Patents Assigned to Schering AG
  • Patent number: 6933385
    Abstract: The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: August 23, 2005
    Assignee: Schering AG
    Inventors: Jurgen Westermann, Johannes Platzek, Orlin Petrov
  • Patent number: 6933395
    Abstract: Process for the production of drospirenone (6?,7?; 15?,16?-dimethylene-3-oxo-17?-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7?-(3-hydroxy-1-propyl)-6?,7?; 15?,16?-dimethylene-5?-androstane-3?,5,17?-triol (ZK 92836) and 6?,7?; 15?,16?-dimethylene-5?-hydroxy-3-oxo-17?-androstane-21,17-carbolactone (ZK 90965) as intermediate products of the process.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: August 23, 2005
    Assignee: Schering AG
    Inventors: Jörg-Thorsten Mohr, Klaus Nickisch
  • Patent number: 6930102
    Abstract: A compund of formula I, an epothilone derivative, its method of preparation, and use as a pharmaceutical agent in treating malignant tumors
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: August 16, 2005
    Assignee: Schering AG
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • Patent number: 6916461
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 12, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 6916921
    Abstract: The present invention relates to steroid compounds of general formula X, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by amino nitrogen bonded to C17 of the steroid skeleton via a spacer A.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: July 12, 2005
    Assignees: Schering AG, Novo Nordisk D/S
    Inventors: Thorsten Blume, Peter Esperling, Christa Hegele-Hartung
  • Patent number: 6914059
    Abstract: Compounds of formula I, their tautomeric and isomeric forms and salts, as well as the process for their production and their use in pharmaceutical agents are described.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: July 5, 2005
    Assignee: Schering AG
    Inventors: Hartmut Rehwinkel, Peter Hoelscher, Stefan Jaroch, Detlev Suelzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdonald McDonald
  • Patent number: 6908989
    Abstract: The invention relates to a process for the production of perbenzylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents benzyl, n means 2, 3 or 4, X means —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of perbenzylated saccharides with 1-O-functionalized side chains on an industrial scale.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: June 21, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Klaus-Dieter Graske
  • Patent number: 6903126
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: June 7, 2005
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • Patent number: 6897224
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I a process for their production and their use as inflammation inhibitors.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: May 24, 2005
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schäecke, Arndt. J. G. Schottelius
  • Publication number: 20050101673
    Abstract: The invention relates to the use of orally available prostacyclin derivatives for the production of a pharmaceutical agent for treating diseases that are associated with bone marrow edemas.
    Type: Application
    Filed: June 6, 2003
    Publication date: May 12, 2005
    Applicant: Schering AG
    Inventors: Cornelia Norden, Nicolas Aigner
  • Publication number: 20050101573
    Abstract: Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 12, 2005
    Applicants: Novo Nordisk A/S, Schering AG
    Inventors: Peter Faarup, Frederick Gronvald, Thorsten Blume, Anthony Murray, Jens Breinholt
  • Publication number: 20050090477
    Abstract: A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17? as well as of the grouping U-V-W-X-Y-Z are indicated in the claims.
    Type: Application
    Filed: July 24, 2003
    Publication date: April 28, 2005
    Applicant: Schering AG
    Inventors: Ludwig Zorn, Rolf Bohlmann, Norbert Gallus, Hermann Kuenzer, Hans-Peter Muhn, Reinhard Nubbemeyer
  • Patent number: 6884796
    Abstract: Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: April 26, 2005
    Assignees: NovoNordisk A/S, Schering AG
    Inventors: Peter Faarup, Frederick Christian Grønvald, Thorsten Blume, Anthony Murray, Jens Breinholt
  • Patent number: 6878750
    Abstract: This invention describes the new benzocycloheptenes of general formula I in which R1, R2 and SK have the meanings that are indicated in the description. The new compounds have selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: April 12, 2005
    Assignee: Schering AG
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • Patent number: 6872197
    Abstract: The invention relates to a reservoir (100) for dispensing free-flowing substances, which comprises the following features: (a) reservoir (100) has flexible reservoir walls (2 and 3); (b) reservoir walls (2 and 3) are one-piece or connected to one another; (c) reservoir walls (2 and 3) form a sealed container, which has at least one opening (12); (d) reservoir walls (2 and 3) are connected at least partially to at least two flat standing elements (6), which are separated in the standing area of reservoir walls (2 and 3); (e) opening (12) has a closure (13), whereby at least portions of reservoir walls (2 and 3) and/or standing elements (6) consist of a composite material, which (i) consists of plastic laminates, or (ii) consists of at least one plastic laminate and an aluminum laminate, here, the laminates are connected to one another. Reservoir (100) is provided preferably to accommodate contrast media.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: March 29, 2005
    Assignee: Schering AG
    Inventor: Norbert Witowski
  • Patent number: 6872180
    Abstract: In the quantification of bodies, especially bubbles, in ultrasonic diagnosis, the problem exists that the concentration of bodies, especially bubbles, is often so high that the image data that is obtained relative to the visualization becomes saturated, such that a quantification is impossible. To solve this problem, it is proposed that the bodies that are contained in the sectional layers of an object under examination first be excited by means of ultrasound to produce characteristic signals and to pick up these signals, to form data sets from the signals, to convert the data sets into an image of the body arrangement in the object under examination and to determine the number of bodies therefrom, whereby at least two ultrasonic signal sets from overlapping sectional layers in the object under examination are picked up.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: March 29, 2005
    Assignee: Schering AG
    Inventors: Michael Reinhardt, Peter Hauff, Andreas Briel
  • Patent number: 6872381
    Abstract: This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain barrier and bind to the CCR1 receptor present in brain tissue of patients having Alzheimer's disease.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: March 29, 2005
    Assignee: Schering AG
    Inventors: Christoph-Stephan Hilger, Bernd Johannsen, Joerg Steinbach, Peter Maeding, Meredith Halks-Miller, Richard Horuk, Harald Dinter, Raju Mohan, Joseph E. Hesselgesser
  • Patent number: 6869941
    Abstract: A pharmaceutical dosage unit comprising drospirenone and an estrogen sulphamate, such as an estradiol sulphamate or an estriol sulphamate for use in hormone replacement therapy is disclosed. This, combination therapy may comprise continuous or discontinuous administration of drospirenone and/or the estrogen sulphamate, such as weekly administration of both agents or weekly administration of the estrogen sulphamate and daily administration of the drospirenone.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: March 22, 2005
    Assignee: Schering AG
    Inventor: Rolf Schuermann
  • Patent number: 6861043
    Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: March 1, 2005
    Assignee: Schering AG
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Patent number: 6855103
    Abstract: A radiolabeled implantable device includes a base, a first layer including Cu and a radioactive isotope on the base, and a second layer including Sn on the first layer. Preferably, the base is formed of stainless steel and the radioactive isotope is a radioisotope of Re, such as 188Re or 186Re. Alternately, radioisotopes of the following elements may be used: Be, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, As, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Sb, Te, Hf, Ta, W, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po, At, Th, Pa, U, Np, Pu, Am, Cm, Bk, Cf, Es, Fm, Md, No, Lr. In addition, a process for producing a radiolabeled implantable device includes depositing a first layer including Cu and a radioactive isotope on a base, and depositing a second layer including Sn on the first layer. The process may further include removing Cr2O3 from the base and/or rinsing the base prior to depositing the first layer thereon.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: February 15, 2005
    Assignee: Schering AG
    Inventors: Ludger Dinkelborg, Klaus Urich