Patents Assigned to Sanford
  • Methods and compositions using peptides and proteins with C-terminal elements
    Patent number: 11059718
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: July 13, 2021
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Anti-clog cap and associated containers and methods
    Patent number: 11053056
    Abstract: Glue bottle anti-clog caps are provided. The anti-clog cap has a body with a mounting section for attaching the body to a glue bottle. The body of the anti-clog cap has a dispensing section that includes a central lumen extending from the second mounting end. The body of the anti-clog cap also has a tip section with a support rib protruding from an outlet of the dispensing section. The tip has a tip plug protruding from the support rib. The anti-clog cap has a nozzle that mates to the body and a tip orifice aligned with the tip plug of the body. The tip section is configured to allow the free flow of glue through the cap. The nozzle can rotate between an open and closed position. In the closed position the tip plug can extend into the tip orifice thereby preventing the flow of glue.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: July 6, 2021
    Assignee: Sanford, L.P.
    Inventors: Craig P. E. Davidson, Ryan Heiser, Joseph Wayne Kreft, Patrick Kevin Shields
  • Sulfonamide compounds
    Patent number: 11046710
    Abstract: The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: June 29, 2021
    Assignees: Daiichi Sankyo Company, Limited, Sanford Burnham Prebys Medical Discovery Institute
    Inventors: Shojiro Miyazaki, Masaharu Inui, Yasunobu Kurosaki, Yuko Yamamoto, Masanori Izumi, Kaori Soma, Anthony Pinkerton, Masamichi Kishida
  • TARGETED DELIVERY SYSTEM AND METHODS OF USE THEREFOR
    Publication number: 20210188909
    Abstract: Disclosed are peptides and peptidomimetics that in some embodiments include the amino acid sequence KRGARST or (SEQ ID NO: 1), AKRGARSTA or (SEQ ID NO: 2), or CKRGARSTC (SEQ ID NO: 3).
    Type: Application
    Filed: June 1, 2020
    Publication date: June 24, 2021
    Applicant: Sanford Burnham Prebys Medical Discovery Institute
    Inventors: Tambet Teesalu, Erkki Ruoslahti, Kazuki Sugahara, Shweta Sharma
  • Monorail mircocatheter and methods for use
    Patent number: 11027097
    Abstract: The present disclosure provides a catheter including a first tubular structure defining a first lumen, the first tubular structure having a first end and a second end. The catheter may also include a second tubular structure defining a second lumen, the second tubular structure having a first end and a second end. The catheter may also include an aperture between the first tubular structure and the second tubular structure. The aperture is located at the first end of the second tubular structure. A first portion of the first tubular structure extends beyond the aperture, and the second tubular structure is positioned adjacent to a second portion of the first tubular structure.
    Type: Grant
    Filed: January 13, 2018
    Date of Patent: June 8, 2021
    Assignee: Sanford Health
    Inventors: Thomas Haldis, Alexander Drofa
  • Slide guide catheter and methods for use thereof
    Patent number: 11027093
    Abstract: The present disclosure provides a catheter system and methods for use that includes (a) a first catheter having a first end and a second end, where the first catheter has a first diameter, (b) a second catheter having a first end and a second end, where the second catheter has a second diameter that is less than the first diameter of the first catheter, and where the second catheter is positioned at least partially within a lumen of the first catheter and is moveable relative to the first catheter, and (c) a wire having a first end and a second end, where the first end of the wire is coupled to the second catheter.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 8, 2021
    Assignee: Sanford Health
    Inventors: Thomas Haldis, Alexander Drofa
  • Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof
    Patent number: 11028061
    Abstract: Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 8, 2021
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Daniel Kelly, Richard Vega, Hampton Sessions, Teresa Leone, Byungyong Ahn, Satyamaheshwar Peddibhotla
  • Formulations for tailored drug release
    Patent number: 11013832
    Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: May 25, 2021
    Assignees: South Dakota Board of Regents, Sanford Health
    Inventors: Gopinath Mani, Sujan Lamichhane, Jordan Anderson, Tyler Remund, Patrick W. Kelly
  • Sulfonamide compounds
    Patent number: 11014939
    Abstract: The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 25, 2021
    Assignees: Daiichi Sankyo Company, Limited, Sanford Burnham Prebys Medical Discovery Institute
    Inventors: Shojiro Miyazaki, Masaharu Inui, Yasunobu Kurosaki, Yuko Yamamoto, Masanori Izumi, Kaori Soma, Anthony Pinkerton, Masamichi Kishida
  • Implant and coating to reduce osteolysis
    Patent number: 11007303
    Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: May 18, 2021
    Assignees: University of Central Florida Research Foundation, Inc., Sanford Burnham Prebys Medical Discovery Institute
    Inventors: Sudipta Seal, Soumen Das, William Self, Dwight Towler
  • Inhibitors of cancer invasion, attachment, and/or metastasis
    Patent number: 11008325
    Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: May 18, 2021
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Paul B. Fisher, Maurizio Pellecchia, Swadesh K. Das, Timothy P. Kegelman, Bainan Wu, Surya K. De, Jun Wei, Mitchell E. Menezes, Luni Emdad
  • Agonists of the apelin receptor and methods of use thereof
    Patent number: 10988475
    Abstract: Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions. The present invention is based on the seminal discovery of a series of potent small molecule agonists of the apelin receptor, which are useful for the treatment of diseases including heart failure, chronic kidney disease, hypertension, and metabolic disorders such as insulin resistance/diabetes and obesity. The compounds disclosed herein are highly specific for the apelin receptor versus the angiotensin II receptor (ATI).
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: April 27, 2021
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Layton H. Smith
  • Glue slime activator and associated methods and kits
    Patent number: 10974159
    Abstract: Glue slime activator compositions, kits comprising glue slime activator compositions and a glue or adhesive of appropriate functionality for crosslinking, and methods of making glue slime activator compositions are provided herein.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: April 13, 2021
    Assignee: Sanford, L.P.
    Inventors: Craig Davidson, Luanne Armstrong, Joseph Wayne Kreft, Jennifer Lauren Kroon, Bryan Stephen Koepp, Lien Hoang Phun
  • Methods and compositions for theranostic nanoparticles
    Patent number: 10973925
    Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 13, 2021
    Assignees: University of Central Florida Research Foundation Inc., Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Memorial Sloan Kettering Cancer Center
    Inventors: Annette Khaled, Jesus Manuel Perez Figueroa, Santimukul Santra, Charalambos Kaittanis, Oscar Santiesteban, Jan Grimm, Hampton Sessions
  • BTLA fusion protein agonists and uses thereof
    Patent number: 10961297
    Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 30, 2021
    Assignees: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, PFIZER INC.
    Inventors: Carl F. Ware, John Sedy, Tigran Aivazian, Brian Miller, Natasha K. Crellin
  • BIOACTIVE GREEN-LIPPED MUSSEL EXTRACTS AND USES THEREOF
    Publication number: 20210077540
    Abstract: A biologically active non-lipid extract comprising of an isolated molecular weight fraction of <10 kDa or <1 kDa derived from New Zealand green-lipped mussels (Perna canaliculus). The extract exhibits biological activity selected from one or more of antihypertensive activity, antioxidant activity, antimicrobial activity, antiviral activity, and antiparasitic activity. The extract includes a plurality of biologically active substances selected from the group having free amino acids; peptides; cryptides; sugars and/or sugar-containing compounds including nucleosides and their derivatives; carbohydrates including glycoconjugates such as glycosides, glycosylamines, glycoproteins, glycopeptides, peptidoglycans; nitrogen-containing compounds including purines; phenolic compounds; minerals; metabolites.
    Type: Application
    Filed: March 27, 2019
    Publication date: March 18, 2021
    Applicant: SANFORD LIMITED
    Inventor: Hong (Sabrina) TIAN
  • Anti-BCMA polypeptides and proteins
    Patent number: 10925969
    Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize B-Cell Maturation Antigen (BCMA) are disclosed. Chimeric antigen receptors (CARs), anti-BCMA binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer and methods of treating or preventing cancer are also disclosed.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: February 23, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Service, Sanford Research
    Inventors: Ira H. Pastan, Tapan Bera, Satoshi Nagata, Tomoko Ise, Yasuhiro Abe
  • Writing instrument sharpener
    Patent number: D919004
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: May 11, 2021
    Assignee: Sanford, L.P.
    Inventors: Michael Alan Jourden, Sarah Morgan Gorlick, Daniel Patrick Sedlecky, III
  • Writing instrument
    Patent number: D921753
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: June 8, 2021
    Assignee: Sanford, L.P.
    Inventors: Hanna Tsuhara, Jacob Ballard, Melanie Kregg, Camila Sayuri Luppi Sato, Craig Davidson
  • Writing instrument
    Patent number: D921754
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: June 8, 2021
    Assignee: Sanford, L.P.
    Inventors: Paul Julius Martus, Ryan Heiser, Hanna Tsuhara