Abstract: The present application relates to shock absorbers for injection devices. According to a first aspect, this specification discloses an injection device including: a medicament container; a stopper translatably disposed within the medicament container; and a plunger rod including: a plunger rod body; and a shock absorber, wherein the plunger rod is operable to displace the stopper; and wherein the shock absorber contacts the stopper during displacement of the stopper by the plunger rod, thereby reducing an impact force between the plunger rod and the stopper.

Abstract: This disclosure relates to antigenic respiratory syncytial virus (RSV) polypeptides for use in eliciting antibodies against RSV. Also disclosed are antigenic polypeptides comprising an RSV polypeptide and a ferritin protein.

Abstract: A device comprising at least one camera, a display, a memory and a processor, the memory storing instructions which, when executed by the processor, cause the device to: display, using the display of the device, a content to be reviewed by the user; detect, using the camera of the device, user's eyes; detect, using the camera of the device, user's eye movements; determine, based on the detected user's eye movements, whether the user has reviewed the content.

Abstract: The present invention concerns antibodies and antigen-binding fragments of antibodies which specifically bind to and neutralize Chikungunya virus (CHIKV) and which are engineered to develop therapeutics in order to treat CHIKV disease or prevent CHIKV infection. The invention also relates to pharmaceutical compositions comprising antibodies of the invention and the use of the antibodies for the prevention and treatment of CHIKV disease.

Abstract: A safety device for a medicament container includes a first sheath having a first ledge and a second ledge, a second sheath telescopically arranged with the first sheath and releasably coupled to the first ledge, and a finger flange having at least one resilient clip adapted to engage the second ledge first sheath.

Abstract: Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A drive train for a wind-up injection device, comprises a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle coupled with a button, a rotationally drivable expelling mechanism, and a clutch element coupled with the torsional energy storage via the rotatable element and comprising a ratchet for maintaining the rotatable element at one of a number of discrete angular positions, wherein via the rotatable element, the clutch element is adapted to transmit a torque from the user handle to the torsional energy storage or from the torsional energy storage to the expelling mechanism, and wherein the ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage, and wherein the drive train is adapted to dampen torque peaks by a flexible impact portion in the area of the clutch element.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: Herein is provided a novel process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate by a Suzuki coupling of compound (3), wherein LG represents a leaving group, with an organoboron reagent: Compound (3) is obtained by activation of compound (4) with a leaving group LG, and compound (4) is obtained by alpha-arylation of methyl 5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxylate with 1-LG?-2,4-dichlorobenzene, wherein LG? represents a leaving group:

Abstract: The present disclosure provides antigen-binding proteins specifically binding GPRC5D, as well as respective antibodies in enhanced ADCC formats, and methods of using them to treat cancers such as multiple myeloma.

Abstract: Provided are methods for identifying and treating patients with cancer, where the cancer expresses CEACAM5. The methods include measuring circulating CEA to identify patients likely to benefit from treatment with an agent specific for CEACAM5. Such patients can have high circulating CEA and only low or medium expression of CEACAM5 on tumor cells as measured by immunohistochemistry (IHC). The agent specific for CEACAM5 can be tusamitamab ravtansine. Such agent can be used in combination with one or more additional agents to treat the cancer. In certain embodiments the cancer is non-squamous non-small cell lung cancer (NSQ NSCLC).

Abstract: Data collection devices for attachment to injection devices are disclosed. In one embodiment, the data collection device includes: a body attachable to a dial member of the injection device, a sensor arrangement comprising a sensor and a scale, and a processor. The sensor is configured to detect a rotation of the body relative to a trigger of the injection device. The processor is configured to detect a rotation of the body relative to the trigger. One of the sensor and the scale is arranged in or on the body and wherein the other one of the sensor and the scale is located on the trigger or is rotationally lockable to the trigger configured to detect a rotation of the body relative to the trigger.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: An injector device includes a housing for receiving a medicament cartridge; a needle unit comprising a needle; and a first sleeve slideable along a longitudinal axis of the housing from a first position, in which the first sleeve conceals the needle, to a second position, in which the needle is exposed from an end of the first sleeve, the first sleeve configured to engage the needle unit so that, during use, movement of the first sleeve from the first position to the second position moves the needle unit from a primary position to a secondary position, in which secondary position the needle unit locates over an end of a medicament cartridge, wherein the device further comprises a second sleeve arranged to move telescopically with respect to the first sleeve, the first sleeve extending from the second sleeve when the first sleeve is in the first position.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable excepients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compostions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.

Abstract: Implementations of the present disclosure are directed to a module for attachment to an injection device that includes a flexible carrier foil configured to be attached to a surface of the injection device independent of a geometry of the surface, at least one light emitting diode attached to the flexible carrier foil in a first position and configured to emit a light signal in a direction based on the first position through a transparent wall of the injection device, at least one photodiode attached to the flexible carrier foil in a second position relative to the first position, the at least one photodiode being configured to detect at least a portion of the light signal from a direction based on the second position and being configured to emit an electrical signal based on the light signal to a microprocessor, and wherein the microprocessor is configured to receive the electrical signal emitted by the photodiode and to determine the position of a stopper and the amount of the fluid within the injection dev