Abstract: Embodiments of the methods and compositions provided herein relate to inducing hair growth in a subject. Some embodiments include screening for agents to modulate hair growth.

Abstract: This disclosure relates to cardiogenic mesoderm formation regulators and methods of use thereof, e.g., generating a multipotent cardiovascular progenitor cell by overexpressing Id1, Id2, Id3, Id4, Evx1, and/or Grrp1 in a stem cell.

Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Abstract: The present disclosure provides a catheter system and methods for use that includes (a) a first catheter having a first end and a second end, where the first catheter has a first diameter, (b) a second catheter having a first end and a second end, where the second catheter has a second diameter that is less than the first diameter of the first catheter, and where the second catheter is positioned at least partially within a lumen of the first catheter and is moveable relative to the first catheter, and (c) a wire having a first end and a second end, where the first end of the wire is coupled to the second catheter.

Abstract: An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

Abstract: Package covers, assemblies, and methods of making the same are provided herein. A package cover is formed of a foldable paperboard blank that has a front panel, a rear panel, a tab extending from the front panel, and a shoulder connecting the front and rear panels, wherein the rear panel defines a notch configured to receive the tab therethrough when the blank is folded into a cover configuration, and wherein the front panel is printed.

Abstract: Dry erase ink formulations containing a resin, a pre-assembled colorant, and a solvent, wherein the dry erase ink formulation has a surface tension of at least 25 dynes per centimeter, and writing instruments including a dry erase ink formulation are provided herein.

Abstract: Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

Abstract: Convertible writing instrument assemblies are provided, including an outer barrel having a tapered nosecone with an aperture for a writing instrument tip and a grip portion, and an aperture for receiving an eraser or a push button therethrough, wherein the writing instrument assembly provides selective access to a volume defined by the outer barrel, and wherein the outer barrel and the volume are collectively configured to operably and interchangeably receive a mechanical pencil insert having the eraser and a retractable pen insert having the push button. Mechanical pencils and pens utilizing the convertible writing instrument assemblies are also provided, along with kits for providing such mechanical pencils and pens.

Abstract: The present disclosure provides an apparatus including: (a) a frame (102) having a first end (104) and a second end (106), wherein the frame includes a plurality of struts (108) arranged between the first end and the second end of the frame, (b) a plurality of channels (110) disposed within the plurality of struts of the frame, (c) an infusion balloon (112) coupled to the frame and arranged such that, in an expanded condition, the frame provides a plurality of openings (114) that the infusion balloon is configured to expand through and extend radially outward from the frame, thereby defining a plurality of grooves (116), (d) a plurality of holes (118) defined in the frame and configured to permit fluid communication between the plurality of channels and the plurality of grooves, and (e) an infusion hub (120) arranged at the first end or the second end of the frame including a reservoir in fluid communication with the plurality of channels.

Abstract: Embodiments include container assemblies for presentation of contents. In one example, a container assembly for writing instruments may include a slideable platform with a threaded hole configured to operably receive a threaded post therethrough, a housing having at least one guide rail, a manually rotatable base configured to rotate, such that rotation of the manually rotatable base moves the slideable platform within the housing along the at least one guide rail, and at least one platform stopper configured to prevent the slideable platform from advancing past the pre-determined height, wherein the pre-determined height is selected such that the writing instruments are retained by the housing in the container assembly when the slideable platform is in contact with the at least one platform stopper.

Abstract: Methods are disclosed for treating periodontal disease, peri-implantitis, or to preserve a tooth socket in a subject. These methods include selecting a subject with periodontal disease, peri-implantitis, or in need of tooth socket preservation; and locally administering into the periodontium of the subject a therapeutically effective amount of a tissue-nonspecific alkaline phosphatase (TNAP) polypeptide, or a nucleic acid molecule encoding the recombinant TNAP polypeptide. Methods are also disclosed for i) promoting alveolar bone regeneration in the subject; ii) increasing attachment of a periodontal ligament to a root surface of a tooth in the subject; iii) increasing cementum formation; and/or iv) increasing mineralization in a tooth in the subject. Pharmaceutical compositions are also disclosed that are of use in these methods.

Abstract: Provided herein are agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Abstract: The present disclosure provides methods of preparing a biological specimen for imaging analysis, comprising fixing and clearing the biological specimen and subsequently analyzing the cleared biological specimen using microscopy. Also included are methods of quantifying cells, for example, active populations of cells in response to a stimulant. The present disclosure also provides devices for practicing the described methods. A flow-assisted clearing device provides rapid clearing of hydrogel-embedded biological specimens without the need of specialized equipment such as electrophoresis or perfusion devices.

Abstract: The present invention is based on the seminal discovery of a panel of targeting peptides and antibodies that can recognize AD brains at different stages of the disease, starting from early to advanced stage. The peptide probes described here are unique in the field and can be expected to advance understanding on early neurodegenerative changes associated with AD and improve the therapeutic outcomes by early detection and intervention in AD. Further, the invention provides antibodies that can be used to treat AD.

Abstract: Described herein are peptides, compositions, and methods for diagnosing, detecting, imaging, monitoring, preventing, treating, or ameliorating diseases or disorders including cancer, inflammatory disorder, and autoimmune disease.