n is 2) useful as flame-proofing agents.
Type:
Grant
Filed:
July 19, 1974
Date of Patent:
June 8, 1976
Assignee:
Sandoz Ltd.
Inventors:
Peter Borer, Hans-Werner Finck, Horst Mayerhoefer, Urs Sollberger, Wolfgang Heinz Mueller
Abstract: This invention relates to an apparatus for the humidification of a gas, and it comprises an outer container having an inner chamber and a top cover. Within the inner chamber is a helix-shaped gas bubble conveyer. Water is introduced into the container, which in turn, fills the chamber. Gas bubbles are introduced into the chamber, and as they traverse the helix pathway, they are saturated with the water. Means are provided for recirculating the water and maintaining it at any desired temperature.
Abstract: Hypolipidemic agents of the formula: ##SPC1##Wherein X is C=O or CHOH,R.degree. is branched lower alkyl,R is hydrogen, alkyl, or halo,n is 1 or 2, andR' and R" are hydrogen, halo, alkyl or alkoxy, e.g., 4-phenoxy-pivalophenone.
Abstract: This invention concerns a novel process for the preparation of 6-piperazinyl derivatives of morphantridine and corresponding ring-substituted and hereto analogues thereof, comprising reacting a compound of the formula: ##SPC1##Wherein A is benzene or thiophene, and X is --CH.sub.2 -- or a hetero atom or group, with a complex comprising titanium, zirconium, hafnium or vanadium and a corresponding piperazinyl derivative.The end products are in general known and useful as neuroleptics.
Abstract: The present invention relates to a method of chemically aftertreating dyed or printed textiles by electrostatically spraying the dyed or printed textiles with a developing or fixing agent.
Abstract: The invention concerns a novel dialyser cartridge comprising a flat membrane tube through which blood to be dialysed may be passed, membrane support material over the outer surfaces of the membrane tube, a split core between which a central portion of the membrane tube and membrane support material is located and about which core said membrane tube and membrane support material are outwardly spirally wound so that the free ends of the membrane tube and membrane support material are situated at the outer periphery of the winding, a hollow cylindrically walled casing encasing the split core and spirally wound membrane tube and membrane support material, blood inlet means for connection to an arterial line and blood outlet means for connection to a blood venous line leading through the circumferential wall of the casing into the ends of the membrane tube, and a pair of end covers fixed to the ends of the hollow cylindrical casing, one end cover having a dialysate inlet for connection to a dialysate supply line a
Abstract: The present invention concerns unsaturated ethers or thioethers of the formula: ##EQU1## wherein R.sub.1 is an aliphatic or alicyclic hydrocarbon, R.sub.2 and R.sub.3 are H or alkyl, Y is cyano, amido, a ketone or an acid ester, ##EQU2## is an ether, thioether or a saturated or unsaturated c--c bond and n is an integer, which exhibit insecticidal properties.
Abstract: This invention provides new compounds of formula I, ##SPC1##wherein R.sub.1 and R.sub.2 are hydrogen or lower alkyl, useful as anti-hypertensive agents.
Abstract: The present invention concerns a novel process for the production of known benzocycloheptathiophene derivatives of the formula: ##SPC1##Wherein R.sub.1 is hydrogen, chlorine, bromine or alkoxy, and R.sub.2 is alkyl. The compounds are useful as specific histaminolytics for use in the treatment of allergic conditions.
Type:
Grant
Filed:
July 26, 1974
Date of Patent:
June 1, 1976
Assignee:
Sandoz Ltd.
Inventors:
Jean-Pierre Bourquin, Gustav Schwarb, Erwin Waldvogel
Abstract: 13-alkyl-17.alpha. -propadienylgona-4,9-dien-17.beta. -ol-3-ones and their 17.beta. -oxygenated derivatives are useful in control of fertility and estrus or the menstrual cycle in warm blooded animals.
Abstract: Sedative/hypnotics of the formula ##SPC1##Wherein R is hydrogen, halo, alkyl, alkoxy or trifluoromethyl, are prepared by reacting a phenyl-2,3-epoxypropyl ether with methyl isocyanide.