Patents Assigned to Schering AG
  • Non-steroidal progesting
    Publication number: 20030232824
    Abstract: The present invention relates to non-steroidal progestins of the general formula (I) 1
    Type: Application
    Filed: March 11, 2003
    Publication date: December 18, 2003
    Applicant: Schering AG
    Inventors: Norbert Schmees, Manfred Lehmann, Ulrike Fuhrmann, Peter Muhn, Christa Hegele-Hartung, Michael Klotzbuecher
  • 11Beta-long-chain-substituted 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring
    Publication number: 20030229059
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring with a long-chain substituent in 11&bgr;-position of general formula II 1
    Type: Application
    Filed: March 27, 2003
    Publication date: December 11, 2003
    Applicant: Schering AG
    Inventors: Gerd Mueller, Jens Hoffmann, Karl-Heinrich Fritzemeier, Alexander Hillisch
  • Composition
    Patent number: 6653298
    Abstract: Disclosed and claimed are methods for oral contraception, or a hormone replacement therapy, or for treating breast cancer, in a patient in need thereof involving administering to the patient, at a dosage of no greater than 200 &mgr;g/day per 70 kg subject, a compound having Formula (I): wherein X in combination with K form a steroidal ring and R5 is a sulphamate group that has of the formula: wherein each of R1 and R2 is H.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: November 25, 2003
    Assignees: Sterix Limited, Schering AG
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Walter Elger, Gudrun Roddersen, Heinrich-Thomas Proske
  • Method for producing 4,4-dimethyl-3&bgr;-hydroxypregna-8, 14-diene-21-carboxylic acid esters and intermediate products obtained by said method
    Patent number: 6653491
    Abstract: The invention relates to a method for representing compounds of the general formula (1). The invention further relates to the hitherto unknown compounds of general formulas (5, 6 and 7) in the form of intermediate products and to the use of 4,4-dimethyl-3&bgr; hydroxypregna-8,14-diene-21-carboxylic acid esters of the general formula (1) for producing 4,4-dimethyl-5&agr;-cholesta-8,14,24-triene-3&bgr;-ol (2).
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: November 25, 2003
    Assignee: Schering AG
    Inventors: Jens Geisler, Eric Winter
  • Histone deacetylase inhibitor and use thereof
    Publication number: 20030216345
    Abstract: To provide a novel apoptosis inducer, and a method of screening an apoptosis inducer. For example, an apoptosis inducer comprising inhibiting HDAC6 such as an antisense oligonucleotide to the gene of histone deacetylase 6 (HDAC6), and anti-cancer agent comprising this apoptosis inducer, and the present invention also provides a method of screening an apoptosis inducer that inhibits HDAC6, and more specifically a method of screening an apoptosis inducer said method comprising the steps of (1) determining whether or not a test substance inhibits histone deacetylase 6 (HDAC6) by using deacetylation of an acetylated substance that can be a substrate for histone deacetylase 6 (HDAC6) or decrease in the expression of histone deacetylase 6 (HDAC6) as an index; and (2) confirming, when inhibition is present, whether it induces apoptosis of the cell in vitro and/or in vivo.
    Type: Application
    Filed: May 15, 2003
    Publication date: November 20, 2003
    Applicant: Schering AG
    Inventors: Osamu Nakanishi, Takayuki Tatamiya
  • Conjugates of macrocyclic metal complexes with biomolecules and their use for the production of agents for NMR diagnosis and radiodiagnosis as well as radiotherapy
    Publication number: 20030206865
    Abstract: The invention relates to conjugates that consist of macrocyclic metal complexes with biomolecules and their production. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as as agents for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Application
    Filed: July 19, 2002
    Publication date: November 6, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Gunther Michl, Thomas Frenzel, Detlev Sulzle, Hans Bauer, Bernd Raduchel, Hans-Joachim Weinmann, Henko Schirmer
  • Metal complex-containing pharmaceutical agents
    Publication number: 20030206858
    Abstract: Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
    Type: Application
    Filed: June 16, 2003
    Publication date: November 6, 2003
    Applicant: Schering AG
    Inventors: Heinz Gries, Ulrich Speck, Hanns-Joachim Weinmann, Hans Peter Niendorf, Wolfgang Seifert
  • Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
    Publication number: 20030203879
    Abstract: The invention relates to the calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid.kappa.N6,.kappa. N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) and its salts, pharmaceutical agents that contain these complexes, for the production of agents for the reduction of effects that are caused by heavy metals as well as processes for their production.
    Type: Application
    Filed: January 15, 2003
    Publication date: October 30, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzed, Ulrich Nieballa, Guenter Michl
  • (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
    Publication number: 20030194371
    Abstract: The invention relates to (ethylene)-(propylene)-triaminepentaacetic acid derivatives that are substituted on both the ethylene bridge and the propylene bridge, as well as conjugates of these compounds with biomolecules. The compounds and conjugates are suitable as agents for NMR diagnosis and radiodiagnosis as well as for radiotherapy.
    Type: Application
    Filed: July 10, 2002
    Publication date: October 16, 2003
    Applicant: Schering AG
    Inventors: Lutz Lehmann, Matthias Friebe, Christoph-Stephan Hilger, Ulrich Niedballa, Johannes Platzek, Bernd Raduchel
  • 17alpha-alkyl-17beta-oxy-estratrienes and intermediate products for their production, use of the 17alpha-alkyl-17beta-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations
    Publication number: 20030191099
    Abstract: The invention relates to 17&agr;-alkyl-17&bgr;-oxy-estra-1,3,5(10)-trienes that have an antiestrogenic action with general formula I. In addition, the invention also relates to 17-oxo-estra-1,3,5(10)-trienes as well as 17&bgr;-hydroxy-estra-1,3,5(10)-trienes as intermediate products in the production of the estratrienes according to the invention. The invention also relates to the use of 17&agr;-alkyl-17&bgr;-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations that contain at least one 17&agr;-alkyl-17&bgr;-oxy-estratriene as well as at least one pharmaceutically compatible vehicle.
    Type: Application
    Filed: November 27, 2002
    Publication date: October 9, 2003
    Applicant: Schering AG
    Inventors: Rolf Bohlmann, Nikolaus Heinrich, Rolf Jautelat, Jorg Kroll, Orlin Petrov, Andreas Reichel, Jens Hoffmann, Rosemarie Lichtner
  • Contraception method using competitive progesterone antagonists and novel compounds useful therein
    Publication number: 20030191102
    Abstract: Competitive progesterone antagonists, including two novel steroids, viz., 11&bgr;,19-[4-(cyanophenyl)-o-phenylene]-17&bgr;-hydroxy-17&agr;-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11&bgr;,19-[4-(3-pyridinyl)-o-phenylene]-17&bgr;-hydroxy-17&agr;-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one, inhibit formation of endometrial glands at below their ovulation inhibiting dose and the abortive dose, and thus achieve oral contraception in females without adversely affecting the menstrual cycle and without risk of aborting a previous implanted fertilized egg or a fetus.
    Type: Application
    Filed: March 31, 2003
    Publication date: October 9, 2003
    Applicant: Schering AG
    Inventors: Krzystof Chwalisz, Walter Elger, Karin Schmidt-Gollwitzer, Eckhard Ottow
  • Near infrared fluorescent contrast agent and fluorescence imaging
    Publication number: 20030180221
    Abstract: A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.
    Type: Application
    Filed: December 20, 2002
    Publication date: September 25, 2003
    Applicant: Schering AG
    Inventors: Naoto Miwa, Michihito Inagaki, Hiroaki Eguchi, Masafumi Okumura, Yoshio Inagaki, Toru Harada
  • C1-C6-epothilone fragments and process for the production of C1-C6-fragments of epothilones and derivatives thereof
    Publication number: 20030176710
    Abstract: This invention describes C1-C6-epothilone fragments and an efficient process for the production of C1-C6-fragments of epothilones and derivatives thereof.
    Type: Application
    Filed: December 23, 2002
    Publication date: September 18, 2003
    Applicant: Schering AG
    Inventors: Ulrich Klar, Markus Berger, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa
  • Oral fludara of high-purity formulation with quick release of active ingredient
    Publication number: 20030176391
    Abstract: This invention relates to a quick-release tablet formulation with >99.19% pure fludara (high-purity fludara) as an active ingredient in a defined composition of residual contaminants.
    Type: Application
    Filed: December 20, 2002
    Publication date: September 18, 2003
    Applicant: Schering AG
    Inventors: Wolfgang Heil, Ulf Tistam, Ralph Lipp, Johannes-Wilhelm Tack
  • Industrially applicable process for the sulfamoylation of alcohols and phenols
    Publication number: 20030171346
    Abstract: This invention describes a safe method for the production of sulfamoyl chloride from chlorosulfonyl isocyanate and formic acid in the presence of a amide catalyst, taming the hazardous nature of this reaction by circumventing heat accumulation processes, as well as the sulfamoylation of alcohols and phenols with the resulting sulfamoyl chloride in N,N-dimethyl acetamide or N-methyl pyrrolidone thereby avoiding the formation of side-products which were inevitable with the methods of the prior art using dimethyl formamide or dichloromethane as a solvent. The current invention allows industrial scale applications and describes as an example the process of manufacture of the biologically active compound 17&bgr;-Hydroxyestra-1,3,5(10)-triene-3-yl sulfamate.
    Type: Application
    Filed: December 23, 2002
    Publication date: September 11, 2003
    Applicant: Schering AG
    Inventors: Jens Geisler, Frank Schneider, Fernando Lopez Holguin, Kai Lovis
  • 8Beta-substituted 11beta-aryl-estra-1,3,5,(10)-triene derivatives
    Publication number: 20030171345
    Abstract: This invention relates to 11&bgr;-(para-substituted)phenyl-estra-1,3,5(10)-trienes with a straight-chin or branched-chain, optionally partially or completely halogenated alkyl radical or alkenyl radical in each case with up to 5 carbon atoms, an ethinyl radical or prop-1-inyl radical in 8&bgr;-position.
    Type: Application
    Filed: October 15, 2002
    Publication date: September 11, 2003
    Applicant: Schering AG
    Inventors: Nico Brauer, Olaf Peters, Alexander Hillisch, Christa Hegele-Hartung, Peter Muhn
  • Vitamin D derivatives with acyloxy groups in the side chains, process for their production, and the use for the production of pharmaceutical agents
    Publication number: 20030166622
    Abstract: The invention relates to vitamin D derivatives of general formula I, 1
    Type: Application
    Filed: November 13, 2002
    Publication date: September 4, 2003
    Applicant: Schering AG
    Inventors: Andreas Steinmeyer, Ulrich Zuegel
  • Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens
    Publication number: 20030162974
    Abstract: The invention relates to intermediate products and a new process for the production of benzocycloheptene C.
    Type: Application
    Filed: October 15, 2002
    Publication date: August 28, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Wolfgang Beckmann, Jens Geisler, Holger Kirstein, Ulrich Niedballa, Eckhard Ottow, Sigmar Radau, Claudia Schulz, Thomas Wessa
  • 16-Halogen-epothilone derivatives, method for producing them and their pharmaceutical use
    Patent number: 6610736
    Abstract: The invention relates to novel epothilone derivatives of general formula (I), wherein R8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the meanings given in the description. The novel compounds are suitable for producing medicaments.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: August 26, 2003
    Assignee: Schering AG
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • Contraception method using competitive progesterone antagonists and novel compounds useful therein
    Patent number: 6608074
    Abstract: Competitive progesterone antagonists, including two novel steroids, viz., 11&bgr;,19-[4-(cyanophenyl)-o-phenylene]-17&bgr;-hydroxy-17&agr;-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11&bgr;,19-[4-(3-pyridinyl)-o-phenylene]-17&bgr;-hydroxy-17&agr;-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one, inhibit formation of endometrial glands at below their ovulation inhibiting dose and the abortive dose, and thus achieve oral contraception in females without adversely affecting the menstrual cycle and without risk of aborting a previous implanted fertilized egg or a fetus.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: August 19, 2003
    Assignee: Schering AG
    Inventors: Krzystof Chwalisz, Walter Elger, Karin Schmidt-Gollwitzer, Eckhard Ottow