Patents Assigned to Schering AG
  • Folding box with fold-down attachment flap
    Publication number: 20040099564
    Abstract: The invention relates to a sealable folding box in the shape of a parallelepiped or cube with attached bottom and cover flaps and an attachment flap—provided with an attachment recess—that is arranged on an edge of the folding box body that extends between these flaps. To this end, the folding-box body—seen in the lengthwise direction of the matrix—has a sealing flap on one end and a combination section on the other end. The combination section consists of an inside area and at least one outside area, whereby the inside area is an attachment flap—provided with an attachment recess—while the outside area is used to attach the combination section to the side wall with which it is in contact.
    Type: Application
    Filed: July 17, 2003
    Publication date: May 27, 2004
    Applicant: Schering AG
    Inventors: Sabine Leifeld, Michael Fuchs
  • Process for the overexpression of dehydrogenases
    Publication number: 20040091987
    Abstract: A process for the overexpression of dehydrogenases, especially for the overexpression of &Dgr;1-dehydrogenases, in particular for the overexpression of 3-keto steroid-&Dgr;1-dehydrogenases, as well as for the bacteria, plasmids and DNA sequences that can be used for the overexpression, is described.
    Type: Application
    Filed: January 31, 2003
    Publication date: May 13, 2004
    Applicant: Schering AG
    Inventor: Tilman Spellig
  • Device and process for quantifying bodies by means of ultrasound
    Publication number: 20040092820
    Abstract: In the quantification of bodies, especially bubbles, in ultrasonic diagnosis, the problem exists that the concentration of bodies, especially bubbles, is often so high that the image data that is obtained relative to the visualization becomes saturated, such that a quantification is impossible. To solve this problem, it is proposed that the bodies that are contained in the sectional layers of an object under examination first be excited by means of ultrasound to produce characteristic signals and to pick up these signals, to form data sets from the signals, to convert the data sets into an image of the body arrangement in the object under examination and to determine the number of bodies therefrom, whereby at least two ultrasonic signal sets from overlapping sectional layers in the object under examination are picked up.
    Type: Application
    Filed: March 28, 2003
    Publication date: May 13, 2004
    Applicant: Schering AG
    Inventors: Michael Reinhardt, Peter Hauff, Andreas Briel
  • 17alpha-fluoroalkyl-11beta-benzaldoxime steroids, process for their production, pharmaceutical preparations that contain these steroids as well as their use for the production of pharmaceutical agents
    Publication number: 20040092492
    Abstract: Compounds of general formula I as well as their pharmaceutically compatible salts are described, in which R1 stands for hydrogen, C1- to C6-alkyl, COR4, COOR4, COSR4 or CONHR5, in which R4 is C1- to C6-alkyl or unsubstituted or substituted aryl and in which R5 is hydrogen, C1- to C6-alkyl or unsubstituted or substituted aryl, in which R2 also stands for hydrogen, C1- to C6-alkyl or C1- to C6-acyl, and R3 stands for a CnF2n+1 group, in which n=1, 2 or 3, or a CH2O(CH2)mCnF2n+1 group, in which m=0 or 1 and n=1, 2 or 3. In addition, a process for the production of the compounds with general formula I is indicated. The compounds can be used for the production of pharmaceutical agents.
    Type: Application
    Filed: May 5, 2003
    Publication date: May 13, 2004
    Applicant: Schering AG
    Inventors: Sven Ring, Gerd Schubert, Ingo Tornus, Guenter Kaufmann, Walter Elger, Birgitt Schneider
  • 9-alpha-substituted estratrienes as selectively active estrogens
    Publication number: 20040087565
    Abstract: This invention describes the new 9&agr;-substituted estratrienes of general formula I 1
    Type: Application
    Filed: June 11, 2003
    Publication date: May 6, 2004
    Applicant: Schering AG
    Inventors: Dirk Kosemund, Gerd Mueller, Alexander Hillisch, Karl-Heinrich Fritzemeier, Peter Muhn
  • 14, 15-cyclopropanosteroids of the 19-norandrostane series, method for producing said compounds and pharmaceutical preparation containing said compounds
    Patent number: 6723715
    Abstract: The invention relates to the new 14,15-cyclopropanoandrosteroids of the 19-norandrostane series of the general formula (I) their synthesis and to pharmaceutical compositions containing these compounds. The compounds of formula (I) have an interesting, mixed androgen/gestagen profile, the androgenic or gestagenic activity predominating, depending on the substitution.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: April 20, 2004
    Assignee: Schering AG
    Inventors: Sven Ring, Walter Elger, Guenter Kaufmann
  • CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
    Publication number: 20040063737
    Abstract: This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Application
    Filed: October 27, 2003
    Publication date: April 1, 2004
    Applicant: Schering AG
    Inventors: Ulrich Lucking, Martin Kruger, Rolf Jautelat, Olaf Prien, Gerhard Siemeister, Alexander Ernst
  • Method for fertility control
    Publication number: 20040058975
    Abstract: The present invention relates to a method for impairing cumulus expansion and oocyte maturation, the method comprising antagonizing EP2 receptor and/or inhibiting cyclooxygenase COX-2. The invention also relates to the use of a pharmaceutical composition comprising an EP2 receptor antagonist (optionally with one or more COX inhibitors) for female contraception.
    Type: Application
    Filed: June 26, 2003
    Publication date: March 25, 2004
    Applicant: Schering AG
    Inventors: Bernhard Lindenthal, Bernd Buchmann, Werner Skuballa, Christa Hegele-Hartung
  • Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharamceutical compositions containing these compounds
    Patent number: 6710039
    Abstract: The invention relates to new unsaturated 14,15-cyclopropano-androstanes of the general formula (I) to their synthesis and to pharmaceutical compositions, containing these compounds. The compounds of formula (I) have gestagenic and/or androgenic activity.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: March 23, 2004
    Assignee: Schering AG
    Inventors: Sven Ring, Walter Elger, Guenter Kaufmann
  • Selected anthranilaminde pyridinamides and their use as pharmaceutical agents
    Publication number: 20040039019
    Abstract: Selected anthranilamide pyridinamines of general formula I 1
    Type: Application
    Filed: June 19, 2003
    Publication date: February 26, 2004
    Applicant: Schering AG
    Inventors: Andreas Huth, Martin Krueger, Ludwig Zorn, Stuart Ince, Karl-Heinz Thierauch, Andreas Menrad, Martin Haberey, Holger Hess-Stumpp
  • Treatment of hypertension in women receiving hormone replacement therapy
    Publication number: 20040034001
    Abstract: A method is described to lower blood pressure and effect hormone replacement therapy (HRT) in a hypertensive woman receiving HRT, comprising administering to the woman effective amounts of drospirenone and an estrogen. In one embodiment, the woman is already taking hypertensive medicine when the method is carried out.
    Type: Application
    Filed: April 24, 2003
    Publication date: February 19, 2004
    Applicant: Schering AG
    Inventor: Adel H Karara
  • Use of Epothilones in the treatment of brain diseases associated with proliferative processes
    Publication number: 20040019088
    Abstract: This invention provides the use of an Epothilone, which shows an average distribution coefficient between plasma and brain of 0.3 to 1.5 in the mouse intravenous bolus injection assay, for the preparation of a medicament for the treatment of a brain disease associated with proliferative processes.
    Type: Application
    Filed: February 28, 2003
    Publication date: January 29, 2004
    Applicant: Schering AG
    Inventors: Rosemarie Lichtner, Andrea Rotgeri, Ulrich Klar, Jens Hoffmann, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa
  • 16-halogen-epothilone derivatives, process for their production, and their pharmaceutical use
    Publication number: 20040014978
    Abstract: The invention relates to novel epothilone derivatives of general formula (I), wherein R8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the meanings given in the description. The novel compounds are suitable for producing medicaments.
    Type: Application
    Filed: February 12, 2003
    Publication date: January 22, 2004
    Applicant: Schering AG
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • 11-Beta substituted 19-nor-17-alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring
    Publication number: 20040014735
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring with a long-chain substituent in 11&bgr;-position of general formula II 1
    Type: Application
    Filed: March 27, 2003
    Publication date: January 22, 2004
    Applicant: Schering AG
    Inventors: Alexander Hillisch, Walter Elger, Rolf Bohlmann, Jens Hoffmann
  • Piperazine derivatives that destabilize androgen receptors
    Publication number: 20040009969
    Abstract: This invention relates to new piperazine derivatives of general formula I, 1
    Type: Application
    Filed: November 22, 2002
    Publication date: January 15, 2004
    Applicant: Schering AG
    Inventors: Arwed Cleve, Christoph Huwe, Volker Schulze, Helmut Morack, Dieter Zopf, Jens Hoffmann, Andreas Reichel
  • Process for the production of 7alpha-methyl steroids
    Publication number: 20040010138
    Abstract: This invention relates to a process for the production of 7&agr;-methyl steroids of general formula I, 1
    Type: Application
    Filed: March 21, 2003
    Publication date: January 15, 2004
    Applicant: Schering AG
    Inventors: Marc Willuhn, Orlin Petrov, Evelin Amoulong-Kirstein, Stephan Vettel, Agnes Matzeit
  • Process for the production of monoamides of DTPA
    Patent number: 6677483
    Abstract: A new process for the preparation of diethylenetriaminepentaacetic-monoamides in which amines can be reacted with sensitive groups, a higher mono/diamide selectivity is achieved, a higher yield of monoamide is achieved and has a simple reaction scheme and working-up.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: January 13, 2004
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa
  • Methods for diagnosis and treatment of tumours
    Publication number: 20040001790
    Abstract: The present invention relates to new methods for diagnosis and treatment of tumours, using novel peptides for binding radionuclides.
    Type: Application
    Filed: January 3, 2003
    Publication date: January 1, 2004
    Applicant: Schering AG
    Inventors: Christoph-Stephan Hilger, Dietmar Berndorff, Ludger Dinkelborg, Dieter Moosmayer, Giovanni Neri
  • 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring
    Patent number: 6670347
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring of formula II, process for their production and pharmaceutical preparations that contain these compounds as well as 17&agr;-cyanomethylated estra-1,3,5(10)-trienes, which produce intermediate products on the way to the 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols. The 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols produce novel selective estrogens, which contrast to standard estrogens, such as estradiol, show a preference for one of the two known estrogen receptors, estrogen receptor alpha.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: December 30, 2003
    Assignee: Schering AG
    Inventors: Gerd Müller, Uwe Kollenkirchen, Dirk Kosemund, Karl-Heinrich Fritzemeier, Walter Elger
  • Perfluoroalkyl group-containing micelle-forming triiodoaromatic compounds, process for their production and their use as contrast media
    Publication number: 20030236407
    Abstract: The invention relates to new, perfluoroalkyl group-containing triiodoaromatic compounds, process for their production, their use as contrast media for x-ray diagnosis as well as for magnetic resonance diagnosis and magnetic resonance spectroscopy by means of fluorine measurement. Subjects of the invention are also diagnostic agents that contain these new compounds.
    Type: Application
    Filed: February 28, 2003
    Publication date: December 25, 2003
    Applicant: Schering AG
    Inventors: Markus Schafer, Bernd Raduechel, Heribert Miklautz, Franz Maier