Patents Assigned to SANDOZ
  • Patent number: 3954408
    Abstract: Apparatus and process for detecting the products of either liquid or gas chromatographic analysis, which products may be either radioactively tagged or not tagged. In one aspect, it provides a moving wire apparatus for conveying a liquid chromatographic sample through a combustion furnace, where the combustion products are conveyed to a catalytic system. Non-radioactive samples are routed through a nickel catalytic converter; and thence, to a flame ionisation detector. Radioactive samples are conveyed from the combustion furnace through either a copper-oxide or an iron catalytic furnace, depending upon whether the sample is tagged with Carbon-14 or tritium. The products of the catalytic furnaces are detected by means of a radioactive detector. Means are also provided for introducing gas chromatographic products into the system for detection.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: May 4, 1976
    Assignee: Sandoz, Inc.
    Inventor: Harry A. Dugger
  • Patent number: 3954847
    Abstract: The purpose of the invention are new benzene phosphonous acid compounds in which two to four benzene nuclei are bound together and which contain one to three phosphorus atoms. The new compounds are free acids, their salts with inorganic cations, their esters, thioesters or amides. The invention concerns also the manufacture of these benzene phosphonous acid compounds and their use for the stabilization of organic materials.
    Type: Grant
    Filed: April 25, 1974
    Date of Patent: May 4, 1976
    Assignee: Sandoz Ltd.
    Inventors: Kurt Hofer, Guenther Tscheulin
  • Patent number: 3954770
    Abstract: Flame retarding compounds of formula, ##SPC1##In whichEach n, independently, is an integer 2 to 5, andR is a divalent radical of formula ##EQU1## wherein R.sub.1 is alkylene or arylene and eachR.sub.2, independently, is alkyl or phenyl,For incorporation in organic materials such as plastics materials.
    Type: Grant
    Filed: October 31, 1974
    Date of Patent: May 4, 1976
    Assignee: Sandoz Ltd.
    Inventors: Horst Mayerhoefer, Wolfgang Mueller, Urs Sollberger, Anton Voykowitsch
  • Patent number: 3954754
    Abstract: This invention provides aminopyridazine derivatives of formula I, ##SPC1##whereinR.sub.1 is amino, or an ##EQU1## group, wherein each of R.sub.3 and R.sub.4 is alkyl of 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together with the carbon atom to which they are bound, form a cycloalkylidene radical of 5 to 12 carbon atoms,R.sub.2 is hydrogen or methyl,A is a --(CH.sub.2).sub.n -- group,Whereinn is 0 or an integer from 1 to 7, or an >N--CO--R.sub.5 group,WhereinR.sub.5 is alkyl or alkenyl of 1 to 16 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, 1-adamantyl, or a --(CH.sub.2).sub.m --R.sub.6 group,Whereinm is 0 or an integer from 1 to 4, andR.sub.
    Type: Grant
    Filed: July 3, 1974
    Date of Patent: May 4, 1976
    Assignee: Sandoz Ltd.
    Inventor: Erhard Schenker
  • Patent number: 3954743
    Abstract: Compounds of the formula ##SPC1##In whichX signifies oxygen or =NH,R.sub.1 signifies an alkyl, alkenyl or phenyl radical which is unsubstituted or substituted,R.sub.2 signifies hydrogen or one of the meanings of R.sub.1 orR.sub.1 and R.sub.2 together with the vicinal nitrogen atom form a heterocyclic ring system,R.sub.3 signifies hydrogen, acyl or an alkyl or phenyl radical which is unsubstituted or substituted, andR.sub.4 signifies the atoms needed to complete an aromatic carbocyclic or heterocyclic ring system,And the ring A and chain R.sub.4 are unsubstituted or substituted,Are useful fluorescent dispersion dyestuffs.
    Type: Grant
    Filed: July 9, 1973
    Date of Patent: May 4, 1976
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch
  • Patent number: 3954987
    Abstract: Disclosed are compounds of the class of quinazolines substituted at the 2-position by lower alkyl and at the 4-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4-(5-hydroxypentyl) amino-2-methyl-6,7-dimethoxy-quinazoline nitrate. The compounds and their corresponding hydroxy intermediates have various pharmacological activities in animals and are useful, for example, as anti-anginal agents and as agents in the treatment of shock.
    Type: Grant
    Filed: December 3, 1974
    Date of Patent: May 4, 1976
    Assignee: Sandoz, Inc.
    Inventor: William R. Simpson
  • Patent number: 3953168
    Abstract: Disclosed is a process for dyeing or printing a voluminous textile substrate comprising natural or synthetic polyamide fibres, which process comprises applying to the substrate an aqueous dyeing or printing medium containing 0.05 to 100 g/l of a foaming agent, forming a foam on said substrate, rolling up the substrate and rotating the rolled up substrate for a period of from 1 to 48 hours at a temperature of from 20.degree. to 60.degree.C to effect fixation.
    Type: Grant
    Filed: July 15, 1974
    Date of Patent: April 27, 1976
    Assignee: Sandoz Ltd.
    Inventors: Sergio Fabbri, Josef Frauenknecht
  • Patent number: 3953419
    Abstract: Novel salts of stilbene-azo or stilbene-azoxy dyestuffs, in which the cations are selected from tetra-alkylammonium, tetra-alkylammonium in combination with lithium, sodium, potassium or ammonium, and ammonium in combination with lithium, sodium or potassium, have good cold water solubility relative to known salts of such dyes. The preferred dyes have the formula ##SPC1##Wherein1. each R' is independently --SO.sub.3 .sup.-M.sup.+ or --SO.sub.3 .sup.-N.sup.+(R).sub.4,wherein each R is independently alkyl of 1 to 6 carbon atoms or alkyl of 1 to 6 carbon atoms substituted by hydroxy, cyano, halo or phenyl, andEach M.sup.+ is independently hydrogen, lithium, sodium, potassium or ammonium,With the proviso that at least one R' is --SO.sub.3 .sup.-N.sup.+(R).sub.4,2. each R' is --SO.sub.3 .sup.-M.sup.+,wherein each M.sup.+ is lithium, sodium, potassium or ammonium,With the proviso that at least one M.sup.+ is ammonium, or3. each R' is independently --SO.sub.3 .sup.-M.sup.+ or --SO.sub.3 .sup.-N.sup.+(R).sub.
    Type: Grant
    Filed: August 6, 1973
    Date of Patent: April 27, 1976
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 3953525
    Abstract: .alpha.-substituted-4-(2,2-dimethyl-1-hydroxypropyl) benzyl alcohols and esters, e.g., .alpha.-methyl-4-(2,2-dimethyl-1-hydroxypropyl) benzyl alcohol, are prepared from the corresponding 1-(4-alkanoylphenyl) alkanols and derivatives and are useful as hypolipidemic agents.
    Type: Grant
    Filed: November 19, 1974
    Date of Patent: April 27, 1976
    Assignee: Sandoz, Inc.
    Inventor: Paul L. Anderson
  • Patent number: 3953163
    Abstract: Disclosed is a tanning agent for leather comprising a chromium or zirconium salt, preferably the sulphate, and an aryl sulphone, the tanning of leather therewith and the use of the aryl sulphone per se in chrome, vegetable or synthetic tanning of leather and in fat liquoring processes for leather.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: April 27, 1976
    Assignee: Sandoz Ltd.
    Inventor: Max May
  • Patent number: 3953600
    Abstract: Citronellyl benzimidazoles, e.g., (.+-.) 1-(3,7-dimethyl-6-octen-1-yl)-2-phenylbenzimidazole, are prepared by reacting an alkali metal salt of a 2-phenylbenzimidazole with citronellyl halide and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: April 27, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 3952035
    Abstract: The invention concerns novel unsaturated fatty acids useful as inhibitors of prostoglandin synthetase.
    Type: Grant
    Filed: April 19, 1974
    Date of Patent: April 20, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Eugene Ervin Galantay, Heribert Wagner
  • Patent number: 3951590
    Abstract: Compounds of the formula ##SPC1##WhereinA is 1,4-naphthylene, substituted 1,4-naphthylene, 1,4-(5,6,7,8-tetrahydronaphthylene) or substituted 1,4-(5,6,7,8-tetrahydronaphthylene), wherein each substituent of substituted 1,4-naphthylene and substituted 1,4-(5,6,7,8-tetrahydronaphthylene) is independently lower alkyl, lower alkoxy or halo,D is sulfophenyl or substituted sulfophenyl wherein each substituent is independently lower alkyl, lower alkoxy, nitro or halo,Each R is independently lower alkyl, andn is 0 to 2,And mixtures thereof, are useful for dyeing and printing natural polyamides such as wool and silk, synthetic polyamides such as nylon, polyacrylonitrile, acrylonitrile copolymers and polyvinyl alcohol on which they build-up well. The dyeings are fast to light and wet treatments.
    Type: Grant
    Filed: March 26, 1973
    Date of Patent: April 20, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventor: Martin Studer
  • Patent number: 3950419
    Abstract: The present invention relates to methods of dyeing and printing of textile materials and specifically to the use of fixing agents in such methods. In particular, the present invention relates to the use of aromatic carboxylic acid esters and amides as fixing agents in the dyeing and printing of textile materials.
    Type: Grant
    Filed: October 9, 1973
    Date of Patent: April 13, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Hans-Peter Baumann, Hans-Georg Karmann
  • Patent number: 3950332
    Abstract: N-substituted amino-N-nitroso-aminoacetamides, e.g., .alpha.-(N-morpholino-N-nitrosoamino)acetamide, are prepared by hydrolyzing the corresponding 3-N-substituted amino-sydnonimines and have been found to be useful as hypotensive/anti-hypertensive and anti-anginal agents.
    Type: Grant
    Filed: February 14, 1973
    Date of Patent: April 13, 1976
    Assignee: Sandoz, Inc.
    Inventor: Paul L. Anderson
  • Patent number: 3948880
    Abstract: Dyes of the formula ##SPC1##WhereinR.sub.1 is hydrogen, chloro or bromo,R.sub.2 is chloro or bromo,R.sub.3 is lower alkyl or substituted lower alkyl,R.sub.4 is --CH.sub.2 CH.sub.2 -- or ##EQU1## and R.sub.5 is lower alkyl or substituted lower alkyl,Wherein each substituent of each substituted lower alkyl is independently chloro, bromo, cyano or lower alkoxy, are highly suitable for dyeing and printing synthetic and semi-synthetic fibres consisting of high molecular-weight organic substances of hydrophobic character, and of textile materials made thereof. Resulting dyeings and prints are fast to thermofixation, sublimation, pleating, solvents, lubricants, dry cleaning, rubbing, ozone and gas fumes.
    Type: Grant
    Filed: May 28, 1974
    Date of Patent: April 6, 1976
    Assignee: Sandoz Ltd.
    Inventor: Wolfgang Groebke
  • Patent number: 3948879
    Abstract: Compounds of the formula ##SPC1##WhereinEACH OF R and R.sub.1 independently is halo,R.sub.2 is hydrogen or halo,R.sub.3 is halo or --OR.sub.4, andR.sub.4 is alkyl or substituted alkyl,And chromium complexes thereof. The monoazo compounds are particularly useful for dyeing natural and synthetic polyamide fibers by producing a chromium complex thereof on the fiber by treating the fiber with 2 moles of the monoazo compound and simultaneously or subsequently treating the fiber with 1 to 2 moles of a chromium-donating compound.
    Type: Grant
    Filed: July 11, 1973
    Date of Patent: April 6, 1976
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore
  • Patent number: 3948946
    Abstract: The invention provides novel cyclic acetals and mercaptals useful as stabilising agents for organic susceptible to degradation by heat or oxygen.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: April 6, 1976
    Assignee: Sandoz Ltd., (Sandoz AG)
    Inventors: Kurt Hofer, Anton Voykowitsch
  • Patent number: 3947460
    Abstract: 5-hydroxy-5-substituted phenyl-pyrrolidones and piperidinones, 3.g., 5-hydroxy-1-methyl-5-(m-trifluoromethylphenyl)pyrrolidone, are useful as sedative-hypnotic agents and minor tranquilizers.
    Type: Grant
    Filed: August 8, 1974
    Date of Patent: March 30, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 3946119
    Abstract: Hypolipidemic agents of the formula: ##SPC1##WhereinR is hydrogen, alkyl or halo,R' and R" are hydrogen, halo, alkyl or alkoxy,R'" is alkyl, andn is 1 or 2.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: March 23, 1976
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala