Abstract: Disclosed are methods and compositions for treating traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Significantly, the peptide alone produces therapeutic effect and so can be used in the absence of any other therapeutic compound.
Type:
Grant
Filed:
December 6, 2018
Date of Patent:
July 5, 2022
Assignee:
Sanford Burnham Prebys Medical Discovery Institute
Inventors:
Erkki Ruoslahti, Sazid Hussain, Aman Preet Singh Mann, Pablo Scodeller
Abstract: Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are provided.
Type:
Grant
Filed:
June 8, 2020
Date of Patent:
June 21, 2022
Assignee:
Sanford Burnham Prebys Medical Discovery Institute
Abstract: The present invention relates to the seminal discovery that BTLA agonist antibodies modulate the immune system. Specifically, the present invention provides antibodies which bind BTLA in the activated state enhancing BTLA signaling. The present invention further provides methods of treating immune and inflammatory diseases and disorders with a BTLA agonist antibody.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
June 7, 2022
Assignee:
Sanford Burnham Prebys Medical Discovery Institute
Abstract: Provided herein are agonists of the apelin receptor of Formula (I): for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.
Type:
Grant
Filed:
August 8, 2018
Date of Patent:
May 31, 2022
Assignee:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Layton H. Smith, Anthony B. Pinkerton, Paul Hershberger, Patrick Maloney, Danielle McAnally
Abstract: Provided herein are biomolecule conjugates, and methods of use thereof, wherein the conjugate comprises a cytokine, typically an immunopotentiating cytokine, and a peptide comprising or consisting of the sequence CSGRRSSKC (SEQ ID NO:1). Biomolecule conjugates of the invention find application, inter alia, in the treatment of tumours, atherosclerosis and fibrosis, and the degradation of ECM associated therewith. Also provided herein are uses of a peptide comprising or consisting of the sequence of SEQ ID NO:1, optionally linked to a detectable agent and/or a carrier, in the detection and/or localisation of tumour, atherosclerotic and fibrotic tissue.
Type:
Application
Filed:
October 26, 2021
Publication date:
May 12, 2022
Applicants:
The University of Western Australia, Sanford Burnham Prebys Medical Discovery Institute
Inventors:
Juliana Binti HAMZAH, Ruth Annelore GANSS, Erkki RUOSLAHTI, Hector R. BILIRAN, JR.
Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Type:
Grant
Filed:
January 14, 2020
Date of Patent:
March 1, 2022
Assignee:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Anthony B. Pinkerton, Paul M. Hershberger, Satyamaheshwar Peddibhotla, Patrick R. Maloney, Michael P. Hedrick
Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
Type:
Grant
Filed:
February 20, 2009
Date of Patent:
March 1, 2022
Assignee:
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Inventors:
Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
Abstract: Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
Type:
Grant
Filed:
February 18, 2020
Date of Patent:
January 11, 2022
Assignees:
LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Nunzio Bottini, Jiwen Zou, Santhi R. Ganji, Stephanie Stanford, Anthony Pinkerton, Thomas D. Y. Chung, Michael Hedrick, Robert Ardecky
Abstract: A balloon catheter having an elongated catheter shaft defining a fluid drainage lumen and a balloon inflation lumen. The balloon catheter includes a fluid drainage port disposed about the distal end of the catheter shaft in fluid communication with the fluid drainage lumen, and a balloon inflation port disposed about the distal end of the catheter shaft in fluid communication with the balloon inflation lumen. A balloon portion is disposed about the distal end of the catheter shaft in fluid communication with the balloon inflation port. A release device is disposed in fluid communication with the balloon portion and the fluid drainage lumen, and includes an activating member. A tether is attached to the activating member of the release device. Tension applied to the tether activates the release device, enabling fluid flow from the balloon portion into the fluid drainage lumen and out of the body.
Type:
Grant
Filed:
January 29, 2019
Date of Patent:
January 4, 2022
Assignee:
Sanford Health
Inventors:
Bruce A. Gardner, Jeffery A Gardner, David Allan Swanson
Abstract: The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the following formula (I): wherein X1 represents a nitrogen atom or CR9, R1 represents a hydrogen atom, a C1-C6 alkyl group, or a C1-C6 alkoxy group, R2 represents a halogen atom, R3 represents a hydrogen atom or a halogen atom, R4 represents a hydrogen atom or a halogen atom, and R5 represents a C1-C3 alkylsulfonyl group, a substituted C1-C6 alkyl group, a substituted C1-C6 haloalkyl group, a substituted C1-C6 alkoxy group, or a substituted C1-C6 alkylamino group, or a pharmacologically acceptable salt thereof.
Type:
Application
Filed:
October 22, 2019
Publication date:
November 18, 2021
Applicants:
DAIICHI SANKYO COMPANY, LIMITED, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Takashi Tsuji, Yasunobu Kurosaki, Koutaro Ishibashi, Anthony B. Pinkerton
Abstract: Various embodiments for a median barrier finishing machine are described. A median barrier finishing machine may include a housing configured to encapsulate at least a portion of a median barrier, where the housing comprises a first vertical wall, a second vertical wall, and a horizontal wall. The median barrier finishing machine may include at least one adjustable member configured to couple the housing to the vehicle and retain the housing a predetermined distance relative to the vehicle while the vehicle is in motion. Further, the median barrier finishing machine may include at least one finishing device disposed within the housing, where the at least one finishing device is configured to contact a surface of a median barrier at least partially positioned within the housing and treat the surface as the vehicle moves the housing along a length of the median barrier.
Type:
Grant
Filed:
October 10, 2019
Date of Patent:
November 2, 2021
Assignee:
Sanford-Meyer, LLC
Inventors:
Elmore Starr Sanford, David Dwight Meyer
Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —N? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.
Type:
Grant
Filed:
April 20, 2020
Date of Patent:
October 26, 2021
Assignee:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Takuya Ikeda, Yoshiyuki Kobayashi, Naoki Miyoshi, Osamu Suzuki, Takahiro Nagayama, Takashi Tsuji, Layton H. Smith, Anthony B. Pinkerton
Abstract: The writing instrument includes a body, a nosecone, and an adapter. The body, nosecone, and adapter each include a generally hollow tubular shape and an inner surface, outer surface, first end, and second end. The first end of the adapter is coupled to the second end of the nosecone. The second end of the adapter is configured to slidably couple to the first end of the body. The writing instrument includes a writing element with a mounting end and a writing end. The mounting end of the writing element is removably coupled to a second end of the body. The adapter includes a track and the track includes a recessed channel in the outer surface of the adapter. The body includes at least one protrusion that extends inwards from the inner surface of the body. The protrusion slidably engages with the track of the adapter.
Type:
Grant
Filed:
September 26, 2018
Date of Patent:
October 19, 2021
Assignee:
SANFORD, L.P.
Inventors:
Kyle Cauwels, David Moraski, James Bergman
Abstract: Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject.
Type:
Application
Filed:
June 8, 2021
Publication date:
September 30, 2021
Applicant:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Daniel Kelly, Richard Vega, Hampton Sessions, Teresa Leone, Byungyong Ahn, Satyamaheshwar Peddibhotla
Abstract: Cassettes and associated label printers are provided. A cassette includes a plurality of surfaces, with a base surface, a top surface, and at least one side surface extending between the base surface and the top surface, wherein the plurality of surfaces at least partially define a volume for dispensably containing a supply of label material, an outlet that provides a path to dispense the supply of label material from the volume, and a locking portion for engaging a complementary locking element of a label printer. The cassettes also include one or more conductive areas or bars associated with the surface(s) of the cassette, which are configured to engaged a corresponding conductive area of the label printer.
Abstract: Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Type:
Grant
Filed:
January 10, 2020
Date of Patent:
September 7, 2021
Assignee:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Nicholas David Peter Cosford, Mitchell Dennis Vamos